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1.2. Ce 3 250
3. 140 GTP 3 006
4. RNAi Adenovirus iter Immunoassay Kit VPK 109 1 4 1 93 1 a 293 1 3 Anti Hexon 4 Cell Biolabs Inc BL MAP Kinase Signaling MAP Kinase Signaling Cytoskeleton Regulation VEGF MS ADV 101 MEK5 DN HU ADV 130 PAK1 HU ADV 202 IL 2 HU ADV 102 MEK5 CA HU ADV 131 PAK1 H
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6. 005 _ i http www cosmobio co jp company tools cbtools_top asp 3 5 15 9 3 8 10 5006 3 26 28 3 29 31 9
7. 4C 1 Easy Trangater TRO1 1 0 660 500ng DNA RNA 4 Easy Trangater si TRO 1 0 500 0 2ug siRNA 24 0 5 TROTS TRO2S Fe EasyTransgater DNA RNA EasyTransgater si SiRNA TRO1 1 m vial 660 reaction 44 000 TR01S 0 5 ml vial 330 reaction 23 000 TR02 1 m vial 500 reaction 46 000 TR02S 0 5 md vial 250 reaction 24 000 4C 20C 7O0C 196C
8. iPod 4 Eric Vivier 2
9. PCR polymerase Chain reaction PCR DNA PCRH 1980 PCR PCR B6 1 76p 4 903168 00 X 2 000 2 100 HBN
10. RNase AWAY DEPC RNase AWAY DNA AWAY RNase AWAY spray type RNase AWAY DNA AWAY 250 CE RNase AWAY RNA RNase DNA AWAY PCR DNA DNase Molecu
11. 006 STKE Related Resources Editorial Guides E M Adler N R Gough L B Ray 2004 Signaling breakthroughs of the year Sci STKE 2005 eg1 2005 E M Adler N R Gough L B Ray 2003 Signaling breakthroughs of the year Sci STKE 2004 eg1 2004 E M Adler N R Gough L B Ray 2002 Signaling breakthroughs of the year Sci STKE 2003 eg1 2003 N R Gough E M Adler Focus issue RNA a multifunctional molecule Sci STKE 2005 eg8 2005 This Week in ST The message IS the messenger Sci STKE 2005 tw332 2005 iDDIng up targeting and translation Sci STKE 2005 tw422 2005 miRNA contributes to neuronal morphogenesis Sci STKE 2005 tw406 2005 Stargazin traffic cop and gate keeper Sci STKE 2005 tw239 2005 Dissecting dopamine s behavioral effects Sci STKE 2005 tw227 2005 A pathway to schizophrenia Sci STKE 2005 tw419 2005 RedistriDution of ST
12. EE EE EE 20 30 0FF R amp D 2006 Cm R amp D 4 ELISA ELISpot Fluorokine 912
13. G GPCH Greengard Sol Snyder 2 a 3 5 4 AMPAR Snyder AMPAR AMPAR
14. Apple chlorotic leaf spot viruS ACLSV Apple Stem Grooving Virus ASGV Apple stem pitting Virus ASPV 3 1 2 Apple proliferaretion phytoplasma ApP ELISA ELISA Extraction Buffer 10x Coateling Buffer Conjugate Buffer 10x Substrate Buffer 5x Wash Buffer Substrate pNPP Egg Albumin Regent Set gG Conjugate FASTKIT Complete Kit Conjugate
15. STIM 1 D DR DISC1 PDE4B CML Bcr Abl Abl
16. PMN 1 PMN qa 1 o 1 PI PMN PI o 1 PI A PMN Z 1 PI 9 Human PMN Elastase ELISA _ oYendor PMN o 1
17. 490nm Creatinine Assay Kit 96 Na0H R amp D Systems Inc RSMl 002 ge d 0 31 20 mg dl KGEO05 Nt 37 000 Ep 4C 0C 7O0C 196C Human PMN Elastase ELISA Polymorphonuclear PMN
18. GD DNA http www feelsoDbio net DNA DNA 1 DNA
19. gt Developmental Cell 1
