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1.
2.
3. Pe
4. OS pu cf
5. OR HAY AF LB GESAMP E A9 6
6. A6 5 4
7. 426 c 2 UPC 8 428 A8 1 GHS 8 E
8. BCF log Kow 3 ngs
9. E H Zs
10. A6 5 14 RAE 414 A6 5 15 E GHS 1 1
11. c d WAFS
12. 4 ee oe be ea S a sie A ene ae lt
13. 1
14. a L E Cso b
15. 7 Fo 8 SDS
16. A9 3 A9 2 6 8
17. E A10 5 2 2 WIR pH HORE A10 2 3 2 A10 5 1 6 pH A10 5 2 3 LF LO A10 5 2 3 1 oy aA 5 A10 5 2 3 2 pH 2 3 2
18. 1 2 3 4 5 P313 3 2 2 3 ee a FIG E Es PT B 3 3 2A 2B 3 4 2 1 1A 1B 8 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P314 3 9 1 2 s PRESLEY C P315 2 5 En U A kI
19. BCF 470 ua Lr A9 5 3 2
20. A4 8 11 8 BHM LFW RBLOBDFHTEIZ BLES SER oe ee ae x A4 3 11 9 B L OR
21. A3 8 4 5 302 A3 3 4 6 A3 3 4 7 A3 3 5 A3 3 5 1 3
22. A5 2 2 A5 2 2 1 A5 2 2 2 GHS GHS
23. 455 A9 3 1
24. RR OECD 301D 1 DOC OECD 301A OECD OECD 301E ee OECD 301 464 A9 4 3 5 6 OECD 301D MITI 1 OECD 3010 OECD 301F
25. 347 3 2 2 H315 P264 P302 P352 P280
26. 2 4 2 Do 835 2210 E OPPTS 835 2210 A OPPTS 835 5270 2 1 T 2
27. ES 01mg7I NOEC ECx lt 1 ey ee AE 0 01mg71l 0 1mg 1 A9 3 3 2 3
28. h pH
29. P270 P321 BE DORER OR GDR BALHA P330 336 3 1 4 H302 P264 P301 P312 P501
30. A3 3 4 2 GAH AVILA RTIS CHE SAAD MSIL EREXOWMAOLOOERCHYD IN A8 3 4 8 A8 8 4 4 3
31. HTI a DOC DSL E b c NR VW d 3 N Si e BODs COD 7 3 70 3
32. 2 mae 3 SDS SDS SDS no
33. A4 8 10 1 2 A4 3 10 2 1EFHIRUEVE
34. 500 500 BCF BCF 4 BCF BCF
35. LAL A9 3 A9 3 1
36. we A9 7 2 1 2 3 A9 7 2 2 4 pH FE pH 1 j E pH
37. 304 2 1 1 1 H201 i 1 2 H202 PE 1 3 H203 in P210 P370 P372 P380 P373 P401 P501
38. 339 3 1 3 H311 KEITA ATE P280 P302 P352 P405 P501 P312
39. E E IOMC ZL SHRMNS AFA GHS OFA SH SAH ZORE IFCSASG3 98 32B 397 A5 2 S A5 2 1 GHS Wk oY ATF f D 3
40. P270 P330 337 3 1 BL 5 H303 P312 338 3 1 1 H310 2 H310
41. E nS NIR VAALCORR CHA WOP REA HE RLS DBA A AREA A9 4 2 4 7 a
42. GHS 4 TEE 3 1C 1 4 A8 2 1 1 EINECS EINECS IUPAC CAS No 999 99 9 EINECS No 222 222 2 1 2 2 SO gt 1 3 CxH 0 1 4 1 5 w w 1 6 1 7 TX Globalexyl UNoxy ILOate HAKA HE 429 A8 3
43. RENAE 4 E F H LT FF FAAS ee ULT RR TME
44. EDTA A9 3 3 5 QSAR OFJ QSAR OFI 1 A9 6 WAR QSAR 1
45. 1mg 1 IT lt RRE DKE IT lt GIR EEO HERR
46. A9 4 3 6 3al a RAT Z TBII BAB 3 E RE NR oats 1 Fr A9 4 4 HEXF A
47. OPPTS 835 2110 2 4 APRE 2 4 1 OECD OECD 1997 487
48. 326 2 13 H EDX 1 H271 P210 P306 P360 P420 P501 P220 P280 3 a up S pi R P283 P371 P380 P375
49. MERPH ANC SACREHMLEME LABEL HEGRE OC PUAE 9 KE P234 BHESBOC BATE P410 P235 Z77 B FNU RZN CW SBHAICLAME L P411 C TEE EERBLERLAG GHS2 8 2 8 P240 215 2 81ZL 9 BS VLMOGEBLEEBA 5HEGE PEAH CBEST OREO S 5 PHE YEBDS EX P280 P420
50. A9 8 4 8 L RCso NOEC 4 LOTR 3 A9 3 5 RNE A A9 3 5 1 RAKE
51. E 4 4 E 4 E E gt l 463 E E A9 4 3 5 ZYV L 7RHRCOPET SIGE A9 4 3 5 1
52. 3 rs A10 6 2 2 HIPER Img 28 A10 6 1 A10 6 2 A10 7 A10 5 2 1 A10 4 a 5 c d
53. A9 8 8 4 ZARA OLE EDTA EDTA EDTA
54. SDS 389 A4 3 11 13 A A4 3 3 2 1 ce GHS 1 3 2 3 A4 8 11 14 BAOSRAGR A4 3 11 14 1 A4 8 11 14 2
55. 1 2 3 4 5 P411 0C 2 8 BAT EF eH BSL ERGS A B C D E F GHS2 8 2 9 EEF 215 2 3 2 15 BAT Ne a ee A B C D E F P412 507C 2 3 1 2 3 P413 kg C 2 11 1 2 P420 2 8 BAT A B C D E F 2 11 1 2 2 18 1 2 14 1 2 15 A B C D
56. E 1 3 ob QSAR E Il E E Lipnick 1991b A9
57. A9 3 2 2 gt Ne EEE 5 HEIL E Pi E ice HRD EE f 4 E E E GHS F OECD 1998 4 C AY
58. A DC BRAK ATE AAO HBAs Cb 456 A9 3 6 A9 3 6 1 f22EE Jot a T k L B A9 3 6 2 A9 3 6 2 1 AIL ine A ks
59. OECD 1998 TONT pea ee biomagnification AN A Sete PEE 3 European Commission 1996 E
60. e O pH g
61. A9 3 5 7 2
62. 362 RIE lt Be 3 9 2 H373 lt lt gt gt lt gt lt gt 5 LDAPULI N COPEE ZS EMER EFAS S lt lt gt gt CI MORD ODIS BEDA ETEO EBREHNCHEA SHWSBGER HECE ERRET O P260 P314 P501 BI CANEIA AIS A RRRIATU ERALZE
63. re 380 A4 3 3 3 PERE INCITS FRE OU CL SEMEN CBD 220 COME E T ORAM OS Riis FRE DPA EE WAH ENDARA BIT 3 ARRARO AME ET CWE I EENT E A4 3 3 1 FBA A4 3 3 1 1 FUADO FHES
64. 477 4 Howard 19 BIODEG E QSAR OECD 1995 Hansch Leo 1995 Meylan 95 Hilal 5 1994 Howard 1992 Boethling 5 1994 Howard Meylan 1992 Loonen 1999
65. im 446 A9 3 2 ARORH E A9 3 2 1 XF
66. 2 ee BD BRL AGRIC HES C Elif ATARNE CHS c ECJ NOEC LCgo gt Nae
67. A9 7 A9 7 1 A9 7 1 1 OECD 1998
68. OPPTS 835 3180 HULE OW 3 7 4 FF FA CER 3 8 FRMEREDDE 3 8 1 FA 1996 1 Probability Program BIOWIN Biodegradability Probability Program US EPA EC
69. A6 3 3 3 4 6 7 8 9 SDS SDS A6 8 4 GHS SDS
70. A9 4 3 3 28 HLF BEA A9 4 3 3 1 DOF B MITI 1992 LKF 27b BA ACES 28 28 E D FE AY fH EKSA E bey a b A9
71. EBEHAN WS AGRIC hE 6 LATEMLEICWIZ HERB L OSPUZLE S REA P234 MEX BOC RAPS P411 P235 C TEE HERCEGA GHS2 8 2 38 2Z77 B FNU EH CW SBAAICLAME L 2 15 2 8 Z V BSE VLMOGEBLEEA P240 PREKINE T IRET SERGE OS WHE P420 EBS EX P280 319
72. A9 5 3 5 2 c BCF BCF A9 5 3 5 3 Kow oT wy Me N E v K v 471
73. 4 H ik FS amp CH Do A9 7 2 A9 7 2 1 2ZEBIES Z OM A9 7 2 1 1 2 A9 3 3 A9 7 2 1 2 A9 7 2 1 2 1 E BR OKAEBET 2 BL ORES A OFA E EIZ LDL MRE E
74. A9 4 A9 1 18 A9 5 QSAR A9 1 14 QSAR OT QSAR TIT 3 ae cS A9 3
75. A6 5 A6 5 1 2 8 10 A6 2 6 9 8 11 3 4 5 7 8 1 4
76. 415 416 7 GHS 418 7 GHS GHS 1 2 GHS AE AEBS Te AS a Oe QOL 2 CQ UNXXXX 2 1 4 10 5 2 d BFR 1 4 10 5 2 a O 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e OLB GATL EGTA OA PL EE SERV ONAE IK BAT B EERI EFAA IED B IIKOT NE GEE ZRF 5 GHS ZEBRA NMAT 3S EBCES 419 2
77. a 386 b Fav c ROO RE d pH e FAR ee LE AA f g h i Q k m FAT FB BE n o n p q r SDS SDS A4 3 10 10 A4 8 10 1 Att A4 3 10 1 1
78. Scow 1982 J 2 6 E 104 108 103 1086 AL EKIEHLAE Scow 1982 LT 2 7 2 AREA mgC L
79. A5 2 2 5 398 A5 2 2 6 GHS 8
80. A3 2 3 8 GHS P805 P851 P338
81. P234 P235 P411 BA SUCREAH CW SAAICILAME L 5 P240 FRE STII ME T IEIET HEBDS EX P280 PR DREO B THE IKBY R Z ERK 0 UVES EEE A FU TOS A CKI tE Fits E LAPEEBICIL RMR LOCHICLE S on BEEBEOC BATZ P410 P411 C BE ERED Li EELS GHS2 829 2 15 2 38 Z V BEV VLMODOGEBLELA 5bHEGE P420
82. pH pH4 7 9 50C 5 10 3 pH 4 7 9 OPPTS 835 2130 OECD 111 2 3 3
83. 333 2 16 1 H290 P234 P390 P406 P284 BIOUZbSEGREAIEL TE RV 334 3 1 1 H300 2 H300 P264 P301 P310 P405 P501
84. E FACIE log Kow log Kow 6 3D BCF A HELT BCF E F 1og Kow 6
85. gt ec Lx A am ID 4 4 1 RRC OV CORE veges BT ORALY WA Scow 1982 4 2 eee
86. Pedersen 1995 A9 4 2 5 ZF 2 BAF CER EE A9 4 3 HRIC OL CORE A9 4 3 1 HLYA
87. 2 A3 1 1 GHS OF 1 2 3 4 H200 2 1 H201 2 1 1 1 H202 2 1 1 2 H203 2 1 1 8 H204 2 1 1 4 H205 2 1 FH 1 5 H220
88. DIZ RLT 2 14 RHENT McKim Goeden 1982 C Opperhuizen 5 1985 Anliker 1988 E Gobas 1986 f 503 CPT 5 MER ARO ERRNO OOT k Sijjm Linde 1995 Opperhuizen Sijm 1990
89. MA A4 3 12 2 a b c d e SDS SDS 390 A4 3 12 3
90. aS E E 1 _ Nat EN HT SORROW gt RIJ ARS E E
91. 1 2 3 4 5 P332 3 2 2 3 P333 3 4 1 1A 1B P334 2 9 1 LT ADF ARRIEN PEREK 2 10 i NEN 2 12 1 2 7 OBRA 1 OKEHE P335 2 10 1 2 12 1 2 P336 2 5 P337 3 3 2A 2B P3388 3 2 1A 1B 1C 3 3 1 3 3 2A 2B P340
92. GHS 3 4 1 C lR ww 6 4 0 5ml 1
93. 4 454 1 1 MWsat MWion E A9 3 5 10 AWE A9 8 5 10 1
94. P230 MEINE LVAD do B t VLIW TB E DRERI CHLOE PR Bb Sl VTA A ERO BLUEAYWORBAR OU HENIEZE H P234 P240 LEHO DRA EKHE Ce GE P250 Ei LEKOR I FENER TCO SHA ROEA MRE E EPE ESTAI ET D ELAS P280 A 305 2 1 1 4 H204
95. 2 A4 3 4 1 LERRAREZ OR A4 3 4 1 1 A4 8 4 1 2 a b c ES BLE ADS RARE MLA MASS L LE OME HER SNORE d PPE A4 3 4 2 Bt BERLE L IIED MERIKE
96. 3 3 1 MY SENO D OECD 1995 3 2 BEDE 3 2 1 EU C 4 FAB 3 2 2 AAA HET a b c d e f 2 100meg 1 CORK 4 3 OPPTS 835 5270 E OPPTS
97. HD SBME ARS log Kw b EK BRED R DARRA IE ERIR ORDD gt LL 4 gt NI E 2 ee 28
98. MOBS DIE BRA ETE WO EBREHUICHY AN TOSHA AE GIEBE RMT O CLARO E UbPDPULT R COPBE ZT SWHEEAITS 3 GHS Hl 4 269 A3 1 2 3 A3 1 2 H300 H310 6 A3 1 2 4 1 4 10 5 3 3
99. Schwarzenbach 5 1993 2 2 Schwarzenbach 5 1993 2 3 WKI 2 3 1 H20 OH
100. 5 2 8 OECD OECD 1995 E v IZOVW CH Pederson E SAR A ele Ces OO D SIDS EN
101. a b c 28 16 gt 0 048 day A9 4 2 4 11
102. HF fiat E A9 2 3 4 4 1 4 1 2 11 3 A9 4 2 2 BABAEME A9 4 2 2 1 ee Fa A9 OECD f ETSY A9 4 2 2 2 OECD
103. P270 P321 EOE ORG PLL LLG EA P330 335 3 1 3 H301 P264 P301 P310 P405 P501
104. 408 A6 3 6 E A6 3 7 AE FARCBAL TIL RL 2 RER 10 A6 3 8 BWEAA OPRWE PF ILHIIZIT SZE 1 1f 3
105. 11 a 11 5cm 200rp m tk PVC 8mm K 350mm 40mm 15mm 2 b 1 0 3 01 100rp m ke A10 5 1 10 A10 5 1 9
106. 2 8 VA B H241 i a P210 P370 P380 P375 P378 P403 P501 CREO RH SACU SAEREMICEBE VIBRE PEEP LOZ PACLE D REDS P234 NOXBILKBI RZ EK TOGA HESEOC BATI HTZ P
107. 462 RRBORSS H A 5 H uu A 20 A9 4 3 2 A9 4 3 2 1 HGCA A9 4 3 2 2 4 E 2 100mg l Ae AL IT OVER HO HH
108. A4 3 3 2 2 a b A4 3 3 2 8 Peat ABN ALE IL RCB ERA ORELIALAD EMAL ERT Do 381 A4 8 4 4
109. r ES TE W ko Affi Peterson P ee ER P 1998 2 2 FASE
110. 2 3 fim 2 3 1 R EY Bike 2 3 2 TERI 2 E gt Le BBE Sift E 1 E
111. FEHR Do 5 3 ee ee 3 ROTT gl A6 5 11 2 A6 3 Ike
112. 10 SHA RET hi 4 i FE 3 pH E E 10 E
113. A9 7 5 3 2 2 L E a L E Cs0 4 b 2 c L Cso 10mg l 3 A9 7 5 3 3 HE lt L E Cs COIU 77 ae b OHE 4 IZ L E Cs0 1mg l 10mg l E E 24 AES Cso E E 1 E 1 Imgl E 2 E 100mg 1
114. A6 5 6 8 SDS A6 5 7 E 1 11 A6 2
115. a3 IC RREI NS VICAR ASN CW SIEFWEAIL BID EDS A6 5 8 4 Spoon 412 A6 5 9 BVGFFOPRAE Hl pak A6 5 10 AR sh A6 5 10 1 f Uae nee gt 0 1
116. A6 4 1 2 A6 4 2 A6 4 2 1 2 1 A6 2 A6 4 2 2 2 1 SDS
117. OECD 1995 amp 1mg 1 OECD 1995
118. Se Coe ee A4 2 2 4 Do A4 2 3 SDS OFF x0 A4 2 3 1 SDS 16 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 xa A4 2 3 2 SDS SDS
119. SDS T A4 2 2 2 SDS 8SDS 977 A4 2 2 3 SDS Sh ee
120. 3 5 F Ft A Hansch E A9 6 2 ABHEOMNHFMLE TERE LORE A9 6 2 1 ade el H SA og Kow amp log C D QSAR A9 6 2 2 JE PU SN 5 EERE DRK CE MEG 3 g X 1990 log Kow a a J Lipnick 1995
121. 315 2 6 x 1 H224 2 H225 3 H226 bs P210 P303 P361 P353 P403 P235 P501 P233 KD HEETE CHET SIGE OS O THVED SE P240 KD HEETE CHET SERGE VED H KEHED do BEX P241 ip a a N HOXE BBE MARE HAAS b 5 VLOG E PEPE RBI MEER EBA BNA EFES AAI CLO FERRER OGLE OFFERS E LEE LTB Bb P242 Pe i eR ss pn per eat linge KERLE DIE RICOR AULA RAL IMICRBO LE IZ O 1ind KOMEAA SPS P243 DRHE CRI
122. A6 5 5 BEIA 411 A6 5 6 BRBLOUGAFE A6 5 6 1 Pea A6 5 6 2
123. L GE Cso H 2 pH ECAR HEAR IC aba 4 1 FE A9 7 1 6 eerie fee ee Li Fh A9 7 1 7
124. A9 7 5 BEELUBEILAOICET EDADA A9 7 5 1 BEB L UDREA BIT EPIRI OBE A9 7 5 1 1 T ite L E Cs0 A9 7 5 1 2 1 482 E 3 E BELLO
125. gt 1 Do A9 4 1 8 FF ORLA Al A9 II A9 4 2 2YEIEF 2 OFFER A9 4 2 1 Ba DEH ee vane Poe a Oa 3 rico cian 8918 A919 881 23
126. P202 P280 356 3 7 1 H360 lt gt lt lt gt gt 2 H361 lt gt lt lt gt gt lt gt
127. PT AX CHA A4 3 1 4 PRA OFS A4 8 1 5 KABB F Wee SDS my uy SDS 8 6 24 A4 3 2 2 WO a
128. Ve MAIC aA TSO Chit CHASE A9 6 4 4 EPA HPV ve HPV SIDS US EPA 1999 1990 UR 2 800 HPV
129. 353 3 4 1 1A 1B H317 e P261 P302 P352 P501 P260 BAAN ER AP SBAAIALAME LT P272 P280
130. 363 3 10 1 H304 2 H305 P301 P310 P405 P501 P331 364 4 1
131. 4 DI Aas B pH G O Gi 4 E A9 7 2 1 2 2 A9 7 2 1 2 8 z CHESS Santore Driscoll 1995 pH DOC 3 s C7 N oo HM gt BY aes ROIARER tA H O 2 H E
132. A9 4 2 4 18 OECD 1997 i A9 4 2 4 14 A9 4 2 4 14 1 QSAR
133. 20 700 European Commission 1996 1000
134. MINTEQ Brown k OSH BLM BLM JOT Allison 1987 EE WHAM Tipping 1994 1 Santore Di Toro 1999 E OECD 2000 480 R gt
135. K A6 2 6 9 2 10 y A6 5 2 A6 3 lt 2 10
136. 9 A9 7 A10 1 3 a MO b
137. z 3 9 283 1 2 3 4 5 P270 3 1 1 2 3 4 3 1 1 2 3 7 3 8 1 2 E 3 9 1 P271 E 3 1 1 2 3 4 3 8 3 3 8 3 P272 3 4 1 1A 1B P273
138. 7 A8 4 2 AGRI BRIE 7 6 3 PR i 7 1 A 3
139. SREI E kL LEO ASH ZEY i f IT NE CHS a b c d FF e 1 fa HA f 4 L E Cs0 Zoe BCF g og Kow A9 2 4 2 NOEC EC 4
140. OECD 1999a 1999b F gt Bb KD BIOWIN JAN G F2 tt AAI 2 bk HAV IIE OECD YOECD
141. E A9 3 4 2 GLP GLP 3 GLP H T
142. eB AKI A9 6 8 QSAR EFN ORUE A9 6 3 1 HE amp ZS FA QSAR CO KE FR QSAR QSAR QSAR E E
143. 437 438 9 A9 1 FR A9 1 1 E a a f b A9 1 2 TSA E Et DD J F5 LIAR ARSE 3 E
144. Zk P337 P313 351 ERIC SD BARS 72 RG PE ARE 3 3 2B H320 P264 P305 P351 P338 ET P337 P313 352
145. 2 1 OECD 9 AO SiS LUMI SHE ORAS 2 ES
146. P202 P280 Es 355 3 6 1 H350 lt gt 2 H351 lt gt lt gt Clit MOREO OILS BABE CHWS E DRAEK ISHEB SN TOSHE ECEE RRT D P201 P308 P313 P405 P501
147. 2 6 BIC EAL CRT A E R AG E 406 A6 1
148. 1 2 1 4 A A3 3 3 A3 3 8 1 3 A3 83 3 2
149. ieee 1 a BE Cso Img log Kow 24 BCF lt 500 448 b A9 2 3 5 A9 2 3 6
150. KERIB LS LEB ES 5g 31 2 E A
151. 444 1mg7l 8 amp FE E E Eg gt ts 4 H pT ira Imgl 9 2 4 3 7 F Am f A9 2 4 4
152. BE os P381 308 2 2 2 H221 P210 P377 P403 P381 309 2 2 MBIA RILL A
153. BORIS LEE GHS 11
154. 1 E 1 4 4 1 a GHS
155. AUS a Ku gl b c ml 108 106 d 5C 25C e 28 70 16 A9 4 2 4 6
156. 4 RZE Te XRF LEP UID EEEE 478 A9 7 1 3 0 FORM a A9 7 1 4 s5 A9 7 1 5
157. 2002 WSSD GHS GHS 5 PE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS The Globally Harmonized System of Classification and Labelling of Chemicals GHS has been developed through cooperation between the International Labour Organization ILO the Organization for Ec
158. 361 RIE lt Be 3 9 1 H372 lt lt gt gt lt gt lt gt 5 LDAPULST R COPEE ZS BEMER EAS S lt lt gt gt CI MORD OIF lt BEDA ETRO E DRAEI AEA SHWSBGE HECE E METS P260 P314 P501 P264 P270
159. A5 2 2 3 A5 2 2 4 27
160. a ii i ee mm eS b NN c A4 3 11 15 ZCOMOFR GHS A4 3 12 12 A4 3 12 1
161. LEDS T SN a oe na LIL EU ra ARICA c v b je m t lan oe 3 USEPA
162. a GHS 1 GHS b R 0 DS c
163. G i A 3 3 4 4 20 OECD 3 3 5 OECD OS ARAWAZA BR OECD Sy EAT HE E o HH
164. E H DoE 1996 ECETOC 1996 US EPA 1996 OECD OECD 2000 23 A9 3 5 2
