（SG-単層CNT） 安全性データおよび TASC 自主
Contents
1. UG 32. CNT CNT I 1 1 SG CNT chemical vapor deposition CVD
3. 2011 8 nt ax P06041 IF HMB 3 1 8 DRRR TC 15 CNT TASC ir Pr
4. 3 4 CNT 0 03 mg m 2 2 A a
5. 1 3 nm 2 BIE BAB PR LEZ OPC CNT D
6. 293 D C OPC OB C a b 9
7. ISO 12103 1 Al test Dust 1H TSI Dusttrak I 8530 880 nm microAeth Model AES1 5 19 100 75 y 1 5x z w 60 y 0 32x r 0 75 0 20 40 60 80 100 ug m3 3 9 1 2 A 6
8. 1 72 K 10 SG CNT 1 24 48 72hr 1 mL Kbl NZW aprons OECD TG405 ie 0 5 Olive oil RY fetter ZIS nett 05g 24 48 72hr ORE ACALBESS OECD TG404 ie Olive oil d 0 4 g Hartley AMEE Ey b RCC L Buehler OECD TG406 26 1 72 hii mw oD 11 SG
9. f EU TASC JHE CNT J AVA SWCNT A Wes NEDO TASC
10. SEM CHE CES 8 11 13 80 nm 25 mme 3 8 cm2 0 3 0 5 L min TEM TEM Af 2 CO gt CHL 29
11. vitro 2 CNT 4 CNT
12. 1 CNT NEDO P06041 0 03 mg m 1 8 5 15 4 NOAEL 2
13. 3 E f NEDO PO6041 CNT 4 J PICBWY CC Fy KRARBRRO 4 NOAEL 0 13 mg m 3 2 3 2 3 8 1
14. ISO International Organization for Standardization ISO TC229 ISO Technical Committee 229 Nanotechnologies ISO 229 LCso 50 Lethal Concentration LDso 50 Lethal Dose LDH Lactase Dehydrogenase Lm Leak rate of the face piece Lf Penetration efficiency of filter TF 4 VE Bila 38 LOAEL Lowest Observed Adverse Effect Level MITI Ministry of International Trade and Industry 2001 METT MWCNT Multi Wall Carbon Nano Tube NEDO New Energy and Industrial Technology Development Organization NIOSH National Institute of Occupational Safety and Health NOAEL No Observed Adverse Effect Level NOEC No Observed Effect Concentration OECD Organization
15. DV TY H FEEL gt CNT CNT CNT CNT SDS
16. mT 3 A B B CNT 28 50 LDso gt 50 mg kg NOAEL 12 5 mg kg 9 C ER ARES RERS
17. 3 0 001 0 1 mg m RENY F C 3 CL3 10 2 1 A OH B a pa b MTTI OECD TG 301C GLP 2 100 mg 30 mg L 28
18. K 15 JIST 8150 2006 2 SE eae 3 10 4 50 4 50 4 100 Tz 4 25 4 25 10 7 eet 50 50 100 25 25 50 1000 1000 cai 10 FE 7 ne 50 5000 bs
19. 2009 3 2009 7 2009 3 A 2009 3 A 2009 3 OOO 2012 9
20. E CPC 10 nm cm 100 nm Scanning Mobility Particle Sizer SMPS Fast Mobility Particle Sizer FMPS Electrical Low Pressure Impactor ELPI 0 5 10 um Aerodynamic Particle Sizer
21. ug m3 gh c b CNT OPC
22. 22 C ATR ARREYIEEE OEL 23 D 24 2 24 A 24 a 24 b ee 26 B 28 MW TASC 29 1 29 2 29 1 ee 29 2 29 3 31 1 ee 32 2
23. CNT 15 D CNT A A ene 4 ene elie i ARES A ee ee X CO CH 40 WM amp 00 40 ao 120 Pe ge 20 le m CNT HRE 0 900 C 0 15 os 60 75 15 CNT 4
24. 10 50 ug m3 ug m3 b B 2
25. CNT CNT CNT CNT HEPA 1 6 H
26. TASC SG CNT CNT Fic H CNT SG CNT CNT CNT
27. CPC 0 01 1 um Bayt AE COIR iti LAL FRE UT OPC 0 3 10 nm 3 3 ACHAT DEIR ED FBI ED I
