特 許 公 報 特許第5754698号
Contents
1.2.
3. GGCCGG6CTGTGTCCCGCICCCRTCAARGSGCAGAACACATCTYAKAGNACTTGCAGCAG
4. CCCGGARSACAGTGCCCTSCTCAGGCAGTATGCTG gt 2 CTGTACTOCGACTATGAAAGCAATCCCCAGCTGCGTCAAGCCATCGAATTTGCCTGTCASG 7 9 CTGOTCAAASCTGAGAASCCTCTCRAAGTCATTAGATTTCTECTATGCAARCERAEATCTG
5. A 2D RES ARO 7 5 BER GenBank 7 7 CAB43288 1 4 EEFPSGDNGVDLLIEDOLLRHNGL1MTSVTRRPAATRQGHSTAVTSDLNARTAPWSSALPQFSTSDP SIANEASVGPTLQTTSVSPDPTRESVLQESPOVPATTVAHTATOQPAAPAPPAVSPRERLMERMH TVPVPPTTVRTDSLGKOAPAGRGTTPASPTUSPEEEDDIRNVIGRCKDTLSTITSPTTQNTYGRN EGAWWKDPLAKDFERI1YVTNYYYGNTLVEFRNLENFRQGRRSNSYKLPYSWIGTGHVVYNGAEFYYK RAFTRNI TKYOLEORYVAAGAM HDVAYEERTPHRWOGHSDVDFAVDENGLHLIYPALDDEGESG EVTVLSKLNAADOLSTQKETTERTGLRRNFYGNCFVICGVLYAVDSYNQORNANISYAFOTHTNTQI VPRLLFENEYSYTTQIDYNPKDRLLYAWDNGRQVTYHVITAY DKFZP586L151 S 0 50 h Z S OH REA 26 88 BC025654 1 5 GenBank 7 2 5 0 3 261
6. 0 685 00000 88 RIN DP685 027 087055 22 Y0VVCKGETHWVDDDCEEIKTPECPAGFVRPPLIIPSVDSERASYMKKGNKUMPNI 51 ILTLPDNERPYVYAPYSEQPDAAGBRYG GDSSMEDTTCERTEF3Y SNYLT8VEDI B AES DP685 22 in situ AIJAI E st BAUAN dpb CHR 5115 LSRSDCC EKLRSCGTESPYMRPVYPTKTFPNILYTLATSLYFE WGGOPIWITAAREQGVKAGTFFWSYVIPHRERRILTILI PFNSEMMVNPLRE 1 DRTYGOLMDGLKQLKLARCVHY ILLPGSLGRIRPRSSNN LKYDPKVIVANI LSKRLHYAYNRRIEDVELLV Pe BRKRHVARKAVDVYKEPTGKCFFHGDHGYDNKINSHOTVEITGYGPEFKYKTKVPEFEN 76 E F 0 685 703630 BERS gt 0 CDLLSLXPAPNNGTRSS
7. GCCACT ane CAACTG TABCTTGCTTSGZGGGC CCACGSSTTEAAGTCCTTTSAGATGTTCTRCANAGCAGCTCGTTGTGATGAECACASATCTGA
8. GACAAGTGTGACGSCECCTCTCTCTSTSTCCTCCTTCSTCCTGCCTCACCGECCPGACARCGAGGA GAGCPGCAATAGCTCAGAGGACGAATCAAAATGGGTAGAAGAACTCATGAAGA GGS7GCGTGACATIGAACATCTCACCAGCCTGGACTTCTTCCGASAGACCAGCCGCAGCTACCCA SAAATCCTSACAC7CAAGACATACCTOCATACATATGAGAGCGAGATTTAACTITTCTGAGCATCT GCAGTACAGTCTTATCAACTGSTTGTATATITTITATATTGTTIP TGTATTTATTAATTTGAAACC
9. CAAGTE resents GTACATGCACAGSCAGA e CTCTTICSCACATTGTTGATCCCAGTSCATCTGAQ Ras T Gi 6 GGGATA 68 22 DP810 O7 5 RRA BARNES 18 YSGTTSTVSTNITL x FSDDICIPVSCGIPESPE IENGSVOGEEFT FPYSCOPSFELOGPSRRICHVDKXKWSP SAPVCRRITCGLPPSIEKAEAYSTGNTYKSNV YHLVGPGNTTCLANGSHSKFLPLCE CEL PLSLLNGKATYENNTVGSTVAYECKSSYSLEG 2 SEQDFYVSONVSIRCREGYCLXGGAVITCNA RGSFYQYGDMITYSCYSGYMLFGP RSICLENGTWDPTEF TCKAVCRE PCONGSVCERPNACSCEDSWMGR1C
10. ACAGCCACCARGCRAGGCGTEAAAGC TGERACATTCTTTTGCTCTGTTGTCATCCCTCACOAGCG 6
11. 000000000000000000000000 10 0000000000000000000000000 000000000000000000000000 2 0000000000000000000000000 000000 00 UUDUDDDUDUUU 00 0000000000 00000 0000000000000000000 000000 9 DD 000000000000000000000000 40 00 00000000000000000 0000
12. 5
13. z CTGAGTChACATASCTAGNAANTGCTANACTSAGGTATS GAG TTGGTTSTC ERASATGTCARATCAC TRG TTGATGG GITET CCTTG CCCCTATA 0000 220 27 10 1 34 GenBank Foruan 9 NP 0084291 AMARES 30 MNGFASLLRRNOFILLVLFLLOIQSLGLDIDSRPTAEVCATHTISVGPKGDDGEKGOPGEELGKHG VGRMGPKGIKGELGDMCORGN TGKTGPT GKKGDKGEXGLLGIPGERGKAGTVEDCGRYREFVGQ LD
14. 0 00000 00 000000 00 000000 0000 00000 00000 0000 0000 000 000000 000 0000 00000 000000 00000000 000 O00 000 00 000000 000000 00000000000 0 00 pen 00000000000000000000 10 000000000000000000000 000 00000 000000000 0000 00000 0000000000000 0000000 0000000000 00000000000 0 000000000 00 DD 0000000000000000 00000 DD 20 0000000000 00000 00000 000
15. 6006266000 600 00 6006650 087 000 0 ATCACAGTTRCGACCTTCAATACCACTTTGGCGTCRTTCEACGT CCTCTEGCATGTGCTAALCTACCTCSARGCCTCACAGACTCCTGCATRARCTACAGCTAC GATCTTTCTGTAGTPCTGASGGCTGTTTATCTTGTCCTTAATCATSACATCAGCTCTCGT ATCTGTGACGTSGCSCTAAMCATTGTGSAATGCTTSCTTCAACTTGSTSTSGTSCCCTGT AGTGAGSGAGCFTTCCAATTCARRGGAGTATCTGGERGTTCCACCTGTCSATTCGGRSGC BTAGTSARGTCTTTSGGSTGTGCCTA
16. 00000 El 4B 444 D7 802809185 8 TRP9TRPERVLVENKLRGLSEALSEAIQ VOAALPHVLHCTATLLSNHRNKLSHQSKLGV AETKLLRTLHHNLLEAPGLCSNDREGGD SSSAFIHCAEROSSPGRPRPSTTRDFDENN RRKEFONSMATVELEVELPSPLVHRYKESDLT LVIQQPSRWERRQOPSEVSAPNATVKPIRN INTAERSSPTNNOSVTULSLNLOSGHTEGLOVVCETTLPDSVPSRPTVSACHRGNSLEGSVSSQT 1 0059 51 EYTPLERLRSSSMVAAARPSLVNTHKTQOLTHKC XSLSTEAPSKVSLTNLRRPA 1L ST7DLGMNT FRKFKSRKEDRERERKSS1FEHHTSKKRQRRMGHPZLLELZOHLDVSPTRSTFSEGS FSGIGEDRRGITERGGWQTTILGKETRRGSSDTATEMESLSARYSHEEHTLVSDNPDHSNSHGENT VKEVRSQISTITVATENTTLASENVSYADFESEHMRKLCNQV EMUPHEPLACANLPRSLTOSC INYSCLEDTOHTDGTHNFVEKNCMLDLSVNGKE 00000 B 40 QV2 NN2006 230401 628 d06 NN2005 020 87 9 GenBank 2 F BI035296 GCAAATIGACCCGGCONGGCAGTTCAGATGCAGCCACTGAGATEGAGAGTCTGAGCSCCAGSCRT a
17. 12 Hs O BB 6 Hs 08 88 6 000 SD i ATLL gy 177 GenBank 7 20575 92 AAB00855 1 ARARA ES 24 CQILISLPTEAVGVNICLGFTARRIKRAEGWEZSGFPTULSDSPSWCNISGSCKGRCFE PDCRCDNLCRSYTSCI FDELCLXTARAWECTKDRCGEVRNEENACH DCLARGDC QUVCKGESAAVDDDCEETKARLCPAGFVRPPLT FFSVDOFRRS YEKKGSKVMPNTIEKLRSC SPHSPYMRPVYPTKTFPNLYTLATGLYPESHGTVGNSMYDPVFDATYHLAGREXFNBRNRGGOPL TATKQGVXAGTFFWSVYITPHERR TLQWLTLPDHERPSVYAFYSEQPDEFSGHKY TRPLREIDEIVGQLMDGLKOLRLHRCVW VGDRGMEDYTCDRTEFLSNYLTNVDD SRIRSKFSNNAKYDPKATIANLTCKKPDQHRFKPYLKQRLPKRLHYANNRRIEDIHLLVERRWHV RKPLDVYKKPSGKCYFFQGDRGFDNKVNSMOTVFVGYGE YKTKVEPFENTEELYNVMCDLLGLK TRPNYPGIMYLQSDFDLGCTCDDKVE SGYSEIFLMPLWTSYTVSKQAEVSSVPDHBLT SCVRPOVRVSPSFSONRCLAYKNDROMSYGFLEPPYLSSSPERKYDAFLVPNMVPMYPAFKRVKHY KGVNVISGPIPDYDYDSLHDTEDKIKQYVEGSSIPVPTHYYSIIT SCLNDPTO PADKCDGFLSVSSFILPHRPDNSEESCNSSEDESEWVESLMKMHTARVRDISHLTSLDTFFR PEILTLKTYLHTYESET 000 SE 2 82 1902 21 0 8565 DHARA GenBank 7 209
18. OCBTTGTGYGAATGTTATCTTTGTTGGAGACCATGGAATGGAAGACCTGACATGTSACAGAACTG h 1 ACCAGAGGAAGTC GACCCAATTACCCAGGCATTATGTELCTTCAGTCTGATTTTGACCTGC GCTGCACCTGTSATGATAAGGTACA
19. 6
20. 000000000000000000 0000000 00 10 00000 000000 0000 000 0000 000000000000000000000000 2 0000000000000000000000000 D000000000000000000000000 0000000 00000000000000 40 000000000000000000000000 0000 00
21. 0000000000 0000 000 00000000 0000000000000 0 0000000000 20 0000 000 00 000 000 DD 00000 000 0000 000 00000000 0000 00000000 000000 000 0000000000 0 000000000 000 Uu 00 000000 0 0000 00 0000 0000 00 30 000000 0000 0 0000 0 0000 0 00 0000 0000 0 00 0000 0 0000 00 0000 000 000000 000 0000 0 00 0000 00 0000 000 000000 000 0000 0 0000 0000 0 00 0000 0 00 gt 0 0000 00 gt 00 0000 0000 00 00000 0000 000 0000 000000000000000000000 000 40 000 000000000 6 gt OO 0000 000000 0000000000000 00000 6 gt 00 0000