165. HPLC De Bruijn 1989 Tolls Sijm 1993 OECD draft Guideline 1998 OECD 498 2 2 2 FAX RRE 2 n OECD 107 1995 20 n 1C 2 2 3 HPLC i HPLC
166. A B I E H gt A A4 3 11 4 oe A GHS A4 3 11 5 3
167. 451 A9 3 5 6 b c d PA A ya 2 e TRI A9 8 5 8 heed PO ma K A9 3 1 A9 3 5 4
168. ABA 1 FE CO 96 HR LCs0 fh OECD 208 EEIE HUT 7 RECO 48 ISR EC ff OECD BIL 202 I IIRA 7 FE CO 72 FREZI 96 FFR ECso ff OECD 201 FKALAEO DD ICLVOKRESHS IDLKEWPILT S COKELEMHONK CHE EARRESHSB PRLE ZKR b OTOMI BRAHSZH Lemna 14 E FAR RRA hea dg f TEE EHET 2 IL IEF COMPRIS ETZ b leh BULLEN TAF LES 4 D E o gt EDDY PARR FMA OHH b CLUE ERESZ NT Zev OECD EFA 210 GAO E EIER 202 Part2 FE EH 211 2 D aADEGAE BELO 201 RAER ME MD ESHER ERE Sf LICK OECD OECD 2006 A9 3 2 3
169. Es P220 P371 P380 P375 P280 P370 P378 K Y RZ EKER SES P283 329 2 14 2 H272 3 H272
170. P370 P378 KB Y AZ EWKAL EGE 327 2 13 H EDX 2 H272 3 H272 P210 P370 P378 P501
171. WBF WAF L E Cso LLso WSF WAF A9 3 5 10 2
172. 6g cm3 509 8 m A10 5 1 9 25mm 0 2 u m PES O8um 5 VW LAL REDET OCW OES TABU LY SEES OEA 523 A10 5 2 LAR A10 5 2 1 PHE SPEUR a b c d e f g
173. E 2 A9 6 4 13 ABLOUS XV acts BRKE fA 3 EF MIL log Kov X ay
174. QSAR QSAR A9 4 2 4 15 EJE H
175. A9 2 3 8 o A9 3 3 2 2 A9 2 3 4 log K 24 KIEL BCF lt 500
176. A9 7 5 4 2 Imm A9 7 5 4 8 1 mm HOFA 1 mm A9 7 5 4 4
177. c A10 5 8 ARO 2 E 1 2 A10 5 3 1 HER Z Y D PROPERES EA A10 5 3 1 1 80 2 THOT OR A10 5 3 1 2 pH 3 E 100mg l AFD A10 5 1 6 A10 5 1 8 10 15ml 2 H
178. A9 6 1 2 Corwin Hansch 1 H P C 5 ZAL K nemann 1981 4 K nemann DJ E 1986 Meyer Lipnick 1989a f Overton 1901 H E E ity gt ae N Meyer Overton
179. E A AAU ALAND bE COBMOEOMOF F Id ste Raia oie eile o 0 1H 2 A9 3 6 2 4 QSAR QSAR A9 4 A9 4 1 A9 4 1 1 iz
180. Hi l HIZEY Y 3 A9 1 7 1 ZS H E oe Al gt i
181. Tk ae E AP TE E L E Cso gt 100mg ole 4 FEN E FF E E E EA AE T E FE A9 1 10 E
182. L Cso a 80 IX E E
183. OECD 1995 Scow 1982 494 3 1 2 WED Monod OECD 1995 4 50 3 1 3
184. SDS ral a AG6 3 5 1 2 404 A6 1
185. f roe RREO X HA LIER CH gi cre eras wale lai BCE BCE E lt BCF MET 4
186. E EF HH 3 ETE Fe ZTL 7 a i E ay H Zz deck weiss E
187. b A A9 4 2 4 8 OECD 302 70 2 UN NN 0 460 A9 4 2 4 9 Tae cain GAS Ses NN A mage
188. DONC Lo CDs A10 2 A10 2 1 pH OGRE ZERO T 92 1 Organisation for Economic Co operation and Development April 2001 519 OECD Environment Health and Safety Publications Series on Testing and Assessment No 29 Environment Directorate A10 2 2 BYL BMORZ Y TBR
189. GHS SDS SDS SDS A4 3 1 2 fEDFFEFR SA 7 4TH E12 SDSL FT SRBHIZOW CO BRAIT LNI EPOS EZ SDS ERT SUHAED FREAFCASBEWIZEBW DS 379 A4 3 1 8 6p OPRAH E EA LOMB
190. A ZS BY AN A9 2 2 1 A9 1 8 W Ss E A9 4 ffi A9 5 A9 8 A9 1 9 FE
191. t SDS 8 b c A4 8 6 1 2 KAFRA LT PVC A4 3 6 2 RELOP LAE A4 3 6 8 EfUADLERMOHFOT ER LVR A4 3 6 3 1 a 32 b A4 3 6 3 2 a b c d e
192. HED AV log Kow 6 6 5 t CLOGP US EPA 1999 LOGKOW US EPA SPARC US EPA 2000b SPARC 1 CLOGP E SPARC log Kow 3 K E Et log Kow la BUY Lipnick 1986 A9 6 4 10 AME BCF A9 6 4 10 1 BCF
193. te D Hig Ma a b c 385C d CO0 2 CH4 3 6 8 490 3 7 3 7 1 OECD 3 7 2 3 7 3 OA ARMA FA TRB L OKA PORRE a b c I 304A OPPTS 835 3300
194. 2 4 479 At a E G A9 7 1 8 1
195. F Ter 96 E 447 OECD No 11 ra 0 1 5g 96 K 96 2 0 te a Re OECD Jo A9 3 2 5 2 RAZ eh OECD E EPA 850 1500 3 7
196. oC RI ee Ss PE WS E A9 7 2 2 REEF OME A9 7 2 2 1 A9 7 2 2 2 3 AE CRH A9 7 2 2 3 24 pH FF
197. 2 4 282 1 2 3 4 5 P250 2 1 EERIE KR TCE SHAA 1 1 1 2 1 3 1 4 1 5 P251 2 3 1 2 3 P260 3 1 1 2 3 8 1 2 R EEEE E RE ETAETA 3 9 1 2 3 2 1A 1B 1C CAPIR h RA LOE HARTS EH PICA SG BIZZY PTA hO 8 3 7
198. 4 4 1 H420 4 2 1 275 276 3 2 A8 2 1 A3 2 1 1 1 4 10 5 2 c A8 2 1 2 GHS 5 TR DAH EJS GHS BREDH 3 A3 2 1 3
199. SARK ARICA CAB Cb EA 10 EE BODs BOD5 ThOD 28 ro Ye BAER COD DAE ER e
200. 2 2 1 2 P390 2 16 1 P391 4 1 1 4 1 1 2 P301 3 1 128 be 3 10 1 2 n P301 3 1 4 7 P312 P302
201. E 1 EOPEIER LOE REO z 3 NM 2 28 28 ae NOES NOEC RIES 486 9 1 2 2 1
202. 918 2 5 H280 tee H280 H280 P410 P403 P410 4 SERENE BIT 3 ELEGY EG e EF NAJO ALGER P200 Z LEHO TS EX HORA YAZI HASN TOBBEK BELTER EE LGAB OEY DREPBD FIED AP EERE EIT OAM OD EEN SRUVGAICRS 314 2 5 ee ma H281 VILA ESI P282 P336 P315 P403
203. 4 fig 10 FE DH DS FR E 14 3 16 28 FE lt 16 28 3 aie FLAS 28 Vala RRt OREO YE DBAVHEEERSAT ERE ARMY LUE E IZ 465 lt 16 PZZ OMF HEDRER ER L TWILL TIR 70 E io AF E 60 28 Fy ED
204. L Cso 10 EE IN ke A A E ee
205. 311 2 3 BL 3 H229 P210 P410 P412 50 C Fl 312 2 4 FL EDR 1 H270 P220 P370 P376 P403 P244
206. Mo a QSAR K Kw EEC A 8 1992 OECD 117 1989 pK A9 5 2 4 2 K n pK pH Kov HPLC OECD 107 1995 117 1989 EEC A 8 1992 EPA OTS 1982 EPA F
207. A4 3 4 8 LIS CEPOL BA E Et S FEW LIBRO br A4 8 5 5 A4 8 5 1 IAKA oe A4 3 5 2 FABRPbEECSHREOERIE
208. 38 1 mgl 10 mg l 100mg l 7 De pH A9 7 2 3 KEBHES 2 E RIET 2 OL BE WR RAAT AE DBP ORE 7A L E Cso 28 E pH pH L E Cs0
209. 4 WHS ART ORE 1 E 2
210. 3 1 1 H330 2 H330 P260 P304 P340 P403 P233 P501 AEF ti BHF CH EaR EES HRED P310 N P271 P405 Lis P
211. HPLC log Kow 0 6 a HPLC log Kow USEPA 1985 ee 1998 K QSAR K A9 5 2 4 3 QSAR log Kow Kov Kov QSAR v ae 4 PC CLOGP LOGKOW KOWWIN AUTOLOGP SPARC
212. PPE a b c d PPE A4 3 8 3 3
213. PPE Te SS eae A4 3 9 9 A4 3 9 1 A4 3 9 2 A4 3 9 3
214. A3 2 2 1 303 2 1 AA a H200 P201 P370 P372 P380 P373 P401 P501 P250 EBD FUN Cb EGE P280
215. 2 11 E SDS HIS E H A6 2 4 K A61 9 V 2 10 1 2 8 9 1 H
216. 4 1 b 2 c A9 7 5 2 4 2 28 A9 7 5 2 4 1 1H E 4 E 2 A9 7 5 8 PEDIREM B A9 7 5 3 1 HRF ADH A9 7 5 3 2 A9 7 5 3 2 1 24 L B Cso 100mg gt L E Cs0 CHAI o 3 4 Ay ara Fe 483 E L E Cso E
217. A9 1 15 H TE D Ah A9 1 16 AS A9 2 ZS A9 2 1 w e EU ples AE 1
218. 9 H 10 25 CEHZ 301C 488 104 108 mL 28 E OECD OECD 301A F E MTTTI OECD g se 3 2 3 OECD 3 2 4
219. c L E Cso d a Sh A9 3 5 7 SHAM DPA A9 3 5 7 1 1mg 1
220. 2 0 1mg 1 1 0mg l 26 oe a 2 E 0 1mg71 1 ol a 8 b 1 o E 0 1mg I 1 0mg I 2 E
221. 3 Be IR w 307 2 2 R 1 H220 P210 P377 P403
222. 3 1 1 2 3 4 ENEAN 3 2 1A 1B 1C 3 4 1 1A 1B 3 8 3 3 8 3 P342 3 4 1 1A 1B P351 3 2 1A 1B 1C 3 3 1 3 3 2A 2B P352 3 1 1 2 3 4 Ped Nene MA al ee ze Fi 7 A D TnA1B SERN bane Ane REI C 2 289 1 2 3 4 5 P353 2 6 1 2 3 BEE ACR H EIAN E BETO
223. P262 P302 P352 P405 P501 P264 P270 P280 P310 P321 ERA DVER E EHET SBE P361 P364
224. Tolls 1998 Tolls 1998 Tolls 1998 LOGKOW log Kow log Kow Roberts 1989 1og Kow log K y A9 5 4 FET SEFT 2LBLUF SOKA A9 5 4 1 F T S BCF BCF
225. ar 2 co RUBE FEE X TEA yu gt EX tac amp KADE A 4M cP E F ie ao 452 4 E F A9 3 5 7 HLA bh BD S AF
226. m AO re le Ade aa alleen log 4 5 Doucette Andren 1987 1988 Shiu 5 1988 Control Act Test Guidelines 499 log Kow 4 5 Ez DIE CO Kow
227. ogs ke i i n MOKED BREN D DI S BBA ETRO EBS o on R atiiagsne oosa p BINT S BIE amp FORC MO BREN mm HED OILS BBA ECR y 2 per o 2 ye emia 941 GR FEATS BHI S a A1 28 8 6 oye e en A i MOD BREN DI S BBBECRISE E a err BR xeenican an cv ag 1950 E ABLES BEE AM MD E PERED DI S BBAE CE 2 gt ai OZ DAEA AN T H351 i OSGA ABRIT lt S BIEK SERE 261 A1 24 3 7 AeA GHS ue ACSA E Te VLAB YEA BR ea i b LHAISBBO BER ASA NEE HET Z MORD LA DIF aea Beet U 1B BR EMIZEED
228. A9 2 3 2 o o a El ZITAT B RURANI BICLVIEVLARAROCHS HF lt
229. GHS HE gt LANL BE i ER EA STOR COMA MTS MORE 979 Ze OS ADB OTS BRAE Ca E BK KEHNUZAE AA CW SHE ABLE S EELS amp i gt b LHA 5 BREN mm LEBEL SE COMBE EBT 2 PE 3 HOPED OILS BBAE CL WZ EBRENIZCHY SAN TOS BO DEITS BEBE ih A1 27 3 10 GHS ERAN BS HE i Zev ele ER EA wen en meen A1 28 a 4 1 2 GHS Hil a p Da
230. ie 9 RAE 9 VV IV Kew 3 466 ee ee PD 9A BSA IID 9 VI A9 5 2 ARTES Z DER A9 5 2 1 A9 5 2 2
231. YB ZHE CDV VT E A9 7 8 RECRUIT SEBUM 3 PEME A9 7 3 1 481 A9 7 3 2 a
232. 1 2 3 4 5 P501 REDIRE 3 2 1A 1B 1C ee 3 4 1 1A 1B NU Mlk E Pe 3 4 1 1A 1B 3 5 1A 1B 2 RR 3 6 1A 1B 2 3 7 1A 1B 2 REE RRM Meta REE HENE E 3 8 1 2 3 3 8 3 3 8 REE Meta PE KE E 3 9 1 2 RIERA 3 10 1 2 4 1 1 2 3 4 1 1 2 3 4 P502 4 2 1 300 3 3 A3 8 1 FX A3 3 1 1 GHS GHS A
233. 331 2 15 EO YZ BAT B H241 R P210 P370 P380 P375 P378 P403 P501 UE BB SN TOS ARE Fa F 7 LA BEEREICHIL PREPRE OSPIZLE 5 RR P234 AOXB IZKBY RZ k TSEHB BATZ CHT Bo
234. A9 5 4 2 FFT S log Kow 1og K 4 4 log K QSAR 1og K 3 A9 5 4 3 IRDOAI BCF log Kow log Kew log Kov Ko 2
235. 106 PEO TV BCF2500 BCF BCF A9 5 2 4 KEE Kow A9 5 2 4 1 Kow K log Kow QSAR QSAR
236. 3 i cb ODER BCF H BCF ct mmer ad Eg k T SRA AY 77k AE A9 5 2 3 8 3 BCF 500 4 1 1 A9 5 2 3 9 A9 5 2 3 9 1 f Jv H R in E f gt A9 5 2 3 9 2
237. 37 44 m 10 20 A10 5 2 3 3 pH ie 10 15ml 30
238. A9 6 3 5 4 g 4 gt ue E
239. SDS SDS a SDS SDS b SDS l c DS 5 er i y ah ae 0 eas mee poe d 4 Siar oi i SDS SDS 9 ERRE a SDS
240. 3 1 1 2 3 1 H330 H310 3 1 1 2 3 1 H330 H300 3 1 1 2 8 1 H310 3 1 H330 H301 RAUNT RICHER 4 LA 3 1 3 3 1 H311 273 GHS 1 2 3 4 H301 3 1 3 8 1 H331 H311 3 1 3
241. 4 A6 3 6 A6 3 1 SDS A6 3 2 3 11
242. E J4 H Lu a ele QSAR f kK BY H 1 H E 4 96 LC50 n a CN SO ThE 1
243. GHS SDS 1 5 GHS SDS CA GHS 4 1 2 TOPIS MEE SIS datz SDS GHS 4 1 3 GHS A4 2 SDS A4 2 1 BGA e ie SDS GHS 1 5 1 5 1
244. Niimi 1991 n ae 1 Henderson Tocher 1987 PA QSAR 2 2 Kow REDE ODBGDALADE A Kov QSAR 2 2 1 K HPLC 2 OECD 107 1995 OECD 117 1983 EEC A 8 1992 EPA OTS 1982 EPA FIFRA 1982 ASTM 1993
245. SPARC log Kow 5 KOWWIN CLOGP 500 SPARC 1 log K 1og Kew DHE TOR a M 1 log Kow Howard Meylan 1997 CLOGP Hansch amp Leo 1979 CLOGP Daylight 1995 n 8942 r2 0 917 sd 0 482 n 501 r2 0 967 n 7221 r2 0 89 sd 0 58 LOGKOW KOWWIN Meylan amp Howard 140 260 n 2430 r2 0 981 sd 0 219 me 0 161 n 8855 r2 0 95 sd 0 427 me 0
246. 1 H400 P273 P391 P501 LEED MELIIL 365 4 1 ZL 2 TEE laf a L H401 3 TEE Mala L H402 P273 P501 LK EELMELIIME
247. A9 2 6 A9 2 6 1 1 GLP f E4 2500 HEIL BCF log Kow 24 H NIS te e o EANTA AF E oe o ge 1mg 1 DOERR 4 HTT 4 ANATH HH K RIR e fa RTE amp FE R
248. A9 4 2 4 12 OECD 111 pH4 pH9 ts 16 UM a ee ae LEE 4 ICBIT E OECD PUECELHEZ ES o 72 AELEOREB UZ OVC REEF BUABUSLGT E EU OFFI RAT LOCOS CAULKEISAEDAEIERB IC LE EREDFT 2 E DHE GT LTV CB FO ANA THK eels 2 BIE L7G A ZEEE CL Zahn Wellen HR OECD TG 302 B amp MITI II REER OECD TG 302 BHA fE JAEIELEL FOE BY CHS BRITS BLE UE LE BABEAV TILES ZU b ZHEHOMBIZBIC HURIEFENTR SNS CHV RRODGEVIABIE CBD BIEL CNABEOCIUE LET SVFFHLCHECHE FOL I CHS MITI I ALANI gt 60 14 HEAD Gi Zahn Wellen gt 70 7 ALLAN 461 tu 2 3
249. 1 209 E E 1 458 ISO 9509 A9 7 1
250. CWE OREO FAIS BS bh AY ORRORI KL Ae HEF A 3 El a 9 1 p ESA H Al gt E 2 FA 457 AA o pH
251. 10 11 12 ILO 1999 Current Sector Uses of Risk Communication IOMC ILO HC3 99 7 A Venema M Trommelen and S Akerboom 1997 Effectiveness of labelling of household chemicals Consumer Safety Institute Amsterdam Leen Petre 1994 Safety information on dangerous products consumer assessment COFACE Brussels Belgium European Commission 1999 DGIII Study on Comprehensibility of labels based on Directive 88 8797 EEC on Dangerous Preparations Magat W A W K Viscusi and J Huber 1988 Consumer processing of hazard warning information Journal of Risk and Uncertainty 1 201 232 Abt Associates Inc 1999 Consumer Labelling Initiative Phase II Report Cambridge Massachusetts Prepared for US EPA Viscusi W K 1991 Toward a proper role for hazard warnings in products lability cases Journal of Products Liability 13 189 1638 US Consumer Product safety Commission 2001 Code of Federal Regulations Subchapter C Federal Hazardous Substances Act Regulations 16 Part 1500 Saouter E G Van Hoof C Pittinger and T Feijtel 2000 A retrospective analysis of the environmental protile of laundry detergents submitted to International Journal of life cycle analysis October 2000 IPCS 2001 Principles for evaluating health risks to reproduction associated with exposure to chemicals Environmental Health Criteria No 225 IPCS 2000 H
252. BCE UE 1 2 BCFOFBRICLSMWEDORODBDLAE 1 2 1 Cd M 1022 94 log Kow gt 3 1 2 2 OECD 305 ASTM a b ec BCF d e f 1 2 3 H GMO BETOZ
253. KEY 5D EIGKA LBS P220 P280 928 2 14 HED 1 H271 P210 P306 P360 P420 P501
254. 9 II E 1 2 OECD 1995 1 3 co IK EERIE COA EY a b c 2
255. 24 FF OPER YC pH sa WO D 2 3 1 HNO A10 5 3 2 A10 5 3 2 1 A10 5 3 2 2 7 7 5 5 6 2 E YAP A10 5 1 10 24 fal amp 28 2 6 1 TE MAR EBRL OCCA A10 5 3 1 1 A10 5 2 3 coe D CHREPT D 28 4 7 A10 5 1 10 1 10 100mgl 7
256. LEC ie A9 7 1 9 a MO b
257. P234 P235 P411 BP SOUCREH CW SBAAICILAME L 5 P240 PET N EUR C SEISE TE EIT PUREE AS DIBA P280 KB Y AZ EWKAL EGE MED EEE AT CWS A CKI tE Fils EE LA PEIRE PIR BERGE LO CAUAE D kero MEEOC BATE P411 C TEBE RBLERLAG GHS2 8 2 8 2 15 2 8 Z V BS VLMOGEBLEEBA DUNSA P420
258. A3 2 8 4 2 3 P241 A3 2 3 5 5 A38 2 3 6 5 HAC AIA FOE 1 P241
259. DOMA SDS PPE DER E EAU SDS 0 De LEE LAR L SIE RPE OBR 407 A6 1 10 3 9
260. ie E E BCF BRA FX A 1 BCF BCF Dy TR BA 59 OECD 305 1996 Pedersen BCF FF AE ae BCF LE
261. 1972 log 1 C A log Kow B 137 QSAR Koy nm ZS E QSAR Overton Hipnick Studien ber die Narkose jf Lipnick 1991a E g 5 FN 3 nl j4 u 4 AFAR E 5 E
262. P210 P370 P372 P380 P373 P401 P501 P234 P240 RIAD i ERIE T o BAR P250 g LEKOR I F N TOSHA ROERE E EE EITA ET A LER P280 HMXIII IRE D 7 29 EMER IRS P370 P380 P375 WEIS SIRE RD 1 48 EK XLT
263. a L R Cso 1 1 453 b c H L E Cs0 H LE Cs i i SZ d A
264. log Kov log Kow Tolls 1998 Pedersen 1995 CLOGP SPARC KOWWTIN LOGP EPA ED log Kow log Kow gt 5 T 1J Yup pH 1 ME Si
265. 2 2 1 H221 2 2 2 H222 2 3 1 H223 2 3 2 H224 2 6 1 H225 2 6 H 2 H226 2 6 3 H227 2 6 4 H228 2 7 1 2 H229 2 3 1 2 3 H230 A 2 2 H231 B 2 2 H240 2 8 HATA 2 15 H241