20. chitinase chiA flash BAC c7j A CE 100 chiA pBacPAK8 9 pAcUW31 pBacPAK 2 EY f lash BAC DNA gc DNA flash BACTM one step baculovirus protein
21. 30 SureSilencing ShRNA 70 RNAi Bioruptor 550W 1
22. 2B005 Joseph Ecker 2005 Estelle Leyser 2 TIR1 1 FT mRNA 1
23. 6S6 42 43 DNA RING E3 1 2 BRCA19 UPS 9397
24. Fluoro Jadee Histo Chem Inc Schmued L Stowers C Scallet A and Xu L Fluoro Jade C results in ultra high resolution and contrast labeling of degenerating neurons Brain Res 1035 2005 84 31 Coffee brown Brick red 823 485nm 525nm Fluorescein FITC DAPI Fluoro Jade CO Dr Larry Schmued Chemicon International Inc MIN Fluoro Jade C 12 amp 1 6 Collagen 12 amp 16 Heparanase 8 AG325 85 000 1 FAOCIT fibrilassociated collagens with interrupted triple he
25. CGRP SP Compound F HPA ACTH HRP ELISA 450nm PGEs LTB4
26. Greengard miRNA miR 430 miRNA miRNA miRNA 1 miR 1 32 cAMP CREB miR 1 32 97 Greengard miR 1 32 in vivo miRNA
27. SDS PAGE Fo SChauber C et al 1998 Nature 391 715 4C 4 9 SDS 1096SDS PAGE 198 Rpt 1 1 GST UbL Rpt 1 6 GST 3
28. Connexin 57 CX57 DTV ANT0011 100 Lug 141 000 MR NR3C2 RSD 2ZH3122H 100 pg 131 000 Connexin 30 2 ZYM 40 7400 100 g 68 000 Munc13 SPS 126 103 50 Mg 101 000 SMP30 COQ7 ACM AB25912 100 pk 64 000 Mycobacterum tuberculosis RV2623 Domancy Regulon ACM AB24291 100 g 64 000 SMP30 CTRP1 ACM AB25972 100 ug 64 000 Mycoplasma ROMINS p120 ACM AB24300 100 g 64 000 A a CTs CN oo a Ag 64 000 Myelin expression factor 2 ACM AB26098 50 g 64 000 SMP30 9 OO i
29. RHosenberg 1 5 12 3 Ca CaMKIH Roger Tsien 1 Ca Ca 3 CaMKH
30. 9 SEK a E3 SCF G 1 APC Bioruptore UCD 50 TOS 28 S APC APC G M 2 2o a EN OT MHC 30 68 7cm 1
31. Er ee Technologies Inc i Banta Cruz Blotechnology Ino SCB 25 G1 8S G2 M HIF UPS UPS HIF FASTKIT NPH 26 von Hippel LIndau VHL ee CBN 26S8 VHL BN BRA 27
32. BMO 104 000 Ubiquitin Conjugating Enzymes E2 sampler pack 26S 26S Proteasome Degradation Kit PW8950 1 kit 48 000 AFR BMO 4 Cosmo Bio News No 55 Cosmo Bio News No 55 ee 60S5 Pa 0S 60S 700kDa 2G6S G0S
33. EE 1 2 _ AI 9 Complete Kit 480 151075 150775 151775 150875 151875 1 kit 480 assay 85 000 Complete Kit 960 151072 150772 151772 150872 151872 1 kit 960 assay 155 000 NP Reagent Set 480 151065 150765 151762 150865 151865 1 kit 480 assay 67 000 Reagent Set 960 151062 150762 151765 150862 151862 1 kit 960 assay 123 000 FASTKIT 25 ng mk 999100174 1 kit 20 test 36 000 FASTKIT 50 ng 999100177 1 kit 20 test 36 000 FASTKIT 25 ng m 999100259 1 kit 20 test 36 000 Bioreba AG FASTKIT 25 ng 7 7 999100260 1 kit 20 test 36 000 FASTKIT 25 ng mg 999100261 1 kit 20 test 36 000 ASGV 5ng m8 50ng M G00 5ppm
34. S S 7 1 50 A
35. Oligo Tyrosine 37C 15 Tdp 1 1 rpo O P O O P O Try topo DA No Tdp1 pg YO 100 250 T4 g 2P ATP Uligo yr 0 5xTdp 1 mi x TyrosyI DNA phosphodiesterase enzyme Cat 004 1 Pat ak AE ie Tdp 1