28. 36 V A A 1 12 TASC ee 2 3 4 5 6 7 8 9 10 11 wm 12 13 14 15 16 17 18 19 20 21 22 2011 CNT 2011 8 17 NEDO P06041 International Organization for Standardization 2012 Technical Report ISO TR13329 Nanomaterials Preparation of Material Safety Data Sheet MSDS First edition 2009 Donaldson K Murphy FA Duffin R Poland CA 2010 Asbestos carbon nanotubes and the pleural mesothelium a review of the hypothesis regarding the role of long fibre retention in the parietal pleura gt
29. 2014 3 E SG CNT E I SG CNT II TASC
30. CNT 10 2 1 Sr AS A ge PARTIE Olt TADb Y Rie HQ Bll _ mg m 0 03 mg m3 HQ II 3 eee Cac L ET BY athe AOA 0 03 mg m
31. EV LCso gt 10 mg L NOEC 10 mg L 12 K 6 SG CNT aki ii mg E lt GLP gt 20 10 100 mg L LCs0 96hr eT OECD TG203 Oryzias latipes HCO 40 mg L FE LCs0 14a re 14 0 10 0 32 100mg L mg L gt ee OECD TG204 Oryzias latipes 1 0 3 2 10 Tween 80 Pek 3 B 28 OECD TG216 GLP 3 1000 mg dry kg Medicago sativa 5 g kg dry soil 1 ECso gt 1000 mg dry soil
32. R 7 SG CNT A S i 3 o en mg kg 5 lt GLP gt 1000 Pesoz 0 gt 1000 OECD TG216 Medicago sativa mg kg dry soil C OECD TG209 GLP D 100 mg L ECs gt 100 mg L BEE SAL FAA HERO RENE THC IER NYE AD HIT K 8 SG CNT Stk on AT S lt ie HE mg L
33. 2 1 sp 1 800 C 4 10 mg L 2
34. pen ial 1 7 4 4 2
35. 0 03 mg m 7 5 U min o SMPS EE gt OPC x 4 APS o 3 2 200 mm 2 25 mm CNT 24 em bef ol Sn 0 LLYDAN Rr Uf aot 01 1 10 Wi KI2500 rpm Dpy hm 9 10 11 97 B 5 12 SEM
36. ze mg L SEENE 9 eet ECs0 72hr 510 yee He pe ee al ME 0 10 0 32 100mgL mg L lt GLP gt Pseudokirchneriella 12 1 0 3 2 10 HCO 40 NOEC OECD TG201 subcapitata 920 ge 0 32 mg L b t Daphnia magna 48 OECD TG202 GLP 7 4 5 10 mg L 10 5 ECso gt 10 mg L Daphnia magna 21 OECD TG211 GLP 0 010 1 0 mg L 1 0 mg L 36 6 20 ECs gt 1 0 mg L NOEC 0 32 mg L
37. CNT 6 26 CNT
38. Qr Qu 1 mday kg QR Mauderly 5389 0 8L kg 2 gt 0 8 X 103x 60X 103X 6hr 0 29 m3 day kg QH 1 10m 70 kg amp UCT 10 70 0 14 m3 day kg DFs DEF CNT Anjulvel amp Asghariam 3 DFr 0 057 DFu 0 118 AMvolr AMvolm Oberdorster 9 Krombach 4D AMvol s 8 7X100 AMvolm 5X101 um3 kg body weight 330g 70kg 3 BASE NanocyITVNC7000 gt BASF CNT NanocyITWNC7000 Dx Nanocyl NC7000 3 NanocyITVNC7000 90
39. Sis CNT fpr PRES TE gt HE BR uv UV DS MBO REIL OLS x ae i G D G D CT enua TEM nee PRA BARE X 3 ole CNT gt a cx ane anyta PORDAS NERD IR 2
40. 9 SG SG CNT CNT ERR CNT Ka He
41. 46 1 mg L 21 10 mg L 72 V CRB EZ SH BREM BB E Ti HRS E RER 36 6 4 E x 2 Ooo 2 DS a 1 100 mg L Tween80
42. 4 D NOAEL 0 13 mg m fev 14 9 SG CNT X Pe 0 2
43. CNT gt Matsumoto 2012 CNT 95 SD AMET v hic RG 50 mg kg 1 4 LDs gt 50 mg kg 15 9 SD HEMED v KIT 0 125 1 25 12 5 mg kg H 1 72 28 5 ug NZW ED CR 0 5 g NZW mo NOAEL 12 5 mg kg i jE OECD TG405 FA RW N 7 PE BOC ti LA OECD TG404
44. siTe FE FE 15 NOAELs 0 065 mg m NOAEL 0 03 mg m Qr X DFR tr Xx dayr SAR 1 NOAEL NOAEL g x CERA x J x DF x UE S g NOAELH mgm OEL NOAELR 3 mg m tr tH 1 AEV See dayr dayH Qr Qu 1 m7 QR Bide 53 0 3kg SALA L 0 189 X 10 Quit ICRP 0 025 1 25L X20 DFr DF CNT DFR DFu SAR SAH m UF
