中高年男性におけるビタミンDの補足は音響的骨
Contents
1. 2 VD 25OHD PTH 0 Meier VD 500 IU 500mg 7 250HD 30ng ml Viljakainen PTH VD 17 5 20 gg Kuwabara 200 IU 5pg 10 1 250HD 14 7ng ml 20ng ml 50nmol VD 800 IU 22. 1 2010 47 45 56 2 1995 D 4 D D 69 103 113 3 10 at available http Www e stat go jp SG1 estat GL08020103 do _toGL08020103_ amp liistID 000001037877 amp req uestSender estat 4 gt 1 1 at available http www e stat go jp SG1 estat GLO8020101 do toGL08020101 amp tstatCode 000000330001 amp requestSender dsearch 5
3. VD 2 5 VD 9 3 7 VD 11 8 10 11 8 10 T TCI 3 VD 28 ug H 2010 2011 7 pg 2009 2010 6 TC S VD 1 7 8 12 VD
4. VD 2006 2006 2010 VD Jes T FFQ Ver 3 7 8 1 VD 4 10 18 19 3 8 AOS 100 ifl 5 3 SOS speed of sound
5. OSI EPA Economic Planing Agency method 4 T Trend HAKE C Cyclical component S Seasonal variation I rregular variation TC S 1 3 EPA 4 T C EPA T C TC VD 0
6. 2 3 VD 3 VD VD 400mg 600mg VD 5 5g
7. VD 45 2013 S r 0 797 VD r 0 543 7 rg VD OSI VD VD OSI S VD OSI S VD Fy
8. TCI TC VD TCIS OSI TCS VD VD D 8 11H 1 4 4 5 2 D 3 47 OSI 6 5 1 4
9. 7 55 63 EPA 4 5 8 10 1 3 Duc 3 D VD VD 4
10. tt 2 OSI EPA 1 S 1B TCI 1C 5 TCHR 1D 10 I IE IA S 1B 8 11 1 4 S p lt 0 0001 2002 6 2009 75 TC RID 2002 6 2009 75 S 1B 10 2006 2004
11. N zm Hr S 3 VD 5 VD 2006 1 VD 3 1 VD VD 100 1 i D 2006
12. VD OSI OSI S 2 VD TC 2011 1D 7 VD 28 pg N 7 pg TC 2009 6 2009 7 y 6 2E 05x 5 592 R 0 7468 p lt 0 0001 si Hr y 9 6E 06x 3 433 R 0 0239 p 40 375 1D 2009 6 TC 2009 7 TC
13. D D D 2006 2006 2010 uglH 1 3 7 71 83 82 89 2 4 7 91 87 88 89 3 H 9 4 65 97 97 102 4 4 7 91 92 95 98 5 4 0 78 92 99 99 6 H 5 6 108 88 94 94 7 4 6 90 88 88 90 8 H 6 0 116 95 92 93 9 H 6 6 128 121 119 115 10 H 6 4 123 126 121 118 11 H 6 6 128 112 106 104 12 H 5 8 111 118 119 109 5 2 100 100 100 100 2 OSI S D 2009 2 2012 5 1 2 3 4 0 007 0 086 0 174 0 052 0 102 WIN Fj p 0 962 0 601 0 296 0 758 0 555 0 431 0 542 0 451 0 263 0 118 S p 0 005 0 000 0 005 0 118 0 494 2 5 8 11 1959 1963 5 11 80g 8 60g 1963
14. VD 28 pg 2010 6 2011 5 47 VD X3 11 8 OSI TCI A B ZE yl A B HEE H TCI TCH E 2002 11 2003 8 5 3 9416 7 3 1393 0 2023 10 2003 11 2004 8 7 3 2452 3 1531 0 0921 3 2004 11 2005 8 8H 3 2692 6H 3 1728 0 0964 5 2005 11 2006 8 11H 3 2887 8 3 1320 0 1567 9 2006 11 2007 8 2H 3 2593 5H 3 1651 0 0942 4 2007 11 2008 8 8H 3 1425 6H 3 0526 0 0899 2 2008 11 2009 8 12H 3 1426 8H 2 9919 0 1507 8 2009 11 2010 8 7ug 2H 3 0826 5H 2 9841 0 0985 6 2010 11 2011 8 28zg 6H 3 1034 1H 3 0462 0 0572 1 2011 11 2012 8 5H 3 0987 12H 2 9758 0 1230 7 4 6 5 1 OSI