36. 39 SUM0 Smtdp Sentrin Pic 1 Gmp 1 NEDD8 Rub 1 9 E9 9 HAD2S 826S5 1985 S5a 2 N C E 33 399 E
37. 806 0 056 1 00 um 0 056 0 087 0 12 015 022 032 040 30 000 Anti gliadin CE 1 ELISA Anti casein CC 2 ELISA ek 115 000 Anti gliadin CE 3 ELISA WB CH 013 Anti B lactoglobulin CD 2 ELISA CH 010 Anti gliadin CE 2 ELISA CH 012 Anti B lactoglobulin CD 1 ELISA WB CH 009 um 045 0 464 0 50 0 547 0 60 0 7O dl a Anti ovomucoid CB 2 ELISA CH 006 Anti ovalbumin CA 2 ELISA WB CH 002 10 mg 30 000 N 450 N 461 N 500 N 550 N 600 N 750 N 800 N 1000 Anti ovomucoid CB 1 ELISA CH 004 Anti ovalbumin CA 3 ELISA CH 003 50 mk 115 000 Anti casein CC 1 ELISA WB CH 007 Anti ovalbumin CA 1 ELISA WB CH 001 100g 50 000 26 Cosmo Bio News No 55 Cosmo Bio News No 55 amp Bioruptor YUCD 250 50W
38. Fluoro Jade C SureSilencing shRNA Tandem IHC Bioruptor UCD 250 No 95 Contents March 2008 _L 1 a ay UDiquitinylatlon as a post translational modificatlon 2 A ContriDution made in 2000 by Professor R John Mayer Professor of Molecular Cell IITTINNINIITT IIIITI II Biology University of Nottingham United Kingdom amended and edited by Dr Paul W E ES 2 28 4 Sheppard Scientific Development Director AFFINITI Hesearch Products Ltd Exeter 26S 5 United Kingdom 20S 20S
39. o NN gt C 9 polyUb D Merck Ltd GBO Ubiquitinated Protein Enrichment Kit 662200 1 kit 25 assays 66 400 6 2006 8 1 500 _ Ki GST UbL
40. 500W 250W 6 50 83 160W 200W 250W 3 5u2 100 UCD 250 10W CHIP 10 NG6 Bioruptor UCD 250 www cosmobio co jp product Dioruptor 28 Cosmo B
41. Vidal Ferrell Meyer 2 G 39 Vidal Vidal Young Snyder G3 3 005 1
42. II oo 60113 products_SBS_20060113 1 asp E coli TG1 PCR Ep FULL WG CE 9 Protein slides barcoded Protein slides barcoded Protein
43. EF UbcH5a C 5A mutant His6 tagged UbcH5a E6 AP E6 p53 UbcH5b UbcH5c SCF Skp Cul F Box UW9055 a UbcH5b His6 tagged Ik Bc UbcH5c6 NF kB 1 UW9060 ne UbcH5b CA mutant His6 tagged p50 p105 C85A UW9065 UbcH5c His6 tagged UW9070 UbcH5c CA mutant His6 tagged UW9075 UbcH6 His6 tagged E2 N 40 UbcH5a IAP Inhibitors of apoptosis UW8710 UbcH7 His6 tagged E6 AP UbcH5 HECT E2 UW9080 lg SOE UbcH8 His
44. 22 IPS 1 1 Cardif CARD 9 MAVS 9 VISA 2 9 C HCV 59 HCV
45. DNA 2 DNA DNA DNA
46. http www cosmobio co jp product campain asp 2006 3 31 50 iPod mini 4GB 1 NOR ABG G0960FF 2006 3 31 0960FF BEN ELISA amp ELISA 25960FF 2006 3 31 BEN ELISA ELISA 25960FF BEN ELISA
47. DNA DNA DNA DNA DNA DNA DNA DNA ATP
48. Elizabeth M Adler Nancy R Goughe and L Bryan Ray3 1 Associate Editor of Science s STKE American Association for the Advancement of Science 1200 New York Avenue N W Washington DC 20005 USA 2 Managing Editor of Science s STKE American Association for the Advancement of Science 1200 New York Avenue N W Washington DC 20005 USA 3 Editor of Science s STKE and Senior Editor of Science American Association for the Advancement of Science 1200 New York Avenue N W Washington DC 20005 USA Science STKE 1 STKE 2005 iT mg Fu