22. 00000 4D DP444 NE RENZO 10 IRRE 9 DMR E 46 GenBank 7 2 tz z BF951817 QV1 NN0228 091100 486 805 NN0228 UTA MIRME 11 6 062056 5 05 5277 77
23. ATTAATTTATTC RTCAAGTATTTTAGOATGGCTARATRATTIGATAATGTGCTGAAAGATCRTTARGH 2677 AGTCCTAACHGCEACTTTP 38 JP 5754698 9 00000 00000 6D 55 lt TIRADE EAA YAVAS 8089238555 NOT E 8 DP685 RAAI Z GenBank 7 7 a NP 078778 1 20 rE BA 00 DP885 IEEE 24586802 BARES 21 CLVACDEGYRLEGS DKLTCQGNEQR 1 VSCRQGFILSUVKEMLRCTTSCKWNVG 050598 5 0 0060 ATGATSACTGTG TCTPDNTCVRCTLTCLESY
24. 00000000000 000000 00000000000 4 000 000000000 00 50 000000000000000000000000 13 JP 5754698 2 2015 7 29 000000000000000000000000 10 0000000000000000000000000 000000000 00 000000 00 0000 00000000 00
25. 0200 2CTTCCYTCTCCATGASGACCRTTTGG
26. GenBank 7 7 5 7 214480 1 59 12 1 Soares NFL T GBC 51 3 12 TSCCCATCCAGRCCTTCCTGTGGCGSCAARACCAGTCC7TTGAGCGAGTGTTGSGSTAGANADCAAGC GCTGCTTTGCCTCATGICCTCCACTOCACTGCAACCCTGCTTTCAAACCGARACARGCTAGGCCA CCAGGATAAATTGSGTGTTSCTGAGACAAAGCTCCTTCACACTCTACACTGGATGCTTCTGGAGG CCCCCCAGGACTGCAACAATGAGCGGTTTGGEGSTACAGACCGAGOC 000 000 000 GATAAATTSSGTSTTG GCCCCCCASSACTGCARCANTGRGCGGTTTGSGGGTACAGACCGAGSCTCCAGCTGGGGT 80000669
27. 000000 000 000 0000000000 D 000000 000000 0000 00000000 0000000 0000 00000 00000000000 000000 0000000 0000 000000000000000 000000000 00000 00000000000 00000000000000000 0000000 000 0000 0000 00000 00000 0 00000000 0 0 000000000000 000 000 000 000 000 000000000000000 000000 00000000000000 00 00000 000000 UUUDDDUDUUDU 00000 0000000 00 00 00 0 00000 0000000000 0000000 D 0000 00 00000 00000 000000 0 000000 00000000 00 000000 20 0000 00000 0000 000 0000000 00 0000000
28. DD 0000000000 0000 000 000000 0000000000000 0000000000 10000000 00000 000 00000000 2 0000000000000000000000000 000000000 000 00000000 D 000000 00000000 0 000000 55 00
29. UJDUDDDDUDUDDDDUDUDDDDDDDDDU 00000000000 0000 20 0000 00000000 000 000000000000000 00 0000 000 0000000000 000000 000000000000000 0000 00000000 000000000 000 000 0000000000 0 00000 00 000000000000000 00000 0 00000000000000000 000 000 0000 0 00 30 000 000 00000000000 00000 00000 000 000 000000000000000 DD UUUDDDDUDUDDDUDUDUDDUDUDUDUDUDUDUD 000000 00 000000000 UUUDDDUDUDDDUDUUDUDDUD 0000000 000 00000000000000000 000 000 40 00000000 000 00000 000000 00
30. EZ E ELVE F 21229 Er E L ER 4 1 Er SSS g OOOO OOOO OOOO EE J J DO OOOO OOOO OOOO og ET ET 1 1 SEE Eq Ea Ei Ea J IGG H IGG J o5 O 5 rz ET OOH HO AO OAH AON OO OOOOH OOOO OOOO OOOO OOO HO OA AOMOO OOOO OOOO OOOO OOO OOOOH UR Er 124 3 JP 5754698 9 5 6
31. 36 5754698 2 2015 7 29 0000 00 CAAGCASTSTICCCAGCAT GCATCTSTGCASCAGTACTTCCCATTGTTCATCTGATGSAG 5 GTTCATGGACAGAATGAG
32. D 000000600 0000 000000 0000000000 0000000 000000000000000000000000 00000000 0 00 000000000600 amp 0 000000000 000 0000000 00 000 000 00 UUUDDDDUDUDUDDUDUDDDUDUDDDUDUDUD 0000000000000 000 2 0000000000000000000000000 000000000000000000000000 amp 00000000000 00 p000 000000 000 000000 000 000000000 0 000 D
33. RAGCTARAGAGGCAGACATLACAGSTSGACACARTACCTGCTGCCCGAGAGCAGATTOCG GCCnCTG6CTGCTCTTGCGACGTCCCTACAGGCCCTTTTGTACAGTSTAGAGSTCCTCACC 2 5 60 6 00000 AJ GenBank FYE 1 Hs2_5191_28_4_3 PNS RAMEE 16 5 5 1 51 5 PPEPOIPLLPRPRSSSMVAAAPSUVYNTHKTQDUTHKCREEER SLSSEAPSK9SLTKLFRRSAVPDLSSDLGMNIFKKFKSRKEDRERKGSEPFHHTGKRRPFR MGVPELLHEDHLUVSPTRSITSTESFSGLEEDRAGIZKGGWQITTLGKFTRRSSSDAATE MESLSARHSHSRHTLVSDLPNPSNSHGENTVKEVRSOESTTTVATENTTLASFNVYGYADE PNEBMRKLCNOVPIPEMPHEPLACANEPRSLTDSCTNY
34. 00000 00 0000 000 000000 0000 000000000 000 0000000 000000 000000000000000 0000 00 0 00000 0000 000000 00 0000 20 JUDDDDUDUDDDDUUDDDDDUDUDDDDUDDDDU D 000 000000000000000 W 00 0000000000000 000000000 0000 0000 00000 00000000 0000 D 00000 D 0000 D on 0 00 D 0000 000 00 00000000000000 D 000 0 000
35. O 0000 D 00000 000000000000000 0 0 00 000000000 00000 49 0000000 00000 00 0000000000000 00 0 000 00 000 00000000 0000 00000000000000000000 000 5 6 5754698 2 2015 7 29 11 12
36. 0 DP685 autotaxin A ORR in situ
37. ACAAGCTSCTGAGTGCTGATGGSCAGTCAGAACCCCCATACACTACCTGGAAGATCCGGACCTCA TCGCTCTSTTGCCTAGGCTGSAGTACAGTGSCCTGATCTCGSCTCACTGCAAGATCCGCCTCCCG GGTTCATGGCATTCTCCTGCCTCAGCCTCCAGARGCANCTGSGACAACAGSCGCCCGTCACCACGC 0000 120 Nocturnin CORA 2227 5277 EMEA GenBank 772477 31 WS XP 0033422 34 jk GeneScan Nocturnin RAE BEALS MAT tO C MFR5PRRLCSALLORDAPGLPRLPAPSLRRPLSPPABVPRPASPRILAAASAASGAANRSCSRTVC SMGTGTSRLYSALAKTLNSSAASQEPEYLVSPDPEHL P1DPKELLEECRAVLRTRPPRFORDFV DLRTDCPSTHPPIRVMOWNILAQALSEGKDNEVOCPVEALKW LILEEILAYQPDILCLOE VDHYFDTEOPLILSRLGYQGTFFPKPWSPCLDVEHNNGFO0GSCALFFL
38. DDUDDDDUDDDDUDDDDDUDDDDDUDDDDU 4 50 20 JP 5754698 2 2015 7 29 39 40 00000 000 000 000 000000000 10 20 2 2 2 2 21 JP 5754698 2 2015 7 29
39. D EJ F 20 OO J OO J E 3 man Bes i 3 E3 ET BE 4 JP 5754698 9
40. 0000 0 000 00000000000000 000000 000 0 0 000 00000 000000000 00 00 000000 000000000 00000000 UU 000000000000000 0000 0 000 0000000 0000 0 000 000 00000 00 0000 0000000000 000 00000 000000000 0000 0000 D 00000 000 0000 000 0 00 000000 0 00000 000 000 000 0000000 0000 0 000 000 00000 00 0000 00000000000 000000 00000000 00000 0000 00000 000 00000 000 U 0000 00000000000000 000 0 0000 0000 00000 000000000 000 00000 00000000000000 000 0 0000 0 0000 000 000 0 0000 000000 0000 0 0000 00000000000 0000000 0000000 000 00000 0000 0 000000000000 000000000 00000000000000 000 0 0000 0 000 00000 000 0 000 00000000000000000000 20 000 00000 0000 0000 000000000 00000000 00000000000000 000 0 0000 000000000000000000 0 0000 000000000000 000000 0000 000000000 000000000000 00000000000000 000 0 0000 00000000000000 000 0 0000 0 00000 000 000000000000 0000 00000 000 0000000 000000000 000 00 0000 0000 0000 000 000000 0000000000
