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2. CC VI 2 k TOR SE WE KA EX AE IE ag C2 iyis B HF W AST GOT ALT GPT 2 3 4
3. VI 8 ME 1 15 15 3 inerte Pres 15 4 15 Vi 9 RE DAS TE A PER EEP RP TPE 15 VI 10 15 VI 11 15 VI 12 ARRA KIET RA 15 V 13 EG RR RC GAR SR PUS DE SEE GA ER 15 WW 14 16 VI 15 1 i EG EE LE E E E EE 16 VI 16 ZA 16 IX St SR Ad RD RDS 17 TX 1 A EeeNker 17 IX 2 ROY du NT a RN 17 O 17 2 WR aie Peur ee Lane fe ue ane 17 3 RE ED EEEIEE 17 4
4. VI 8 1 1 3 I ji Y 7 1 VI
5. 2 AK D VE A AS Hd AR AIO PTE dl VE AKIO piwe m E H t PA A AI D piwe IL PE H 8 1
6. 15 1 Las D aL AF nhi CCE 3 HIT HIT 100 WW 2 VI 6 6 16 IX
7. Drug Sef et y Updat a I I 1 H 1 1 2 DFA 2 II CAS 1 1 2 fi 3 1 ne ee K n TV
8. 250 mL 20mL Na 250 mL 200 mL 250 mL 20mL 2 1mL 200 250 20mL 1
9. 3 4 1 2 EE 3
10. 100 kg 56 200 400 kg 96 152 4 2 1 2 3 4 5 6 S 3 4 1 2 7 3 4 5 lt gt S
11. 2 3 4 5 6 TU 7
12. 1 2 1 20g 130mg 100g IERARHIE JS 9 LD 1500 2000mg kg P 2 250 kg 1 000 kg 15 3 7 14 1 000 3 000 kg 10 000 kg 4 5 180 240g 2 000 28
13. 6 Lis 7 8 9 E pee 4 5 200 mL 4 000 20mL 20mL 10 i 30 250 mL 5 000 20mL 20mL 10 30 i EMA CU Na 250 mL X 7 8
14. 15 55 VI N S 3 1 HHRE TOR 87 2 619 24 12 1 1 4 69 7 5 1 N S Les 7 RS 1 2 CYP450 3
15. FAX IF 2006 7 10 3
16. X 1 3 2 3 XX M 1 2 3 4 5
17. 40 1C du 75 5 RH ne 127 Lux hr Na 250 mL 20mL 25 2C ss 60 5 RH 40 1C 6 75 5 RH 127 Lux hr V 6 7
18. 10 5 4 RE RN ER ER EE RS 10 5 5 10 6 VI 5 11 6 D 11 6 2 CYP450 11 6 3 11 6 4 11 6 5 11 7 7 VI 6 DE ELERIN EE EE CS CE RL 11 1 PS SCT RE EE EE ET NP ER IE 11 2 HENE NNER ECE IE CRN SERRE 11 3 SA RR AE ES 11 VI 7 r Re PR Le ee nue ere Lena tan 11 1 SA 11 2 11 3 RS eS 11 VI 12 Vi 1 E 12 WW 2 RARE RE 12 VI 3
19. 2 3 Se 4 5 6 HIT heparin induced thrombocytopenia HIT 4 HIT
20. 1 1 2 3 HIT HIT
21. 2006 3 15 200 mL 21800AMZ10232 250 mL 21800AMZ10231 9 200 mL 2006 7 7 250 mL 200 6 7 7 10 11 12 13 99 En S 4 200 mL 3334402P1030 250 mL 3334402P2044 5 1 C 2624 2001 2 1485 2002 3 Goodman amp Gilman The Pharmacological Basis of Therape utics 8th ed 1313 1990 4 Howell W H Amer J Physiol 71 553 1925 5 Brinkh
22. pH 1 3 1 7 Na DO pH gt Na 200 mL 20mL pH 1 2 3 4 5 6 7 8 9 10 11 12 13 14 lt 10 0mL 10 OmL 0 1mol L HC1 0 1mo1 L NaOH 1 49 6 56 pH 12 73 Na 250 mL 20mL pH 1 2 3 4 5 6 7 8 9 10 11 12 13 14 lt 10 0mL 10 0mL 0 1mo1 L HC1 0 Imol L NaOH 1 45 6 56 pH 12 73 8 Na 154 mEq L C1 154 mEq L 0 9w v 9 10 11 V 12
23. 2 1 2 z heparin cofactor 59 3 VI 1 1 0 1 1 0 mL 2 3 3
