スリー・ディー・マトリックス（7777）
Contents
1.2. 1992 MIT Shuguang Zhang
3. TDM 641
4. 7777 SR Research Report 2014 7 25 DDS Drug Delivery System
5. SR Weaknesses
6. pH bFGF PDGF Shared 6Qesearch http 7 www sharedresearchjp Copyright C 2013 Shared Research Inc All Rights Reserved 78 81 w
7. SBS DIC
8. 2013 5 3 D Matrix Asia Pte Ltd PT Tegushindo Lestaritama TDM 711 15 FDA TDM 641 PMDA RPN 2
9. SR
10. pH TDM 621
11. s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 Scaffold GLP Good Laboratory Practice pH
12. 5558104 3 D Matrix Inc 2014 6 17 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w
13. DDS 7777 SR Research Report 2014 7 25
14. TITITITITIKIKIKIKIKIKIKIKIKIKIKI1I1 1 2014 4 107 1 523 1 525 2015 4 TDM 621 10 418 4 483 4 466 3 564 SR 3
15. TDM 631 TDM 631 TDM 631 f Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 28 81 7777 SR Research Report 2014 7 25 TDM 631 X TDM 631
16. 510 k s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 SR TDM 511
17. MIT MIT MIT 2001 5 3 D Matrix Inc 3 D Matrix Inc 100 6 3 D Matrix Europe SAS 1009 3 D Matrix Asia Pte Ltd 100 Re Shar ed esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved Shared 7777 3 3 D Matrix Asia RAe Ltd SG
18. FDA 2015 4 2014 1 14 C E E U C E C E 7777 SR Research Report 2014 7 25 2014
19. 3 2012 7 2012 7 31 2012 360 RNA
20. SR Tnc SR tnc http www sharedresearch jp Email info sharedresearch jp 3 31 12 03 5834 8787
21. 1 000 2013 5 3 DMatrix Asia Pte Ltd PT Teguhsindo Lestaritama TDM 711 2012 2 15 FDA TDM 641 PMDA 2014 4
22. TDM 621 2014 4 PMDA 2014 3 PMDA 2014 4 2015 4 2015 4 2014 4 106 4 178
23. s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 3 D Matrix Asia Pte Ltd 2012 10 100 2012 9 2012 9 6 Massachusetts Institute of Technology MIT
24. DDS siRNA PuraMatrix Becton Dickinson and Company CPC Scientific Inc 3 3
25. TDM 711 TDM 711 TDM 711 Shared Gcsearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved Shared 7777 SR Research Report 2014 7 25 GLP
26. TDM 621 2010 1 97 2011 4 TDM 621 5x7 2011 5 PMDA
27. SR GCA
28. sShared 6Qesearch http www sharedresearchjp Copyright C 2013 Shared Research Inc All Rights Reserved C w lt Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 102 0083 3 2 4 HF 7 03 3511 3440 2004 5 19 2011 10 24 HP http www 3d matrix co jp index html 4 TIR IR http www 3d matrix co jp ir index html Shared GYesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25
29. 3 III 1 1 2 II 3 1 ic ssa E T esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 1
30. 2 3 2014 5 12 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 3 D Matrix Asia Pte Ltd 3DMA A STAR
31. MIT MIT 2014
32. 2014 6 4 TDM 621 OO Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved PF 7777 SR Research Report 2014 7 25 3 D Matrix Asia Pte Ltd TDM 621 2014 6 3 CE Health Sciences Authority 3 D Matrix Asia Pte Ltd
33. s Shared GYesearch http Www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 gt TDM B2 1 TDM 621 C 1987 C
34. CE TDM 621 2011 5 1 4538 10 TDM 621 2012 4
35. 5057781 MIT 3
36. CRO PII II 1 2 3
37. MIT ea 9 sShared eSsearch http Www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 8 7777 SR Research Report 2014 7 25 CSL amp 1 4502 2009 Medmarket Diligence 1 4503
38. 1 2 2014 6 FDA 510 k l 510 k FF AR EA SEP ESR ARP RP A
39. 2012 9 5 MIT 7777 SR Research Report 2014 7 25 507629 MIT 3 2
40. w es a T Shared Wesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 40 81 7777 SR Research Report 2014 7 25 170 TDM 621
41. 3 D Matrix Inc PanaceaGel 3 D Matrix Inc MIT 3 D Matrix Inc Shuguang Zhang 2014 1 15 TDM 621 CE 3 D Matrix Europe SAS TDM 621 CE 2014 1 14 EU TDM 621
42. 753 354 3 14 26 48 310 309 2012 4 300 TDM 621 2011 5 PMDA TDM 621 sShared 6Qesearch h