15. 1 600mg 2010 60 69 505mg 556mg OSI EPA 2 S 8 10 12 2 p lt 0 0001 p 0 170 OSI S 5 1 3 S 1 4 TC 2C p 0 090
16. Jan 03 Jan 04 Jan 05 Jan 06 Jan 07 Jan 08 Jan 09 Jan 10 Jan 11 Jan 12 D 3 35 3 30 3 25 3 20 3 15 3 10 3 05 3 00 2 95 Jan 02 OSI TC y 6E 05x45 529 y 9 6E 06x 3 4346 F R 0 6766 R 0 0233 vat NL Jan 05 Jan 03 Jan 04 Jan 06 Jan 07 Jan 08 Jan 09 Jan 10 Jan 11 Jan 12 E 1 04 1 03 1 02 1 01 1 00 0 99 0 98 0 97 0 96 OSI Jan 02 Jan 03 Jan 04 Jan 05 Jan 06 Jan 07 Jan 08 Jan 09 Jan 10 Jan 11 Jan 12 x 1 OSI A TCSD B S C TCI D TC 2002 6 2009 6 2009 7 2012 5 E I F D LT E 45 2013 pd OSI x 109 TCSD Jan 10 Jan 11 Jan 12 OSI S Jan 09 Jan 10 Jan 11 Jan 12 s
17. 2006 2010 1 VD 5 2 pg 8 12 6 3 rg 8 12 121 1 7 85 8 12 1 7 p lt 0 01 1 VD VD 9 12 1 VD VD 6 8 VD 1963 1 D 2009 2 2012 5
18. 7 1 3 1 ED B 1 1 1 2002 6 1 56 9 2012 5 30 66 10 10 2002 6 1 65 2kg 167cm 3km 20024E6H 2009 5 2009 5 2012 5 30 65 5kg 166 5cm
19. 11 1 8 VD 1963 2 5 8 11 1965 1971 5 1972 11 2010 60 69 VD 6 7 g 6 7 pg 11 VD 5 2 pg 8 12 6 3 pg 6 3 pg VD 8 12 VD 6 7 pg VD
20. 1 2 2009 6 1 5911 2012 7 31 63 1 3 2 81 7kg 170cm 83 2kg 170cm 1 30 2003 20 30 1 4000 2003 2 VD VD 2 2 VD Nature Made D 3 5pg SX 2009469 H 1 H 2010 3 31 7 1 2
21. at available D http www data jma go jp obd stats etrn index php 6 1993 29 179 185 C7 f REB 2004 EXCEL pp36 73 8 1990 BL 9 1963 at available http wwwO nih go jp eiken chosa kokumin eiyou 10 http www mhlw go jp bunya kenkou at available kenkou eiyou chousa html 21 2009 13 pp111 119 12 Holick MF 1995 Environmental factors that influence the cutaneous production of vitaminD Am J Clin Nutr 61 638S 45S 13 Kobayashi T Okano T Shida S Okada K Suginohara T Nakao H Kuroda E Kodama S Matsuo T 1983 Variation of 25 hydroxyvitamin D3 and 25 hydroxyvitamin D2 levels in human plasma obtained from 758 Japan
22. OSI TC 272 f 268 294 L y eda 3 4059 R 00776 A TCSD D Jan 09 Jan 10 Jan 1 1 Jan 12 MJ m 20 15 10 5 0 Jan 09 Jan 10 Jan 1 1 Jan 12 2 OSI B S C TC 2009 1 2012 7 10
23. H 7 pg 2010 9 1 2011 3 31 7 2 3 8 28 rg 3 VD VD 2009 2 1 2012 5 30 VD 5 DT VD 200 g VD VD pg 1 1 VD VD
24. OSI TCS 10 8 9 7 S EPA TC I S S TCI TCI 9 TC I I 9 I TCI 9 I TC VD 7 7 TC OSI TCSI S 10 3 2
25. xXx D VitaminD Supplement in Elderly Males Reduces Decline of Osteo Sono Assessment Index in the Winter Season Fumiyuki TAKEHISA Jinichi YAMAKI Preceding studies has revealed that the osteo sono assessment index OSI of a elderly male Examinee 1 shows a seasonal change in which OSI declines in the winter season but increases in the summer season and further it falls with the advancement of age To examine if such