266. 2 12 1 2 3 P233 2 6 1 2 3 RR HEE CHE FETE IRE Z IDT PI BENE OS HEGE 2 9 1 2 10 1 3 1 1 2 3 KD PEIEE CIEZKIE RTE ELE T H HEED PETER Miia we ME HENE R 3 D 5E 3 8 3 3 8 P234 2 1 1 1 1 2 1 3 1 4 1 5 2 8 A B C D E F 2 15 A B C D E F 2 16 1 P235 2 6 1 2 3 FLKHEYGAKIRD 1 PL OID FK PELE CG ARHED E S IRE RIEZ TGE 2 8 P411 B FNIEK EN CWSBBAIZILAIE A B C D E F ae se se 2 11 1 2 P418 BICUER EN CWSBNALBIE LTL 2 15 P411 BICUCRKANCWSZAANALBIE A B C D E F 281 1 3 4 5 P240 2 1 1 1 1 2 1 3 1 4 1
267. 7 MER SDS I XBEBLELOGE CH ERBOU SR SELKAUC GOS ERTED RID Elk Ki SNK BAGEL BRA AGHA BIT SGN WELD 8 ADN EB KETENE PIERKE IZ E SIERO AGENDAS 3 RN GLEE 5 9 MARPOL 79 78 Z 1973 FOAMING L ERORE DK ODLUREINUZAT 6 1978 O ECEE VI 10 IBC Code amp 4 JERI Fd CIF FEAILED 0 OM MIO PER DR BITO BME S u EV AY AS VRBEBIL KI bO WIEESN E FPO ERET SBOP I EE bY A NBEBE IS 12 KRhYDRVABRIL LEH ARETRMEUILT ER h y2 RKNVARWIEW J 13 Py FAR ABRIL MRAZ OWPR ER OIEDRELYARBL OGRA ZOU TORODD OIRRC S AED FRERITIT SV FUE ARHKIEV I 393 394 5 396 A5 1 FF A5 1 1 ARS 1998 RE D4 ao LAbai 1 8 Son 1
268. E ASN E 3 440 L Cso NOEC b
269. a b c A e f SDS OF 7 A4 8 8 8 fHA HRBK PPE ZEOMA RAE A4 3 8 3 1 PPE SDS 5 eid ate
270. 1 2 3 4 5 P280 BOE Mex 2 13 1 2 8 OME 2 14 1 2 3 2 15 A B C D E F 3 1 1 2 3 4 RE FRIREKEHET S E 3 2 1A 1B 1C RRE PLS RE RAE ETET D E 3 2 2 NT a T ae ee ee 3 4 1 1A 1B o PEE E R E 3 3 1 CC EE 3 3 amp Bi sual an 3 5 BE 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 P282 2 5 P283 2 13 1 Ex 2 14 1
271. 387 A4 3 10 3 RA ERI THEE gt Bits GEL I FAP A4 3 10 4 BUSSES A4 3 10 5 ARFEIL Oe ya ETE 5 E 3 Ed Ons I RE Ey TOJA 3 5 A4 3 10 6 HEZIBERRI 4 SDS 5 E A4 3 11 11 A4 8 11 1 GHS
272. CLOGP LOGKOW AUTOLOGP SPARC SPARC WD log Kw QSAR US EPA EC CLOGP US EPA EC 1993 Pedersen 5 1995 CLOGP 469 LOGKOW A9 5 1 A9 5 1 K QSAR log Kow CLOGP log Koy 0
273. 4 ZLo THROTLE E ines ES FY EDEL MI ere Fa o A5 1 4 3 A5 1 5 eae ee o o
274. 1 o EF BLEED log Kw 24 AH 4 1 4 1 1 4 1 2 EFEM log Koy E we N HZ BEK si LADS AA BCF BME
275. P280 a 325 2 12 K 3 iik h H261 P231 P232 P370 P378 P402 P404 P501 KEY RP RETZ HA A b 5 l WIAR EK EPOKA EPP Cit BBE P280
276. d A4 83 7 1 2 a b c A4 3 7 2 BiR SI ZERRERS SD8 9 a G Gi Gi iv v vi b i G 384 iii iv y WE vi
277. E f E Bruijn 1989 QSAR log log Kow Overton E PREIE FELDER L DERRE QSAR QSAR
278. 1 3 E i i A9 4 2 3 BODsCOD 5 BODs Baii Sabova VRRP OE SNAT OBES A9 4 2 4 COMBED b dA HEL A9 4 2 4 1 KA TRE A9 4 2 4 2 4 1 4 1 2 11 3 ce gt In 0 3 In 1 28 0 043 day 1 ts ln 2 0 043 16 A9 4 2 4 3
279. 3 4 1 1A 1B H335 3 fe 3 8 H336 3 Be 3 8 H340 MOK DIS BS 3 5 1A 1B A ETC EBREHUIZHY Sf TW3BGF A PER ERRET O H341 ae MORO O T 3 5 2 BBA CLAWS EBREHN HAAR TU A PEE E RRT 3S H350 MOD OILS BERAE 3 6 1A 1B CRW EBREHICHA SH TOSHA A BOIS BET Z 272 GHS 1 2 3 4 H351 MORD OLS E 3 6 2 BAET EBRENIZHA EN TOSH A AECE RRT D H360 5 3 7 2 1A 1B D
280. P321 ERA DVER E EHET SBE P361 P364 340 3 1 4 H312 P280 P302 P352 P501
281. 2 E b 1H h ma C amp D A9 7 1 5 A9 7 1 6 A9 7 4 EDZE A9 7 4 1 log A9 7 4 2 A9 7 4 3 BCE DOT PS ANA FACE BCF LAWS BREWS Kow 2 Ffi Ay y
282. Comotto 1979 Wakabayashi 1987 Goodrich 1991 Toshima 5 1992 ADHEPE LZ F 468 BCF A9 5 2 3 9 4 BCF 1000 xEAI OT OECD 805 1996 BCF
283. Del It UREA CL EPA CA BREET SEGA DAWA SND A3 2 3 7 5 P284 FP SIAN TIRED ZEETNEHA OL ONL A D CHS DPA OLA TRB L CWS EVD REA HARA
284. 3 4 4 3 5 STP Yt 2b LvaT RR STP OECD 303A Coupled Unit ISO 117383 EU C 10 Nyholm 1996 3 6 BERHIZAELE 3 6 1 ISO 11734 1995 B ASTM E 1196 92 OPPTS 835 3400 3 6 2 8
285. A4 3 12 4 APE E 3 SDS jiz A4 3 12 5 fet SDS E 1 j 1 DEH DC NR a Aah Nace fee f4 pa es HoR HE E SDS OF 3
286. A8 4 5 2 2 0 43mg l 72ppm 13 GHS NOEL mg F344 0 12 6 13 3 20 0 24 JO UE SATE 5d w os k BAL PHO eee 10 os 0 RDR BARONE
287. P210 P370 P378 P501 KEY RD EWKECEBS P220 P280 330 2 15 R F BAT A H240 P210 P370 P372 P380 P373 P403 P501
288. 4 E 489 20 E E MITI II 3020 MITI I 301C 8 8302B OECD Zahn Wellens OECD 3 4 KZ IzLl ga RR y 341 KER ISO DS14592
289. Nyholm Torang 1999 ASTM E 1279 89 95 OPPTS 835 3170 HM 3 4 2 a BAK b 1 100z g l 3 4 3
290. P410 ra P411 B FNU RZN CW SAAICLAME L P411 5 P240 PEKEN HRR CREST SERGE OS 5 THE HEBDSEEX P280 Bs C TEE HERCEGA GHS2 8 2 8 215 2 81ZL V BS VLMOGEBLEEBR 5HEAE P420 332 2 15 C H242 D H242 E We He H242 F H242 P210 P370 P378 P403 P501
291. mgl ene Co C t 3 k mgl1 b Ct A 1 e mg l aon A Ci t mgl k 1 c Ce A 1 e B 1 e mg l 526 Fit H eer C t mg l a 1 b 1 C A B mgl d Ct a 1 e c n 1 be ne gt n b mg l ee GS C t mg l a mg l b e d 1 8 n cd 7 8
292. 322 2 10 K wy 1 H250 P210 P302 P335 P334 BE P222 SERA EEE ROBM BEL BR ONDD A a P231 P232 P233 P280 AOKI AREKE MEST BE P370 P378
293. ROR WE A3 3 1 2 GHS 1 3 2 2 1 A T GN 5 4 A5 1 1 A3 3 1 3 GHS A8 3 1 4 6 TIPCS Z129 1 A3 8 1 5 A3 3 1 6
294. L 1 i 1 4 E J k gt tH OECD Environment Health and safety Publications Series on Testing and A
295. Lr 4 BCF kD OPER EE ERX k OECD 305 1996 n Kow E K K og BCF log Kow K 4 E ty Fil E Q TH 2
296. Pederson 5 1995 Langenberg 5 1996 US EPA 1993 A9 6 4 12 4 A TL ABL ORAS ST 3 EK elt E SAD 4 EE IL TO log K s E QSAR QSAR
297. x SfE F TES Ae in Ne ai AYE 2 OECD 1995 Nyholm Ingerslev 1997 2 3
298. 3 A4 3 11 6 SDS A4 2 2 8 SI Be Ua ane SDS PRC SDS A4 3 11 7 TRIED D SIT lt BIER OIRR
299. GHS A4 3 14 3 HXFFOSERIEZ FX A4 8 14 4 ATORE BESR A4 3 14 5 RHA EH IMDG code l k AMAA L LTDA TnA DEA bLASNTY ADR RID ADN 4 UN EF ARAM E IL
300. pH A10 2 8 2 A10 5 1 6 A10 5 1 8 e g h pH G G 527 k 1 m n o p 528 10 11 10 Draft Report of the OECD Workshop on Aquatic Toxicity Testing of Sparmgly Soluble Metals Inorganic Metal Compounds and Minerals Sept 5 8 1995 Ottawa OECD Metals Working Group Meeting Paris June 18 19 1996 European Chemicals Bureau Meeting on Testing Methods f
301. BCF 2 log Kow 2 1 A E RHFB 2 1 1 nm log Kow log Kow log Kew 2 1 2 2 1 3 n Kow EU Kow J log Kow K log Kow
302. P260 P308 P311 P405 P501 P264 P321 FR P270 RAOR BRERA ABE AY 728 MTEL at BA 359 ENE lt ge
303. e QSAR QSAR ff 1 2 8 2 A9 3 6 2 3 A9 2 6 2 3
304. yA 210 4 200 E H A9 3 2 6 A9 3 2 6 1 PRAZA E ARR 1 Part 1 PEER 3 K A9 3 2 6 2 3 US EPA OPPTS 850 1350 1 BREE NED amp J VTE ALR gt A9 3 2 7 3 202 Part 2 He SE TAE J4
305. 1 E RI BCF o E QSAR QSAR QSAR
306. 4 BCF He JERAT is ae 72 SE HH 1995 BCF BCE EB KOS BN OECD 305 BC ney EJE 9 RR
307. 2 1 P372 1 1 1 2 1 3 1 5 1 4 Hilo BIS OKR 1 48 P380 HEE A IIRS 2 8 BATA P373 2 15 BATA P370 2 8 B AORERE YRZ EK P380 2 15 AAT B P375 P378 295 A3 2 4 1 2 3 4 5 P401 2 1 REE
308. OECD 1993 r2 0 89 P3 FCS pH European Commission 1996 part III log Kew log Kw 0 9 log Kow 3 t European Commission 1996 3 PC EIE
309. OECD 1994 Biodegradation Probability Program ome 3 8 4 EU TGD EC 1996 Biodegradation Probability Program EC 1996 3 8 5 Biodegradation Probability Program f VW Mh 492 1 F 1 1 OECD
310. a 2 3 8 10 b 2 4 10 c 2 6 7 10 d 2 11 e 9 2 10 410 A6 2 2 6 amp 10 1 og weir MO f 9 1 100 50 Saan 1 100 5 E Ea 1 Me 5 ES RED mzz 0 10 4 11 E 5 12 7 30 502 25 a EREAR O RMD AR N IZNELA E APIID E 5 PD DEERE ZT TERA COME BEA REITIZXEBHET S A6 5 3
311. 2 12 1 2 ERA EERO BAP LES EADS GE P230 2 1 LRI ME pt DD BV VLA FD 2 Z HUE 1 1 1 2 1 3 1 5 WTH H HR BEDS VTA ACEY ABLOEAQOGER GOMER ED 280 1 2 3 4 5 P231 2 9 1 2 10 1 2 12 1 2 3 HB E EIRE EK POMS E FPO BM FB BFE P232
312. A3 1 2 1 a H hazard statement b 2 3 4 RRA EE c 200 210 220 280 lt A A3 1 2 2 A3 1 1 A3 1 2 A3 1 3 A 1 2
313. A9 5 3 5 ZRIENE TERI A9 5 3 5 1 J A CSTEE 1999 2 TT A oe TRECHS
314. OECD FF 1H me LAFF RR LOMA 57 Wan EOR a 445 H d
315. SDS SDS 3 A4 3 8 1 3 A4 3 8 2 HIZLI BRADE
316. AE BRP WHORE L ERORE w w 6 0 005 ml ee A 8 100 Z nik FAIRE HI MRR HER K OY NICE Si ee LGU eos ee 7 1 60 1 5 A 5 A8 4 4 ABE EMS L WR AE ELE A8 4 5 SF IIRIS BICOL SHEER A8 4 5 1 HINES BIC L SBI TOWABAPNE Rko TREAS JERRI RERA EEZ E O T REED d HPL ID DIC GHS A8 4 5 2 KITS BIC L BEHE A8 4 5 2 1
317. E 103 105 m1 2 o Ks So F E OECD 1995 ugi 3 2 COMODEBAORPTE 3 2 1
318. P321 P332 P313 P3334P3138 BF AV LMS E IEL T BAY P362 P364 348 3 2 ZL 3 ie He H316 P332 P313 P38884P318 ZF NILE b 5 E ITE L T DR 349 3 3 _ ee
319. 3 4 1 1A 1B H334 P261 P304 P340 P501 P260 BASE iH AT B GAILE LT BLY P284 1 OXRI Fh ORHI BIT B 64 PIZRD ZEBIMESAO 7 ONEF E CBF I LRRADOZT TEBY LU CWSBGINMEA LTS Au P342 P311
320. EYE GLP pe A HA HH ISO a GLP ASTM NM GLP Mensink 5 1995 Pedersen 1H Pedersen eR
321. NO Ve SDS SDS MNO a GHS er ae SDS SDS
322. OH pH pH 2 3 2 OECD 111 pH OPPTS 835 2110 OPPTS 835 2130 PH 2 OECD 111 pH
323. fi Vv rh E tx BLE Ht Kowz6 DH A9 6 4 10 2 A9 6 4 11 BCF fi log Kow 5 5 Bruijn 1989 KY IAAL Jd ARS VY fe log Kow E 1log K QSAR
324. DoE 1996 ECETOC 1996 US EPA 1996 OECD OECD 2000 OECD A9 5 3 2 2
325. SDS 8 ffi T S BHAKBLORBAAOBREBIRIT SOL A4 3 13 1 2 A4 3 13 1 8 A4 3 18 1 4 A4 3 18 1 5 Luas A4 3 14 14 A4 3 14 1 AARE 4 4 A4 3 14 2 TEHKE
326. A9 2 2 DACAR L UDAHA 4 1 4 1 2 4 4 1 1 A9 2 8 R A9 2 8 1 ee a A e E 1 2
327. OECD 306 1996 Kow A9 5 2 3 6 BCF Hf ED BCF E H ar o aps E ray nn BCF fE ASTM E 1022 94 BONO BCF SS A9 5 2 3 7 log K 6 BCF log Kow 467
328. a b c d 9 3 ec E gcm3 520 E ppm RL AMT SIE E g h i Q m2g BET Ns SDS A10 5 A10 5 1 ABBA LAE A10 5 1 1 a b c d e g h i Q k J MVS LOWE SICA AG YTV K A10 5 1 2
329. E L E Cso at E 1 E L E Cso ED L E Cso X BORTE LE Cs 100mg l Ne
330. 3 4 mE os mez 1 ERAN H334 1A BRAN ER H334 1B ER AA 1834 a HE ZNLT 2OBFINE BY WERSI Lo THRIN TW SGA HANS 260 A1 21 G 3 4 GHS ER SH 1 D ab BER EH i Beke 1A C e ico H317 ARZ pa a D Zev a a MAMITZEN DY MERITELE o TEARS CW BGAIC HA SH 3 A1 22 3 5
331. H amp M COM MECT SWRA EICRA LL TIA AER TTIE Fl j INE THAW 1 2 j E BSNS fil
332. n 501 Clk CLOGP PC version 3 32 EPA s d 0 58 n 7221 log Kov CLOGP CLOGP CLOGP P Se Li Na K pH LOGKOW 7 0 9 D log K LOGKOW a log Kow P 8S Europai log Kow CAS
333. 1mgyl 28 pH ECO pH 28 A10 5 1 9 6 pH H EJE CHE H HRL pH 10 15ml E 1 HNO EL ae 20 38 10 28 H 100mgl
334. A ATA log Koy HATIA HYT A9 6 3 4 oc 8 QSAR Veith 1989
335. Brown D S and Allison J D 1987 MINTEQA1 Equilibrium Metal Speciation Model A user s manual Athens Georgia USEPA Environmental Research Laboratory Office of Research and Development OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances Document ENV JM MONO 2001 6 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD 2001 Guidance Document on Transformation Dissolution of Metals and Metals Compounds in Aqueous Media Santore R C and Driscoll C T 1995 The CHESS Model for Calculating Chemical Equilibria in Soils and Solutions Chemical Equilibrium and Reaction Models The Soil Society of America American Society of Agronomy Santore R C and Di Toro D M et al 1999 A biotic ligand model of the acute toxicity of metals II Application to fish and daphnia exposure to copper Environ Tox Chem Submitted Skeaff J Delbeke K Van Assche F and Conard B 2000 A critical surface are concept for acute hazard classification of relatively insoluble metal containing powders in aquatic environments Environ Tox Chem 19 1681 1691 Tipping E 1994 WHAM A computer equilibrium model and computer code for waters sediments and soils incorporating discrete site electrostatic model of ion binding by humic substances Computers and Geoscience 20
336. a 5 A4 3 5 3 JHEGLAORWLGS E PL A4 3 5 3 1 382 A4 3 6 6 A4 8 6 1 AnN DFPMBE BDA FE NEAME A4 8 6 1 1 RASBEAOS LT a
337. 2 3 1 2 3 P412 A3 2 5 1 2 3 4 5 P501 2 1 BLOEI p 1 1 1 2 1 3 1 4 1 5 2 6 1 2 3 4 nee 2 8 ABCDEF 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 A B C D E F 8 1 1 2 3 4 3 1 1 2 3 4 3 1 1 2 3 299
338. 2 8 2 3 3 1 BROZORE 8 1 1 g 1 2 100mg l 107 g l
339. A10 5 4 4 4 E A10 6 A10 6 1 K Y 2RR 20 23C 1 5C pH E A 24 A10 6 2 MAR LI PHORECWET 3 A10 6 2 1 AZAR a Ct Co kt mg l t 0 mg mgl a
340. E A4 8 12 8 H BCF ORE E 3 HE H HE k UREE E avr JAH n gt 391 2 ETIL E FTN EET B BE A4 3 13 13 A4 3 13 1 ETE A4 8 18 1 1
341. FE H EH E BROT FI ral E a b c A9 1 10 OECD REDKI a REYR 4 E
342. 15 7 525 1mg A10 5 4 AREA A10 5 4 1 _ 7 A10 5 4 2 7 A10 2 3 2 A10 5 1 6 pH pH 0 2 E 7 100mg7l pH IED A10 5 4 8 gt 8 5mg 709 6 0mg
343. 2 8 B 2 15 H242 2 8 2 15 C D E F 270 GHS 1 2 3 4 H250 2 9 1 2 10 H251 2 11 1 H252 2 11 2 H260 2 12 1 H261 2 12 2 3 H270 2 4 1 H271 2 13 1 2 14 H272 2 13 2 3
344. A E A6 4 A6 4 1 XREN A6 4 1 1 Bill 6 2 A
345. A9 3 6 2 2 Pedersen 1995 US EPA AQUIRE A9 3 6 2 8 AG BK DHRC f GESAMP aA ZIR F2 DADER ioe E lt 4 Lees E E OECD
346. 3 2 1A 1B 1C 3 4 1 1A 1B REE RRA libeas EE MENE lt 3 3 8 8 3 8 P306 2 13 1 P360 at WIN 2 14 1 P308 REEERE MENE 1 2 na FIG ER Pa11 3 8 P308 3 5 1A 1B 2 i a T FEIRE E pag 3 6 1A 1B 2 3 7 1A 1B 2 FERE PEFLICMT SERIE 3 7 P332 3 2 2 8 P333 4P318 as S tAML TRAY P313 Be ie er E PE BIT OS P333 3 4 1 1A 1B p3
347. EE Zhao TR J amp Z B RUKA VN E fA RRT AH log Kow 6 A9 3 A9 4 DIIS RR sa H 4 Hi CLT SC AREA E He Se EFE AIS mg 1 MEDS i CLOT 1 Eg
348. mg NOEC ETE A9 7 5 2 2A DIARRE A9 7 5 2 1 A9 7 5 2 2 gt L E Cso i LE Cs 100mg l 10 A9 7 5 2 3 4 A9 7 5 2 4 A9 7 5 2 4 1 7 7 3 a E LE C
349. pH 5 6 Scow 1982 pH 5 8 pH 4 5 BU OPPTE 496 9 BCF K 1 BCF 1 1
350. A9 3 2 4 ezti H FA 4 H 3 A9 3 2 5 A9 3 2 5 1 H BB CIR E DOH BEKO OECD 1999 EPA 1996 ASTM 1999 ISO EU E 1 al E FE RA E E AR eee Vy ro GAR fC THOME FT PILZITAN DNS gt AIGRHUZSIT AR N CW SAR b EMH CE LI NOEC FLO OECD
351. P280 P303 P361 P353 RE ERI RERIK E EIIN B BIT BIRE OE Fit OXF LT CHA BU SIE LEBAT I NOXBE GOS P363 P304 P340 P310 P321 P305 P351 P338 ERICA 2 aa
