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DIニュース2012.03

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10. 1 pt 2012 Mar Vol 21 No 3 PHS446 3 PHS453 310 BPI 6 mE a LT 0 EH 0 1 Ep Hz a FE 0 2 ai m ui LL 4 6 Pt CONTENTS oo RAGN 7 DSU No 206 2 287 2 4 5 The NEW ENGLAND JOURNAL of MEDICINE EE LEHED TH A113 HOWEMEER 1 7 LL 18 Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture RESULTS The rates of any new Clinical fracture were 8 G9o in the zaledronic acid group and 13 995 in the placebo group a 35 risk reduction With zoledronic acid P 0 001 the TesDective rates of a new Clinical vertebral fracture were 1 7 and 3 896 P 0 02 and the resDective rates of new nonvertehral frac
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15. tures were 7 6 and 10 7 P 0 03 In the safety analvsis 101 of 1054 patients in the zoledranic acid group 9 6He and 141 of 1057 patients in the placebo group 13 39c died a reduction of 2896 in deaths from any cause in the zoledronic acid group P 0 01 The most frequent adverse 8 6 musculoskeletal pain 13 996 adverse eftects on the 1054 101 9 6 vascular adverse event 1057 141 13 3 WO ETOUDS 28 1 9 2 13 3 9 6

DIニュース2012.03

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