change are specific to this Examinee 1 only we measured the OSI for 3 years on a coworker Examinee 2 and obtained the same result as in Examinee 1 As this seasonal change is thought to potentially relate to the generation of VitaminD in the skin we performed the intervention test of VitaminD in succession to the preceding studies Supplementation of it for 7 months starting from September to March of the following year with not Tu g day but 28 u g day of VitaminD proved suppression of the decline of OSI due to the winter season and the advanced age From these results the OSI of Japanese elderly males was found to show seasonal changes such as decreasing in the winter and increasing in the summer but this decrease was suggested to be able to be reduced by VitaminD supplement from early autumn to early spring
26. 3 VD 5 3 1 1C TCI VD VD TCI TC VD 2 5 3 VD
27. amp 28ug H 1120 IU VD 100 IU VD 250HD 60nmol L 40nmol L VD 1558 IU H 16 IU oZ 500IU 800IU VD Holick 22 VD 400 800 IU 800 1000 IU VD
28. Reid D M 2011 Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes a major cause for concern Osteoporos 1nt 22 2461 2472 Holick M F and C Chen T C 2008 Vitamin D deficiency a worldwide problem with health consequences Am J Clin zz 87 1080S 1086S Holick M F 1996 Vitamin D and Bone Health 7 Nutr 126 11595 116458 E ar S 3 50 3 40 3 30 3 20 3 10 3 00 2 90 Jan 02 OSI x 10 TCSD NT Jan 05 Jan 03 Jan 04 Jan 06 Jan 07 Jan 08 Jan 09 Jan 10 Jan 11 Jan 12 B 1 04 1 03 1 02 1 01 1 00 0 99 0 98 0 97 OSI S Jan 02 Jan 03 Jan 04 Jan 05 Jan 06 Jan 07 Jan 08 Jan 09 Jan 10 Jan 11 Jan 12 3 50 3 40 3 30 3 20 3 10 3 00 2 90 Jan 02 OSI TCI
29. TI transmisson index OSI OSI SOSXTI SOS TI L OSI SOS TI 45 2013 A0S 100 3 VD OSI 18 19 26 18C 8 28C 18C 5 2002 1 2012 7 MJ m pq Pj 6
30. 0pg 10 1 19 3ng ml PTH 800IU 2 LC 17 5 20 kg VD 5 OSI S 1 2 3 4 5 0 232 0 353 0 458 0 407 0 287 0 172 p 0 161 0 030 0 004 0 011 0 081 0 172 SEX 0 289 0 472 0 613 0 592 0 433 0 193 p 0 079 0 002 0 000 0 000 0 006 0 239 si Br 500IU 800IU 12 5g 200g 250HD PTH 7 7pg
31. 45 2013 VD VD 25 OH D 250HD 250HD PTH 91 0 14920 amp 7 Need5 X 250HD
32. TCIS B 2002 6 2003 5 9H 2003 6 2004 5 5 TCIS 3 4003 3 3 3360 2 TCIS 3 1412 3 0907 2004 6 2005 5 9 1 7 2007 6 2008 5 E 8 2008 6 2009 5 8 0 3 4210 2 2005 6 2006 5 1H 3 8323 2H 3 1503 2006 6 2007 5 H 3 2780 3 1170 H 3 2380 2009 6 2010 5 Tug 1 3 1145 2 9497 0 1648 3 1075 0 3135 3H 3H 2H 5H 3 0189 0 0878 2010 6 2011 5 28ug 12H 3 1067 4H 2011 6 2012 5 7H 3 1037 12H 2 9994 0 1043 4 CD 7 8 VD 8 5 xg VD 7 8 VD 1 8 5 x g 60 69 11 6 7 rg VD