352. SDS D9 y RATHER DRET r CA 3 2 SDS GHS SDS SDS GHS A4 2 2 ARHIFS amp A4 2 2 1 SDS SDS
353. NH A6 5 8 2 ID A6 5 8 3 SDS
354. A4 2 4 2 SDS 7 SDS A4 3 16 A4 2 6 ST 1 A4 3 SDS SDS GHS A4 3 1 1B A4 8 1 1 GHS 0 EL Ti
355. SN Fa x GHS GHS 1 H H E ee nye O PHJ 301 1 4 6 3 E RTR N
356. a A Ae EEL 2 491 MITI I 41 MITI 1 E O aS Hi MITI 1992 25 3 8 3 EU QSAR Q SAR US EPA EC 115 QSAR 9 QSAR US EPA EC
357. 2 R 20 2 A6 3 gt i 60 120 30 45 45 75 75 105 20 30 20 30 20 30 45 75 Oo a ala el wln 30 ji 30 45 120 180 413 A6 5 12 A6 5 12 1 KI Dif Ml E 2 FYE 1 i A6 5 12 2 1
358. A9 3 5 6 TZEE A9 3 5 6 1 A9 3 5 6 2
359. E AIT 5 CHS D s Dt Ae E E 495 ly P E ena een een 1 10mgC l
360. LCs mg 2 lt gt 83 ppm 4 83 ppm 3 0 5 mg l fas 85 ppm 6 aa 85 ppm 8 oe 8 85 ppm lt 430 A8 4 1 3 ES GHS 3 200 1000 mgykg LDso mg kg 790 2 ou 720 HE 24 3560 mg kg 2 8 830 HE BIPIE Li E lt R WEE 14
361. 1 amp H271 ia 2 amp H272 3 4 H272 A1 14 2 14 DEBTI p EAE GHS ao 1 Hari a a 2 H272 3 H272 257 A1 15 1 2 15 4 Na GHS a em Oo WEB EA 5 BATA RR H240 B OBEN H241 ee H242 C D J lt gt a A H242 Ap PEE Me G ETEL R no I SERA LENGE L 5B 2 SARIN BIT B EGY EG HA ALO FEA 181 BOG SAUD PF B BITOR PIZ
362. 6 CHT SO 2 2 4 MEFE tL log K 2 4 Cs HPLC HPLC log Kow 0 HPLC OECD 117 1989 EBD TEV lt Cis T 25C tt
363. A9 5 5 fWEXF A A9 5 5 1 A9 5 5 2 BCF BCF T log Kow BCE BCF BCF A9 5 5 3 Kow
364. H E Ya Oi FE E RIFVT PA E A H BS O E E iA
365. MI Ht SSH i WAF H 2 BA E Ef L E Cso 1mg l ly Ay TEN gt gt E P 1 TE SHAE H
366. 2 12 R 1 H260 2 H261 a P223 P302 P335 P334 P402 P404 P501 SERA ENF ROM BLEL BRENSB P231 P232 P370 P378 KEY RP RE CEHA R b gt BV Razza oka e HPD BAHT E LATE RITET 3 4 SLES BBE
367. KEY AZ EMK AC EGE 323 2 11 1 H251 2 H252 P235 P407 PAIB B FNIEK AN TV SBBANALGUE L P413 kg C P280 P420 324
368. NOEC NOEC H NOEC NOEC 4 NOEC ECx 1mg l H
369. P333 P313 P321 P362 P364 354 3 5 1 H340 lt gt 2 H341 lt gt lt gt ICIL MOKED 5 OILS BDA ETRU E DEIZ MEA AP CWSBHE AECE ERRI Do P201 P308 P313 P405 P501
370. pH EKRE II CO 3 A 20 23 1 5 11 100mg 5 A10 5 1 9 LIRA OTHE Ly 24 3 A10 5 1 10 HNOs1 2 pH 1 524 A10 5 2 3 4 A10 5 2 3 5 a b
371. ENE lt Be 3 8 3 H335 H336 P261 P304 P340 P403 P233 P501 BI UCAIEIA AIS ARRAS E ORARH P260 BASE iH AP B AILEE LT DR P312 P271 s EF this HEHE CH ERRI ENE S TRAEDS P405
372. L E Cs0 gt 100mg L _ KEDDRE L E Cs0 LE Cso A9 7 5 1 je Jo j H 1 Nosr PIM ee R 24 HERD BLAMED 2y FAL gt L E Cs0 ORULE G2 ORAH 7 NO YES YES L DCso lt 1 xo YES 1 sp apes ae poe ei 2 28 NO aos NOEC 2
373. log K w LT QSAR QSAR K s QSAR 472 Kow OF A9 5 5 4 Do A9 5 5 5 a b c A9 6 QSAR A9 6 1 H A9 6 1 1 FR BCF i ii i ii m HH F i ii DEH f
374. 1 5 3 3 s5 A4 2 4 2 4 3 SDS 1 SDS A4 2 4 8 SDS A4 2 4 4 A4 2 5 A4 2 5 1 SDS A4 8 A4 2 5 2
375. ARS 7 HE 1 pH Fl pH ER Bh 10 pH PN 10
376. DR 7 OM COD 5 50 ORCD 306 OECD 306 DOC BA 1 ThOD EUC 9 C 12 3 3 2 a b c 3 3 3
377. ED gt F A9 2 4 H 3 igas GR UN E a
378. a 1 L E Cs0 L Cso 1 E b 2 L Cso 2 ts LOA E L E Cso at c A9 7 5 3 3 3 28 A9 7 5 3 3 2 28
379. 366 4 1 1 H410 2 TEE TAR L H411 P273 P391 P501 LEED MELIIL 367 4 1 ZL 3 TEE Mla 72 L H412 4 VE Mala a L H413
380. A4 8 2 1 F DE E RILEOORE A4 3 2 1 1 A4 8 2 1 2 GHS 2 8 4 ae On EE eae E NN OT Ee ES RN Aa l E lt BORER falas 1 1 1 Oe ASKU A4 3 2 2 ZEZE A GHS FS EBSF A4 3 2 2 1 A4 3 2 2 2 A4 3 2 8 MRE LCABANRWCOMODERA Blt
381. A9 3 6 A9 4 3 A9 4 4 A95 oen a e EE ER 2 Ek ERR A9 5 1 F A9 5 2 A9 5 3 BCF K A9 5 4 A9 5 5 BN A9 6 1 A9 6 2 A9 6 3 QSAR A9 6 4 QSAR A9 7 A9 7 1 FR A9 7 2 A9 7 8 A9 7 4 EDERE A9 7 5 T IV V V ao BCF Kw
382. BLOG 3 N EZ 2 ABTA k ZS A9 7 ffi 1 IMO AIER Bo i A 4 2f 4 1 g 3
383. 21 ILO OECD GHS GHS GHS GHS GHS 2002 12
384. E GAT OECD 201 EA 3 4 A9 3 2 7 2 4 FX Do VET VARRILE AR Cm 0 AER LOE Lemna 221 US EPA 850 4400 kA E ECso PH 14 4 OECD E Lemna 448 ES a
385. QSAR log Kew HH E F H A9 6 4 8 2 QSAR gt Ua
386. scl eet 12 AIR E g 432 A8 4 5 2 3 114 444 mg kg NOEL mg kg fal 0 44 222 6 11 1 amp 444 9
387. 278 K A3 2 1 1 2 3 4 5 P101 P102 P103 K A8 2 2 1 2 3 4 5 P201 2 1 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P202 A B 2 2 F
388. N pe JN Se Whee 2X 5 N ee eure tee TOS i E eae P Hh JEEE e a J A PNAS BO AiO ica orn CAs nen bea nee 7 SDS SDS 405 A6 1
389. Zs F 3 Hes IRAT Hipnick 1989b 473 E n BCF2500 2OYAILEWIREMO REED b S BCF lt 500 2OMAICVLAQIEMIO THELEIL ZV BCF log Kow log Kow 24 COMAIVMLELMRMGO THIER db 5 log Koew lt 4 COPACI EERE PREKET Z T2 mm 78 EBRD DDZ BCF log K log Kow QSAR gt log Ko 4 COMAIANLEYEMO THEVED b 5 log Koy 4 COPATE EO REEI ZZ n QSAR
390. 0 8 oe a b A6 5 10 2 R SYED FOR FEARS VE CA A6 5 10 3 4 2 2 2 AAR 2 A6 5 11 A6 5 11 1 ue ry 1
391. A9 3 3 2 4 Lemna a b c L E Cso NOEC 1mg l A9 3 3 3 25 BA 4
392. vans 306 2 1 1 5 H205 P210 P370 P372 P380 P373 P401 P501 PSHE P230 ARIETE ZMD bo SV WLM TS 7 001 RUE CHE EE Fir BR NR D LIE ES EIA BL OR EMIOGE OLHE LEI P234 P240 EID OTR EAU Ci BEE P250 RIED FUN BIR TOSHA ROTHER E TLE EITA ET D ELR I P280
393. 3 E TH E RD L E Cs0 100 mg l ZB ZG Ae JB 7 A9 7 5 3 3 1 3 L E Cso MEA A9 7 5 3 3 2 7 tt 7 3 E
394. Kow 3 QSAR Ko A9 5 2 8 ERAZ BCP A9 5 2 3 1 BCF BCF A9 5 2 8 2 OECD OECD 305
395. 1 9 A9 7 OECD EU 5 11 A10 1 2 E 4 a E
396. A3 2 2 A3 2 2 1 a IP precautionary statement b Se 3 AHL OE 4 oe 5 Bes EDN Lao c A3 2 2 2 A3 2 2 3 A3 2 1 A3 2 2 A3 2 3 A3 2 4 A3 2 5 A3 2 3 A3 2 3 1 5 1 Hil 2
397. BCF BCF 2500 f Wy BCF 500 BCF log K 4 A92 4 3 E E A9 2 4 5 HERM ETEM TF 2 ORE TREE A9 2 5
398. E 1mg l E L E Cs0 E 4 ae 1 Pee ae H H E A9 3 5 8 AB TICHET SZ OMOZK AIDS N SILE K a 2 Sc Cee Lies b
399. P273 P501 LL EEZMELIIOE 368 4 2 1 wie H H420 P502 369 370 3 4 Bhi A3 4 1 A3 4 1 1 BRL 2 A8 4 1 2 GHS
400. P320 3 1 1 2 OMG ORG BL BIL P321 3 1 1 2 3 LOMA ORS BLE LE 8 1 BE 1 2 3 4 ERA DPIN E EMRET OGRE ERIA I A E O a AA 3 1 3 FEE OEE GUTLIUE BLE ELLE AE AY Ze it AF Et AA 3 2 1A 1B 1C ieee nee nhs e ee ae A A ee 3 ZANA GAT 2 3 4 1 1A 1B 3 8 1 Kak PRED LE BLL P330 3 1 1 2 3 4 3 2 1A 1B 1C P331 3 2 1A 1B 1C 3 10 1 2 288
401. Van Dem Berg 5 1995 CHEM CR AOTC ee lt CL KEDA lt k 9 V 1 a EC guidelines Comission Regulation EC No 440 2008 of 30 May 2008 laying down test meshods pursuant to Regulation EC No 1907 2006 of the European Parliament and of the Council on the Registration Evaluation Authorisation and Restriction of Chemicals REACH b ISO guidelines ISO http www iso ch c OECD guidelines for the testing of chemicals OECD Paris 1993 http www oecd org env testguidelines d OPPTS guidelines US EPA
402. gt EMRE 3 ILE Sinan EOS eV ONES IIT SBI oe eee EREDI AMENT ORM ERACO RERA EEO TRO HER EET 5
403. A6 2 b 2 8 2 8 8 E 9a d 10 2 8 c 9 2f e 11 1 a 1 11
404. 7 RARE ey Eee GHS 1 lt amp H251 moa a J XN m ES AERA A1 12 2 12 F RATE poe RE GHS a H260 Hai S ike tHE FF mps isi SS a ERMAN EIT BEEE EPR CZ ARI BE RL OGERRLA CLS BCE LY PRIH E BOLE CHS 256 A1 13 CHa M I 2 13 Z2 ong PEt
405. FA 1 2 100mg l COED CMV BARRIER EE CLALIT LC et w BE JES K BE OECD NGo 301 OECD 1992 E SHAD E OECD 7 ISO 11348 T E 2
406. QSAR E me E n log Kow E BCF QSAR QSAR 475
407. ii e 425 3 a 2 XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXX XX XXXX XXXX XXXXXX b 4
408. log Kov 8 2 Kow De Bruijn 5 1989 HPLC K Kov n FE 225 log K y
409. thal EFAS IRIE FRIZ Koc WX EE PRZ Kow Et BYDAOS 2BAF CE SEBEL A4 3 12 9 LOAF ERE ee TE LA EED E AFT 1 E Kow 22 FHI CXS R rl K
410. JO A9 4 2 2 3 ile 301D 10 fk ZUJE ae 10 MERER 28 4 4 1 2 11 3 BHR 3010 OECD
411. Lemna gibba Lemna minor E H EVE BER A9 3 8 KERBHEDES QSAR Rand 1996 A9 3 3 1 AHEHE A9 8 8 1 1 3 E ae 50 LOw 50 A9 3 3 1 2 M Z 5 1 1
412. aes 1 1 1 2 1 3 1 4 1 5 P402 2 12 1 2 3 P403 2 2 1 2 2 4 1 2 5 2 6 1 2 3 4 7 PMOI KLE CHEZE TED Bs S SEES DRAZO 5 ERD E 2 8 MEDRAN TOS A CKE ABCDEF HEIE File E E II A BEB BILD acl oe ct IZ HENGE E RZP PE S RE 2 15 BEESZOC RATS A B C D E F 3 1 1 2 3 ME hi BLE CH ERRE E ETHE REOR EE HENS lt BE 3 NR 3 8 3 3 8 2 P404 2 12 1 2 3 296 1
413. ee T BCFE5 ELT m L E Cs0 1mg l AF 2078 DA ES 1mg 1 BCE aoe is 00 orl TTT SR ERA HEM 4 i ee REIZE A9 2 3 7 F 38 E3 ro DIRE A9 2 4 wa A9 2 4 1
414. kE Wu 409 3 Be 2 2 E A6 4 2 3 2 11
415. 100C 10 30C 10 de Henau 1993 4 4 pH pH ee pH 6 8 5 pH
416. 2 14 H280 2 5 H281 2 5 H290 2 16 1 271 A3 1 2 GHS 1 2 3 4 H300 3 1 1 2 H301 3 1 3 H302 3 1 4 H303 3 1 5 H304 3 10 1
417. 2 9 1 NOX ILAKEXKMK pia REM OR OM CRED CED 2 P302 3 1 1 2 3 4 Peau ei Pt hee 2 2 sia eee 1 1A 1B RN NN 4 ane ae a P304 3 1 5 F Franti yo P312 292 A 1 2 3 4 5 P304 3 1 1 2 3 4 i
418. log Kow E TALE ONO BUS SEF OATH IF H THH log Kow 8 3 FF Kow gt 9 log Kw FAN E A9 6 4 9 2 E pKa
419. o A4 3 12 5 A4 3 12 9 EE Be SDS 1 RH Ag BSH CA jena aa EATS E A4 3 12 6 BEBE E PREKE A4 3 12 7 4A A4 8 12 8 tBPOBALE
420. 1 2 GHS 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e BFR RAB LRM ORBLE E TEIRRI DIS Z ETERNE EFNA IED FAMEWUKORAETIL LEA BEE RRT O GHS ERICH CHATS LBCES 420 3 2 2 A p GHS AS MD OO 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10
421. EAT OF F f xml 1 ADVIS BEDHMET 2 KP EE BODzCOD 4 A9 4 1 2 4 1
422. NaHCOs 65 7mg 1 KCl 5 75mg l CaCls 2HsO 294mg71 MgSO4 7HzO 123mg l pH pH A10 5 1 7 A10 5 1 4 2 0mg l A10 5 1 5 NaF 8mg l SrCls 6 H2O 20mg l HsBOs 80mg l KBr 100mg KCl 700mg CaCls 2 H20 1 47g l NasSO4 4 0g l MgCls 6 H20 10 78g l NaCl 23 5 1 Na2Si03 9 HzO 20mg l NaHCOs 200mg 1 34 0 5g kg pH 8 0 0 2 ASTM E 729 96 A
423. i A amp fe Eo cat oo RRT BOREHFL 2 E Ki ee H221 eae oe apan IIZ BMNIEH HEN nd re pa ve BUER ZAR TOARE H230 oad i ZL B EMRE FM l ANGE 7 IEN p A gt 8 BREN aog KIEL Zev Ae a ERMAN IT BEEE EPR CZ ee aL BE RL OGERRILA CLS HACE LY BREIL E BIROFE CHS Al 3 2 3 oe Gus G a i H222 1 H229 gt PANEB LATED WIP Yl H223 iy 2 H229 REKT Pree 3 a H2
424. 1 E A9 7 1 REL JAD L Lu BCF E m m Fe FOI BCF ld ADSM EX A9 7 1 LE Cso
425. 248 1 250 1 tae RA FIERRO MEV CIM 8 B1 CAbITHBAN OWS SHIRA FIERO KISHOA AKEE ENS A BILE EERO BOLRWL KP SN a COLL A1 1 2 1 ene cus EET S a HE CHL H200 FFI ce 1 1 H201 1 2 H202 e 1 3 H203 1 4 amp H204 BER 1 5 H205 MER RERE 1 6 i BRA EHER L ZL L AN a 9 SBE BE 1 1 12 BRO 1 8 OIII ERTIES b OWAI EEIN CONS GWEG SEES FID 3 R A BRIEF S ARRIA DIAO L 251 A1 2 2 2 GHS ae ie i ak
426. 3 GHS 277 4 5 PATER A EE eR a FS A E A8 2 3 2 2 E A3 2 3 8 2 P280
427. B P376 2 4 1 P377 2 2 1 2 P378 2 6 1 2 3 4 KBY AP EIRKECEGE 2 7 12 es eee 2 8 B C D E F 2 9 1 H 2 10 1 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 B C D E F 291 1 2 3 4 5 P380 2 1 2 1 1 1 1 2 1 3 1 4 1 5 2 8 AB 2 13 1 2 14 1 2 15 A B P381
428. On Si RE A Eins EOCBTOC 1008 9SAR 476 e h QSAR A9 6 4 9 nn KEG Kow A9 6 4 9 1 2000a LOGKOW log Kow K Hi log Kov Z Rri A9 6 4 9 3
429. Syracuse Research Corporation Biodegradability OECD 1993 i J SAR OECD 1994 Pedersen 5 1995 3 8 2 6 TZ JION WR A HET Lae 142 FEN un lie 162 188 E 97 804
430. n 128 sd 0 38 Broto 5 1984 110 n 1868 me 0 4 ProLogP 501 502 9 TV 1 Sa I 1 1 4HADKES Ss DMA OMY jAAIL Ae HUT DH 7K REZ FEO Mite BKOMRRMAORA AIC Keath p 1 2 pH Opperhuizen 1986 Clit KAHH 1 3 MAH McCarthy Jimenez Shrap Opperhuizen 1990
431. 28 TEK 10 4 E Z 28 10 RADH DD Ja C BASE IC BY UZE 2 ERK 459
432. 5 E Ay REDI Et OR NN Abbt Fm E BRAT PUL COMPOXRERETS EDS WHE A5 1 2 ae ULSD GHS E f 1 E PAnR RI ED GHS DORH EEIZ TVA ZA ORE D5 BREA ALL CHEO RE FILA RUC R CLE RE RES E AAU DS ET
433. ASTM E 1022 94 OECD 305 1996 OECD 305A E 1981 OECD 305 1996 ASTM E MY IAA Bee FI FR eee es Spacie 95 FD H AS 497 OECD 305 1996 ECETOC 1995 1 BCF 7 s k k2 7zz
434. a A4 3 11 2 SDS a b c d e f g h i j y RN J4 By PAIS Sze MaE lt WRG SDS BK SAU TVA KEELE WT SNE CHS A4 3 11 8 A4 3 11 1 388
435. fae P312 945 3 1 BL 5 H333 P304 P312 346 3 2 J Rl 1A 1C H314 P260 P301 P330 P331 P405 P501 H INDIRA ZN ISIE OP TAK ORF BEET EPH LMAVGE P264
436. 1 4 10 5 2 c 1 4 10 5 2 e BAR 424 7 GHS a GHS 200 1 b c d GHS GHS
437. 3 1 3 H331 H301 3 1 3 3 1 H311 3 1 H331 H302 3 1 4 3 1 H312 H302 3 1 4 8 1 3 H332 H312 3 1 4 3 1 H332 H302 KAAT V RECALL EVRAT D LAS 3 1 4 3 1 H312 3 1 H332 H303 3 1 5 3 1 H313 H303 8 1 5 8 1 H333 H313 3 1 5 3 1 H333 H303 KAANE V RICHER LE
438. A4 3 15 1 RAR MCRALZE RILOR BIT DN A4 8 16 16 SDS SDS SDS 1 15 a SDS SDS SDS b SDS c SDS
439. A5 2 2 9 ADI E lt RE 100 1 399 CPSC
440. E EW EIGA 8 a 3 fi Vv BCF Wofford 1981 A gt log Kov BCF log BCF log Kow f BJJ Spacie Hamelink 1982 Gobas 5 1989 Petersen Kristensen 1998 E Connel 1990 EDS dD 504
441. a b c d JE 493 24 az 2 5
442. m ae Jj Je J H PHEA AV E Z A9 1 3 a E A HE agii EN wE a E He EP HE aie chronic aquatic toxicity 4 FE A9 1 4 ZOR EN F LCS
443. 8 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 279 1 2 3 4 5 P210 2 1 1 1 1 2 1 3 1 4 1 5 2 2 1 2 2 3 1 2 3 2 6 1 2 3 4 2 7 1 2 2 8 2 A B C D E F 2 9 1 2 10 1 2 18 1 2 3 2 14 1 2 3 2 15 A B C D E F P211 2 3 1 2 P220 2 4 1 2 18 1 2 3 2 14 1 2 3 P222 2 9 1 ERA ETE RO BM PLES FRONS 2 10 1 BS P223
444. 1 8 1 pE ee Ue E T 100 7 4 1 2 ZS HE 1 3 7 1 7 6 EH 3 TWH 7 6 DEP 4 24 100 2 ES 431 A8 4 8 MUOSTS BBA GE ARE NN 3 GHS 1 a
445. 2 eg lt E fea 1982 d Im 1 0 95 kz BCF 6 28 Kow k248 D ees log ke 1 1 o 2 69 0 53log Kow Gobas 1989 log ke 1 47 0 41 log Kow o HE nR E HH OECD OECD 305 1996 ASTM
446. 3 6 2 8 10 5 5 NN 6 10 A6 5 8 KA AG6 5 8 1 SDS NN
447. 4 1 1 2 3 LEEZGMELIINE 4 1 1 2 3 4 P280 2 1 Pe 1 1 1 2 1 3 1 4 1 5 2 6 1 2 3 4 2 7 1 2 H 2 8 A B C D E F 2 9 1 H 2 10 1 H 2 11 1 2 2 12 1 2 3 284
448. BCF I 1 2 4 BCF 1 2 5 log Ko 6 34 BCF BON BCF Crish Cwater