41. D 0 000 00000000000 00000 000 00000000000 00000000 0000 00000 000000 000 00000000000 000 000 000 0 UUDUDDDUDUUDUDDUDUDUDDUDUDUDDDUDUD 00 00 000000000000000 0000 00000000000 000 000000 00 00000 000000000 00 00 20 00000000000000000 0000 00 000000000000000 00 00000 0 0000000 0 00000 0000 000000 00 0000 0000 0000 000000000 00 000 000 0000 00000000000000 000000000 30 0000000000000 00 0 0000000 000000000000 0000 0000000 000 00000000000 00000 0000 00 0 0 000 00000 00000000000000 000 0000000 00000000 00000 00 00000000 000 0000000000 000000000000 00 00000 000 40 00000000000000000 00 0
42. 0000000000000 000000 D000000000000000000000000 00 0000 0000 4 000000000000000000000000 000000 000000 00000000000000 000 00000 00000000000 B 00000000000 0000000000 000000 0000 0000000 0000000 00000 8 0000000000000 000000 0000000000000000 000000 50 000000000000000000000000 16 JP 5754698 2 2015 7 29
43. 0 0000000 0 50 000000000000000000000000 000 0 0000000 0 000 00000 UU 000000 0000 0000000 0000 00 D 10 20 JP 5754698 2 2015 7 29 00000000000 00 D 000 00000 0000000000 000 00 000 00000
44. 0000000000000000000000000 0 000 8 000000 0000 00000000 00 000 00000 40 D D 00000000 D D D D D D D 0000000 s 000000 31 JP 5754698 2 2015 7 29
45. 00000 000 0 0000 00000000 00 0000 0000000 0000000 UUUDDDUDUUUDDUU D D 20 0000000000 00 0000 00 000 000 00 0000 0 D 0000000000 00 0000 00 0000 0000 000000 0 30 00 0 0000 00000000000 0000 00 0000 000000 0 D 000000 0000 00 00000 D 00000000000000 0 0000 000 00000 00000 00 0 000000000000000 40
46. 000000 0 0000 000000000000 000 0 00 9 10 20 JP 5754698 2 2015 7 29 D 00 0000000 0000 000000000000 00000 00 000000 00000 000 000 00000000 0000000 000000000 000000 0 D 000000 000 000 00 00000 00000 00000000000 00000 000 0000000 00 00000 DD 000000 0000000 D 0000000 0000 0000000 0000 000 0000000 D 0000 00000000 00 0000000000000 0000 000000000000 0000 000 0000
47. Oooo ooo 1 2 2 d 1 1 2 1 1 1 1 1 1 3 2 q 2 2 2 0 SS p Ell 5 19 JP 5754698 2 2015 7 29 37 38 DUUDUDDDDUUDDDDUUDUDDUDUUDDDUDUDD 000000 0000000000000000000000000 0000000000000000000000000 0000000000000000000000000 20 0000000000000000000000000 ODDO O000000000000000000000000 0000000000000000000000000 O000000000000000000000000 000000000000000 004000000
48. 00000 00000000000 00 00000 33 JP 5754698 2 2015 7 29 DKF2p586L151 AX ORBE I 2 F U IS 7 DP119 ORR 2 F DKFZp5861L151 7 880 a FS AL050137 1 F GenBank 7 t 899 91893 DP119 6 7 ATGAAGGGG
49. WAAAAU2P APLLLLPEVILLEGRPYEADSKV SMAYPLPLV1CPALVVAQVSGSTIPPIGTSEPPDVOTVEPTEDD11ONRATDNQENVLSQL MAYPLPLYUCFALYVARVSGSSTPPTGTSEPPDVOYVAPTEDDV1QNERDNOENVLSQO MAKPRLLVLYFALYUVPASVSSTVUTGYEEPPDAQTVAPAEDETIONENTUINOENVLS0L MTEMKIRCVLINAFALTSASPKSHLXLERKTK DNNDTLOVEZDNOER1LSOIL MGLLLY1FCCVFCUYRAN DURATLSORONOE LY EREPEPVIMI FOR FOVRMTSTGSDCRFCRCIMRPLTEDACAR RTGSVRVEDFYTVETVSSGADEK CC PSDP D00RMTSEGSDCRCEC1NPPLSKDNCST2RSGSARVRDFYTVETVESGADPCR CSC FGODLDGVRMTSEGSDCRCECTNPPLSYDNCSEVRSGRARVEDEYTVETVSSGTDCR CSC LGDY6EYKAVSEQSDCOCKCYVRPLGRDACORINOSASRKEDEYTVETITSGSSCY CAC LGDYDXVRAVSEGSDCOCECVVRPIARDACORINESASRKEDEYYTVETIUTSGSS LGUYDXVXAMSEGSDCOCKCVVRPLGRDACOPINASASRKEDEYTVET T LGDYDKVKALSTRQSDCGCXCVVRELSASACOPIRESRAT2ODEYTYET IGDYDEVRTLSEGSDCQOCRCYVRPESRSACERIEEAQAKZEDFYTVSPVTAGPNEOKXCNC 160 1 18 SUNPCENEVEREKLKRGA TAPPS INPCENENRMEKLKRCAPELLK VAPPSAVRPCEGOPRIQFLREADSEDLK VAPPSAVXPCEGDFRLQFLREADSRDLK VAPPRALNPCEGDPRLQKLRRADSQDLKVGPGMOQCLGRPSTFETSRSGKAMVEDSKPPI 4 TAPPSALHPCESDFRLKKLRQAGEDATX 502000018 gt 13 230 240 HSMVDLLEGT OSMVOLLEGT QSMVDLLEGA LSTLIDMLEGA FIASGE PVEPPLSTITOMLEGA PSLSBFTTQTPRKAPCTYTIVLAY
50. 000 00 0000000000000000000 0000000 00000 00 000000000000 0000 000000000000 000 000000000000000000000000 50 30 JP 5754698 2 2015 7 29 1 E
51. 000000000 000 0 00 00000 00 50 000000 5 5754698 2 2015 7 29 00000 00000 00000 00 10 000 000000000 00000000000 000000 00000 000000000 D 0000000000000000 0000000 0 0000000 000000 00000000000 000000000 0000 000 000000 D 0000 0000000000 0000000000 000 000000000000 0000000000000000000000000 0000 00000000000 D000000000000000000000000 00
52. 0 000000000000 000000 00000000000 0000 00000 00000 0000 0 000 0000000 000000000 0 000000 0000 000000 00 0000000000 000000 30 00000000 000 0000000 000 000000000000000000 000 000 0000000 00000 000 0000000 00 00000 000000 000 0 4 00000 00000 00 0000000000 000000 00000000 0000000 00 00000 00000 0000 0000000 000 0000000000 000 0000 00000000000 00 0000000 00 000 000 0000000000 00000 00000 000000 D 0000000000
53. AGMCACTTAGAGGTACTACTAACCZGGTGI mRNA 889 13 SCCASGAGCAGGACG6CSGCCG6GCGGCATCCCCCTG SGATGCTTCT 6 6 5 amp 7000660060 2677 7260030606 1026066008 GAAAAAGRAARTRATFTAA 4H GenBank 7 2 AYRE Hs2 5191_28_4_1 992 578 14 MVKRKSSSGOFCUGGPRGT PLPIQTFELHRCTSFYYDCTRHGOKLGVAETKLLETLEWMLLE APQDCNNEFF6STDRGSSNGGSSSAFIBQVENQGSPGOPCQSSSNDEEENNRRKIFONSM AIVELEVFLFRPLVHRIKESDLT ASGLVIVOPMWEARQPGVSGEFTALVEPIRNTITE KRSSFINSQSRTCESSHODARALEVL LYOEFLMCNSPEDTSYGD EKERN di GenBank 7 2 a 1952 5191 2843 P BARNES mRNA 6 578 6 GTTGC GTTCTGCGCTSCCTACTTCAGCCCCATTGSTCTGAGGAAGGCACTCAGTGGSTCT 7 SASCCAGATATTCCTCICCTGCCCAGACCCAGGAGTAGCTCCATGGTGSCAGCAGCTCCC
54. 75 SHEA B 0 06 540 DP685 SOE b BLU nb BE ba BAU REPO 0 8050 5600 67 06 ATGCACACTECACGGSTGCCGGACATTGAGCAGCTCACAAGCTTGCACTTCTTCCGAAAGACGRG
55. 569060 GACCTCAGCACCCAGARAGAGACGACETGGAGGACGCLCCTECGGAAGAALTTCTATCGGAACTG TACACCACGCAGAFAGACTATAACCCCAAGCACCSCCTGCTCTACSCTTGGSACAATGGCCACCA 6 6 6 6 ACCAGCACCTT GYACAARTCAAAGA GTACGTEATGGOTTTTIGTCTCAGGCTGTTTAGATECCGGATIGTACATUGF TCCCCAGSCCAGG CCCTITOTECCCGOTG 5 6 65 8 6 56 60592 6758 gt 0 ACACACTTGACCCTBCAAAAAGAAGCACAGTSGGGCCACTACCACCTTETGTGTGTCTSTGTGCA 6 00 00000 TATGTGCTGGTCTCATCCTTCACAATTTATATTTTTOTGCAAATGAACTTCTCCTTCTSACCAGT AACTA
56. 000 0000000000000 0000000 00000000000 0000 0000000 00000 000000000 00 0000 00 000000 000 00000 000 000 00000 0 00 00 000000000000000000 0000 0 00 00 000 000 00000000000 UU 00000000000000000000 00000 000000000 0 000 000000000 00000 00 0000 0000000 000 00000 0000000 00000 00000000 0000000000 40 00 0 000 000000 000000000 00000 D 0000000 D 00000000000 00 00 00000 0000000000 000000000 0000000 000 00 0000000 000000000000 50 000000 00000000000000000 7 JP 5754698 2 2015 7 29 13 14
57. 50 22 5754698 2 2015 7 29 00000000 0000000000 50 23 JP 5754698 2 2015 7 29