49. PIG K DP TLC Echelon 2 TLC ELISA PI 3 4 5 Pa PIS K PI 3 4 5 Ps pmol PIPs 3 0x 1 08cells CS PIPs Mass ELISA 96 U PI 3 4 5 Ps PI 3 4 5 Ps PI 3 4 5 Ps d6 ehelon P MB PIPs Mass Strip PIPs Strip
50. Caron Lefkowitz CAMP Akt Akt 2A PP A DDR 8 D2DR Greengard D DR Akt D2DR 32 Cosmo
51. 005 2006 SCB 2006 siHNA 18 000 19 000 siRNA 9 800 58 000 1 1 19 36 Cosmo Bio News No 55 Cosmo Bio News No 55
52. gp S _FIuoro Jade C HE CP Te sm ci Fluoro Jade C Fluoro Jade Fluoro Jade B 3 NPA FIuoro Jadee C FlIuoro Jade CO DAPI GFAP
53. SCF E3 UPS ER ER 9 P26S 8 _ RAD23 Parkin
54. Tandem IHC Detection Kit Anti Rabbit HRP Anti Mouse ALP 4000 1 1 kit 86 000 oO Tandem IHC Detection Kit ll Anti Rabbit ALP Anti Mouse HRP 4001 1 1 kit 86 000 a I 7 I 7 1 J lt 7 nL 10 0 ELISA
55. UEV UDp13p 9 UEV mp 5065 19S 195 6 ATPase HEC S7 ATPase FE S4 ATPase
56. 0 ER ES SS 32 TT 9 13 ER MHC 3 NMM 56S MHC 3 198S 5 I FN y
57. Quartett GmbH QT 122 500 S Ep 4C 60C 70C BETHYL 30 4 48 5 63
58. 0 2 14 3 28 4 42 1 49 5 56 63 ELISA 9 19 1 14 16 FAX http www cosmobio co jp index asp 2006 ES G0 5mg ELISA 83
59. CAMP D DR CAMP I CaMKI Greengard CaMKIH John Kuriyan Angus Nairn CaMK TH Ca CaMK II 1 Cag
60. DAB A DAB B Fast Red Fast Red gG Fluorescein Or HiLyte Fluor 555 or 647 Dye IgG conjugate 1 Fluorescein HiLyte Fluor Dye Fluorescein or HiLyte Fluor Bcl X HabMAb Pink p53 mouse mADb Brown Epitomics Inc l 3 i Relative Fluorescence Intensity arbitrary unit Tandem IHC Staining Kit for AIF Anti Rabbit ALP Anti Mouse HRP 4015 1 1 kit 50 130 000 1 0 Tandem IHC Staining Kit for Bax Anti Rabbit ALP Anti Mouse HRP 4016 1 1 kit 50 130 000 a 0 a i Tandem IHC Staining Kit for Bid Anti Rabbit ALP
61. 208 865 PA700 198S cap PA700 ATP G0S 3 S08 PA28 11S5 SDS
62. Cosmo Bio News No 55 29 Anti J Anti A DUTT 1 ZYM 40 5900 100 ug 68 000 Nucleobindin 1 Precursor ACM AB26093 50 Lg 64 000 SLC18A2 AB26073 64 000 A 549 ACM AB25816 100 ug 64 000 0 SLITRK4 AF2860 75 000 Acetyl CoA acetyltransferase cytosolic GNW CB A22016 100 g 69 000 Encephalopsin CMN AB9423 50 g 90 000 Ocular Albinism 1 Nettleship Falls OA1 CMN AB9231 50 g 90 000 SMARCC1 AB26304 64 000 Acidovorax Avenae Subsp Cattleyae BRA 170625 0 1 mg 29 000 Endogenous Retrovirus Type K Capsid Protein ABI HERM 1831 5 100 g 108 000 Olfactory Receptor Homolog to Mouse MOR105 3 CMN AB9460 50 g 90 000 Sortilin AF2934 75 000 Actin like protein 6A GNW CB A22437 100 ug 69 000 Endogenous Retrovirus Type K Envelope Protein ABI HERM 1811 5 100 g 108 000 Olfactory Receptor OR6N1 CMN AB9462 50 g 90 000 SP2 0 Host Cell Proteins AB25815 64 000 Activator 1 38 kDa subunit GNW CB A21946F 100 ug 6