45. CNT TASC GE CNT AR ER CNT NEDO 3 P10024 SG CNT TASC 2 1 2014 10 CNT TASC NEDO
46. NOAEL 0 13 mg m NOAEL al P06041 CNT NOAEL 1 8 BIO ARB 15 0 03 mg m a5 b Q BULTWS 0 03 mg m3 0 03 mg m3
47. SG CN T TASC CNT TASC INEDO lt gt E mail tasc3 ml aist go jp 0 2014 1 lt gt CNT TASC GE lt gt M CNT CNT GD
48. gt Rayer lt GLP gt a a 4 UM 3 100 n 0 gt 100 OECD TG209 mg L 13 3 A ADME B lt gt Liou 2012 227 CNT 52 SiO gt 37 TiO gt 19 15 10 94 137
49. iy OECD BA SAUD N HJ CNT 2 CNT E TE V TASC MDCK HE L 7 2014 6 WPMN ZN 2015 2 WPMN 1 ISO QSO TC229
50. I 9 30 3 SMPS OPC APS SMPS OPC APS 10 1 B 1 SEM 10 hm 11 0 002 mg m 1 C 26 b lt 0 01 mg m
51. 3 3 A 3 B CNT CNT 12 nm 2 CNT CRIES EU DNA CNT 3 nm 4
52. WE ha PARR AMIE HQ 2 HQ 1 HQS1 1 HQ gt 1 0331013 29 K E 21 3 31 4 2012475 A
53. NIOSH CIB 65 35 CNT ce
54. SG CNT TA SC 2012 12 28 2 2014 6 30 H 2 1 2014 10 27 CN TASC T 305 8565 1 1 1 305 8569 16 1 x SG CNT
55. 13 Ae a 12 CNT 49 13 CNT SEM 28 I TASC lt gt
56. 3 1 2 mg kg 6 SD 0 04 0 2 mg kg 1 4 5 0 04 mg kg 0 2 mg kg 0 2 mg kg 1 mg kg Wistar RREZ v PIZ 0 03 0 13 mg m CNT 4 6 S OECD TG412 ER MED
57. j 5 SG CNT DEREC T A EE _ By 3 ee mgL lt GLP a PKA 48 0 42 0 94 100 mg L ECs0 48hr 510 OURh Ber Daphnia magna 2 1 4 5 10 HCO 40 mg L a ECs0 214 19 a 010 1 lt mae zie 21 0 Hs 1 10 mg L mg L 5 gt es OECD TG211 Daphnia magna 032 10 Tween 80 NOEC 214 0 32 mg L c Oryzias latipes 96 OECD TG203 GLP 10 mg L 50 LCso gt 10 mg L Oryzias latipes 2 OECD TG204 GLP 20 BOB PURRE 0 10 10 mg
58. cm lt 0 01 mg m 1 C Eb lt 0 007 mg m 0 03 mg m 1 B 1 SEM CNT 8 8 SEM b H KR amp IAZ
59. BOD DOC 0 OECD TG301F GLP 100 mg L 30 mg L 28 BOD DOC H 0 MITID OECD TG302C GLP 9 30 mg L A 100 mg L 28 BOD DOC 0 Tt 2 SG CNT ae BER ee oe ee aa BOD PE ae DOC ED Se ee 2i mgC ed aay a e ae 9 g c Cyprinus carpio
60. Fy CNT 3 OP CNT 31 1 SP in vitro CNT CNT CNT 4 2013 10 1 Ho
61. WG3 O TS 19337 ISO TC229 JWG2 2012 11 1 TASC H ISO TS 12025 Dustiness V C TASC ortex Shaker 3 TASC ISO TC229 OBCD7WPMN OECD 2012 12 H 18 ENV JM MONO 2012 40
62. CNT E BSA h in vitro in vitro X 14 CNT CORA H CNT CNT 6H CNT
63. Downstream Handling Processes 5 2013 11 H E NIOSH General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories RO RV ORT AEA COVE RERHEIC BIT SR Current Strategies for Engineering Controls in Nanomaterial Production and CARRION Sts 3 i
64. a A c i i 6 1 i 100 cm 1 3 g 30 cm ii Vb 24 CNT CPC OPC at 1 A
65. 19 LOAELk 0 1 mg m Choe 2 NOAELs 0 05 mg m OELg NOAELs 20 4 0 0025 mg m lt 4 NIOSH gt NIOSH BMD I 9 CNT Pauluhn 3 Ma Hock 2 2 3 BMD BMDS2 1 2