24. 5 000 20 000 5 6 7 CAS 9041 08 1 i 1 H i 2 HD 2 1 2 95 3 4 ER 5 6 7 1 0g 100mL pH 6 0 8 0 3 4 5 V 1 1
25. HIT heparin induced thrombocytopenia HIT WI 6 6 WW 15 3 3 4 VI 5 6 1 DIC
26. in vitro 13 Jii 1mg 130 14 15 V 2 ns y Res Tr CC 2 Lee White WBAPTT 2 3 1 000
27. _ ww NN R e ns VE S
28. Na 200 mL 20mL 1 20mL 4 000 Na 250 mL 20mL 1 20mL 5 000 2 pH pH 5 5 7 1 BEI pH 3 0 9 1 1 4 2 1 Na 200 mL 20mL 1 20mL 4 000 Na 250 mL 20mL
29. 1 20mL 5 000 2 pH pH 3 RE FE V 3 4 WAAL 5 Na 200 mL 20mL 25 2 C PE 60 5 RH
30. 4 5 6 1 2 3 4 40 96 90 1e 3 3 4 40 96 90 7 7 1 2 3 VI 1g 2 1 DIC L
31. IV 1 RN RA RR CRE IV 2 1 2 3 IV 11 IV 12 1 2 3 3 ph EN ee een mt male H E at RSS rotor A ER GE A ce RAL LI I 1 H IV 13 Pi A 1 IV 14 EC EER I RIA RC ER CR 7 1 IV 15 SS 7 1 V 8 2 V 1 DE ete ae ETENEE IREE AEN 8
32. WI 8 1 2 9 10 11 12 PA 13 gt 5 E VI 14 1 2
33. D XX M 2 I 1 1 Na 200 mL 20mL Na 250 mL 20mL 2 Heparin Sodium 200 Units mL amp 250 Units mL Syringe 20mL Fuso for Dialysis 3 McLean 1916 Howe11 Ho1t 1918 2 1 JAN 2 Heparin Sodium JAN 3 4
34. 3 000 1 500 1 500 1 500 1 500 1 1 500 2 500 n gt 8 1 2 3 4 1 2 3 4 b Tu 5 1 2 VI 1
35. CE GAS 17 X TR RE RR E RE E RR Et 18 X 1 18 X 2 18 X 3 18 X 4 K ne do an allez opera Set nr on ae ges aie 18 X 5 18 X 6 RSE SERS EER 18 X 7 19 X 8 19 X 9 19 3 k I 1 McLean 1916 Howe11 Ho1t 1918 10 Howe11 1925 mast cell
36. 2 V 2 HERU 8 2 V 3 8 2 8 2 2 8 2 3 8 2 4 8 2 1 EA 8 2 2 HE 8 2 3 8 2 4 8 2 5 75 8 2 1 8 2 3 8 3 3 RE 0 0 ME E 9 3 9 3 9 3 9 3 9 3 9 3 3 VI 10 3 VI 1 10 3 1 10 3 2 r PB FE BIRT 10 3 D 10 4 4 10 4 VI 2 Se du a de En 10 1 SENS AU DER NAS Ye MA da Mt 10 2 10 4 3 OR re EO at 10 4 CODA 10 5 10 4 6 ME HER 10 4 VI 3 10 4 VI 4 10 4 1 fiii RE OE REE 10 4 2 nee atee sue dE us la CAE ot Dire 10 5 3
37. 2006 7 1 D 813334 IF 1998 9 Na 200 mL 20mL Na 250 mL 20mL Heparin Sodium 200 Units mL amp 250 Units mL syringe 20mL Fuso for Dialysis Na 200 mL 20mL 1 20mL 4 000 Na 250 mL 20mL 1 20mL 5 000 JAN Heparin Sodium JAN lt 2006 3 15 200 6 7 7 2006 7 7 JL
38. ouse K M et al Amer J Physiol 125 683 1939 6 Quick A J Amer J Physiol 123 712 1938 7 JP DI 2001 1601 2001 8 Olsson P et al Acta Med Scand 173 619 1963 9 Wessler S et al Anesthesiol 27 475 1966 10 Thomas D et al Chest 102 1578 1992 11 29 1491 1987 12 Seifter J et al Amer J Sci 216 234 1948 1 T 2 2926 2006 536 8523 3 30 3 XI lt gt a a RE RTS es ss lt _ WV AL 7 A a Go D RDS d Poe sm AE TD
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