63. UD 1 Hershko A Heller H Elias S and Ciechanover A J BioLChem 258 8206 8814 1883 2 Tamura T Tanaka K Tanahashi N lchihara A FEBS Letters 282 154 158 1881 Ubiquitin Proteasome EY E 1 E2 E3 mixture Anti ubiquitinX ubiquitin chain 21A8 Anti Lysozyme 20G1T2 mm IL 4C G0C 7O0C 196C Hokugds LT LE TE LE LT IT er I re li Fraction BC15 E 1 E2 E3mixture BC 16 Ub Sepharose BC18 Ub GO00g E1 E2 E3mixture 90 2 30 15 128 59 SDS PAGE CBB e O
64. 6 RN 2 7 ee 8 7 amp Fluoro Jade C Chemicon International Inc CMN 10 26S UPS eo Heparanase Quartett GmbH QRT y R Bethyl Laboratories Inc BET PIPs Mass Assays Echelon Biosciences Inc ECL 12 i ME
65. ADbI CML Tsien JAK V61 F 9329 Tsien Michael Karin RNA RNA IKK kB IKK
66. J EL LLVY AMC AMC Lactacystin 06 SDS EA CP PA T T TT 1 cS 10 X Suc LLVY AMC 20S Lactacystin AMC Chemicon International Inc MNM 20S Proteasome Activity Assay APT280 1 kit 81 000 TEL 03 5632 9610 FAX 03 5632 98619
67. DNA Tdp 1 Topogen Inc IO Tdp1 Assay Kit 1004 2 250 assay 50 000 Topogen Inc IO Anti Tdp1 HU WB IF 2016 A 25 unit 25 000 Anti Topo 2B HU 2010 3A 25 unit 25 000 Anti Topo 3A IHC p not WB 2015 250 unit 75 000 Anti Topo 3B HU 2010 4 250 unit 82 000 Anti Topoisomerase 1 HU WB 2012 2A 25 unit 25 000 Anti Topoisomerase 2 p 170 WB IF 2011 1A 25 unit 25 000 2 Topogen Inc MIONI TDP1 2004H 1 250 unit 68 000 SDS PAGE 68kDa Tdp1 Topoisomerase 2005H 1 500 unit 58 000 Topoisomerase Il peptide CT 2011 2 50 Ag 45 000 Topoisomerase Il p170 2000H 1 200 unit 58 000 Topoisomerase Il p170 Marker Set 2011 3 20 unit 43 000 Topo I in vivo Link Kit 1021 200 assay 95 000 I DNA in vo Topo I in voLink Kit No 1022
68. S05 2 5 gl 9I cmmEulga 188 1 AFR 2 le MuUUUA 7 We 1 1996 UPP UPP
69. LITE IL HaOe LuminQal scar A B 4ES 1Dnm P3 scar a a PVDF UO 300 I scar Target protein A 1 2 3 4 B 1 2 3 4 detection 0day
70. sl La 360 UN ELISA RID 196C Cosmo Bio News No 55 Cosmo Bio News No 55 5 S _ PIDPs Mass AssaySs PIPs Echelon PIPs Mass ELISA PIPs Mass Strip PIPs P13 kinases PIG3 K PI 4 5 Ps PI 3 4 5 Ps
71. S nv Parameter V Kit ELISA PGEs P 450 NSAID PGEs B4 LTB4 Substance P SP 1 1983 1 Substance P TT PAR 2
72. SDS PAGE 50x502 20xUbiguitin Activating Enzyme Solution E1 Human recombinant E1 His6 tagged 10xUbiquitin Conjugating Enzyme Solutions E UbcH1 His6 tagged UDcH His6 tagged UbcH3 His6 tagged UbcHe6 His6 tagged UbcH5a His6 tagged UbcH7 His6 tagged UbcH5b His6 tagged UDcH8 His6 tagged UbcH5c His6 tagged UbcH10 His6 tagged Ubc13 Mms2 His6 tagged 20xBiotinylated Ubiquitin Solution Bt Ub 20xXMg ATP Solution 2XNon reducing Gel Loading Buffer 10XUbiquitinylation Buffer E TE E TE ve Mg ATP TE ve ATP E1 AI UbcHl B UbcH2 C UbcH3 D UbcH5a E UbcH5b F UbcH5c G UbcHe6 H UbcH7 1 UbcH8