43. KOL Key Opinion Leader s Shared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w Shared Yesearch http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved e 7777 SR Research Report 2014 7 25 2014 4 3 2014 3 14 2014 4 3 2014 4 3 56 13 1 049 707 1 058 696 1 059 697
44. s Shared GYesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 13 4 14 4 15 4 16 4 17 4 32 107 10 418 14 307 18 473 395 599 1 704 1 387 1 725 636 1 024 1 909 1 975 1 783 999 1 518 4 483 6 796 8 213 978 1 524 4 466 6 779 8 196 978 1 525 3 564 4 678 5 450 SR TDM 621 TDM 621
45. 2017 4 2013 6 2013 4 FDA IDE Investigational Device Exemption 2015 4 2015 4 2016 4 2014 1 CE EU EU CE CE 2015 4 CE EU 28
46. TDM 711 3 sShared eSsearch http Www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved J 7777 SR Research Report 2014 7 25 TDM 711 1 1 1 ek http www sanramonoraleurgery com boneerafting htm MD
47. 2015 4 Shared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved we s Shared Yesearch http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved e 7777 SR Research Report 2014 7 25 Massachusetts Institute of Technology MIT MIT MIT
48. 2016 4 TDM 641 2015 4 2016 4 TDM 631 2015 4 2016 4 TDM 711 2012 2 2015 4 TDM 511 2014 4 FDA 510 k CE
49. 2 3 4 PMDA FDA 5 PMDA FDA 6 2 3 7 TDM 621 TDM 711 TDM 641 TDM 631 TDM 511
50. PCT SR Re Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 3 D Matrix Inc MIT AMENDED AND RESTATED EXCLUSIVE PATENT LICENSE AGREEMENT FIRST AMENDMENT SECOND AMENDMENT THIRD AMENDMENT TO AMENDED AND RESTATED EXCLUSIVE PATENT LICENSE M I T 3 D Matrix Inc M 1 T SR 2014
51. TDM 621 2011 5 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 2009 4 1 8001 TDM 621 Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd
52. 2000 4 MBA e gt SadQeweami http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 1999 JASD
53. 2015 4 TDM 621 4 6 gt SadQeweami http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved sy 7777 SR Research Report 2014 7 25 3 613 122 6 1 704 184 9 1 909 86 2 TDM 621
54. 4 a B a TDM 711
55. 3 2 3 2013 5 20 TDM 621 CE sShared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 8 w 7777 SR Research Report 2014 7 25 3 D Matrix Europe SAS TDM 621 CE 2013 5 17
56. TDM 621 PMDA 2011 5 TDM 621 2014 3 30 1 4471 2010 6 18 2011 12 2014 1 TDM 621
57. 2013 4 2015 4 2014 4 4 747 4 495 2 055 1 691 2 049 1 685 1 752 1 441 2015 4 2013 4 2014 4 2014 4 2014 4 2015 4 2013 3 2013 3 21 ISO13485 ISO13485 ISO13485
58. Shared 6Qesearch la http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved e Shared Yesearch http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved e 7777 SR Research Report 2014 7 25 amp 2014 7 2014 4 1 TDM 511 2014 4 2014 2 2014 2
59. 1 000 ASEAN 2014 3 2013 6 13 2013 7 2013 7 31 2013 7 5 SMBC s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 2013 7 5
60. 6 2016 1 344 iDATA Research 2016 1 078 millennium 30 509 2016 1 344M ii ipATA 1 600 M 1 400 1 200 1 000 800 600 400 200 0 CY06 CYO7 CY08 CY09 CY10E CY11E CY12E CY13E CY14E CY15E CY16E SEALANTS mHEMOSTATS 2016 1 078M 20 AM 2010 2016 1 000 800 600 400 200 0 CY10 CY11 CY12 CY13 CY14 CY15 CY16 al Shared esearch http Www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25
61. PMDA 2013 4 2014 4 2013 4 2014 4 2013 4 2013 4 2015 4 2014 4 4 495 3 845 1 691 1 091 1 685 1 085 1 441 936
62. LICENSE AND SUPPLY AGREEMENT 3 D Matrix Inc PuraMatrix 2007 10 3 D Matrix Inc 2008 2 Becton Dickinson and Company SUPPLY AGREEMENT PuraMatrix RADA16 7777 SR Research Report 2014 7 25 2008 3 2008 10 TDM 621 2009 4 2009 7
63. 509 300 Ce 7 000 6 058 5g14 5 931 006 180 176 3 4 2173 0 1474 0171 3170 7 169 2 168 6 a 5 000 4 000 3 000 wm 1 000 100 o ee ee 07 08 09 10 11 12 13 14 2006 2007 2008 2009 a gt Shared csearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25