66. 3 3 BW SAR SAH BWr BWg BWr 0 3 kg BWu 73 kg SARMSAH BWBWi tr x da DF BW 1 NOAELy NOAEL x ZO OR Se DFR EWR L ty x dayr Qu DFy BWR UF 6 x 60 x z 0 189 x 1073 73 1 0 065 x 1 8 x 60 x Z 03 3 25x103 03 0 029 0 03 mg m
67. Lares 10 95 BMCL NOAEL 0 00019 0 0019 mg m NIOSH NIOSH 5040139 0 001 mg m 8 TWA REL 0 001 mg m3 0 5 16 NIOSH K 14 CNT ug m3 A NEDO CNT 30 1 8 15
68. ADME Absorption Distribution Metabolism amp Excretion APS Aerodynamic Particle Sizer BALF Bronchoalveolar Lavage Fluid BCF Bioconcentration Factor BET Brunauer Emmett Teller Theory BMD Benchmark dose BMCL Benchmark dose lower confidence limit BMD aE PETE DUBE CAT TS NOAEL BOD Biochemical Oxygen Demand BSA Bovine serum albumin BW Body Weight CAS No Chemical Abstracts Service Number CNT Carbon Nanotube CPC Condensation Particle Counter CVD Chemical Vapor Deposition DOC Dissolved Organic Carbon EHS Environment Health and safety GLP Good Laboratory Practice
69. OEL 0 03 mg m 30 hg m3 2 4 4 um 50 OEL E a
70. TASC Z Fe NEDO pala BETHE ROR EL 10 TASC SG CNT gt EE HEE P 2 SDS 2012 12 1 TASC
71. XE SE H A CAMERA MY GRRR KE NIOSH CNT NIOSH 5040 EREA E CEO ARE RUE LER MAE AMES EO CO CH FID chee NI C PARIE OEL CNT
72. ee 16 d REME 16 e _ 16 f 16 g 17 D 17 a I A549 yj7o tettetett 17 4 ee 17 3 NN E E E 21 1 21 A Oe 21 B
73. 2 CAS 308068 56 6 3 LTD 1 SG CNT D KS TEM 128 n 170 3 03 1 1 nm BET No n 10 1064 37 m27g TGA 99 ICP MS Al Fe Ni 4
74. R 2013 4 E 3 2 2 2 1 gt as LEF Q TW 2012 12 2014 6 2014 10 1 2 A a b c REO ARERR I 1 1
75. inflammation and mesothelioma Part Fibre Toxicol 7 5 Murphy FA1 Poland CA Duffin R Al Jamal KT Ali Boucetta H Nunes A Byrne F Prina Mello A Volkov Y Li S Mather SJ Bianco A Prato M Macnee W Wallace WA Kostarelos K Donaldson K 2011 Length dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura Am J Pathol 178 6 2587 2600 Nagai H Okazaki Y Chew SH Misawa N Yamashita Y Akatsuka S Ishihara T Yamashita K Yoshikawa Y Yasui H Jiang L Ohara H Takahashi T Ichihara G Kostarelos K Miyata Y Shinohara H Toyokuni S 2011 Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Proc Natl Acad Sci U S A 108 49 E1330 1338 Nagai H Toyokuni S 2012 Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis Shedding light on fiber entry mechanism Cancer Sci 103 8 1378 1390 Finnish Insttitute of Occupational Health 2013 Evaluation of the health effects of carbon nanotubes lt http www tsr fi c document_library get_file folderld 13109 amp name DLFE 9367 pdf gt Matsumoto M Serizawa H Sunaga M Kato H Takahashi M Hirata Koizumi M Ono A Kamata E Hirose A 2012 No toxicological effects on acute and repeated oral gavage doses of single wall or multi wall carbon nanotube in rats J
76. SOD 7 ICAM 9 C SD 0 04 2 mg kg BALF BALF LDH 18 IL 18 0 04 mg kg 6 3 0 2 mg kg 6