73. 8655 BIOMOL E2 tag UbcH1 His6 tagged E2 25k in vitro E1 ATP 48 UW9020 2 UbcH2 His6 tagged DNA DNA RAD6 ijn vitro ES3 H2A UW9025 E1 E2 E3 2G6S ch UbcH3 His6 tagged DNA Cdc34 UW8730 665 UbcH5a His6 tagged UbcH5a b c E2 c fos UW9050
74. ELISA PMN 2 8 1 50nm2 x 1 PI 16m8 TMB 1 1m2 2 2M HCI 1 1 m2 10 75m2 300ng m6 3ng m6 100 15 6 1 000ng m6 450nm Biovendor Laboratory Medicine Inc i BV RD191021100 1 kit 52 000 Human Clara Cell Protein ELISA Laboratory Medicine Inc ELISA 13m2 HRP 13mg 50ng 1 10m2 2 X10 100m2 TMB 13m2 1 3m62 HU Rabbit HU Clara Cell Prote
75. SUMO SUMO SDS PAGE SUMO SUMOylation Kit BIDOMOL CS 20xSUMO Activating Enzyme Solution SUMO E1 His6 Aos 1 Uba2 20xSUMO Conjugating Enzyme Solution SUMO E UbcH9 20xSUMO Enzyme Solutions SUMO1 SUMO02 SUMO3 His6 mature SUMO1 His6 mature SGUMO0 His6 mature SUMOd 10XSUMOylation Buffer 20xControl RANGAP1 SUMOylation Target Protein Solution RG1 GST RHANGAP1 fragment 418 587 20xXMg ATP Solution SUMO Antibody Solutions SUMO 1 C term rabbit polyclonal PW9460 SUMOZ 3 N term rabbit polyclonal PW9465 BIOMOL International LP BMOM UW8955 1 kit 105 000 AFR BMO 26S
76. hen ae Joseph Ecker 1 fi Fo HF Paul Greengard Ravi Ilyengar Michael Karin Solomon Snyder RHoger Tsien Marc Vidal Eric Vivier 2005 RNA
77. a AlF RabMAb Pink Ki T gt OY LiLyte Fluor 555 or 647 Dye HiLyte Fluor 570nm 670nm HiLyte Fluor M AnaSpec HiLyte FluorW555 CV G HIiLyte FluorWW647 CV W5 Cy M3 Cy M5 Amersham ALP or HRP mouse mAb ALP or HRP
78. 54 A1 1 AG AS 85 12 3 SEKISUI CC 0 0 pH
79. NC11 16 Anti Collagen 12 Rabbit Anti Collagen 16 Rabbit Anti Heparanase 1 Rabbit Anti Heparanase 2 Rabbit Anti Heparanase 3 Rabbit IHC p IHC f IF ELISA 031504505 500 pk 171 000 IHC p IHC f IF ELISA 031504605 500 pk 171 000 IHC p IHC f IF 080503317 1 mg 122 500 IHC p IHC f IF 080503417 1 mg 122 500 IHC p IHC f IF 080503517 in vitro i EE b ra Pa i ji 1 LE bg i 4 4 ui 3 BE i 1 6
80. S6 ATPase TS 06 26S6 Thermoplasma 9 9597 2 08 7 7 C8 o 7 198S 6 ATPase 1858 9
81. Topoisomerase Assay Kit 1015 1 100 assay 50 000 DNA I 1015 2 250 assay 75 000 Topoisomerase Drug Screening Kit 10181 100 assay 45 000 I Topoisomerasell Drug Screening Kit No 10091 Eukaryotic Topoisomerase Il Assay Kit 10111 100 assay 63 000 IT KDNA I Topo Il Immunofluorescence Kit 1030 50 assay 73 000 Topo I FITC Topo Il Immunoprecipitation Kit 1035 50 assay 73 000 1 Topo 1 WB Marker 2011 4 20 unit 43 000 9 Cosmo Bio News No 55 Es
82. PIPs 1 0 PIPs FPP NaS tHE mp pt mira EL mW oe lipkds Fram coll lyiatse a te Thr Hoe Hr frre Ca art 1 mm FU Ra of FIP Meh PIP Mass ELISA Sr Fete SE motrarted pi Tnrm ce rae rt me rn ay Quickly quarrtfies up i FE Gh iat EE TT HLLE HELL ELI ELLEErETLEI PIPs ELISA Plate Echelon o D PIPss Mass ELISA K2500 1 kit 136 500 PIPss Mass Strip Kit K2400 1 kit 53 000 io ehelon Insf l 4 5 Ps rs EE Insf 1 3