58. D 0000 00000000000 000 000 0000 00 000 000 UUUDDDUDUDDDUDUUDUDDUD 0000000 00000000000 000 0 000 0000000 UDDUDUDBDDDUDDDUDUDDDDUUDDDU 50 00000 00000000000000 25 JP 5754698 2 2015 7 29 00 0000 000 00000000000 000000000 0000 000000 0000 0000 00 0000 D 0 000 00000000000000000000 0 0000 0000000000 00 0000 0000 000 00000 00 00000000 00000 000000000000 0000 0000000000000000 00 0000 0 000 00000 000 0000000000 000000000 00000
59. 2 5 15 JP 5754698 2 2015 7 29 0 000 00 00000000000000000 _ 0 0000 0000000 00000 000000 000 0000000000 0 0000 0000 00000 000000000
60. GAAGT AGAGTTTTAACAGGACAAACATATTT T 000000 BJ 148 RAO 36 MLILLAFIIIFHITSAALLEISTIDNAWWVGDNFSTDVWSACATNHSTCTPITVOFREYOSICQAV QACMVLSTIPCCVAFLVEILOLFRLKOGERFVLTSIIOLLSCICVMIAASIYTDRHEELHKSIEY BIEVSKGOYGYSFVLAWIAFAFTLISGVMYLVLRKRK 000000 140 L08823 AYE 2 2 mRNA 0458885 GENBANK 7 31 0302184 BARRE 37 CAGCACATCCCGCTCTGGECTTTAAACGTGACCCCTCGCCTCGACTCGCCCTGCCCTGTGAAAAT GCCTGAAGCAGGGAGAGAGGTTTGTCCTAACCTCCATCATCCAGCTAATGTCATGTCTGTGTGTC CCITCATCAGCGGCATGATGTACCTCATACTOAGCAAGCSCAAATESACTTCCCGAGCTGGGT TG CITCTGCTGCAGTACAGAATCCACATTCAGATAACCATTTTGTATAT
61. 0000 0 0000000 0 00000000 0 0000000 D 00 0000 0000000000000 0 0 00000000 000000000 0000000 0000000 00000 UU 0000000000 000000000 0000000 0000000 0 000 000 000000000000000 00 50 000000 m 24 JP 5754698 9 48 47 0000000 0000000 00000 DD 00000 00000 10 00000000000000000 00000
62. E Eq T T EL E El E E E T 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8 000 00000 0000000000000 50 18 5754698 B2 2015 7 29 36 35 000 000 000 000 000 SD Ed EET 161 37 7 1 ss 20
63. s ENIYKKYCLEYNYDYENGFRIGN TCCCCAACTTSTACACCCTTGCTACTGGACTCTATCCTGAATCACATSGAATCGTTGGCAATTCA 4 css 8
64. 0000000000000000 0000000 00 0000 00 00 000000 00000000000000000 00 0000 2 0000000600 0000 00000000000000 00000000 00 0000000000000 0000000000 00 000 000000 00000000 0000 000 000 000000000000 000000 000000000000 30 0000000000000000000000000 000000 000 0000000 50 11 JP 5754698 2 2015 7 29 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 23 a zl 8 5 SS
65. CAGGAAGCAACCTCTGCTOGTCCCATCCTGAGCCCTGAAGAAGAAGATGACATTCGGAATGTGAT AGGAAGGTGCAAGGACACCCTCTCTACAATCRCAGGACCGACCACCCAGAACACATATGSACGGA ACCGGGCCTTCACCCGARLCATCATCAAGTETGACCTGAAGCAGCGTTATGTGGCTGCCTGGGCC ATGCTGCACGATGTGGSCCTATGAGSAGGCCACTCCTTGSCSGTGGCAGGGTCACTCGGATPGTGGA CTT27GCT6TGGATGAGAATSGCCTGTGSCTTATCTACCCAGCTCTGGSATGATGAAGGTTTCAACC ees G03 GCATTGTCGCCT AGGAGGTCATTGTCCTGAGCAAGCTCANTSCCGTGGACCTGAGCACGCAGAAGGAGACCACGTGG 4 SCCACCCT 72 CAC gt 55 5 26 6 0 T1CCCCCTGACTCTGSCCCTTTSCAGCCT BOGUT GTGGGT CGS TOOT GET ESCAG 5
66. 00000 D0000 000 001000000000 000 00000 00000 000000000000 0000 0000000000000 000000000 000000 00000 000 0 000000000000 00000 000000000 0000000 000 00000000000 00 00 0000 00 000000000 000000000000 00000000000000 00 0000000 0 00000000000 0000000000000 000 00 0 000000 0000000 20 00 00 0000000000000 000000 00000 0000000000000 00 00 0 0000 0000000000000000 0 0 000000 00000 D 00000 00000000 00000000000 000 8 000000 00000 0 00 000 0000000 0000000000000 00 00
67. 600032641 AMRA 5 25 6 6 GCAAGACAAGSCUTGTTTCGSSTCATACCAGGTANTATCCTTGYTCACTTTPSCChTCSGSCSYCAN 6 1010000000 001607600 TACCAAATERGGAAAR SE CCTCTCACTGCTCAGAAGLCTGCTTGTCCCLGGGAGACTGLTSTACL CATCGIACATGRAGAAAGGCAGCAAGCTTATSCCCAACATTSACAAACTGCEGGTOCTGTGECACC CATGCTCCCTACATGAGGCCTGTGTACCCTACAARAACCTTCCCTAATCTSTATACGCFOGCCAC
68. IFT gt 11900 490 500 10 520 530 FOSNLTBDITTPTTSTSSBTTTTIOTTSTNS AEPESAEQDEAEPRSSERVOLASGTTELILPPESTAGOIST EVLATPAPFELOCENKPVPS HTAAVTTDASTIQAAASSBEPAQASASASSEVEPAPOASDEELLATPOT SATRRPATTR HAARVSTDASVQRTALSSEPAQXSASAPS LVDYASOAPDRQLLASPOT SVTSRPRRTROGHSTAVTSDLNARTAPRSSALPGPSTSDPSIANIASVGD TOT UEPSPTSYSALTVTESSVGINAXBEVTTIVMTASVTGSRTDSVTDLTQLSPRVRETLT 1 5 TEF TIVPPELTG LPAMVPGD1FVEALPLVPLUPUTV TTOOPVKEXYSISHDEENE gt PITIPHVTRPDLHPSVPSQGRED NHRRPHPQRPITSLLPTEPPSGPEVSSQIRER gt GYDESPEZPGTAQQEATSAGPILSPESSDDF N IS GEDMAPEDGTARQEATSASP21SPEEBDDIRNVLGVPKO a SERPHISAAFLNGUIISVOPS RYDSIAXDAPAGNOTTPAS ne VPMRHVEICLKXRVSVLLSENHWQGLPOYQA PA PPRETEVLKERLOLEC ECTLRAYEPPVIMPSYGRRZG
69. Y OO 3 ET r ET EF SP T ua Y ses e aaa EE 1 ET ES ET ren EET ER EET EST t LT I F PC EZ GE pt I Eg TIE T GLET F Pu mat SE Sra ca mat WH 3 CU m x ET 172651 ZT EL DL ET CEER ELG 0 O90 A a ES TGE A ez usa 3 1 h El Rf e N i FT L AGEA ET t
70. n zz zz SI man t 000 0000000 0000000 10 ZR E Tp 000 000 0000 D 000 00 0000000000 00 00 00000000000 00 00 2 JP 5754698 2 2015 7 29 T EI 20 EF ES 2
71. VDBRVRVS9SELGLGYESDETVLFRYCSGTCDAAVRNYDLSLKSVRSRKKI8RKEKVRARPCCRPL AYDDOVSFLDAYNPYYTVNELSAKECGCV 41 5754698 2 2015 7 29 0000 150 LVAD neurturin OEA GenBank Porya 5 NM 004558 1 BENE 41 CTCGAACCCTGGACGCCCGSGBST TIGCCCGCCTGGCCCAGTACCGTGCACTCCTGCAGSGGGCCCCG G6GGCCCCGGCGGSCGGCGCSCGCGTGCGCGGTTGGGGGCGCGG6CCTTGCGGGCTGCGCGAGCTGG GCAGGCGCCTGCGAGGCTGCCGCGCGCGTCTACGACCTCSGSGCTGCGARCGACTGCGCCEGSCGGCG 0000 160 neurturiri MADFA MAES GenBank 7 8 NP_004549 1 gt 42 MORWKAAALEVLCSSVLSIWMCREGLLLSHRLGSPALVPLHRLPRTLDARIARLAQOYRALLOGAP DAMELRELYPWAGRPPGPFRRRAGPRRRRARARLGA
72. 000000000 D C000 C0000 46 0 UD 000000 0 000 0000000000 000 00000 000 00 00 0000000000000 Oooo 0000000000000000 0000 000000000 00 0 0000000000 000000 00000 000000000 00000 0000000000 0000 00000000 0000 00000 0000 D 00 30 00000000000000 00000000 000 00 00000000 000000 0000 000000 0000000 00000000 00 000 00000000000 000000000 00000000000000000 000 0000 0 00000000 00 4 000000000000000000000000 000000000000 D 00000000 000000000 00000 0000000 000000000000000 000 0000 000000 000 D
73. 19908 000000000 45000 00212 7 290 2015 7 29 4300 O ooog D0000 O O 0 5754698 24000 271 6 50 2015 6 5 51 1 0000 0000 0000 0000 0000 33 15 38 00 1 18 3 00 3 04 2006 01 0000 2006 01 0000 2006 01 0000 2006 01 0000 2006 01 0000 33 15 37 02 1 18 3 00 3 04 000001 00 5500 000000 2010000 1 1 N 2010 91670 P2010 91670 220 41 120 2010 4 12 2004 506842 P2004 506842 150 50 301 2003 5 30 2010 229133 2010 229133A 221 101 141 2010 10 14 221 50 120 2010 5 12 2013 9082 2013 9082 1 251 50 170 2013 5 17 011963 2 141 51 291 2002 5 29 OOOO 020829 4 141 91 171 2002 9 17 730000 79010 79010 313010482 000000 00000 0000000 00000 00 0 00000 00000000 0000 100114890 000 0000 1 00099483 00 000000 OHO MAO ES ESP E 4 E T TD OB OO ZJ EP k u
