ビタミンE摂取量が母体の健康状態と胎児の発育に及ぼす影響について
Contents
1. MICROPLATE READER Model550 BIO RAD 540nm 90 EE 3 E GPO DAOS MICROPLATE READER Model 550 BIO RAD 600nm 4 TBARS 9 1 15 10 75 1 4S0l 10mM BHT 2 62. EE 2 100 89 E E E 9 BE 2 E E 7
3. weight low middle high M a tocopherol 0 0005 0 0075 0 5 d Casein 20 0 20 0 20 0 L cystine 0 3 0 3 0 3 B cornstarch 39 7 39 7 39 7 Q cornstarch 13 2 13 2 13 2 Sucrose 10 0 10 0 10 0 Palm kernel oil 7 0 7 0 7 0 Cellulose powder 5 0 5 0 5 0 Mineral mixture AIN 93G 3 5 3 5 3 5 Vitamin mixture 1 0 1 0 1 0 AIN 93 vitamin E free Choline bitartarate 0 3 0 3 0 3 H Butylhydroquinone 0 0014 0 0014 0 0014 Q0 27 v 0 3 18 2 B SLS
4. E low middle hish TBARS E E Table 2 a ICR 90 EE middle
5. 2007 AJIZ pp 43 1998 7 E pp 479 487 1985 8 Miller E R Il Pastor Barriuso R Dalal D Riemersma R A Appel L J Guallar E Ann Intern Med 142 1 37 46 2005 9 Ask 29 203 209 1981 10 Spayd R W et al Clin Chem 24 1343 1350 1978 11 Uchiyama M Mihara M Anal Biochem 86 271 278 1978 Bradford M Anal Biochem 72 248 1976 pp 11 1989 4 6 12 13 94
6. 7 E Fig 2 Fig 2 a E Fig 2 b HDL E E TBARS Fig 3 TBARS low middle high
7. Table 3 1 low high middle Fig 4 a b low FEB k U high middle 1 1 Table 3 low FEB high ff X middle Elow high JA a 20r x k k 1 8 H 1 6 F 1 4 F 1 2 F E 10r 0 8 0 6 0 4 0 2 0 1 1 low middle high E Table 2 Effects o
8. 20gl 0 6796 TBA 2 1501 80C T 60 1 60041 2 10 535nm du 50 ei BIO RAD TEP 1 1 3 3 TBARS TEP 10 Bradford Img TBARS 5 Posthoc Bonferroni Dunn Fig 1
9. BE 1 400IU E E BE E E 1 1 3 JcLICR fedes ene CH 22 24C 45 55 2cm 12 8
10. HDL LPL E TBARS E Elow high E BE 1 AJE pp 38 1998 a RTT 2 pp 61 1989 3 pp 79 1990 E pp 287 294 1985 5
11. E 20 225mm X 338mm x 140 h mm 1 10 1 E low 0 0005 middle 0 0075 96 high 0 5 29 E wv 8o Table 1 w L Bm Table 1 Composition of experimental diets 7 E
12. low 6 4 3 high 7 perg 5 L 3 1 Table 2 b 3 Wa 2 1 I 91 80 60 eb 40 20 0 Fig 1 18 16 14 12 g dl Fig 2 hemoglobin level a blood triglyceride level b Several bars are means and SD low middle high 80 60 20 low middle high Body weight a and body volume b of the mouse fed each experimental diets for 25 weeks Several bars are means and SD b mg dl low middle nancy B
13. The cause was not clear the vitamin E intake of inappropriate quantity may cause pregnancy abnormality Because pregnancy abnormal ratios increased that growth insufficiency of the fetus was observed low group and high group in vitamin E It suggested that the surplus intake of the vitamin E have possibilities to cause bad influence to pregnancy E E E BE 10 2 E
14. Bull Mukogawa Womens Univ Nat Sci 56 89 94 2008 or AT PURUS R Influence of vitamin E intake to state of health of mother s body and fetal development Examination using laboratory animals Tomomi Imamura Shino Takahashi Chieko Ouchi Yuki Sakaiya Noriko Nishimura Rie Matsui Eriko Yasui Noboru Horie Department of Food Science and Nutrition School of Human Environmental Sciences Food Science and Nutrition Major Graduate School of Human Environmental Sciences Mukogawa Women s University Nishinomiya 663 8558 Japan This study is focused on overdose of vitamin E In particular we examined its influence on pregnancy us ing a laboratory animal It showed no change of hemoglobin level and triglyceride level in blood by the difference of vitamin E dose However it showed that antioxygenation of the vitamin E was shown because the fall of TBARS value in the brain that was taken have much vitamin E intakes
15. f vitamin E on pregnancy a A result of becoming pregnant or not It is shown with num bers of mother mice b The details of the preg nancy abnormality It is shown the numbers of fe tuses a TUE Non pregnancy Dost of vitamin E pregnancy normal abnormal low n7 6 2 1 3 middle n7 6 1 5 0 high n7 7 2 2 3 b The number of abnormal fetuses Doseof Theratio of an Observation vitamin E abnormal fetus immature fetal death only the placenta low 7 55 4 53 0 1 3 middle 0 0 69 0 0 0 high 10 94 7 64 1 5 1 Table 3 Numbers of the average fetuses per one mother mouse fed each experimental diets Dose of vitamin E The number of fetuses low 13 3 2 75 middle 13 8 1 64 high 12 8 3 03 b 20r 18 xk l6r l4r 12r cb 1 0 0 8 F 0 6 0 4 F 0 2 0 1 n 1 z low middle high Fig 4 Effect of Vitamin E on state of the growth of the fetus Length a and weight b of the fetus on 18th day after mate Several bars are means and SD p lt 0 05 p 0 01 p 0 001 03 KA E EE WERE
16. l pregnancy 8r 7 8 g 6r E Eel E 3 4L Bar g lt 2 B IF 0 high 180 160 140 120 100 80 60 40 20 non pregnancy Bl pregnancy low low middle high middle high Effects of vitamin E on blood biochemical parameters in mouse fed each experimental diets Blood DOn preg Fig 3 TBARS values of brain homogenate of mouse fed each experimental diets Several bars are means and SD 02 non pregnancy Bl pregnancy p 0 05 AGE low 7 6 high 10 9 high E low high
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