83. 20S Proteasome Assay Kit 205 96 well 5085 Suc LLVYAMC AMC Ex 360nm Em 460nm epoxomicin P50S5 CS 208 human erythrocyte Guc LLVY AMC MW 763 9 20S6 Epoxomicin MW 554 7 7 amino 4 methylcoumarin MW 175 1 1 2 volume BIOMOL International LP BMOM AK740 1 kit 89 000 0S
84. GPCR Paul Greengard 1 DoDRH cAMP L Huei Tsai 4 Par 4 D2DHR CAMP D DR 9 D DR Par 4 cAMP Par 4 D2DR
85. 10 KD M 10 KD M En Membrane Enhancement Solution 1 x solution 250mg ELISA ELISA E IP IP IHC ICC Membrane Blocking Solution 1 X solution 250mg IHC ICC IHC AmpliCruzi HRP Primary Secondary Dilution Buffer 5x salution 100mg PVDF 2005 06 I 0 202 41
86. S flash BACIW flash BACTM ORF 1629 BAC Bacterial Artificial Chromosome flash BAC DNA 1 100
87. ShRNA shRNA SUDerArray BiOSCience COrDoration KH00088G _KH00088N AKT1 AKT2 KH00289G KHO00289N AKTS KH01317G KH01317N ARAF KH00061G KH00061N BAP1 KH02153G KH02153N BIRC2 KH00340G KHO00340N BRAF KH00712G KH00712N CASP3 KH00107G KH00107N CASP7 KH00110G KH00110N CASP8 KH00359G KHO00359N CD80 KH00860G KHO00860N CD86 KH00826G KHO00826N CDC2 KH00116G KH00116N CDC25C KH02198G KHO02198N CDC42 KH00729G KH00729N CDK4 KH00118G KH00118N CDK7 KH00935G KH00935N CHUK KH00649G KHO00649N CYLD KH18819G KH18819N E2F2 KH00918G KHO00918N ELK1 KH00140G KH00140N ENG KH01140G KH01140N ETF1 KH10052G KH10052N FBXWT7 KH06317G KHO6317N GSK3A KH01354G KH01354N GSKSB KH00787G KH00787N HDAC1 KH01735G KH01735N HDAC2 KH01717G KHO1717N HDAC3 KH05911G KHO05911N HRAS KH00159G KH00159N IKBKB KH00780G KH00780N ILK KH00737G KH00737N INPP5D KH00788G KH00788N INPPL1 KH02318G KHO02318N IRAK1 KH00835G KHO00835N ITGAV KH00628G KHO00628N JAK1 KH00770G KH00770N JAK2 KH00758G KH00758N JAKS3 KH00778G KH00778N KRAS KH00181G KH00181N LRDD KH02157G KH02157N MAP2K1 KH00711G KH00711N MAP2KZ KH00096G KHO00096N MAPSK14 KH00332G KHO00332N MAPSK2 KH01773G KH01773N MAPSK5 KH00744G KHO00744N MAPSKZIP1 KH01804G KHO01804N MAP4K1 KH01788G KHO01788N MAPK1 KH00715G KH00715N MAPK14 KH00750G KHO007S50N MAPK3 KH00721G KH00721N MAPK8 KH00720G KHO00720N MAPKAP1 KH16946G KH16946N MAR
88. 2004 S00 a eg i Ny NE Wi i FE LL Sheppard Vice President Amber Veysey Administrative Assistant Dr Ben Voysey Technical Sales Specialist Mrs Sylvia Arthurs Order Processing and Accounts Dr lan Varndell Vice President Dr Paul Mr Matthew Parnell Operations Manager Miss 5 1 Amerik et al 1997 EMBO J 16 4826 4838 2 Behrens et al 1998 Science 280 596 599 3 Berezutskaya et al 1997 J Biol Chem 272 30135 30140 4 Bo
89. Elsevier 15 1 4 5 IPs IPs ER ER EF STIM EF ER 6 19 STIM
90. lgG 0 1 mg 151015 150715 151715 50815 151815 1 0 mk 500 assay 25 000 lgG 0 2 mg 151012 150712 151712 150812 151812 2 0 mg 1 000 assay 44 000 Conjugate 0 1 mg 151025 150725 151725 150825 151825 1 0 mg 500 assay 29 000 Conjugate 0 2 mg 151022 150722 151722 150822 151822 2 0 mg 1 000 assay 53 000 a Positive Control 151053 150753 151753 150853 151853 12 assay 5 000 CD Negative Control 150043 150043 150043 150043 150043 12 assay 5 000 7 0 CS 1 oS 24 C Y 4 11