64. SR Inc SR Tnc Shared Researcn SR Inc SR Inc SR Inc SR Tnc
65. CE TDM 621 2014 5 30 3 2014 2
66. Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd PT Teguhsindo Lestaritama Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd 2014 6 2015 4 TDM 621 14 000 1cc SR b TDM 641 TDM 641
67. KLab TOKAI CI
68. TDM 621 ISO13485 TDM621 2013 2 2013 2 4 TDM 621 FDA IDE TDM 621 US01 2013 2 1 FDA IDE Investigational Device Exemption s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w s Shared Research http Wwww sharedresearch
69. MIT EE US 5670483 MIT 1997 9 23 2014 11 29 NM Ne US 6548630 MIT 2003 4 15 2017 7 21 ri nl PuraMatrix WO 06 014570 0 2008 6 _ 316133 MM 6 US 5955343 MIT 1999 9 21 2014 8 21 PuraMatrix US 6800481 MIT 2004 10 5 2017 3
70. s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 SiRNA 21 23 RNA siRNA RNA RNAi RNA mRNA MTA Material Transfer Agreement
71. SharedQewemrh http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 TDM 621 TDM 621 TDM 621 8 LMA Informed Consent 0 2 a
72. TDM 621 2010 4 2011 4 PMDA 2010 8 2010 9 Daewoong Pharmaceutical Co LTD s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 PARTNERSHIP AGREEMENT Excelsior Medical Co Ltd LICENSE AGREEMENT TDM 711 2011 3 FDA IDE 10 4 11 4 12 4 13 4 14 4
73. 2011 Phase 1 2011 4 158 2010 4 402 150 2010 4 400 641 2010 4 174 50 TDM 621 122 482 2010 4 65 510 60 534 61
74. SR Research Report 2014 7 25 esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 MIT 3
75. 1 2 3 3 2013 4
76. 2015 4 TDM 621 2016 4 14 307 6 796 6 779 4 678 TDM 621 40 TDM 621 100 TDM 621 3
77. TAIB JAIC Asian Balanced Private Equity Fund 2010 9 200 400 2010 9 300 600 Excelsior Medical Co Ltd Daewoong Pharmaceutical Co LTD 2011 10 1 352 700 2013 7 2 289 550 2014 7 5 051 1 270 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 10 4 11 4 1 8 5 EPS 7 870 6 EPS DPS 0 0 BPS 137 634 2 1 600 13 568 EPS 4 5 EPS DPS 0 0 BPS 86 0
78. TDM 621 PMDA C E 6 CE 45 2013 2013 5 3 D Matrix Asia Pte 7777 SR Research Report 2014 7 25 Ltd 3DMA PT Teguhsindo Lestaritama TDM 621 TDM 621
79. 10 4 11 4 12 4 4 PlcD i 1 28 434 131 2 13 18 100 FCF 1 2 40 452 231 573 498 1 400 A 75 79 79 B 11 10 90 C 1 20 FCF NI A B C 467 318 SR 647 56 703 983 86 36 210 1 139 http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 1 680 83 1 763 2 360 102 40 485 1 948
80. CE EU CE EU EU 0 MDD CE EU TDM 621 CE 2013 5 15 2013 5 31 1 2 2013 4 2013 4 19 2013 4 3 2013 4 32
81. DDS MTA
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83. TDM 621 RADA16 TDM 621 97 gt Shared Research http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 Le nsama 2 i gt _ WT TDM 621 US gt
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86. 70 2019 4 http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 2007 10 579 1 448 3DM Investmen LLC Massachusetts Institute of Technology 2009 11 500 1 250 4 JAIC
87. EU CE TDM 711 2012 2 15 FDA TDM 641 2012 4 2012 6 13 2012 4 1 107 1 TDM 621 2 TDM 641 3
88. RNA 2013 4 2012 7 17 2012 8 31 1 2 4 604 9 208 2012 6 2012 6 18 TDM 711 sShared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 TDM 711
89. TDM 641 TDM 711 2012 3 2012 4 TDM 621 3 D Matrix Europe SAS 2012 10 3 D Matrix Asia Pte Ltd 2013 2 TDM 621 FDA IDE 2013 3 ISO13485 2013 5 PT Teguhsindo Lestaritama sShared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved amp w 7777 SR Research Report 2014 7 25 TDM 621 2014 1 TDM 621 CE
90. 800 2015 4 2017 4 2 800 2014 8 2018 4 200 2014 11 2016 4 800 2015 4 1 600 000 2014 6 24 2014 6 26 0 90 1 00 sShared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 8 w Shared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25
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92. 1 524 4 466 1 525 3 564 1 SR 2015 4 10 418 4 483 4 466 3 564 TDM 621 50 55 TDM 621 SR TDM 621 TDM 621