33. bone mineral density in early and mid puberty girls a cross sectional study Br J Nutr 96 124 130 Viljakainen H T V is nen M Kemi V Rikkonen T Kr ger H Laitinen E K A Rita H and Lamberg Allardt C 2009 Wintertime Vitamin D Supplementation Inhibits Seasonal Variation of Calcitropic Hormones and Maintains Bone Turnover in Healthy Men Bone Miner Kes 24 346 352 Need AG Horowitz M Morris HA Moore R Nordin C 2007 Seasonal Change in Osteoid Thickness and Mineralization Lag Time in Ambulant Patients J Bone Miner Res 22 757 761 Himeno M Tsugawa N Kuwabara A Fujii M Kawai N Kato Y Kihara N Toyoda T Kishimoto M Ogawa Y Kido S Noike T Okano T Tanaka K 2009 Effect of vitamin D supplementation in the institutionalized elderly J Zone Miner Metab 27 733 737 23 24 25 26 27 45 2013 Kuwabara A Tsugawa N Tanaka K Fujii M Kawai N Mukae S Kato Y Kojima Y Takahashi K Omura K Kagawa R Inoue A Noike T Kido S and Okano T 2009 Improvement of Vitamin D Status in Japanese Institutionalized Elderly by Supplementation with 800 IU of Vitamin D3 ZNutr Sci Vitaminol 55 453 458 suf 2009 RERE D AAIEN 8 291 296 Macdonald H M Mavroeidi A Fraser W D Darling A L Black A J L Aucott L O Neill F Hart K Berry J L Lanham New S A
34. ese healthy subjects J Nutr Sci Vitaminol 29 21 281 14 Nakamura K Nashimoto M Yamamoto M 2000 Summer winter differences in the 25 hydroxyvitamin D and parathyroid hormone levels on Japanese Int Biometerol 44 186 189 15 Nagata M Takamoto S Itoh M Ono Y Suzuki A Kotake M Zhang X Nishiwaki Yasuda K Ishiwata Y Imamura S 2005 Seasonal changes of serum 25 hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population Bone Miner Metab 23 147 151 16 Nanri A Foo LH Nakamura K Hori A Poudel Tandukar K Matsushita Y and Mizoue T 2011 Serum 25 Hydroxyvitamin D Concentrations and Season Specific Correlates in Japanese Adults Epidemiol 21 346 353 17 Itoh H Mori I Matsumoto Y Maki S and Ogawa Y 2011 Vitamin D Deficiency and Seasonal and Inter day Variation in Circulating 25 hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers A Longitudinal Study Industrial Health 49 475 481 18 Meier C Woitge HW Witte K Lemmer B Seibel 19 20 2D 22 5 MJ 2004 Supplementation With Oral Vitamin D and Calcium During Winter Prevents Seasonal Bone Loss A Randomized Controlled Open Label Prospective Trial Bone Miner Kes 19 1221 1230 Viljakainen HT Palssa1 A K rkk inen M Jakobsen J Cashman KD M lgaard C Lamberg Allardt C 2006 A seasonal variation of calcitropic hormones bone turnover and
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