74. 6 00 00 000 0000000000000 50 000000000000000000000000 29 JP 5754698 2 2015 7 29 00000000000000000000 0000 00 000000000 0000000 000 0000000000000 0000 000 00000 00 0 D 000000000000 00 00 0000 000000000 00000 0 0000000000000 00000 6 DD CH 00000000000000 000000000000 00000 0000000 0000 C 000000000
75. g 2 2 8 EST 3 EET ST ST 9 1 057 OOOOOGOOOOOO XOOO GREGG 8 8 8 8 0 3 5 x 8 8 0 8 8 5 12 JP 5754698 2 2015 7 29 23 24 000000000000000000000000 10 0000000000000000000000000 D D D D D D D D D 000000000000 D D D 000000000000000000000000 0000000000000000000000000
76. 00 10 WE474 Ba 10 2 ee 10 43 0 RARE 27 6 GCTCGGCTTAACACATNCATCANGTTTGTAMARGAATSGTTTTTGCNGGOCTTNAGSSGGACCGG TGGSAAAAATTCTTCCTYTTT PTGGC 0000 108 7h WE474 28 OBL AREA MSRKKEQQLRKYGTLVVLFIFOVOTFGFDVORRPTPOVCSTHTILPSPKGDDGEXGDRGEVOKXQE KVGPKGPKGNKGTVGDVSDOGMLGKI1GPIGGKGDKRGAEGISGVSGKKGKAGT
77. 00 00000 00 00000 0000000 0000 00 0000000000000 0000 50 0000 000000 32 JP 5754698 2 2015 7 29 00000 0000000 0000 00000 00000 0000 00 00 000 00 0000 000000000 000000 0000 00000000000 000000 00 00 0000 000 00000000 000 0 0000000 00000000000 00000 0000000 000000 0 000000 00 000000 00 000 00 0000 00 00 000000 0000 00000000000 00000 0000 000 00000 000 00000000 000000 0000 0000000 000000 0000000 000000 0000000 00 000 0000000 000000000 0000000 000 000000000 00
78. 000 00000 00000000000000 000 0 00 000000000 0 000 00000000000 0 00000000 00 00000 000 0 000 0000 00000 0000000000 0 0000 00 0000000000000000 0 000 000000000 000 0 000 000000000000 00000 DD 00 00000000 00000 0000 000000000000 000 000 000 00000000000 0 0 000 0 00 0000000000000000 5 00000 00000000 0000000000 26 5754698 B2 2015 7 29 51 52 000000000 000000000 0000 00000 000 00000 00000 000 0 UUDUDDDUUU 00000 0 00000 000000000 00000 00 000 00 000000000 0
79. 000 000 000 000000000000 00000 SOOO 000000 20 00000 000000 0000 0000 000000 00000 0000000000000000000000000 4 000000000000000000000000 50 14 JP 5754698 2 2015 7 29 1 1 EJ go J EF 2 EF OO E m 0
80. 0000 00 0000 0000000000000000 000000 000000000 00000 000 0 000 000 00 0000 0000 00000 00000 000 00000 000 0000 0000 0 0000 00000000 D 0000 00000 0000000000 000 40 000000000 00000000 0000000 0000 00000 0000000 00000 0000 00 0000 000000000 000 0000 U 00 000000 000000000000000000 00000000 00000 00000000 D 000 0 0000 000000 0000000 000000000000 0000 0000 000000000000 000 00 000 000000 00000000 000 Oooo 000000000 0000000 0 00 00 0000 0000000 0000 00 000000000 00000000 0000000 000000000 0000000 00000 00 00000000000000 000 0000 50 0 0000000000 000 000000000 28 JP 5754698 9 56 55
81. 00000 00000000000 0000000 C000 000 000 00000 000000 0 10 JP 5754698 2 2015 7 29 UUUDDDUDUUDU 00000000 0000 00 000 0000000000000000 000 000 0000 000000 00 0000 0000 000 DD 00000 B 00000 00000 000 0 0 0000000 00000000000000000 0000000000000000 00000 0000000000 000000000 000 000
82. 00000 000000 00000000 0 0000000 000 00 00000 000000000 00 0 000 0000000 0 00000 0 000000 0 00 0000000 0000 0 000 0000 00 00000 000 00000 00 0000 000000000000 0 000 00000 000000 0 000000 4 00000 0 00000 00000 000000 000000 0 0000000000 0000 0 0000000000000000 00 0000 0 0000 000000000000000 00 0 0000 0 00000000 00000 000000 000 0 00000 000 00000000 0000 0000000 00000000000 0000 0 000 00000000000 000 0000000 000000000 0000000000000000 00 0000 0 000000000000 000 00 50 0000600 27 5754698 2 2015 7 29 53 54
83. 000000 000 0 00 000 0000000 00 0000 00 0 00000 000000 0000000 000 0000 00 000 0 0 00000 000000 00000 000 000 00000000000000 0000 00 000000000000 0000 000 000 000000000 0000000 000 0 0000 0000 00000 0000 00000000000 000000 00 00000 000000000 0000 000 00000 000000000 00 0000 0000 000 00000000000 000000000 00 0 0000 00000000 0000 00000000 00000 000 000000000 0000000 000 0 000 00000 0000000 0000 20 000000 0 000 0000000 000000000 000 00 00000 000 00000000 0000 0 000 000000000 0000000000 0 000 00000000000 00000 000 0 0000 00 0000000000000000 0000 0000000000000 0000000 00000 0000 00000000 0 000 0000000 00000 0000000 00 00000 000000000 00 000 000 0000000000000000 00 0000 0 0 0000 gt 000 00 0000000 00 000 0 0000000 000000000000 000 0 0000000 0000 00 0000 000000 00000 B 0000000000000000 00 0000 0 00000 0000 0000 00000000 00 0000 00 0 D 0
84. 0000000 D 000000000000000000000000 4 000 000000 UUUDDDDUUDUDDUDUDUDDUDUDUDDUDUDUD 000000000000000000000000 50 17 JP 5754698 2 2015 7 29 34 33 00 0000000 0000 0000 0000 000000000000000000 EGO G 1 Zl TT IT lu T TPT Ha R E GOA ES thu ET ET T RHE EGE GD G E G
85. 00000000 000 000000000000000 00000 0 0000000 D 000000000000000 0000 00 0 D 000000000 00000000000000 0000 0000000 000 00000000 0000000 000000000000 DD 00000000000 0000000 000 DDUDDDUDUDUDDUDUDUDDUDUDUD 00000000000000 00000 0000 000 00000 00000 0 0 00000000000000 000000 D 000 0 0000000 000000000 00 00000000000 000000 D 0000 00 0000000
86. 0000000000 00000000 000 00000 00000000 000000000 D 0000000000 000000000 00 00000000 0000 20 000000000000000000000000 0000 000000000 00000000000 0 00000 0000000 0000 00 000 0000 00 00000000000000000 00000 000000000 0000000000 00000 00 00000000 00000000 000000000000000 00000000 000 000000000 0000000000 000000 00000000 00000 00000000 00000000000 00000 00000000000000000 000 00 00000000000000000 00000000000 0000 0000 0000 30 000000000000000000000000 00000000 DD 000000000 DD 0000 00000 00000 000 000000 000000 0000 0000 00 0000 0000000000 000000000 000 0 0000 000 0000 00 0000000 00000 000000000000000000000000 4
87. 1LPCLNG PYXCECFFGR A CHYAVCQSPCLNGGKCIRPRACYCPSSKTGHDCSRKRKAGYYHE 60 5 5 lt Q 92 AQ F lt 4 LY 42 POLYDOM ETSA 05 EX 80 7 8 319 866 23 C 9 F mRNA DOREY GenBank 7 Z 17 3 NM_024500 1 19 ACCAGGAGGAATCAGCAS TTGCATTCCATGICUCGATCAMAATCACACCTCTCCACCTGGARGCACATCCCCTGAAGA AAG ee C CCGSTGTGT6GASCGCCACTGTTI BACTGTGGCANSCAGCCAGCCAAATTTGGGA 207 1