93. 2014 7 1 St John of God Hospital St John of God Hospital Department of Surgery Bernhard DAUSER M D 4 000 2014 7 11 2014 4 2014 4 2014 6 25 7777 SR Research Report 2014 7 25 1 270 000
94. Forsyth Institute 2012 2 15 FDA 2012 4 2012 4 12 2012 4 1 100 550 300 456 256 477 255 478 TDM 621 TDM 621 1 4538
95. JASDAQ 2008 2012 7 2014 4 35 19 38 9 3 4 IR 2 4 w es a T FF sShared Wesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved lt Shared Yesearch http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved e 7777 SR Research Report 2014 7 25 IDE Investigational Device Exemption FDA
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97. 32 977 978 2013 4 19 TDM 621 PMDA ISO13485 TDM 621 FDA IDE Investigational Device Exemption CE EU s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25
98. 3 4 gt e Il 7 ts A Le e my 2 A4A a 2 esear ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 SW Strengths Weaknesses Strengths MIT
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101. MIT 3 D Matrix Inc 2003 4 MIT Exclusive Patent License Agreement MIT 2004 10 3 D Matrix Inc License and Supply Agreement 3 D Matrix Inc 2007 10 3 D Matrix Inc 3 D Matrix Inc sShared 6Qesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved amp w 7777 SR Research Report 2014 7 25
102. Mizuho International Plc 2014 7 9 2014 6 20
103. MIT 1 4 1 MIT MIT 2 3 4
104. TDM 621 2009 2015 4 5 RADA16 Shared Giesearch http 7 www sharedresearchjp Copyright C 2013 Shared Research Inc All Rights Reserved 38781 Shared 7777 SR Research Report 2014 7 25 0 3
105. 1 4521 TDM 621 1 000 MR 100 TDM 621 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 MR 700
106. TDM 621 Shar ed esear ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 1 Informed Consent 2 3 TDM 621
107. Exploit Technologies PTE LTD ETPL A STR Institute of Bioengineering and Nanotechnology IBN Dr Charlotte Hauser ETPL 3DMA 6 q
108. 2013 5 3 D Matrix Asia Pte Ltd PT TeguhsindoLestaritama T D M 621 s Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25 TDM 711 2012 2 15 FDA TDM 641 2014 4 PMDA 2013 7 23 2 1 145 3 328
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111. 1 850 1 077 152 1 069 160 1 070 130 2011 5 TDM 621 PMDA 2013 4 2014 4 2013 4 2014 4 2013 4 Shared Research http Wwww sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved w 7777 SR Research Report 2014 7 25
112. Compositions and methods for cardiac tissue protection and regeneration EP2089047 3 D Matrix Inc 2012 10 2012 10 15
113. R A D 3 RADA 16 pH ADME 30 DDS 18 81 Shared eSsearch http Www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved J
114. 2004 10 3 DMatrix Inc LICENSE AND SUPPLY AGREEMENT 3 D Matrix Inc MIT MIT Scientific Founders 2007 10 3 D Matrix Inc 1992 MIT Shuguang Zhang 2001 5 MIT 3 D Matrix Inc 2003 4 3 D Matrix Inc MIT Exclusive Patent License Agreement 2004 5 2004 10 3 DMatrix Inc
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116. PT Teguhsindo Lestaritama TDM 641 2 100 MTA MIT
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120. 1 145 3 318 2 2014 4 1 2013 9 6 2014 4 1 48 341 341 201 3 1 465 2013 4 261 TDM 621 TDM 621 PMDA
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136. 3 2014 1 2014 1 31 3 D Matrix Inc 7777 SR Research Report 2014 7 25 MIT B Bridge International B Bridge 3 D Matrix Inc PanaceaGel 2 B Bridge
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143. esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 7777 SR Research Report 2014 7 25 c DDS DDS DDS bFGF PDGF A6K siRNA
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147. 2015 4 2013 4 2014 4 68 81 7777 SR Research Report 2014 7 25 2014 4 2014 4 2015 4 TDM 621 2012 11 2012 11 20
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