77. 4 EI 2 or 5 1 1 3 1 Tweens 0 04 mg kg HE 0 PBS Zn p RIE 0 2 25 mg kg BALF BALF HO 1 pages MER L Ae BOK T D 77 4 3 13 de SR 3 1 25 m 6 _ 0 PRS OECD TG412 5 R BIO 1 3 a 3 b
78. ECso 50 Effect Concentration 30 ELPI Electrical Low Pressure Impactor FID Flame ionization detector FMPS Fast Mobility Particle Sizer HCO 40 PEG 40 Hydrogenated Castor Oil 40 HEPA High Efficiency Particulate Air filter HO 1 Heme Oxiganase 1 1 HQ Hazard Quotient ICAM Intercellular adhesion molecule ICP MS Inductively Coupled Plasma Mass Spectrometry ICRP International Commission on Radiological Protection IL 1B Interleukin 1 beta 1B in vitro DTE in vivo 38
79. FAME Ze FAV Ze in vitro Ye 1 OECD TG474 OECD TG471 OECD 2 K 12 SG HUS CNT in vitro TA97 TA98 12 5 25 50 100 TA100 TA1535 S9 200 500 pg plate S9 OECD TG471 WP2uvrA pkM101 0 1 CMC S9 In vitro REIRI E 300 500 1000 ERU TA 6 NN S9 pies SOmix 6hr NMM ng mL SOmix 24hr dN ANI 1 M RR ye 3 T bake OECD TG473 0 1 CMC SOmix 6hr 13 SG CNT in vivo sof 4 ay 2 ee a 2 eels ae DE IKE 5 N
80. OECD TG305 GLP 19 5 50 ug L RRK 60 BCF K 3 SG CNT oe CNT HRB BCF mg L Az Wy Yee 15 lt GLP gt a 0 005 Fee OECD TG305 80 Cyprinus carpio 0 050 1 9B 2 A a Pseudokirchneriella subcapitata 72 OECD TG201 GLP 19 1 0 3 2 10 mg L 5 1 16 46 50 ECs gt 10 mg L HEARE NOEC 0 32 mg L R 4 SG CNT
81. lt gt 10 NIOSH 39 CNT CNF 1 Recommended Exposure Limit REL TWA ENRHES CNT 0 7 30 Derived No effect level DNEL 44 Bayer 3 CNT 50 Occupational Exposure Limit OEL lt Baytubes gt TWA Nanocyl 3 CNT 2 5 lt NC7000 gt 1 1 20 3 ee A p 1 optical particle counter DA F OPC
82. ee 32 4 ee 33 1 OECD ee 33 2 ISO ee 34 35 RER cerereeeeecececoeoeocereseeoecesecosoeoscececocoeoeceseceeoeoesososoececereroe 38 1 I TRE
83. HORR 15 0 08 mg m CNT MWCNTN 44 nm 18 CNT 0 PEROT EDS AME CEH SINKS PAAR BIE 0 03 mg m CNT lt 2 Baytubes gt CNT Baytubes Baytubes 33 Baytubes 13 AKARE NOAELs 0 1 mg m3 3 Ajustment Factor AF Baytubes OELg 1 6 0 05 mg m3
84. OECD TG474 m PBS REE g D a IL A549 in vitro I A549 48 E 0 1 mg mL TEM 4 1 CNT 24 ROS
85. 3 OELy NOAELR X H AF retained dose AF kinetics AF retained dose AF geposited dose x eee A CIR AFam volume x a x AF kinetics QR DFR AMvolH AMvolR _ 0 14 m day kg 0 118 10 0 29 m3 day kg 0 057 5 x 1011 8 7 x 101 1 2 x 5 7 1 OELy 0 1 x A 0 05 mg m OELa mg m3 AFretained dose Ei ak 7 AFeeposited dose 7 HIE PREC AF kinetics CNT pjs 60 Gzg 1 10 AFam volume H C kzi 7
86. 2 SO OECD Nanos CNT Do afety http www nanosafety jp twitter Nanosafety ISO SO TC229 20
87. CNT CNT 539 14 SY 3 11 X CNT CNT CNT CNT CNT
88. CNT CNT CNT NEDO 3 BASE 3 NIOSH 3 lt 1 NEDO CNT gt NEDO CNT CNT MWCNT N MWCNTN MWCNT N 4 NOAELs 0 37 mg m 3 NOAEL 1 8