88. 28 0 CTGTAGGGACTAAASTCCCTACTGTCSCATCTCTCATGGCCTATCCCCTGCCATTGGTTCTCTGC EBER AKMEN RAEN OTHER T TTGCTCTGG7GGTSGCACAGSTCTGGGSGTCCACTACACCTCCCACAGGGACAAGCGAGCCCCC 51725 1 1956100 TOATGTSCAAACAGTSGAGCCCACGGRACATGACATTCTGCAAAACGAGCCGBACAACCAGGASR CAGTGCAAATGTGTSGTGAGACCGCTGGGCCGAGATGCCTGCCAGAGGATCARCCAGGGGGCTTC CAGGAAGCAAGACTTCTACACTGTGGAAACCATCACCTCGOGCTCATCCTGTAARTGTGCTTGTE TTGCTCCTCCGTCTGCCGTCAATCCCTGTGAGGGAGACTTCAGGCTCCAGAAGCTTCGGGAGGC T CCTCCTALAGCTGCATTCGCTTACCACTARARCTCGTGGGGCSAETSGATAARCTGGAGGAGGANE 2 DP119 EP 2 6 2 2 586_151 129972527 70 3 0 565 AGGAAACTGTGTCACAGCAGATCAACTECAYCGAAC CCTGAGGACGCAGCCACTGGTCCCTCCT BERN 1 TRENES UTR CHS GC amp GCGATGAAGCCGCAGC6GCCCCTGCAGAGACAGGTGCACCTGAGAGGTCGGCTGGCC
89. 8 NA73457 Dr 2640 Dr 15100222918 FLJ90228 261151 TP100178517 09011483 Dr 05030117 De PP119 ag 13587 Dr RAISES 12100221918 Mm 51730228 DEPZPSBELIS1A Me 12100178517 11453 Dr 25930117 brats NAT34 7 0 NAL2640 Dr 12100221918 1080228 5 1161 2200178822 00811453 br ctl Dz 92119 8573457 Dr Dx 19100221838 28 Mm 5108 58650 2 Ra 8 146 19100178817 Ct911453 Dr Dr 0000 00 vens ag NA73457 Dr 12648 Dr 19100221918 1 190224 29596155 68 1 01911453 Dr 01930117 r 09 73457 Dz 12440 pr 12200221918 FBS DKEZPSEELISI 46 Rm an 19190178517 HS etal Dr Og 0273657 Dr 2640 pr 1100221918 7190226 DrPARBRSLSL Mm 17100170537 911693 Dr 620117 Dr 29313 373457 Dr 12105221318 Mm 98 DKFEPS8SU M51 Mm AR TFT00178517 6911453 0 7 29339 0000 00 NA73457 2640 Dr 1100241918 0099538 Hs PKPZPS86L1 10017851 CtgK1453 P lt 09030217 De 00129 Gg E 3 444 OER DP0444 JP 5754698 2 2015 7 29 NMSLRSMTPYRANRNEDSEGET
90. AATCATTATTTTTIGAGG 000000 14D EMP2_ Er RURA 07 2 EMP 2 XMP AIH GenBank 724723791 P54851 WANA 38 MWLVLLAPIIAEBITSAALLETATVDNAWWVGDEFFADYWRICTNNTNCTVINDSEQEYSTLGOAVO ARTMYLSTILCCIAFFIFVLQLFRLKQGEREVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKF YPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK 0000 15 RA770 RA770 Neurturin 02319 5 80 76 aLI MIYA E ua RRE 99 od AoT 30 12 819088 st MB 512508 dpb 0000 16 770 16 2280 RA770 562 54606802 0918085 39 SG61CGACCCACSCGTCCGGGTGAGCGTChGCGAGTTGGGCCTGGSGCTACGAGTCGGACGAGACCG T TTGTTCCGCTACTSCAGCGGCACCTSCGACGCGGCCGTCAGGAACTACGACCTCTCGCTGAANG AGCGTGCGCAGCCGGSAAGAAGATCAGGAAGGAGAAGGTGCGC6CSCGGCCCTGCTGCAGGCCGCT GGCCTACGATGATGACGTCTCCTTCTTGGATGCCTACAACCGCTACTACACCGTCAATGAGCTOT ZGGCCAAAGAGT CTRECTGTGTSTGAAGCGCCGCCTICGGGOGTCGCTCAATGEG GAAGCCC GTECTGGGGETGGCCATGGACCCCGCACCGCTGCCCECCECATSGACLTCCCGTGTCCAGTTGSA 6 566 0000 84 168 SIH RA770 40
91. AGAAGACTTLCTETTTGGCASCGAGGCTTTTTACAGCTGTEACCCTGGTTTCGARC VGC ShCCAAGCCGAAGAATTTGCCACSTTGACAAGAAGT GAGCCCCTCTGCTCCTGTGTGTAGG 3 6 CTCTGAGGTGGATTTTTA I
92. AWHYDFAN DPR TYVTNYYYGNSLVRFANLENFKOCRWE ROTLRAVDPPV PIKES YGRYZGIWUKDPAARDORT Y VINY Y YGNSI VEFRNLENFEOGEKS IDTLSTI PCPTTORTYSRNESAKKDPLAKDORTYVINY YYGNTLVEFRNLENSKOGRWS FDTUSTITOPTTONTYORKESAMMRIPLAIDDRT 00108 YVTNYYYGNTLVEFRNLENFKQGRHK EDTLNF15E2ITIDNTYGFEEGAWMKDPLDOPOKTYVTHYYYGINNLLSPZNIDVFROGRET EDTLASI 800001 1 DPTDH Y ST RVVYQZAV YY WENI T RNE IKYDERORF VASAMA PINSY E aje IV PAVESE IVLSPLDPADLSVHRETTRKTALRAN XKWR38SDIDEAVDRSGIMVIYPAYDPRDENOPEVIYLSRUDPGDLSVHREFTNKTRYAFN RROGASOVOFAVTENGLALI Y PALDS EDFROEVTVLSKURAVELSTQKETTERTPGLR PN RMQOG8SSVDYAVOENGLELIYPALPD ZSFSDEVIVLISKUINAVOLSTQRZTTWRT OLRERN RWOCHSOVDPAVOFNGUNLI YPALDD BOPSORVTVLSKLHAADT STQXETTNPTGLESS RRRGOSIMPLALIPISIMV I Y PALDD BEFLQEV IV LBESAPTDLEMKAETTKRTGLIRB TMG08S91D2SVDESGLNLIPR12D EGFHD8V1ILSKURASDI QUEKSWRTGLRIN ANZUSEDVDPAVDZNGIWVIYPALSY NOFKDEVI VLSRLNAADLSTOKETTHRTGLREN EYONCFLVCGTLEAVOTINQQZSNAVAPDTATGTOARPJUPELNENAY TT IDYNPKER FYGREFVECGVLYAVOSYNQ NAN i SYAFUTHENTQIVPALLF ENEYEYTTOI DYNPKDR S AFOTHTNTQLVPRLLFENCTSYTTQTDYHPEDR FYGROFV1CSNLYAVDSYUQENANISYAFOTHTSTQIVPRULPEREFSYTTOIDYRPEDR LUCGYLYATDSYNQQDYNLSYAPDTHTETOVIPHLPFSINYTYVIGIZSEPKE
93. C CGCGCGRGAAGGAGCCTGGGAGCATLCECCCACAETCLCCGTACASTCGGCTCGACTCOGTGCCC TYCGGCCCCAGCCGGGCTCCGCTCCTCGGGCGCGSCGAGGGGSCCGTG62GGCGGCGGCGCCCGGCaAT GTTTCATAGTCCSCG6CSGCTCTSCTCGGCCCTGCTGCAGAGGGACGCSCCCGGCCTGCGCCGCC TGCCCGCCCC amp AGGGCTSCGCCGCCCGTTGTCCCCGCCGGCTGCTGTTCCCAGGCCCGCATCCCCC CGGCTGCTGGCGGCGSGSCCTCG6GCGGCCTCGGGCGCCGCGAGGTCGTGTTCCCGAACAGTGTGTTC CATGGGSAACCGSTACAAGCAGACTCTATAGTGCTCTCGCCAARGACACTGAACAGCAGCSCTGCCT CCCAGCACCCAGAGTATTTGGTGTCACCTGACCCAGAGCATCTGGAGCCCATTGATCCTAAASAG CTTCTTGAGGABTGCAGGGCCGTCCTGCACACCCGACCTCCCCGGTTCCAGAGGGATTTTGTGGA AAGCTCTTGGAGAAGGCARAGACARCTTTGTACAGTGLCC TGTTGAAGCACTCAAATGGGAAGEA AGGRAATGYCTCATCCTOGAAGAAATCCTGGCCTACCAGCCTGATATATTGTGCCTCCARGAGST CCAACCAGGTGSCCATTGCACAGACCCTGGACTSCAAGGAGTCAGSCCGACAGTTCTGCATCG CTGTTACCCATCTAARAGCACGCACTGGCTCEGACCGCTTTCGATCAGCTCARBGCTETGACCTC
94. CCGACCCTCGCTGAGAACTGACTTCACATAAAGTGTGGSAACTCCC 0000 TAD neurturin GenBank 7 240 gt NP 032764 44 MRRWKAAALVSLICSSLLSVWHCQEGLLLGHRLGPALAPLARPPRILDARLARLAQYRALLQCAP DAVELRELS PWARRIPGPRRRAGFRRRRARPGARPCGLRELEVRVSELGLGYTSDETVLFRYCAG ACSAAIRIYDLGLRRLRQRRRVRRERARAAPCCRPTAYEDEVSFLDVHSRYHTLOELSARECACV 42 5754698 2 2015 7 29 00000 0005754698000001 app 43 JP 5754698 2 2015 7 29 51 lnt G 0000 306 2006 01 0000 3 06 0000 310 2006 01 0000 3 10 0000 109 2006 01 0000 1500 00000 000 79000 00000000 0000000 00000 00000 79000 000000000000 0000000 000 000 00 000 000 00 560000 0000000000000000000 00000 000000000000 0000000 000 000000000000 00000000000000 000 0000 590 00000 0000
95. CCTTCTTTCGTGCTCTGAARCCTCTGGCTCCTGAGGSTCARGGGCTGGAGSGTTTCTTCCTC W28 27 DP119 EBA 2 VVYNGSFYYNRAFTRNIIKYDLKQRYVAAWAMLBDVAYEESTPNRERGHSDVDFAVDENGLWVIY PATSYEGENQEVIVLSKLRAADLSTOKETTRRTGLRKNFYGNCEVICGVLYAVDSYNKENARISY AFDTHTNTQIIPRLLFENEYAYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY 00000 El 2F DKFZP586L151 RICA 5 GenBank 7 2 25654 1 6 MAYPLPLVLCENRLVVAQVWGSTTPPTGTSEPFDVOTVEPTEDDILONEADNOENVLSOLLGDYDK VKAVSEGSDCOCKCVVRPLGRDACORINQGASPKEDFYTVETITSGSSCKCACVAPPSAVNPCEG DFRLQKLREADSRDLKLSTIIDMLEGAFYGLDLLKLHSVTTKRLVGRVDKLEEEVSKNLTKEREQI KEDVEEFEIRTELNKRGKENCSDMTLESMPDIRSALQRDAAASBYAHPEYEERFLOSETVSOQINSIE LORTQPLVPPANMKPQORPLORQVHIRGRLASKPTVIRGITY KVSEEENDIEEQRDELFSSDS GVDLLISDQOLLRQEDLLTSATRRPATTRHETAARVTTDASIQAARASSSEPAQASASASSPVEPAPQA SORELLATPQTTTVEPEPTGVMPSTOVSPTTVAE TAVQPLPAMVPGOIPVEALPLVPLLPDTVST DMPSEEGTAGOEATSAGPILSPEEEDDIRNVIGRCKDTLSTITGPTTONTYGRNEGAWMKDPLAK DDRIYVTNYYYGNTILVEFRNLENFRQGRWSNSYKLPYSWIGTGHVYYEGAFYYNRAFTRHIIKYD LKQRYVAAWAMLHDVAYEEATPHRUQGHSDVDFAVDENGLWLIY PALDOEGEFNOEVI