449. E 3 EL a gt 7 1mg 28 A10 2 3 2 pH pH 5 5 8 5 pH
450. SPARC a Niemel LEBHNER DO ONE log Koy M E HEER T 6 A EERIE EIT log Kow OR a PRS GLEE COBBROBRILAYO log Row 2T ZOPRAPPABIEHZ PHT B E EEE n 501 r 0 967 TemaNord 1995 581 b log Kow MEME ARMS LU CPR THY hL 18058 MEI Ch LEE ZA Syracuse Research Corporation 1999 LOGKOW i log Kow 4 8 DHANI amp SAET CHE CHS ERM SAT A9 5 3 BOF Kow I B L THIRRI BAEP FX A9 5 3 1 BCF log Kow A9 5 3 2 BERMEA A9 5 3 2 1
451. yy oe 1 H318 ERRORE P280 P305 P351 P338 es P310 350 ERIC S D BERS 72 3B GPE ARE 3 3 2A 7 P264 P280 P305 P351 P338
452. 1 A9 3 2 7 1 3 BRED 2 FR ESTES HP CHE LC BERD 1 3 hte Lt a eae He ya I 4 48 96 US EPA OPPTS 850 1035 21 E 1 211 E SEAN AA E MERE OECD 210 FOl
453. 1000 3 2 2 SHAA B 3 2 3 4 ie fit 3 2 4 DA RN ly BJE E a Ie
454. 3 2 1A 1B 1C 3 3 1 3 3 BE 2A 2B P306 2 13 1 2 14 1 P308 F lt RERI BORMARSSBA 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 ALR BEE ILICH T A EARLEN 3 7 3 8 1 2 P310 8 1 1 2 3 HE EA E E 3 1 12 Lee AIEEE RA 8 1 1 2 TE 3 2 1A 1B 1C 3 3 1 3 10 3 1 2 P311 3 1 3 Fa n n aly a PTB TA Se ma NISA 3 8 P312 le 3 1 4 a oo ee 3 1 5 0 ele ss i DEE EK GI 8 SRT 3 1 4 ee 3 1 5 3 8 3 3 8 3 287
455. A3 3 8 8 A3 8 3 4 GHS ze HE GHS P101 P102 P103 GHS A3 8 4 A8 3 4 1
456. GHS Dead MIR ERE IZ LEMIEC TC CURIE CASH ZEIT TUPACH A4 3 3 1 2 L fMAOBHAA EW A4 3 3 1 3 fEFYAO CAS BFE ZOMODKESF CAS REO A4 3 3 1 4 ZHAKBDHAN TRY BBR FYAODIUNCBT 3 FMD e PREIE RI A4 3 3 2 HAH A4 3 3 2 1 GHS SORE A4 8 8 1 8
457. 1 j a 1 b 3 i ii iii iv v c d A6 5 12 3 A6 5 13 Aer ME AS 5 10 Bl IF 1 Ie GHS Fa ay GHS 100
458. E COLD RM diy AS F E 5 1 HE E log Kow E yal ARIA ERT Dae
459. PINE A ee a RU Coe Oe 3 LFER LFER log E BCF E TORD ARD an dg H log Kow LFER FE UV
460. Q g Sa gt z4 4 10 E Cet EARM EE 10 MITTI I OECD HEAR OECD 301C FEL AN ii 10 E ro 1 JORE OECD 14
461. c log Kow NOEC A9 3 5 9 A9 3 5 9 1 A9 3 5 9 2 TERY vh N pH log Kov HOKE oe F
462. http www epa gov opptsfrs home guidelin htm e ASTM ASTM http www astm org standards 5 2 OECD Test Guideline 201 1984 Alga Growth Inhibition Test OECD Test Guideline 202 1984 Daphnia sp Acute Immobilisation Test and Reproduction Test OECD Test Guideline 203 1992 Fish Acute Toxicity Test OECD Test Guideline 204 1984 Fish Prolonged Toxicity Test 14 Day Study OECD Test Guideline 210 1992 Fish Early Life Stage Toxicity Test OECD Test Guideline 211 1998 Daphnia magna Reproduction Test OECD Test Guideline 212 1998 Fish Short term Toxicity Test on Embryo and Sac Fry Stages OECD Test Guideline 215 2000 Fish Juvenile Growth Test OECD Test Guideline 221 Lemna sp Growth inhibition test EC C 1 Acute Toxicity for Fish 1992 KC C 2 Acute Toxicity for Daphnia 1992 EC C 3 Algal Inhibition Test 1992 EC C 14 Fish Juvenile Growth Test 2001 EC C 15 Fish Short term Toxicity Test on Embryo and Sac Fry Stages 2001 EC C 20 Daphnia Magna Reproduction Test 2001 OPPTS Testing Guidelines for Environmental Effects 850 Series Public Drafts 850 1000 Special consideration for conducting aquatic laboratory studies 850 1000 Special consideration for conducting aquatic laboratory studies 850 10
463. BCF F ufa Fifi EDY KA E 2 H BOA eA SVT KE EO BCF BCF BCF A A9 5 2 3 9 3 4 RA A Zx H E H DRZ 4 1 fF E BCF
464. GHS VOT Tez ay 1 EF 1 EFA KAA HVS RE o AAE ARS i 1 E NE SDS EE
465. P210 P370 P378 P240 AED PAEKAN BUR Ci BHA P241 BRAD ERR 3 CARED EET 5 THD b EHA WOLRIS BARR MALE MHI BEDE ILM OBRENES EEDE BE HED db BAC ETS ABU CL Y PEHE DEE WA RC DERE ELAM L TERY P280 KDY AZ EMKELEGE 7 318 2 8 F BAT A H240 SOS P210 P370 P372 P380 P373 P403 P501
466. 208 D2 V AR OMORI AMERA OB ERRI EBDSE BD LUNG BIRIT CaCk 2H20 RU MgSO 7H2O DRIE SO63841 OREO GFDL EET FIAT AAR RAGYMLE Z Mk ARRA INT AIUFL BIZ OZC 2 7 DA AM AASV Vv FWA CES 522 A10 1 NaHCOs 6 5 mg l 12 6mg l 64 75mg l 194 25mg l KCl 0 58mg l 2 32mg 1 5 75mg 5 74mg CaCls 2HzO 29 4mg l 117 6mg l 294mg 29 4mg l MgSO4 7HzO 12 3mg 49 2mg1 123 25mg l 123 25mg l CORE 0 50 0 10 0 038 0 038 pH 6 09 7 07 7 98 8 5 Yt 1 pH 4 FACT Facility for the Analysis of Chemical Thermodynamics http www erct polymtl ca tactfact htm A THALE bO CHS te 2 ZO haU pH Hf 6 0 8 0 22 COR MERGER AT COW SDS AKIT pH5 5 HF ES BHODALLV pH8 5 OMMRIL BB F CLERAN ATH SP TV 220 A10 5 1 8 _ EORR ENE 2 HEAL pH A10 5 1 9
467. A3 4 1 8 2 A8 4 2 A3 4 2 1 GHS a X GHS b 01 02 03 A3 4 1 A8 4 1 GHS01 GHS02 K GHS03 GHS04 D GHS05 GHS06 GHS07 D GHS08 GHS09 971 372 3 5 A3 5 1 1992 6 24 92 58 EEC 3738 374 4 SDS 376 A4 1 FRX 4 SDS 4 1 1
468. A9 6 4 5 KAN US EPA 2000a ECOSAR US EPA 2000b SAR A9 6 4 6 SN EPA SAR A9 6 4 7 1 AY F
469. BOD 70 DOC 3 ThOD EE EUC 5 5 3 2 5 gt 709 3 8 KAHENE 3 3 1 gt 60 ORCD 302A C ASTM E 1625 94 1 60 CO2 38 5 ya A
470. E A9 5 2 3 8 A9 5 2 3 8 1 N E BCF BCF ZS N BCF eo a gt i gt Lo l tR i o gt A9 5 2 8 8 2 E og 4
471. I 3 EF bund 212 242 EES SEBO O MNAO AFO CHRIS SB REDEE A TGR E AR ERM DIEE Jo LFBRDG BAUE AMO RM EFF ONE UIRA HZ EH ETB SE CHS 8 WE ATGBEAE WAIL ARE LMM E IL 383 f A CIAD MHEICY AMR GORA Dike ACRE OHA b BS A4 3 6 3 3 A4 3 7 7 A4 8 7 1 ZELRRORODPLBE A4 8 7 1 1 a b c
472. PUD HOTTA TS A SEED A10 5 1 2 pH8 DIF AA PADRE 521 FAN CH1 5 C A ps HCL IR 1 2 HPO EZR 1 27 17 2 87 Al0 5 1 3 1SO6341 2 O 2um pH8
473. 2 6 A Pe apis Gus ti a va n fam VUF gt RSI i oo MARE EUR ijod X H225 3 H226 4 PEKT L H227 a ERMA BIT 3 EIDE EFNA TIE ARI BE BL OGEFRILA CAS ACBL BREIL E DROE CHS A1 7 2 7 1 ee aes ER GHS 1 A ff H228 2 ff H228 254 A1 8 2 8 A aus ne en PEF EP i BATA H240 9 B 9 H241 am
474. 3 8 2 H371 lt lt gt gt lt gt lt gt 5 LDPAPULI COREE ZT SMA E AIS S lt lt gt gt Clk MOKED OIF lt BEDA ETEO E DAEB AEA SHWSBGE HECE ERRET O P260 P308 P311 P405 P501 EX REER EORR DDA P264 P270 360
475. 5 LWNISEBEONRELERT B lt lt gt gt Clk MOKED OIS BEDRA FTU EBREW SEB ASBR CW SAE ELIE SE MTS P201 P308 P313 P405 P501 P202 P280 357 3 7 BL GAWD TEE
476. LAS Roberts 1989 2 3 3 LOGKOW KOWWIN Syracuse Research Corporation 1 C HNO 1og Kow Hg log Kow TemaNord 1995 581 2 2 3 4 AUTOLOGP Devillers 1995 800 FAH C HNO FF AUTOLOGP 1 AUTOLOGP 4 2 A Commission 1996 2 3 5 SPARC SPARC EPA E SPARC Id QSAR log Kow
477. QSAR A 450 A E QSAR A9 3 4 MDBA A9 3 4 1
478. RID ADR 442 H 2 cra 2 2 3
479. SE Cm i 2 RAL PRANK HAMM L H401 8 RAL BRANRW ERMEBLL H402 a 9 DFNI EHI OFRRRBLEE ANS 263 TERED EIT 3 EERE EP ABA CL BA IIZEI LC SROABESASA CONF S Mh DIRE FHES D BAER OKTI o MORA FIEBLOGNAL ETABA ra A1 28 b Cf E 4 1 ins a Peed ze RPE gt H411 BAR BRAN peed IEE LO ok 0 a Zl Ene BAR BRAN wEREZ FIRE E VK RiEs L yas aL M a MRM BAT BETERE e EPO COIL BR IBLOLIILC GRDA EFAA CH N F EMODGIRA GHB b BAAI OBRRIL EL ADGIRA BIEBLOGN AL E FARM Z FR 9 DFNIL EHEZ OKTOBA E ANS A1 29 4 2
480. US E E ESN fe EARTE g BITS IMEI 24 ELW OMS FOE E E OECD 202 3 28 H IIE lt T D OECD Do A E
481. 1 BCF 4 3 C BEDOK HED 5 Opperhuizen Schrap 1987 Simi 1993 Black 1991 BCF BCF H E 2 2 1 4OHADKES
482. 321 2 9 1 H250 P210 P302 P334 BE P222 SERA EEE ROBM BBL BR ONDD A a P231 P232 P233 P280 OXEL HRNEC EHTO Z E P370 P378 KEY AP EMKEU EBS
483. A8 4 8 ZRH SF A8 4 9 Rae E 433 3 lt BE BA 21 41 amp 4 80ppm 6 15 0 12 TR 0 48 mg l 21 41 amp 4 80ppm 6
484. C H N 0O P ERIS log Kow gt 92 1og Kow LOGKOW 4 lt log K C H N 0 Si P Se Li Na K KOWWIN lt g gt Hg 1og Kow pil AUTOLOGP log Kow gt 5 C H N 0O P 8 Kow AUTOLOGP SPARC log Kw gt 5 D SPARC SN ND bea KOWWIN pO a CLOGP KOWWIN CLOGP AUTOLOGP log Kow
485. Hy Hipnick E A9 6 3 2 Seats n os E A9 6 3 3 HE eT tee aoe 1 El ARANCIO FRF 4 A
486. c G ii A i G Gii iv cg ie A4 3 8 8 A4 8 8 1 FHV X 2 A4 8 8 1
487. ee orl WHJ E 34 dg E 1 2 A9 1 5 oT MRE
488. ee OLTE J SAR E E 1995 QSAR log Kow F Tp 1 H A9 6 4 8 ECETOC
489. eine ogs a i i BER EN ae OY RERU HEBEL i420 Zev BS 264 2 FUER 266 3 268 3 1 ffi A8 1 1 FRX A3 1 1 1 A3 1 1 2 GHS A3 1 1 3 A3 1 2
490. 28 6 8 5 pH A10 2 3 3 Imm A10 3 E A10 4 1
491. A9 3 5 5 1 1mgyl E 1mg l 1H 1 E WSF 7 FA t4
492. E GHS OR GHS Ui ia GHS FP JIN Sd gt os SI gt Fee A
493. E ISO 11 RTE DR BAY rai V eRe BEC MEER I OECD 301C 100mg l 301D BE bki ISO 9509 Ret AZ L CRM 348 HI EV E A9 4 3 5 5 0
494. P312 P321 RAOUL ECHMIET BLE P362 P364 341 3 1 BL 5 H313 P312 342
495. QSAR HYDROWIN 1 67 Syracuse Research Corporation QSAR RU 1 5 Niemel 2000 A9 4 2 4 14 2 QSAR BIOWIN 3 67 Syracuse Research Corporation 0 5 OECD 1994 Pedersen 1995 Langenberg 1996
496. 1 a 1 E A9 4 3 5 2 a b c d e A9 4 3 5 3 A9 4 3 5 4 Cs SE
497. AEB ae CRE 50 1ppm 1mg l A9 3 3 2 BMEEIE A9 3 3 2 1 FEDOR RHEI A9 8 3 2 2 1 1 10ppm 1 10mg l 2 10 100ppm 10 100mg 1 3 100ppm 100mg 1
498. Fe AN f BRE AR E E UCSC ERG 2004 1 CNS OR ANSI TA A8 3 2 A38 3 2 1 A3 3 2 2 A3 3 2 3 ERI EDERA EN ERS a f
499. OECD 2001 Skeaff 2000 VI 5 LE Cs 485 A9 7 1 YES
500. Toxic Substances USEPA 1985 2 3 log Kow REDE DD QSAR DH 49 6 QSAR OE BB D E 2 3 1 Kow QSAR 2 3 2 CLOGP Daylight Chemical Information Systems 1995 Hansch Leo Hansch Leo 1979 E S log Kow log Kow Niemela 1993 C log Kow 7 ELTRO HT H N O Be ZRG o gt r2 0 967 7000 version 1 2
501. FBT ERD LNMBAWGE P261 3 1 3 4 P260 BIC HH AN BAILEN 3 4 1 1A 1B 3 4 1 1A 1B HENE R 3 3 8 HENI R 3 3 8 P262 3 1 1 2 P263 4 3 7 P264 3 1 1 2 3 4 3 1 1 2 3 2 1A 1B 1C 3 2 2 3 3 2A 2B 3 7 3 8 1 2 1
502. SO6341 A10 5 1 3 A10 5 1 4 A10 5 1 5 0 2um A10 5 1 7 0 3 20C 28 z TE X p 0 2pH pH IT L lt tha E 5 LOQ Y
503. TE a O 441 A9 1 11 A9 1 12 JA n a ARS
504. Tolls J 1998 Bioconcentration of surfactants Ph D Thesis Utrecht University Utrecht The Netherlands Toshima S Moriya T Yoshimura K 1992 Effects of polyoxyethylene 20 sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate Ci2 LAS to fish Ecotoxicol Environ Safety 24 26 36 USEPA 1985 U S Environmental Protection Agency Office of Toxic Substances Toxic Substances Control Act Test Guidelines 50 FR 39252 US EPA EC 1993 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships US EPA 1996 Ecological effects test guidelines OPPTS 850 1000 Special considerations for conducting aquatic laboratory studies Public Draft EPA712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm 513 Van Den Berg M Van De Meet D Peijnenburg W J G M Sijm D T H M Struijs J Tas J W 1995 Transport accumulation and transformation processes In Risk Assessment of Chemicals An Introduction van Leeuwen C J Hermens J L M eds Dordrecht NL Kluwer Academic Publishers 37 102 Wakabayashi M Kikuchi M Sato A Yoshida T 1987 Bioconcentration of alcohol ethoxylates in carp Cyprinus carpio Ecotoxicol Environ Safety 13 148 163 Wofford H W C D Wilsey G S Neff C S Giam amp J M Neff 1981 Bioaccumulation and metabolism of phthalate esters by oysters brown shrimp and sheepshead min
505. oe A8 4 6 FDMNE OBIERA tr A8 4 7 ERRUA PYRE Ames in vitro inviio in vitro Ames 03 15 mg 5 F IVC CHO 0 1 0 8 mg ml 6 S9 0 08 04 mg ml S9 CHO 7 SCE CHO 7
506. 1 2 3 4 5 P301 3 1 1 2 3 4 3 2 1A 1B 1C 3 10 1 2 P302 2 9 1 2 10 1 2 12 1 2 3 1 F 1 2 3 4 3 2 2 EREHE 3 4 1 1A 1B P303 2 6 1 2 3 3 2 1A 1B 1C P304 3 1 1 2 3 4 5 3 2 1A 1B 1C 3 4 1 1A 1B REE ANd eee HEE 2 SERIE 3 8 3 Kee REM ee PE HENI BR EER 3 8 2 3 1 2 3 4 5 P305
507. 1996 A9 5 2 8 8 BCF Kow A9 5 2 3 4 1 GLP II 1 A9 5 2 8 5 BCF 3
508. 3 4 5 P362 3 1 4 BAME 3 2 2 P364 EREE 3 4 1 1A 1B P370 2 4 1 ZE P376 P370 2 6 1 2 3 4 KRY RD EIGKE PEGE 2 7 1 2 BOERE E APE BE DS P378 2 8 C D E F 2 9 1 H 2 10 1 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 C D E F P301 3 2 1A 1B 1C P330 P331 P302 2 10 1 pe E P335 RC 2 12 1 2 TAREV KIC EET OBE P334 i HOXEIIEH LZ P303 2 6 1 2 3 Bag
509. 4 2 1 2 2 146 2 2 8 C 45 24 CO 208 3 2 5 2 6 PaCO 7 2 7 glem3 0 887 0 890 2 8 1 5 04 2 9 IRIE mg kg C 2 10 mg kg C 0 99 w w 2 11 Jog Pow 2 12 CC 81 7 90 6 v v 1 2 8 4 CC 2 18 2 14 2 15 A8 4 A8 4 1 RMEREHE A8 4 1 1 0 GHS 4 300 2000 mg kg LDs mg kg 1480 2 1500 H mg kg LD EGHE 0 89 gcm ml kg 8 740 HE A8 4 1 2 BA 0 5mg l z D
510. 5 e S H81 H333 a EBR RMXICBIT 3 EGA E FNABHAWN S 6 TAIZ OV CL HERA FBO 6 amp 2 AM A1 18 3 2 as ae aug seme 1 FS 72 BZ IE DIG H314 PEJE BE Pe ERI 2 4 EKAN ge se H315 REKET ER Afr mg oF it kat S 3a H316 a KEEP ENE EITI OJo 259 A1 19 3 3 ans 1 E I H318 272A FRE ew eek Py H319 2B IE a K wail AE H320 Zev A1 20
511. 6 073 1023 515 516 10 518 A10 1 FRX A10 1 1 10 ORC f iy SSIMs OECD
512. 885 8110 ISO 9408 9439 10707 E 4 a BAR EM ORAR BIR CES OPPTS 1 2 50cm gt Nae
513. P284 3 1 7 1 2 P ples Ea E eine SEI BE Se eb pm S KER JMi T R 3 4 1 1A 1B WL Cl SHAICIEAL CRY 285 1 2 3 4 5 P231 2 9 1 y oa AIIE REEERE E TEE RIT P232 9 2 12 1 2 3 WEDS ORA WERE OME EPOCI T O a e a AIC BEREE E OTE ESY K A8 2 3
514. 1 8SDS SDS SDS 3 A4 3 8 1 2 SDS
515. 290 1 2 3 4 5 P371 2 18 1 2 14 F 1 P372 2 1 1 1 1 2 1 3 1 5 1 4 ERX BUT BLERK 1 48 HEE A IARR 2 8 A 2 15 BATA P373 2 1 1 1 1 2 1 3 1 5 1 4 EMIZIB 7 2 HEHE A IFRS 2 8 A 2 15 BATA P375 2 1 1 4 R I BUT SIBEBBRD 1 49S SEED 2 8 B 2 13 1 2 14 1 2 15
516. 3 4 5 P405 3 1 1 2 3 3 1 BE 1 2 3 3 1 1 2 3 3 2 1A 1B 1C ME 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 8 1 2 3 PE HEE E 3 3 10 1 2 P406 2 16 1 o oO Ze gt fia Aes BIN ALE PECA EE P407 2 11 1 2 P410 2 8 1 2 3 ee FEF FUL APA O AREA P200 2 LEB is aa eee DCW SMEAD RSI LPM anne ple AH CW BABAIZILAUBR LT EL BME PROTEZ EP EENE BUT BOD EER ERWGAIZ IRB H 2 11 1 2 2 15 A B C D E F 297
517. 3 _ BCF Kor BCF A9 5 8 8 BHH ODOR MABLOERWA 4 log Kov QSAR E log Kow A9 5 3 4 2BfEDKS IY
518. 4 E 1985 E t j ECETOC 1995 ATOPA Sijm Linde 1995 Be 2 cee eR BANC READ ICBIAT E Z ERN gt 4 3nm open WEL TOD 3