89. CNT 100 cms foe 30cm 280X370X272 mm EL 5 8 L min 13 2 6 ii i Hi i ii ii 1 cm3 Nw En mo Pr aed Hi adan LHII pr 6 04 16 12 16 19 16 26 16 33 16 40 16 46 16 55 17 02 17 09 0 O n D oo 0 40 0 30 0 20 0 10 cm nnn LA Nw 16 04 16 12 1619 1626 16 33 1640 16 48 1655 1702 1709 0010 0 009 0 008 0007 0 006 0 005 0 004 0 003 0 002 0 001 mg mr nnn BA 16 04 16 12 1619 1626 16 33 16 40 16 48 1655 17 02 17 09 7 10 CPC OPC 25 7 CPC OPC i CPC lt 10 cm OPC lt 1 cm3
90. X ul 0 01 1 um Re EC OPC 3 O 7 O 0 3 10 hm at condensation particle counter CPC OPC
91. EA Oe 3 TAR ESIVTWS F E FEU SIV OA 1 mg L 10 mg L TI REL a b c 4 NEDO
92. gt Bmail tasc3 ml aist go jp NEDO P10024 AQ Ai National Institute of Advanced Industrial Science and Technology AIST ASEO Research Institute o Single Wall CNT Science for Safety and Sustainability INEDO IP10024
93. 2 3 4 2 1 A B 2 A a b c B C 3 A o B ee 14 C ee 14 a ee 14 b 15 c
94. 2 mg kg LDH 0 02 20 0 2 2 0 mg kg 3 i A 1 3 0 2 2 0 1 TweenS y SN 1 3 0 PBS Wiha RREO 5 6 2 0 mg kg 29 CECD SD 0 2 1 mg kg KE BALF LDH IL 1B 6 0 2 1 0 mg kg 3 0 0 04 0 2 i H 1 0 mg kg ERTSE OREA 6 0 2 1 0 i 3 6 1 Tween8 mg kg 0 PBS OSE LEOINTE AMS LORY EE 6 1 0 mg kg ATIR Ei KAK ER AHA ERE i 3 0 2 mg kg 0 004 02 Ae ae O G z ww mg kg x5 ee Pa aye oe Sy hE 1
95. 44 Engineered Nanoparticles Review of Health and Environmental Safety ENRHES Project Final Report 2010 http ihcp jrc ec europa eu whats new enhres final report 45 TASC 2013 NEDO P10024 lt http www aist riss jp main modules product nano_tasc html gt 46 Hashimoto N Ogura I Kotake M Kishimoto A Honda K 2013 Evaluating the capabilities of portable black carbon monitors and photometers for measuring airborne carbon nanotubes J Nanopart Res 15 2033 47 Ogura I Kotake M Hashimoto N Gotoh K Kishimoto A 2013 Release characteristics of single wall carbon nanotubes during manufacturing and handling J Phys Conf Ser 429 012057 48 Ogura I Kotake M Shigeta M Uejima M Saito K Hashimoto N Kishimoto A 2013 Potential release of carbon nanotubes from their composites during grinding J Phys Conf Ser 429 012049 49 NIOSH 2012 General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories DHHS NIOSH Publication No 2012 147 May 2012 50 NIOSH 2013 Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes DHHS NIOSH Publicat
96. APS ES B 1
97. CNT 29 ES ate ee ARIEL 1 24 48 72hr OECD TG406 Sle Hartley wm aril NN tf Buehler 4 e lt gt Pietroiusti 2011 CNT Cheap Tubes Imc p SWCNT o SWCNT uo SWCNT CD1 o 100 ng 2 Fujitani 2012 CNT MWCNT 7 ICR 2 mg kg 4 mg kg 2 f TG473 fF B DLE el KR 3 16
98. Toxicol Sci 37 3 463 474 Hata K Futaba DN Mizuno K Namai T Yumura M Iijima S 2004 Water Assisted Highly Efficient Synthesis of Impurity Free Single Walled Carbon Nanotubes Science 306 5700 1362 1364 2012 FP MPRE RP YF TASC 2011 15652 2011 15607 TASC 2011 15653 TASC 2011 45707 2011 95405 2011 95406 TASC 2011 A110431 2011 95407 TASC 2011 A110430 TASC 2011 Al110432 2011 95404 23 Liou SH Tsou TC Wang SL Li LA Chiang HC Li WE Lin PP Lai CH Lee HL Lin MH Hsu JH Chen CR 35 Shih TS Liao HY Chung UT 2012 Epidemiological study of health hazards among workers handling en