96. G AGATCATCCCTCTCAGGCCTGGCNGR TGGTGTGGLSGACCICCTGGACHTINGCTCTGTG CGCTSCAACCGTGGCARCTGGCCAGAGTGGATGAAAGSGCACCACGTGAACATCACUANG AAAGSACTTTCCCGGGSACGCTCTCCCATTGTGGGCANCAAGCGARACCASAAGCTGCAG TOGAATGCARCSAAGCTOTITCTACCANTGGGGAGACGCARTTGGCGTOCGATTCAATGAG CTG TSCCACGGSGAABRGTGAGAGCCCAGCCARCCTGCTGGGTCYCATTTACGATGAARGAG
97. GCCAAAGAACARAT TSGAAGAACTAAATAAACGCCTTCAY ACAGATGTCCEATGGATTCCTTTTTCCICCCTATCTGAGCTCTTCCCCAGAACCGAARTRTGATG GSGSTGAGGGACATCGAGCATCTCACCGSTCTGGATTTCTACCGSARGACTAGCCGTAGCTAT
98. ISEARLKTSVKXFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLE ADYVAKSGPFRVFISVNDLEREGOZMFTDNTPLONYSNWNEGEPSDPYGHEDCVEMISSGRENDT EC8LTMYFVCEFIKKKK 0000 DP160 160 situ MTV RAES ABOLOPRE DP160 15 FES nt CROT AE ma BUT BAUERT st dob 835 0000 ARTIRIR ZAK 5 DPI 361902 65 55 AEG Gs 520 E 9 55 0000 El 12 DP160 191 El 12A ONO DP160 927 40 921 1 4000862 LNBs 31 TATAR ATHY LORY DP160 Nocturin TGCAGCTTGTTCCATGGGAAACAGCACCAGCCGGCTCTACAGCGCGCTCGCCAAGACGCTGAGCA GCAGTGCCGTGTCCCAGCACCAGGAOTGCCTGGAGCAGCCCANCTCGGCGCAGCTSGAGCCCATA GACCCCAAGGACCTACTGGAGGAATGCCAGCTCGTTCTGCAGARACGGCCACCTCSCTTCCAGNG GAACTTCSTGGACCTGAAGRAAAACACAGCCAGTAACCACCGCCCCATCOGGGTCATGCAGTGGN ACATNCTCGCCCARGCTCTCGGARGAAGGCAAAGACAACTTCGTTCAGTGCCCCATGGRAGCTCTG AAGTGGGAGGAAAGGAAGTGCCTCATCCTGGAGGANATCCTTGCCTACANGCCGGATATCTTGTG CCTGCRAGRASTCGACCACTACTTTTACACCTT 0000 128 IN DP160 32 AACSMGNSTSRLYSALAKTLSSSAVSQBQODCLEQPNSAQLEPIDPKDLLEECQLVLQKRPPRFOR NFVDLKKNTASNHRPIRVMOWNXLAQALGEGEDNFVQCFMEALKWEERKCLILEEILAYKPDILC LQEVDRYFYY 0000 126 CORA 4 Ek HFEF CCRN4L DEARER GenBank 7240779 99 XM 0039432 39 GGACGCAGCGGTGTTSCACCTCCCTCTCCGSCTCTGCTGCCCGGGATTTCCCCAGAACCTSCG
99. KPFVLQLFsSVAP LLEFPDAARRGeSKSVSAQCLFDLIQSLELETTDILOILELVKR LKSLDECYGNEDL VAYAPESPRSLONLMVUEALVPCYLORLKRQTSQVETVPA it SVEVLTRENLELLEEGQS LPREELDERIAREEFRRSRESL 0000 00 46 DP444 Mm DP444 Gg Or 5 HODATE OPA 20 40 8s MXVKRYEESROOEQDOGRGIFLPICTPLVROTSAFLRFKEGKQYSASCYSFERVUVESKL IS DPA44 XVKRXSS9GO8ODOSRG12LPIQTYLWROTSAPLRPKUGYQYKUASCVSEERVUNENELEG 20858 oe ERTLVENELHG DP444 Dr 1 DP44 LSPALSTANQSI SRERLVGAALPEPNACTATLSNRNETRGONLIVAE hpasa 04 LSTALSEATQSISPWSLUVQARLPHYTHCTATHTSEREKZQEQDKLGVAETKLLHTSMMIL 44 Dr L3PKLTEALQSISPEEUVQANTPIPELAICTST 139 140 0 444 He 946 Drass Deasa LOE 55 FOS DRTSSHGGESSAS 0 PAPSTTNOETINNRAKFF GSB 096 0 190 220 210 320 220 240 meses TYYLEVFLPAPTANR2IFRSDLTFRLASGUVIWOPKMEHRCPOVSOFFKLVKPJRN Dady ESDLTFRLASGLYINQPVWRHRQTEVSAFNALNKPT
100. LNHLLRANVYRPPVPDEVAKPLYPVALPSASDF01GCTCDDKNKLDEL 4 BAN NKRFRVKGTEEKHLLYGEPAVLYPTKYNILHEHDFESGYSETFLHPLWTSYT15SK GI EBB 2517 DPBS LASCVREDLKRISPGNSQOSCSAYRGD5KOLSYSFLFPPOLSSSAEAKYDAFLIT 40585 NYFQRVLVKRYATEFRRGVNV1SGPIFDYOYDSUBDTPEKIKQEV SAIPVPTHYYAIITSCLDPE TQPADKCUGPLSVUSYILPHREPDNDESCRSMEDESXWVEDILKMHRTARVRDIEQLTSLDEFRKTS 200 RSTTEILSLKPYLHTFESEI B 8 XL Z 7 93 BIRT ORBEA GenBank FYE AE 1467201 23 1001067000 60006 6770 0677600777 6 0
101. ONRFKLVNSANIRLTAHTL KTHOVAIAQTLECKESGRQFCIAVTHLKARTGWSRFRSAQGCDLIONLONITOGAKIPLIVCGDF NAEPTEEVYRHFASSSLNLHSAYKLLSADSOSE TPKE RTSGECRHTLDYIWYSEHALNVRS ALDLLTESOTGPNRLPSFHYPSDHLSLVCDFSFTEESDGLS 0000 iE 13 RA977 ORR RA977 0000 RA977 40 5754698 9 00000 00 14 RA977 14 RA977 0 890 55 35 IE UTR BIL f ACGCACGCACCTCTGCCTCTGCAGGCGGATGAGGGGSCACTTITTSADAAATTATTT GTTGATICTTCTGGCTTTCATTATTATATTTCACATAACTTCAGCAGCGCTOTTGTTCAT CTATTGACAATGCCTGGTGGGTAGGAGATAACTTTTCTACAGXATGTCTGGAGTGCATGTGCCACA 6 6 0 0170760 50 TGGTGAAATGG T 0 STTCTT6GCCTCTOTCASI Shi
102. R SYAFDTHTETOMIPRLPP LPT YTTO1DYRPKEP CGVI YRUDEYNKRRRNT SYAFDTHTUTOT IPRLLPENEYAYTTOLDENPKDR 390 VLYAHDNGHGLTET LAS VUEAWDNGHQLTYYLNEVY 3 AWLNGAQVTYUVIERY KUYAWDYGHOVTYHVIFAY LLYAKONGHOVTYHYIFAY 000000 0 2575 DP444 REEF a lt gt 249 TII RERS UAR 24 RORE 000000 b DP444 5 49 122 L 35 5 UE 24 BAO a b in situ 724 gt EEC Renit 2889 JP 5754698 2 2015 7 29 00000 4 02444 8091 8918891858 7 L 6 06 5
103. RPCGLRELEVRVSELGLGYASDETVILERYC AGACEABARVYDLGLRRLRORRRLRRERVRAQPCUCRPTAYEDEVSFLDAHRSRYHTVHELSARECA cv 0000 16E neurturin DHEER GenBank 008738 1 43 SGAGGGAGAGCGCGCGGTGGTTTCGTCCGTGTGCCCCGCSCCCGSCGCTCCTCGCGTGGCCCCGC CAGTGGCTSGSGCCGSGCCGGGCTCGGGTGGTCGGNRGGAGTCACCACTGACCGGGTCATCTGGANS CCCGTGSCAGGCCGAGGCCCAGGATGAGGSCGCFSGAAGGCAGCGGCCCTGSGTGTCGCTCATCTGC GCTTGCCCCGCTACGACGCCCTCCACGCACCCTGGSACGCCCGCATCGCCCGCCTGGCCCAGTATC GCSCTCTGCTCCAGSGCGCCCCCGACGCGSGTSGAGCTTCGRGANCTTTCTCCCTSSGCTGCCCSC A CCCG66G8CCGCGCCGTCC AGCGSGGTCCCCGGSCGTCGGCGGGCGCGGSCCGGGGGCTCGGCCTTG TGGGCTGCGCGAGCTCGAGGTGCGCGTGAGCGAGCTGSGCCTGGGSCTACACGTCGGATGAGACCG TG GTGTTCCGOCYACTSCGCASGCGCGTGCGAGGCS CGCATCTACGNCCTSGSGCCTTCSG LGCCTGCGCCAGCGGAGECGCGTGCGCAGAGAGCCGGCGCGGGCCCACLCOTGTTIGTCGCCCGAC 0 TG
104. RR DP444 ERHNATVELSUPLFAPLTNRTHEEULTPRLAGGLVIAQPARTIRQODWPAFSALIKPLAR 290 DPA 127 1 500 us IZTAKRBSPTNSQSCTCES2SSDTRQQGEGMOVYSE3LQOSPSTS Drang IV1AKRSSPTNNQSVTCESLNLDSG pTEGLQVUCETTUPDSVE gt SKVTVSACIRGUSLE DF444 130450 JCEAVJCESALSDESSSTSATOCGCARGNSLE 395 i l 09444 GSLESOTSQERSPNSRASIV E SSLSSOTSAERGPEVSRASLNLPPOGRSRYATYFUVAVIRCLIANPEWSERGTOESIAY GSVSSOTSOERGTPHPRVSMVIPPCQKSRYNTYFDVAVLRCLLQOPHZSEEGTQGELNYYS 07666 Dr ORAR TATY FOVAVLRCLNQPUNTEEGVHWALIYYL 230 RS PA Dr444 QRLRIMLZERPESPP DF444 QRURMMLTEKPBET Drass GRLRHHLOEKPSEEP 016 82 PRPRESSMEAAA PSI INTEXT 0000 0 D444 22221 07444 07444 2272 prasa 09484 2220 07444 09444 Deasa 4 00000 Dr PRPRSSEMVANTPSLVNYNSIT 40 456 560 8 Griminamprrsstsseneekvs PKYZRSPXT QAR8 Q5LYEKCHEESZSLSPEAFSFVSLYOLRRSKITPDLEEDLMSIFXZFYSRK DREB QLlWwCWSEEXELSTEAFSEVSLTIXIRPZKVPpLLSTOLGNSIPKXPKERSRIRERERKG Dr QONPLEMEESRELESETASRVSVTLRRGAVPDI R 1 KG sac 1 LV