519. 4 H227 P210 P370 P378 P403 P501 P280 es KEY AP EUR AL EGE AAD SHET OREO S STHUBHS AKER 1 BLOM OGAAERRLK CHE La 317 2 7 1 H228 agr H228
520. 5 RIED O RP EKK NT CB EGE 2 6 1 2 3 RUDEC O V TOREO S PJ PEED DS EE TIAE 2 7 1 2 AIAD R EAPN R TCO DHE T 2 8 AAT A B C D E F AA ERTAUC BUR CY EET OREO S SATHEVEB DS E amp 2 15 A B C D E F BPE STH BOR CY RIES ORED S THALEBDS e amp P241 2 6 1 2 3 TRIED TEFEVE Cab ET OREO S TREMER bB L HOXE BSBA BREE LA Hiab SV VIM ORRE RET B EDIE LE HDR b BRACE XFS EJAT E V REICHES D BEIR c OFFER BAISBIBL TE RU 2 7 1 2 AYUCAEBEET B THB bBGE HOXE ESBS BREE FA Hiab 5 l VIM ORGEE PRET B E DIE LE HDR b BRACE XFS EA CLO RERED D BEIR TOWER ALB L TE RV P242 Eo 2 6 D PEIEE CHREIEIRVE ELE T THELESS HEGERBLORDL FKL RLF RIER IZ LEV BE CUIRE IHICRBO LE FE BED FKLRLE B 0 1m RM OREP AYN APS P243 2 6 1 2 3 DRE CHIET 8 REE EO CS THE HEBDS E amp LAK CEO FER LIUED BB GEN AE COPE EG FILA L TERY P244
521. 6 3 6 QSAR H 1 QSAR A9 6 3 7 QSAR H A9 6 4 KERHA FIERAN QSAR DEH A9 6 4 1 a b c d e LT Ait N pi A9 6 4 2 QSAR
522. E EE OECD 1E MITI 301F OECD 10mg l FARRER HECHT OR ORCD 209 6 gt E EVE H
523. E3 E 3 2 28 E 1 i ji 3 4 NOEC 484 A9 7 5 4 HTE E KIA A9 7 5 4 1 _
524. ELS RS A10 2 2 1 RRM E A10 2 2 2 E E AK 100mgl 24 24 FOF A10 2 3 NGO BBL NEE STILLS A10 2 3 1 ZIAR EDR TROUT It 1 10 100mg l 100mg l gt alee JH a 3
525. HEM ee CA RR HH E FS 70 70 FE BODs COD 0 5 E PICIS EAM CW LeU RGET A9 5 A9 5 1 Ok iH DS G Gi QSARN Biodegradation Probability
526. Program VC 0 5 Gi iv RTO HES DAWES A9 5 1 2 Ree DVO BE RCONT H A9 7 E 1
527. RRX BIT 3 LEAVE ORT AEATRE LIE FAAS S 5 IMDG Code 13 KiE EN AGP A PEWS 6 ADR I Kil SNK ES TOBRO MEK BIT AIMEZ J 392 A4 3 14 6 HARODE ODHT A4 8 14 7 MARPOL73 78 IT9 kU IBC Codern IMO MARPOL73 78 II TIBC Code 1 18 A4 3 1 1 IBC Code17 IMO MEPC 2 Circular A4 3 15 15 SDS T 13
528. TEMES LTE atO TA L H230 B TEMES LTE Gf EL H231 jo aE P202 ERD TORIL EFHUZF RELA ACES BEEBE EOARL CWS HEHE BIT E ERR OLTI JIKER DOCH EN OREEBHD Lo 310 2 3 1 H222 H229 2 H223 H229 P210 P410 P412 50 C P211 PRA E ToL OAD LEVY E P251 Ek
529. as possible This fifth revised edition of the GHS contains various new or revised provisions including inter alia a new test method for oxidizing solids miscellaneous provisions intended to further clarify the criteria for some hazard classes skin corrosion irritation severe eye damage irritation and aerosols and to complement the information to be included in the Safety Data Sheet revised and simplified classification and labeling summary tables a new codification system for hazard pictograms and revised and further rationalized precautionary statements
530. hydrophobicity and steric factors Chem 17 8 1631 1644 Bintein S Devillers J and Karcher W 1993 Nonlinear dependence of fish bioconcentration on 7 octanol water partition coefficient SAR and QSAR in Environmental Research Vol 1 pp 29 39 Black M C Millsap D S McCarthy J F 1991 Effects of acute temperature change on respiration and toxicant uptake by rainbow trout Salmo gairdneri Richardson Physiol Zool 64 145 168 Bodor N Huang M J 1992 J Pharm Sci 81 272 281 Broto P Moreau G Vandycke C 1984 Eur J Med Chem 19 71 78 Chiou T 1985 Partition coefficients of organic compounds in lipid water systems and correlations with fish bioconcentration factors Environ Sci Technol 19 57 62 CLOGP 1995 Daylight Chemical Information Systems Inf Sys Inc Irvine Ca CSTEE 1999 DG XXIV Scientific Committee for Toxicity and Ecotoxicity and the Environment Opinion on revised proposal for a list of Priority substances in the context of the water framework directive COMMs Procedure prepared by the Frauenhofer Institute Germany Final report opinion adopted at the 11 CSTEE plenary meeting on 28 of September 1999 Comotto R M Kimerle R A Swisher R D 1979 Bioconcentration and metabolism of linear alkylbenzenesulfonate by Daphnids and Fathead minnows L L Marking R A Kimerle Eds Aquatic Toxicology ASTM 1979 vol ASTM STP 667 Connell D W Hawker D W 1988 Use of polynomial expressions to
531. 09 1984 Activated sludge respiration inhibition test OECD guidelines for testing of chemicals OECD Test Guideline 301 1992 Ready biodegradability OECD guidelines for testing of chemicals OECD Test Guideline 302A 1981 Inherent biodegradability Modified SCAS OECD guidelines for testing of chemicals OECD Test Guideline 302B 1992 Zahn Wellens EMPA test OECD guidelines for testing of chemicals OECD Test Guideline 302C 1981 Inherent Biodegradability Modified MITI test II OECD guidelines for testing of chemicals OECD Test Guideline 303A 1981 Simulation test aerobic sewage treatment Coupled units test OECD guidelines for testing of chemicals 1999 OECD Test Guideline 304A 1981 Inherent biodegradability in soil OECD guidelines for testing of chemicals OECD Test Guideline 306 1992 Biodegradability in seawater OECD guidelines for testing of chemicals OECD 1998 Aerobic and anaerobic transformation in aquatic sediment systems 1999 12 OECD 1999 Aerobic and anaerobic transformation in soil 1999 10 OECD 2000 Simulation test Aerobic Transformation in Surface Water 2000 5 OPPTS 835 2110 Hydrolysis as a function of pH OPPTS 835 2130 Hydrolysis as a
532. 1 Niemela J 2000 Personal communication to OECD Environment Directorate 20 March 2000 Nyholm N U T Berg amp F Ingerslev 1996 Activated sludge biodegradability simulation test Danish EPA Environmental Report No 337 Nyholm N amp F Ingerslev 1997 Kinetic biodegradation tests with low test substance concentrations Shake flask test with surface water and short term rate measurement in activated sludge In Hales S G ed Biodegradation Kinetics Generation and use of data for regulatory decision making From the SETAC Europe Workshop Port Sunlight September 1996 pp 101 115 SETAC Europe Brussels Nyholm N amp L Torang 1999 Report of 1998 1999 Ring test Shalke flask batch test with surface water or surface water sediment suspensions ISO CD 14592 1 Water Quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations ISO TC 147 SC5 WG4 Biodegradability OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monographs No 68 Paris 1998 OECD 1994 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships OECD Environment Monograph No 88 Paris OECD 1995 Detailed Review Paper on Biodegradability Testing OECD Environmental Monograph No 98 Paris OECD 1997 Guidance document on direct phototransformation of chemical in water OECD GD 97 21 Paris OECD 1998 Harmonized integrated hazard classi
533. 10 5 1 6 pH pH 7 6 8 5 pH 28 AE 5 5 8 5 ECO pH A10 2 3 2 A10 5 1 7 pH8 1 COs pH 0 2pH 10 7 pH7 6 pH8 8 5 pH CO pH A10 1 2 FFI AWE TZA EEET ER h aL OPERBAEBL OSEE BIS STF ON RM FZ EHMANSE LIL FX ORGBLELAWIEDF SEGANL FET LRELEAROKHBYKE ILE OECD202
534. 10 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1010 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1020 Gammarid acute toxicity test 850 1020 Gammarid acute toxicity test 850 1035 Mysid acute toxicity test 850 1035 Mysid acute toxicity test 2000 E9 FUE OE OCHO BLU GT BIL ORM amp SV VLEO MBOHBNIE CC EHKI LEFT ELEBDA 5 2 KF RRO BID ASHE ANEDB 2014 4 A2 ARLE AKA LTH AU 505 850 1045 Penaeid acute toxicity test 850 1045 Penaeid acute toxicity test 850 1075 Fish acute toxicity test freshwater and marine 850 1075 Fish acute toxicity test freshwater and marine 850 1300 Daphnid chronic toxicity test 850 1300 Daphnid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1400 Fish early life stage toxicity test 850 1400 Fish early life stage toxicity test 850 1500 Fish life cycle toxicity 850 1500 Fish life cycle toxicity 850 1730 Fish BCF 850 1730 Fish BCF 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4450 Aquatic plants field study Tier III 850 4450 Aquatic plants field study Tier III 850 5400 Algal toxicity Tiers I and II 850 5400 Algal toxicity Tiers I and II 3 ASTM E 1196 92 ASTM E 12
535. 12 1 GHS ZET 3 ERKI OO LADO E 2 Ch B EUR NEB ILO DEBRA EVE UB IEL YF 3 ERED 0 I FPR OL RKFOFRRHIF AI Lo CHB ENE 403 A6 2 5 SDS
536. 13 Fee 2 5 3 P315 P337 3 3 2A 2B RRA TEED P313 P342 3 4 1 1A 1B p311 te P361 3 1 1 2 3 Ps64 A 293 1 2
537. 18 0 12 0 24 0 48 mg l A8 5 1 Patty F Ed 1994 Industrial Hygiene and Toxicology 4th Ed pxxxx xx New York Wiley Interscience 2 Smyth H F Carpenter C P Weil C S and Pozzani U S 1954 Range finding toxicity data Arch Ind Hyg Occup Med 3 Fasey Headrick Silk and Sundquist 1987 Acute 9 day and 13 week vapour inhalation studies on Globalene Hazexyl Systemol Fundamental and Applied Toxicology 4 Wyeth Gregor Pratt and Obadia 1989 Evaluation of the developmental toxicity of Globalene Hazexyl Systemol in Fischer 344 rats and New Zealand White rabbits Fundamental and Applied Toxicology 5 Ete 434 9 436 9 RN EC NR A92 NE A9 2 1 A9 2 2 A9 2 3 A9 2 4 A9 2 5 A9 2 6 V e E SE S E EE EEA AEN EEA A A9 3 1 JF A9 3 2 A9 3 8 A9 3 4 A9 3 5
538. 284 OXRI 16 Fit ORAC RIT B 641 PIRRO ZEREM OI OCHACO J MAOZ SHRM L CU SGA LTH Ab P320 KA OM BAN ORG BELELGE 343 3 1 3 H331 P261 P304 P340 P403 P233 P501 P260 BAZ RER AP B BILENE LT Fl BEER CH ELISE EED TREE
539. 29 a PREKA BIT 3 RUG EFL CL RL BR RPILOGRUL EE CULA ORS EF BEILRIO_OlLIR 8 EE HITEROF FE CHS 252 A1 4 2 4 z a p Ae GHS ao KERER a FER sept mee A1 5 2 5 FEB BER yeas g ERE L GHS RE a H280 We oF at of H280 H281 ube oF H280 VO OD a RE BIT 3 EERIE A AA RIL BER BL ORRULE CRS ATEEN PAROI E OIROLE CHS OIRRTILAIE SUL TRA KET AI ANLER APR 47 7Z 472 lal BBO E 253 A1 6
540. 327 1995 SRC AUTOLOGP Rekker amp n 800 r2 0 96 sd 0 387 Devillers 1995 Manhold 1992 66 SPARC log K EPA Rekker amp De Kort n 1054 r2 0 99 1979 n 20 r2 0 917 sd 0 53 me 0 40 Niemi 1992 MCI n 2039 r2 0 77 n 2039 r2 0 49 Klopman 1994 98 n 1663 r2 0 928 sd 0 3817 Suzuki amp Kudo 424 n 1686 me 0 35 1990 n 221 me 0 49 Ghose 1988 110 n 830 r2 0 93 sd 0 47 ATOMLOGP n 125 r2 0 87 sd 0 52 Bodor amp Huang n 302 r2 0 96 sd 0 31 me 0 24 1992
541. 4 3 3 2 4 5 4 BODs COD 20 5 3 50 0 1 day 3 28 10 A AZ E 7 E E DEN HEH A9 4 3 4 REPRE 3 E 4 AY fiery E
542. 411 P235 C ARRABA GHS2 829 PALIB A SUCRAEN TOSHIB NEL 2 15 28 IZE V bBVWVEMOGEBLEL ER DUSHA P240 R EAEN RRE T SEESE RTEZ T TREED P420 DISHA P280 320 2 8 x C H242 D H242 PL BATE H242 F H242 P210 P370 P378 P403 P501
543. 5 2 2 7 NOAEL Bibl 1 ADI AEI 1 1 A5 2 2 8 3
544. 5 2 e EFL BRU GNC MEESTE o CILIS ERBAC GHS PNVEERIS AEBS A421 4 2 200 7 2 1 4 10 5 2 1 4 10 5 2 a BAR 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e ba GHS ERRAI BIT 3 EEE EP AKA ED B GIARRE HBL ORPISHMARP ERICH CHRIS EBCES 422 5 1 2 1 4 10 5 2 a 1 4 10 5 2 1 4 10 5 2 c 1 4 10 5 2 e PEE GHS RGR EIT Z HADES EFAA EOS IKERKE ORT IIMAD DUT MA CHRIS I EB CHE 423 6 2 2 A 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2
545. 79 89 95 Standard test method for biodegradation by a shake flask die away method ASTM E 1625 94 Standard test method for determining biodegradability of organic chemicals in semi continuous activated sludge SCAS EC C 4 A to F Determination of ready degradability Directive 67 548 EEC Annex V 1992 EC C 5 Degradation biochemical oxygen demand Directive 67 548 EEC Annex V 1992 EC C 7 Degradation abiotic degradation hydrolysis as a function of pH Directive 67 548 EEC Annex V 1992 EC C 9 Biodegradation Zahn Wellens test Directive 67 548 EEC Annex V 1988 EC C 10 Biodegradation Activated sludge simulation tests Directive 67 548 EEC Annex V 1998 EC C 11 Biodegradation Activated sludge respiration inhibition test Directive 67 548 EEC Annex V 1988 EC C 12 Biodegradation Modified SCAS test Directive 67 548 EEC Annex V 1998 ISO 9408 1991 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by determining the oxygen demand in a closed respirometer ISO 9439 1990 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of released carbon dioxide ISO 9509 1996 Water quality Method for assessing the inhibition of nutrification of activated sludge micro organisms by chemicals and wastewaters ISO 9887 1992 Water quality Evaluation of the aerobi
546. 8 YORE A9 7 1 2 E M NOs M E CN 2
547. A Swisher R D Schroeder Comotto R M 1975 Surfactant structure and aquatic toxicity Symposium on Structure Activity correlations in Studies on Toxicity and Bioconcentration with Aquatic Organisms Burlington Ontario Canada pp 22 35 Klopman G Li J Y Wang S Dimayuga M 1994 Computer automated log P calculations based on an extended group contribution approach J Chem Inf Comput Sci 34 752 781 Knezovich J P Lawton M P Inoue L S 1989 Bioaccumulation and tissue distribution of a quaternary ammonium surfactant in three aquatic species Bull Environ Contam Toxicol 42 87 93 Knezovich J P Inoue L S 1993 The influence of sediment and colloidal material on the bioavailability of a quaternary ammonium surfactant Ecotoxicol Environ Safety 26 253 264 Kristensen P 1991 Bioconcentration in fish Comparison of BCFs derived from OECD and ASTM testing methods influence of particulate matter to the bioavailability of chemicals Danish Water Quality Institute Mackay D 1982 Correlation of bioconcentration factors Environ Sci Technol 16 274 278 McCarthy J F Jimenez B D 1985 Reduction in bioavailability to bluegills of polycyclic aromatic hydrocarbons bound to dissolved humic material Environ Toxicol Chem 4 511 521 McKim J M Goeden H M 1982 A direct measure of the uptake efficiency of a xenobiotic chemical across the gill of brook trout Sa velinus fontinalis under normoxic and hypoxic condit