99. for Economic Co operation and Development OEL Occupational Exposure Limit OPC Optical Particle Counter REL Recommended Exposure Limit ROS Reactive Oxygen Species S9 Supernatant of liver homogenates after centrifuged at 9000Xg 9000Xg SA Surface Area of lung SDS Safety Data Sheet MSDS Material Safety Data Sheet SEM Scanning Electron Microscope SMPS Scanning Mobility Particle Sizer SG Super Growth SOD Superoxide dismutase TASC Technology Research Association for Single Wall CNT Carbon Nanotubes TEM Transmission Electron Microscope TG Test Guideline TGA Thermo Gravimetry Analyzer TWA Time weighted average WPMN Working Party on Manufactured Nanomaterials OECD 39
100. 13 1 1 OECD OECD EHS WPMN 2013 3 13 CNT CNT CNT 59 33 2 ISO IS ED EB CNT LCE AMARC E OAR principal material II 2 PS 2015 WPMN
101. H Nakazato T Nakanishi J Tanaka I 2012 Pulmonary toxicity of well dispersed multi wall carbon nanotubes following inhalation and intratracheal instillation Nanotoxicology 6 6 587 599 37 Pauluhn J 2010 Subchronic 13 week inhalation exposure of rats to multiwalled carbon nanotubes toxic effects are determined by density of agglomerate structures not fibrillar structures Toxicol Sci 113 1 226 242 38 Mauderly J L 1986 Respiration of F344 rats in nose only inhalation exposure tubes J Appl Toxicol 36 6 1 25 30 39 Anjilvel S Asgharian B 1995 A multiple path model of particle deposition in the rat lung Fundam Appl Toxicol 28 1 41 50 40 Oberd rster G 1995 Lung particle overload Implications for occupational exposures to particles Regul Toxicol Pharmacol 27 1 123 135 41 Krombach F Miinzing S Allmeling A M Gerlach JT Behr J Dorger M 1997 Cell size of alveolar macrophages an interspecies comparison Environ Health Perspect 105 Suppl 5 1261 1263 42 Ma Hock L Treumann S Strauss V Brill S Luizi F Mertler M Wiench K Gamer AO van Ravenzwaay B Landsiedel R 2009 Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months Toxicol Sci 112 2 468 481 43 65 lt https staff aist go jp kishimoto atsuo NIOSH CIB65_text_JPN_ pdf gt
102. Lf 100 Lm Lf CNT AVA HE D CNT CNT NIOSH RO RD TEE Lm HQO 1 E MECH L 3 30 16