105. S PISTE SPGA KONOHI L 3 PPHETOKP ROFL LUD LUE PIAS SPOS IGUETORAG I EKNOWQTTI L SL PYHWSCKERORPMENPTE T2120 0 SEDLEHRTGRKRQPRNGUPF 560 570 530 LERA Nm GXLTSRGSEDANTSMEATSART Dr lt Mo TERSNEASUNTI KESVRSQE STITNAT 429 YNTTLASFXVGYADFFFREHMRYI FRITLASPIRASYROFTSETMRKIAWOVT PENFNEPLACANLPUSITOSTINTSCLEDTO Dr PT PEMPCEPLACENLPRSLTOSCTHTSLEDAD 5 5 56 EVYE KAV YI VIND rset 3 APTANA DE T t TMupILESGWUDTMVRGKNYWRE 1 749 125 5 DP810 DER 37 000 JP 5754698 9 0000 00 B 6 DP810 8291 SA I RUDS 62 425 FT E57 3 EI gt 4 2 GAATTCGGCACGAGGATCACOCACGTCATACTXCTOGOGGACRACTICAACTCTGAGCACAART 0607560 0 gt 0 6000 0070 SC
106. SYI HIDGTNSFVHKNSMI DLSVVLEAVYLVLNHDISSRACDVALNIVECLLOLGYYPCVEXRRKKSENKENETLEKRP SEGAFQFKGVSGSSTCGFCGPADESTEPVSKHRLALTMLIKXIVKSLGCAYGCGEG DRLRHQY AONCLTKLYKLDXMOFRQTMEDY VNKDSLENVVTIA LEGECM NKAGPGNRPLTIVDHKSTAQNYEGI EVSAMFKSLITRCASTTHELASPENLGLYCOTROLY QFIKEAEGNVERSVLLSALLDSAEXLAVSKAVELNEOESKPAGSKSDEQHOGARLGREDE WRKMFKSQSAASDTSSQSLQDTSECTTARSGTTSDRRARSRSRPI SLRKRLKLE LLDISSVDRLSYIROSSRVKFTSAVKL SEGSPGSGMENGRDEEENFE HSVDDHLSPNCOGGKSKNVYNLGALRQGMERTOFLLNCCEPLT I PDASILAAALD LEBPVYARAALFLECARSVHURCHRENEPEHMKGHHPNITKKGI SRGRSFTVGNKRHOKLO WNAAKLEFYONGOATSVRENELCRG SPANLLGLIYDEETKRRLRKEDEEEDLDOSKE 4 LRLDPELDRHRYERKISFAS LKSDAGVEEXKVPSRKIRIGGS RLLQIXGTRSEFQVEKGGSLSS ODSESSAEELQLSQSRDTVTDLEGS PWSASEPSIEPEGMSNAGAESNYRBNMSWLHYMILLCNOQSFICTHVDYCHPHCYLBNSR SCARLVRAIKLIYGPSVDSLRESSNIESSVALRGRKQKFCSDKSCLST PSLEKRVSDANLE GKKDSGMLKYIRIQVLLPGSESFMELLTGRGLQTAYLLMFSTYNTSWYSVGIKPLOLVMS LSPAPLSLLITRAARTL PETYORLRAVLXFHTLERFRYQYR PRN QA EEEKKRLSREASLITAIPITQEACYEPTCTPNSEPEEEVEEUTNLASRRLSVSPSCTSST SHRNYSFRRGSVRSVRSAVSASDEEHTIEHTPNHEVPQPPQRVEPACICANVLE DOGEVREDSVAVSAVAQQVLWNCL1EDESTVLRRF1EK14 FPAQTEHTLFRYLVSLIMYFYVATPCEWSHOAISATI AQQT FKKSFSARAVSRSEQRABRI CEVKLLVTASMPGTKTLVYHCQUECOIFTOLPYE amp VLFLISLTOKIPTABRKQSHVSHLQEZDLLRLPSFPRSAIDASESLFSOPQAGKELFGLDT LOKSLWIQLLEEMFLGMPSEFFWGOEIMLFLNVFNG5LILBFEDSALLRQYSATVINTAV BRFXHLFSLSGYQWILPTWLQVYSDYESNPQLRQAISFACHQFYILHR
107. TCCAA GCCCACCGTOATCAGGGGAATCLCCTACTATAAAGCCAAGGTCTCTGAGGAGGAAAATGACATAG
108. TCG GAAATTCTGACCCTCAAGACATACCTGCATACATATGAGAGCCAGATTTAACTTCCTGGGCCTSG SCAGTOTACTCTTAGCAACTG 000 E 8F HON RILAFE EORATP Am H 2 GenBank 7 242721 a 85 AAH032841 802008 915 26 MARQOGCFGSYQVISLEFTFAIGVNLCIGFTASRIKRAEWDEGPPTVLSDSPWINTSGSCKGRCEEL QEVGPPOCRCDNLCKSYSSCCHDFDELCLKTARGWECTEDRCGEVANEENACRCSEDCLSRGDLCC TNYOVVCKGESHWVDDDCEEZRVPECPAGEVRVPPLI PEVUGFRASYMKRGSAVMPNTERLRSCG THAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATPHLAGREXFNARWHGGQPLE TIATKQCVRAGTFFWSVSIFHERRELTILONLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEHT NPLREIDKTVGQLHDGLKOLNLHRCVRYIFVEDHGMEDVTCDRTEFLSNYLTNVEDITLVPSTLG RIRPKIFNNLKYDPKAT JANLTCKKPDQBPKXPYMKOALPKRLAYANNRRIEDLHLLVERRRRVAR KPLOVYKKPSGKCFFOGDHGFDNKVNSMQTYFVGYGPTFKYRTKVPPFENIELYNYVMCDLLGLKP APRRGTHGSLAHLLRINY CRPTLPEEVSRPUYPGIMYLGSDEDLGCTCDDKVEPKRKLEELRRRL HYKSSTEERHLEYGRPAVLYRTSYDILYHTDEESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTN CVRPDVRVSPGFSQNCLAYKNDKQMSYTGFLFPPYLSSSPEAKYDAFTVTRMVYPMYEAFKRVWTEF ORVLVHKYASERNGVNVISGPIFDYNYDGLRDYEDETKOYVEGSSITPVPTAYYSIITTSCLDFTQP ADKCDGPLSVSSFILPHRPDNOESCNSSEDESKWVEELMKMHTARVRSIEHLTGLDEYRKTSRSY SEILTLKTYLATYES 000 Z 9 474 OER WE474 39 5754698 2 2015 7 29 00
109. TGSITSTGSTGARGGXNCACCGAGGGCTCTCTGGA 6 6 0 00 CBATCCCGCAEAATTTCCCTCCGRARGARGCTTAARCTCCCCATAGSGRACTGSCTGAR
110. TPYYTNY OQ 259 LYSMDLMKVRAYMNKVV LFEMDLLXVS YINEVVS FYGLOLLKLESVTTKVG RVDRLEBEVSIO FEGLDLLKLASVTTKING RVDKLEREVSKN FYGLOLLKLAS PYOMDLLKLISVTTKILD 1 anniv inana taa RMD Eleva FYGMDDLKLRSVTYYLLE 10 500 007 LSRESNEVVKDSVRALSEQLRRY LTKEKEQ1KEDVEETRTSELNXRGKEECSDN TLESMPDI RSALQRDAA 5 LTKENEQT KSOVELIRTELNRRIGKENCSIN gt 4 SNMPDERSAILQRDAA LTESNEQIKEDMEE1RTPMNVPOXERCSEN T LOSMPDIRSALGRDAA OTSEKLRTYSXSeRP PTTLPSYIQEKS LTZEKVSVKGERGOG PSKAQOTAGGQGRIANYIS TOKS KRST RIRI POPTAR GSEAQIZARGKGRDO15KYGSVOKSPAPRGUPEPPREKULOVEKLR KEBGKGSFUQPTAX AAYPME ESERRFLQOEERTVSQQIRSIELLRTQEUVPPAAMKPOPPLQRQVELRGRLASK AAYKHPESQYEEXPLQSETVSQQIRBIELLRYIOPLAPPTVRKPRQPSQRQVELRGRLASK EYEERFLGEETVSQSINSIELLOTRPLANLPZVVKSOR TSLRQGN DEAAAPQUMESKYEBKFVGD TDBGSDLNKATTALOB 0 PDQRRYEUXFVGNQOPEKPVLKSESEGQE 1 PENLAQQQA 0 0 PRALAQQQAVIRGPTYYKAGRQ FNTEAVADNALOGTSWLEQLPPRVEGRENS PTVIRG1TYYKAENSEERNDIZEDNOELFSGDSGYDLLIEDOLLRDEQ LLT PIVTRGITYYKAKVSEESND I ZDOHDELPSCNSGV LLI EDQLLRQED LLN VIRG17YYKAKVSEEENDIFESQOQODEFFSGDRSVO1LIEDOLLR DSG LMT KITVRGITYYRIDPVDEMDS RNLXETSAS VTOTGAL KEHLRASTOSTINT 3 0000 00 ctg30117 07219
111. TTTGGAAGCAATGTGCTAAG GC TGCTGTTC STTCTGCTATTTATA TTGCTETGCAAAAGTE arachan T CTT 0 GCCT e CTCTOAATTTCAGGCATIACTACCCTACTTTTTAAAKAARGTGTTTCTGCTSTITGCTGAATACAT 00000 00 STTTTAAATAAACAGATGTAGGTIT T TGAAATATTA AAGGCTGAAAGTAGATAGTCTCTAAGY TGGGTGTTTGGCTAGTCTT TAAGCTGAAA TGCCACTOACTISAAGASATGCTTCTICAGTTTOTTSCCTIAATART GCTTAGSIT JCAAATATTTARGATARAGATSTATAT
112. VCDCG 0000 100 20 Aire 10 0 BLIP GOLEC10 GenBank NM 005438 2 29 CTOCGAGACCCTTTTCTGAGG lt ACACACACAATITCACCAGGRECCARAGGAGATGATOCY GAAARAGGAGATCCAGEACAAGAGGE
113. VLSKLNAV JLSTQKETTWRTGLRRHFYSNCFVICCVLYAVDSYROPNANISYAFDTHTNTOIVPRLLFERTYS YTIQIDYNPKDRLLYAWDNGRQVTYBVIFAY 0000 00 2 RED E Dr 227 4 6 759 Dr Z22 Danio rerio Gg 57 P N DP119 X gt F 2a NA73457 8 2660 Pr 7100222918 7190228 Wa DKEZPBEELESLE Mm CLIBAR Zn 12100136517 11453 br Dr 02119 Gg MNAT345 Dr 2640 Dr 1199221518 Fuj9a228 us OKF2FSS6L1S148 Mm cuisait 1199179517 Hy 11493 Dr 17 br 73457 Dr NA32640 10100221918 022 5861151 1586 12100176517 5811453 Dr 930217 Dr 09219 73457 Dr 12540 Dr IPI00221918 90228 DKPZPS8613518 Mm LLIBA Rn 1 100179517 0000 00 Dr etg10117 Dr DS RA23452 Dx 60 Dr 1100221918 1390228 Dxrepseellgitk 2278517 011453 De De DP319 RATS Dr NAL2640 Dr 1100221918 Mm 190228 DKFGPS06L15188 CEIBA Rn 1210017452 Ctg11433 Dr Dr Sra Gg NA73457 Dr NA12640 Dr 12109221918 Me FL290228 Ba 9005851153 85 Mn 1100178517 6 65311483 Dr argit Dr Gg M22345 MAY2640 Dr 12100221918 Mm 2 DRPEPSBELLE1 Crna 19100178517 09611453 Dr MKR1VELYACLLMMSSHVSSQOSZI
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