548. AWL TS COREE ZT EIERE ANTS HA DREE D OILS BRAG CHWS E BREN CHE APU CW BEE BERE ERRET B H361 3 7 Bt 2 UDOWILT NTO ERII IMB ZE FB MOLERO OIF BSH ETRO E DENEA EN CWSEE HECE RRT B H362 3 7 H370 LODAITITR COLBEEZ IS 1 BIRETE MORD O OIF S BAA 3 8 ETRU EDAEN AEA SN TUBE HECE ERRATZ H371 LPAAMILTIR CON REEERE KEN lt 2 HER LNT SMa EATS MORD O OIF 8 8 SBRBAE CRW EBREHNC A ANT EGE HECE LETS H372 HEM MAE KEIT R 1 DAWITTR CORBLEZIT SMBH 8 9 FAITE MORD DIES BRAECE OT EDEBE AN TOSA FEE IEE 2 LRT B H373 2 6 LODRLI SCOPBEZ 3 9 VT SWAS EATS MOED DISS BA PETRO EBREMIZH SN TOB A AECE ERRET S H300 3 1 1 2 3 1 H310 H300
549. Ae Rr STP A9 4 2 4 10 TT
550. BLEH F NARI EET ELE TNA O GE 3 3 BAEEHOS E RRISNI CLLEREE COMEILIFA EPR CHAI EFAMNOMS 2 532 2 A1 16 G 2 16 a assal K2 ogs 1 Gr H290 258 A1 17 3 1 a F GHS aag a 7 EF A H300 1 H310 H330 H300 2 ER LSV ECET LEMAR H310 RA H330 H301 am 3 ECRITS AT H311 H331 H302 4 ER D 2 gee H312 H332 a gt larn H303
551. D BL P311 f P405 P271 P321 FR BRA OE ILE PLEA 844 3 1 4 H332 e P261 P304 P340 P260 BAVC RBR AP BRACIERE LT BLY P271
552. E F P402 2 12 1 2 3 P404 ee P403 3 1 1 2 3 oe ene Be 3 CRS RERE MEESE SOL eC ME 3 8 3 3 8 P403 2 6 1 2 3 AKER ALES 1 F L OEE PEDS t I D OBS S IRIE ES AT REVED P235 D Sith 298 1 2 3 4 5 P410 2 5 P410 4 TERME IZB FS ELEN e ETRO P403 Atta FP 200 T TOB ERROR LY VR Z RA NTO SBA ILHURLU TB RU ELR EV PRERASTE BHAT FEIDE E T DIE OD ETARA P410 507C
553. EB L H362 P201 P308 P313 P260 EH PICA SH BIEZ VP RK AOMF UB KET SBP LAUROBA P263 P264 P270 358 ENE lt ge 3 8 1 H370 lt lt gt gt lt gt lt gt 5 LPAPULI COREE ZT SMA EAS S lt lt gt gt Z MOREO DIES BEDRA CAV 2 EBRIEHKC AEA SHWSBGE HECE ERRET O
554. ES OREO S 5 PEHE SEX AAI L V FER ALER DAAL OER E E LEE LTB fl P280 EEDI LEAMA FALE BIT BIFGEO LE FIIL CEA OG TEE LEGAL NOX E GOS P370 P378 IKRY XP EWKE CEB FIKEI 18 E OFERAEDS D VIET OREZ OS B TREED D O hD ON ON HL NAD 316 2 6 ZL
555. Effects of Chemical Substances OECD Paris Document ENV JM MONO 2001 6 OECD 1999 Guidelines for Testing of Chemicals Organisation for Economic Co operation and Development Paris OECD 2000 Revised Draft Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris OECD 2006 Current approaches in the statistical analysis of ecotoxicity data A guidance to application OECD Environmental Health and Safety Publications Series Testing and Assessment N 54 Pedersen F H Tyle J R Niemeldi B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide TemaNord 1995 581 US EPA 1996 Ecological Effects Test Guidelines OPPTS 850 1000 Special Considerations for Conducting Aquatic Laboratory Studies Public Draft EPA 712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm OECD Monograph 11 Detailed Review Paper on Aquatic Toxicity Testing for Industrial Chemicals and Pesticides Rand Gary M Fundamentals of Aquatic toxicology Effects Environmental Fate and Risk Assessment 2 Boesten J J T I amp AM A van der Linden 1991 Modeling the influence of sorption and transformation on pesticide leaching and persistence J Environ Qual 20 425 435 Boethling R S PH Howard J A Beauman amp M E Larosche 1995 Fac
556. H305 3 10 2 H310 3 1 1 2 H311 8 1 3 H312 3 1 4 H313 3 1 5 H314 3 2 1A 1B 1C H315 3 2 2 H316 3 2 3 H317 3 4 1 1A 1B H318 BR7RORG 1 3 3 H319 2A 3 3 H320 2B 3 3 H330 8 1 1 2 H331 8 1 3 H332 8 1 4 H333 8 1 5 H334
557. HEOL Fi l A 3 2 2 1A 1B 1C e LEBA NOXBER P360 2 13 1 2 14 1 P361 2 6 1 2 3 fate ae HE REZ 3 1 1 2 3 3 2 1A 1B 1C P362 3 1 4 3 2 2 3 4 1 1A 1B P363 3 2 1A 1B 1C P364 3 1 1 2 3 4 3 2 2 3 4 1 1A 1B P370 2 1 1 1 1 2 1 3 1 4 1 5 2 4 FE 1 2 6 1 2 3 4 2 7 1 2 2 8 A B C D E F 2 9 1 2 10 1 2 12 1 2 3 2 18 1 2 3 2 14 1 2 3 2 15 A B C D E F
558. IFRA 1982 ASTM 1993 pH OECD log Kow 2 OECD 4 Ott n ARAN OECD log Kow 8 2 K OECD Guideline n
559. Ley E A Be E FJ EDE IE ID I rar ILS SM CVV ERED BK E LS BSAC Zev GED kk ZI TT FEZ HED
560. OLE Hd HEDO E HH E4 np E 1 E L Cso 2 E3 E3 Na E 4 28 ggs NOEC A IZ E E 1 L
561. OMAT SLRS 3 1 5 3 1 H313 8 1 3 H333 H315 3 2 2 2B AR H320 3 3 274 A3 1 3 GHS 1 2 4 H400 4 1 1 H401 4 1 2 H402 4 1 3 H410 1 4 1 H411 2 4 1 H412 3 4 1 H413
562. ON NN 378 Ae SDS SDS SDS SDS wa vB EDERA EM SDS EZR LT AG 1 5 3 2 1 E 1 3 A4 2 4 SDS A4 2 4 1 SDS
563. SP CO SB A HEALS BEB E ae 8 I p KB ONREEMTS 4 oe 2 i IED OILS BEA E TCA H361 d OT E BAERE SANT OSHA BECIS BEB ea wen wean 2 DL pen ARA H362 d A1 25 3 8 GHS fags PH lt gt OME LIMITEZE gt SBE COMES E HET 3 Mh ORE 1 A2 DIES BAAS CHV 2 H370 HERNE EN CV SBA HE IRS BERELE amp i gt b LARUE ERSA PE eS ZIT AEA COMA 2 RRT 2 p tki MORH DIE BBAEZEC H371 E d L DRENTE EP TUS HERITS BEB ie eee H335 3 0 wee H336 262 A1 26 WEERA E Id lt Be C 3 9
564. UE BIC L BUZI gt RHEE O OI BHEN E REIS LURHIE BO RICHER E Fe LR EAS Fill CHR SDE DDNCOVWY COPPRMEBET S SDS A4 3 11 10 HOSEL GHBHEOMEZ E A4 3 11 11 HEH A4 3 11 12 REOUL FHT 2BLUGS
565. X T e 3 JE Wh 2 L E Cs0 NOEC L B Cs 3 A 2 PRLE IEOR B pH Siz Benen
566. a BELT BEES TY eS KA RE EP BLO KER eee ee 0 i 4 3 HAE 20 25C W 35C 0
567. c biodegradability of organic compounds in an aqueous medium Semicontinuous activated sludge method SCAS ISO 9888 1991 Water quality Evaluation of the aerobic biodegradability of organic compounds in an aqueous medium Static test Zahn Wellens method 2 LLFOY X btF 2000 E9 AHEAD DB DCHY BLO EII ORM BSVVLCORRFOMGMI Ss CC ECM HUZ EBT ELERBDA J 506 ISO 10707 1994 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of biochemical oxygen demand closed bottle test ISO 11348 1997 Water quality Determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri Luminescent bacteria test ISO 11733 1994 Water quality Evaluation of the elimination and biodegradability of organic compounds in an aqueous medium Activated sludge simulation test ISO 11734 1995 Water quality Evaluation of the ultimate anaerobic biodegradability of organic compounds in digested sludge Method by measurement of the biogas production ISO DIS 14592 1999 Water quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations in water Part 1 Shake flask batch test with surface water or surface water sediment suspensions 22 11 1999 OECD Test Guideline 111 1981 Hydrolysis as a function of pH OECD guidelines for testing of chemicals OECD Test Guideline 2
568. describe the bioconcentration of hydrophobic chemicals by fish Ecotoxicol Environ Saf 16 242 257 Connell D W 1990 Bioaccumulation of xenobiotic compounds Florida CRC Press Inc pp 1 213 De Bruijn J Busser F Seinen W amp Hermens J 1989 Determination of octanol water partition coefficients with the slow stirring method Environ Toxicol Chem 8 499 512 Devillers J Bintein S Domine D 1996 Comparison of BCF models based on log P Chemosphere 33 6 1047 1065 DoE 1996 Guidance on the aquatic toxicity testing of difficult substance Unites Kingdom Department of the Environment London Doucette W J Andren A W 1987 Correlation of octanol water partition coefficients and total molecular surface area for highly hydrophobic aromatic compounds Environ Sci Technol 21 pages 821 824 Doucette W J Andren A W 1988 Estimation of octanol water partition coefficients evaluation of six methods for highly hydrophobic aromatic compounds Chemosphere 17 pages 345 359 Driscoll S K McElroy A E 1996 Bioaccumulation and metabolism of benzo a pyrene in three species of polychaete worms Environ Toxicol Chem 15 8 1401 1410 ECETOC 1995 The role of bioaccumulation in environmental risk assessment The aquatic environment and related food webs Brussels Belgium ECEOOC 1996 Aquatic toxicity testing of sparingly soluble volatile and unstable substances ECETOC Monograph No 26 ECETOC Brussels E
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570. ent n Octanol Water Pow Slow stirring method for highly hydrophobic chemicals Draft proposal for an OECD Guidelines for Testing of Chemicals 3 2000 E9 AHEIO BS OCHY LUD FILL ORAM bSIVLEOREOMMISEC TC EB HCE TST Z BEADRA J 508 9 VI 1 APHA 1992 Standard Methods for the Examination of Water and Wastewater 18th edition American Public Health Association Washington DC ASTM 1999 Annual Book of ASTM standards Vol 11 04 American Society for Testing and Materials Philadelphia PA DoE 1996 Guidance on the Aquatic Toxicity Testing of Difficult Substances United Kingdom Department of the Environment London ECETOC 1996 Aquatic Toxicity Testing of Sparingly Soluble Volatile and Unstable Substances ECETOC Monograph No 26 ECETOC Brussels Lewis M A 1995 Algae and vascular plant tests In Rand G M ed 1995 Fundamentals of Aquatic Toxicology Second Edition Taylor amp Francis Washington DC pp 135 169 Mensink B J W G M Montforts L Wijkhuizen Maslankiewicz H Tibosch and J B H J Linders 1995 Manual for Summarising and Evaluating the Environmental Aspects of Pesticides Report No 679101022 RIVM Bilthoven The Netherlands OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Environmental
571. fication system for human health and environmental effects of chemical substances Paris Document ENV JM MONO 2001 6 Pedersen F H Tyle J R Niemela B Guttmann L Lander amp A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide for substances to be evaluated for classification as dangerous for the environment Nordic Council of Ministers 2nd edition TemaNord 1995 581 166 pp Schwarzenbach R P P M Gschwend amp D M Imboden 1993 Environmental organic chemistry 1st ed John Wiley amp Sons Inc New York Scow K M 1982 Rate of biodegradation In Lyman WJ W F Reehl amp D H Rosenblatt 1982 Handbook of Chemical Property Estimation Methods Environmental Behaviour of Organic Compounds American Chemical Society Washington DC ISBN 0 8412 1761 0 Chapter 9 Struijs J amp R van den Berg 1995 Standardized biodegradability tests Extrapolation to aerobic environments Wat Res 29 1 255 262 Syracuse Research Corporation Biodegradation Probability Program BIOWIN Syracuse N Y http esc syrres com esc1 biodeg htm Westermann P B K Ahring amp R A Mah 1989 Temperature compensation in Methanosarcina barkeri by modulation of hydrogen and acetate affinity Applied and Environmental Microbiology 55 5 1262 1266 510 3 DE Anliker R Moser P Poppinger D 1988 Bioaccumulation of dyestuffs and organic pigments in fish Relationships to
572. formation Service US Dept of Commerce Springfield VA Schrap S M Opperhuizen A 1990 Relationship between bioavailability and hydrophobicity reduction of the uptake of organic chemicals by fish due to the sorption of particles Environ Toxicol Chem 9 715 724 Shiu WY Doucette W Gobas FAPC Andren A Mackay D 1988 Physical chemical properties of chlorinated dibenzo p dioxins Environ Sci Technol 22 pages 651 658 Sijm D T H M van der Linde A 1995 Size dependent bioconcentration kinetics of hydrophobic organic chemicals in fish based on diffusive mass transfer and allometric relationships Environ Sci Technol 29 2769 2777 Sym D T H M Part P Opperhuizen A 1993 The influence of temperature on the uptake rate constants of hydrophobic compounds determined by the isolated perfused gill of rainbow trout Oncorhynchus mykiss Aquat Toxicol 25 1 14 Spacie A Hamelink J L 1982 Alternative models for describing the bioconcentration of organics in fish Environ Toxicol Chem 1 309 320 Suzuki T Kudo Y J 1990 J Computer Aided Molecular Design 4 155 198 Syracuse Research Corporation 1999 Tas J W Seinen W Opperhuizen A 1991 Lethal body burden of triphenyltin chloride in fish Preliminary results Comp Biochem Physiol 100C 1 2 59 60 Tolls J amp Sijm D T H M 1993 Bioconcentration of surfactants RITOX the Netherlands 9 Nov 1993 Procter and Gamble Report ed M Stalmans
573. function of pH and temperature OPPTS 835 2210 Direct photolysis rate in water by sunlight OPPTS 835 3110 Ready biodegradability OPPTS 835 3170 Shake flask die away test OPPTS 835 3180 Sediment water microcosm biodegradability test OPPTS 835 3200 Zahn Wellens EMPA test OPPTS 835 3210 Modified SCAS test OPPTS 835 3300 Soil biodegradation OPPTS 835 3400 Anaerobic biodegradability of organic chemicals OPPTS 835 5270 Indirect photolysis screening test Sunlight photolysis in waters containing dissolved humic substances 507 4 ASTM 1993 ASTM Standards on Aquatic Toxicology and Hazard Evaluation Sponsored by ASTM Committee E 47 on Biological Effects and Environmental Fate American Society for Testing and Materials 1916 Race Street Philadelphia PA 19103 ASTM PCN 03 547093 16 ISBN 0 8032 1778 7 ASTM E 1022 94 1997 Standard Guide for Conducting Bioconcentration Tests with Fishes and Saltwater Bivalve Molluscs American Society for Testing and Materials EC 1992 EC A 8 Partition coefficient Annex V Directive 67 548 EEC Methods for determination of physico chemical properties toxicity and ecotoxicity EC 1998 EC C 13 Bioconcentration Flow through Fish Test EPA OTS 1982 Guidelines and support documents for environmental effects testing Chemical fate test guidelines and support documents United States Environme
574. i Pa a 3 2 1A 1B 1C ce Ot 0 7 hee oI ADS P353 294 1 2 3 4 5 P305 3 2 1A 1B 1C 3 3 1 P351 3 3 2A 2B P338 P370 2 1 1 4 Hl BIS BLOKS 1 48 BIEX IXIL T P380 2 15 B P375 P371 2 13 1 E ILE 2 14 i P380 P375 P370