103. ays Regul Toxicol Pharmacol 61 2 192 198 30 Fujita K Fukuda M Endoh S Kato H Maru J Nakamura A Uchino K Shinohara N Obara S Nagano R Horie M Kinugasa S Hashimoto H Kishimoto A 2013 Physical properties of SWCNTs in cell culture and their dispersal due to alveolar epithelial cell response Toxicology Mechanisms and Methods 23 8 598 609 31 Bide RW Armour SJ Yee E 2000 Allometric respiration body mass data for animals to be used for estimates of inhalation toxicity to young adult humans J Appl Toxicol 20 273 290 32 ICRP 1994 Human respiratory tract model for radiological protection In Smith H ed Annals of the ICRP Tarrytown New York Internation Commission on Radiological Protection ICRP Publication No 66 33 Pauluhn J 2010 Multi walled carbon nanotubes Baytubes approach for derivation of occupational exposure limit Regul Toxicol Pharmacol 57 1 78 89 34 Luizi F 2009 Responsible Care and Nanomaterials Case Study Nanocyl European Responsible Care Conference Prague 21 23 Oct 2009 lt http www cefic org Documents ResponsibleCare 04_Nanocyl pdf gt 35 NIOSH 2013 NIOSH Current Intelligence Bulletin 65 Occupational Exposure to Carbon Nanotubes and Nanofibers April 2013 36 Morimoto Y Hirohashi M Ogami A Oyabu T Myojo T Todoroki M Yamamoto M Hashiba M Mizuguchi Y Lee BW Kuroda E Shimada M Wang WN Yamamoto K Fujita K Endoh S Uchida K Kobayashi N Mizuno K Inada M Tao
104. gineered nanomaterials J Nanopart Res 14 8 878 892 24 Kobayashi N Naya M Mizuno K Yamamoto K Ema M Nakanishi J 2011 Pulmonary and systemic responses of highly pure and well dispersed single wall carbon nanotubes after intratracheal instillation in rats Inhal Toxicol 23 13 814 828 25 Morimoto Y Hirohashi M Kobayashi N Ogami A Horie M Oyabu T Myojo T Hashiba M Mizuguchi Y Kambara T Lee BW Kuroda E Shimada M Wang WN Mizuno K Yamamoto K Fujita K Nakanishi J 2012 Pulmonary toxicity of well dispersed single wall carbon nanotubes after inhalation Nanotoxicology 6 7 766 775 26 Ema M Matsuda A Kobayashi N Naya M Nakanishi J 2011 Evaluation of dermal and eye irritation and skin sensitization due to carbon nanotubes Regul Toxicol Pharmacol 61 3 276 281 27 Pietroiusti A Massimiani M Fenoglio I Colonna M Valentini F Palleschi G Camaioni A Magrini A Siracusa G Bergamaschi A Sgambato A Campagnolo L 2011 Low doses of pristine and oxidized single wall carbon nanotubes affect mammalian embryonic development ACS Nano 5 6 4624 4633 28 Fujitani T Ohyama K Hirase A Nishimura T Nakae D Ogata A 2012 Teratogenicity of multi wall carbon nanotube MWCNT in ICR mice J Toxicol Sci 37 1 81 89 29 Naya M Kobayashi N Mizuno K Matsumoto K Ema M Nakanishi J 2011 Evaluation of the genotoxic potential of single wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity ass
105. ion No 2014 102 Nov 2013 51 TASC 2013 NEDO P10024 lt http www aist riss jp main modules product nano_tasc html gt 52 BPE 2013 53 International Organization for Standardization 2012 Technical Specification ISO TS 12025 Nanomaterials Quantification of nano object release from powders by generation of aerosols First edition S89
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