575. inth Volume ASTM STP 921 American Society for Testing and Materials Philadelphia PA 304 315 Opperhuizen A Schrap S M 1987 Relationship between aqueous oxygen concentration and uptake and elimination rates during bioconcentration of hydrophobic chemicals in fish Environ Toxicol Chemosphere 6 335 342 Opperhuizen A Sijm D T H M 1990 Bioaccumulation and biotransformation of polychlorinated dibenzo p dioxins and dibenzofurans in fish Environ Toxicol Chem 9 175 186 Pedersen F Tyle H Niemel J R Guttmann B Lander L and Wedebrand A 1995 Environmental Hazard Classification data collection and interpretation guide 2nd edition TemaNord 1995 581 Petersen G I Kristensen P 1998 Bioaccumulation of lipophilic substances in fish early life stages Environ Toxicol Chem 17 7 1385 1395 Rekker R F de Kort H M 1979 The hydrophobic fragmental constant An extension to a 1000 data point set Eur J Med Chem Chim Ther 14 479 488 Roberts D W 1989 Aquatic toxicity of linear alkyl benzene sulphonates LAS a QSAR analysis Communicaciones Presentadas a las Jornadas del Comite Espanol de la Detergencia 20 1989 35 43 Also in J E Turner M W England T W Schultz and N J Kwaak eds QSAR 88 Proc Third International Workshop on Qualitative Structure Activity Relationships in Environmental Toxicology 22 26 May 1988 Knoxville Tennessee pp 91 98 Available from the National Technical In
576. ions Comp Biochem Physiol 72C 65 74 Meylan W M and Howard P H 1995 Atom Fragment Contribution Methods for Estimating Octanol Water Partition Coefficients J Pharm Sci 84 83 Niemela J R 1993 QTOXIN program ver 2 0 Danish Environmental Protection Agency Niemi G J Basak S C Veith G D Grunwald G Environ Toxicol Chem 11 893 900 Niimi A J 1991 Solubility of organic chemicals in octanol triolin and cod liver oil and relationships between solubility and partition coefficients Wat Res 25 1515 1521 OECD 1993 Application of structure activity relationships to the estimation of properties important in exposure assessment OECD Environment Directorate Environment Monograph No 67 OECD 1998 Harmonized integrated hazard classification system for human health and environmental effects of chemical substances As endorsed by the 28 joint meeting of the chemicals committee and the working party on chemicals in November 1998 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris Opperhuizen A Van der Velde E W Gobas F A P C Liem A K D Van der Steen J M D Hutzinger O 1985 Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals Chemosphere 14 1871 1896 512 Opperhuizen A 1986 Bioconcentration of hydrophobic chemicals in fish In Poston T M Purdy R eds Aquatic Toxicology and Environmental Fate N
577. k 1986 Charles Ernest Overton Narcosis studies and a contribution to general pharmacology Trends Pharmacol Sci 7 161 164 R L Lipnick 1989a Hans Horst Meyer and the lipoid theory of narcosis Trends Pharmacol Sci 10 7 July 265 269 Erratum 11 1 Jan 1990 p 44 R L Lipnick 1989b Narcosis electrophile and proelectrophile toxicity mechanisms Application of SAR and QSAR Environ Toxicol Chem 8 1 12 R L Lipnick 1990 Narcosis Fundamental and Baseline Toxicity Mechanism for Nonelectrolyte Organic Chemicals In W Karcher and J Devillers eds Practical Applications of Quantitative Structure Activity Relationships QSAR in Environmental Chemistry and Toxicology Kluwer Academic Publishers Dordrecht The Netherlands pp 129 144 R L Lipnick ed 1991a Charles Ernest Overton Studies of Narcosis and a Contribution to General Pharmacology Chapman and Hall London and Wood Library Museum of Anesthesiology R L Lipnick 1991b Outliers their origin and use in the classification of molecular mechanisms of toxicity Sez Tot Environ 109 110 131 153 R L Lipnick 1995 Structure Activity Relationships In Fundamentals of Aquatic Toxicology 2nd edition G R Rand ed Taylor amp Francis London 609 655 Loonen H Lindgren F Hansen B Karcher W Niemela J Hiromatsu K Takatsuki M Peijnenburg W Rorije E and Struijs J 1999 Prediction of biodegradability from chemical struc
578. ls and sparingly soluble metal compounds in aqueous media cadmium LISEC no WE 14 002 January 1998 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media cadmium oxide LISEC no WE 14 002 January 1998 OECD Guideline for testing of chemicals Paris 1984 Guideline 201 Alga Growth Inhibition test OECD Guideline for testing of chemicals Paris 1984 Guideline 202 Daphnia sp Acute immobilisation test and Reproduction Test OECD Guideline for testing of chemicals Paris 1992 Guideline 203 Fish Acute Toxicity Test OECD Guideline for testing of chemicals Paris 1992 Guideline 204 Fish Prolonged Toxicity Test 14 Day study OECD Guideline for testing of chemicals Paris 1992 Guideline 210 Fish Early Life Stage Toxicity Test International standard ISO 6341 1989 E Determination of the inhibition of the mobility of Daphnia magna Straus Cladocera Crustacea LISEC Craenevenne 140 8600 Genk Belgium CANMET Natural Resources Canada 555 Booth St Ottawa Canada KI1A 0G1 AFR ADL BIL ALEGE SNEH 2014 E4 A2 Bias AfEXGAL THR 529 530 gt SDE GHS 1992
579. nows Ecotox Environ Safety 5 202 210 1981 4 QSAR Boethling R S Howard P H Meylan W M Stiteler W M Beauman J A and Tirado N 1994 Group contribution method for predicting probability and rate of aerobic biodegradation Envir Sci Technol 28 459 465 De Bruijn J Busser F Seinen W and Hermens J 1989 Determination of octanol water partition coefficients for hydrophobic organic chemicals with the slow stirring method Environ Toxicol Chem 8 499 512 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Hansch C and A Leo 1995 Exploring QSAR American Chemical Society Hilal S H L A Carreira and S W Karickhoff 1994 Quantitative Treatments of Solute solvent Interactions Theoretical and Computational Chemistry Vol 1 291 353 Elsevier Science Howard P H Boethling R S Stiteler W M Meylan W M Hueber A E Beaumen J A and Larosche M E 1992 Predictive model for aerobic biodegradation developed from a file of evaluated biodegradation data Envir Toxicol Chem 11 593 603 Howard P And Meylan W M 1992 Biodegradation Probability Program Version 3 Syracuse Research Corp NY Langenberg J H Peijnenburg W J G M and Rorije E 1996 On the usefulness and reliability of existing QSARs for risk assessment and priority setting SAR QSAR Environ Res 5 1 16 R L Lipnic
580. ntal Protection Agency Office of Pesticides and Toxic Substances Washington D C 20960 EPA 560 6 82 002 1982 8 Code of Federal Regulations Protection of the Environment Part 790 1998 7 1 ONLINE US National Technical Information System EPA FIFRA 1982 The Federal Insecticide Fungicide and Rodenticide Act Pesticide Assessment Guidelines subdivision N chemistry Environmental fate and subdivision E J amp L Hazard Evaluation Office of Pesticide Programs US Environmental Protection Agency Washington D C 1982 ONLINE US National Technical Information System OECD Test Guideline 107 1995 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water Shake Flask Method OECD Test Guideline 117 1989 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water High Performance Liquid Chromatography HPLC Method OECD Test Guideline 305 1996 Bioconcentration Flow through Fish Test OECD Guidelines for Testing of Chemicals OECD Test Guideline 305 A E 1981 Bioaccumulation OECD Guidelines for Testing of Chemicals OECD draft Test Guideline 1998 Partition Coeffici
581. onomic Co operation and Development OECD and the United Nations on the basis of a mandate given in Agenda 21 by the 1992 United Nations Conference on Environment and Development UNCED in Rio de Janeiro The GHS addresses classification of chemicals by types of hazard and proposes harmonized hazard communication elements including labels and safety data sheets It aims at ensuring that information on the physical hazards and toxicity from chemicals be available in order to enhance the protection of human health and the environment during the handling transport and use of these chemicals The GHS also provides a basis for harmonization of rules and regulations on chemicals at national regional and worldwide level which is also an important factor for trade facilitation While Governments regional institutions and international organizations are the primary audiences for the GHS it also contains sufficient context and guidance for those in industry who will ultimately be implementing the requirements which have been adopted Adopted in December 2002 by the Committee of Experts on the Transport of Dangerous Goods and the Globally Harmonized System of Classification and Labelling of Chemicals the GHS is regularly updated revised and improved as experience is gained in its implementation The Plan of Implementation of the World Summit on Sustainable Development WSSD adopted in Johannesburg in 2002 encourages countries to implement the GHS as soon
582. or Metals and Metal Compounds Ispra February 17 18 1997 OECD Metals Working Group Meeting Paris October 14 15 1997 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media zinc LISEC no BO 015 1997 J M Skeaff and D Paktunc Development of a Protocol for Measuring the Rate and Extent of Transformations of Metals and Sparingly Soluble Metal Compounds in Aqueous Media Phase I Task 1 Study of Agitation Method Final Report January 1997 Mining and Mineral Sciences Laboratories Division Report 97 004 CR Contract No 51545 Jim Skeaff and Pierrette King Development of a Protocol For Measuring the Rate and Extent of Transformations of Metals and Sparingly Soluble Metal Compounds in Aqueous Media Phase I Tasks 3 and 4 Study of pH and of Particle Size Surface Area Final Report December 1997 Mining and Mineral Sciences Laboratories Division Report 97 071 CR Contract No 51590 Jim Skeaff and Pierrette King Development of Data on the Reaction Kinetics of Nickel Metal and Nickel Oxide in Aqueous Media for Hazard Identification Final Report January 1998 Mining and Mineral Sciences Laboratories Division Report 97 089 CR Contract No 51605 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media zinc oxide LISEC no BO 016 January 1997 LISEC Staff Final report transformation dissolution of meta
583. p oe H242 C D AAT en J So gt a tte H242 ete ZEE Mel G KETEL BREE sey TERA ELENA PRE L BLT BIZOUY AE SARIN BIT 3 ELEGY EG HA ALD FJA 181 BAUGH SPUD PF BEIT ORF PIZ L BLEH F NAAR EET ELLE FARA OG 3 3 BEBO E RREN ARB COMBLE AT ENLUO CHAI EF AMMOB25 W2 5 3 2 2 PAMADI A1 9 2 9 ee cus gee H250 i 255 A1 10 2 10 GER Sp CERE BRASE 4y TERE GHS H250 i A1 11 2 11
584. ssessment No 27 Environment directorate Organization for economic Co operation and Development April 2001 439 4 EY E A A9 1 6 Hy E 25 pay sare l aa F AK H ESO EMMEL ARS Aei
585. tors for intermedia extrapolation in biodegradability assessment Chemosphere 30 4 741 752 de Henau H 1993 Biodegradation In P Calow Handbook of Ecotoxicology vol I Blackwell Scientific Publications London Chapter 18 pp 355 377 EC 1996 Technical guidance documents in support of the Commission Directive 93 67 EEC on risk assessment for new notified substances and the Commission Regulation EC No 1488 94 on risk assessment for existing substances European Commission Ispra 509 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Brussels June 1998 Federle T W S D Gasior amp B A Nuck 1997 Extrapolating mineralisation rates from the ready CO2 screening test to activated sludge river water and soil Environmental Toxicology and Chemistry 16 127 134 Langenberg J H W J G M Peijnenburg amp E Rorije 1996 On the usefulness and reliability of existing QSBRs for risk assessment and priority setting SAR and QSAR in Environmental Research 5 1 16 Loonen H F Lindgren B Hansen amp W Karcher 1996 Prediction of biodegradability from chemical structure In Peijnenburg W J G M amp J Damborsky eds Biodegradability Prediction Kluwer Academic Publishers MITI 1992 Biodegradation and bioaccumulation data on existing data based on the CSCL Japan Japan chemical industry Ecology toxicology amp information center ISBN 4 89074 101
586. ture modeling of ready biodegradation test data Environ Toxicol Chem 18 1763 1768 Meylan W M and P H Howard 1995 J Pharm Sci 84 83 92 514 OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monograph No 68 OECD Paris France OECD 1995 Environment Monographs No 92 Guidance Document for Aquatic Effects Assessment OECD Paris F Pedersen H Tyle J R Niemel B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification Data Collection and Interpretation Guide for Substances to be Evaluated for Classification as Dangerous for the Environment 2nd Edition TemaNord 1995 581 Nordic Council of Ministers Copenhagen January US EPA 1999 Development of Chemical Categories in the HPV Challenge Program http www epa gov HPV pubs general categuid htm US EPA 2000a The Use of Structure Activity Relationships SAR in the High Production Volume Chemicals Challenge Program http www epa gov hpv pubs general sarfinll htm US EPA 2000b ECOSAR http www epa gov oppt newchems tools 21ecosar htm US EPA EC 1993 US EPA Joint Project on the Evaluation of Quantitative Structure Activity Relationships Commission of European Communities Final Report July G D Veith R L Lipnick and C L Russom 1989 The toxicity of acetylenic alcohols to the fathead minnow Pimephales promelas Narcosis and proelectrophile activation Xenobiotica 19 5 555 565 5
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