91. 196 _ Yeast Mouse E GS SDS PAGE 662099 Human Dog Human Dog T 419700 M Saccharomyces cerevisiae A B mock polyUb
92. Perspectives Editorial Guides STKE Reviews WConnections Maps NNN 2 2 SU Signaling database 6 10 This Week in Signal Transduction Summary
93. SiRNA 4 1 x 105cell 360 2 37C 5 COs 5 0 80 0 2pg siRNA 40u2g DMEM u Easy Trangate si W 0 37C 5 COs 4 siRNA 109 FBS 37C 59 CO0s 4 24 RNAi FITC siRNA Easy Trangate siTV 3T3 90 America Pharma Source LLC Tonics RNase DNA
94. 4C 1 5 DNA serum free 2 serum free 1 Invitrogen Lipofectamin Lipofectamin 2000 CELLFECTIN Roche FuGENE6 Novagen GeneJuice Promega Tfx 20 ChiA flash BAC LBAc ef2 1 eENE onFieg Transfer Vector CA 1 fflash BAC DNA GENE IORF1689 Reconbinant Virus Oxford Expression Technologies 100150 5 reaction 100 000 100151 24 reaction 432 000 100152 96 reaction I Cosmo Bio News No 5 TEL 03 56328 9610 FAX
95. TIR1 Ecker mRNA Flowering Locust T FT mRNA 5 F
96. 2 500 GS 2 Wnt S ga Ga 5 Cosmo Bio News No 55 Cosmo Bio News No 55 E3 E E E3 E1 Ub E2 Ub E 1 E82
97. FT DNA DNA extraction kit 1 100 002 1 kit 19 000 Bioluminescence kit 1 100 007 1 kit 19 000 Transgenesis kit 1 100 006 1 kit 19 000 DNA DNA analysis kit 1 100 008 1 kit 19 000 9 PCR PCR kit 1 100 003 1 kit 19 000 DNA DNA degrating kit 1 100 004 1 kit 19 000 DNA DNA binding kit 1 100 005 1 kit 19 000 DNA DNA electrocataphoresis kit 1 100 009 1 kit 19 000 1 Cosmo Bio News No 55 S 8 Ep Tdpl 4C 0C 7O0C 196C Tdp 1 Tyrosy DNA Phosphodiesterase Tdp1 D I DNA dp1 1 DNA 3 Topo ED
98. G0S5 Cosmo Bio News No 55 MHC S08 11S 3 EBV LMP EBV CFTR 1 9 UPS
99. mRNA ZBP 1 mRNA ZBP 1 Src mRNA mRNA RNA RNA miRNA miRNA Paul Greengard miRNA Schier 1 miRNA
100. atig I i 2 3 Nm FF M13K07 TG1 WI3K07 LE TEL EO i hl Eh I ja Spring Bioscience SBS PHDS 101 1 kit 44 000 CDNA CDNA
101. David Bredt Roger Nicoll Snyder D D2DR Gi 3 5 cAMP CAMP PKA
102. J C Rain L M Camargo P J Whiting M D Houslay D H R Blackwood W J Muir D J Porteous DISCT and PDE4B are interacting genetic factors jn schizophrenia that regulate cAMP signaling Science 310 1187 1191 2005 0 5 Rosenberg S Deindl R J Sung A C Nairn J Kuriyan Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme Cell 123 849 860 2005 J Liou M L Kim W D Heo J T Jones J W Myers J E Ferrell Jr T Meyer STIM js a Ca sensor essential for Ca t store depletion triggered Ca influx Cur Biol 15 1235 1241 2005 J Roos P J DiGregorio A V Yeromin K Ohlsen M Lioudyno S Zhang 0 Safrina J A Kozak 8S L Wagner M D Cahalan G Velicelebi K A Stauderman STIM 1 an essential and conserved component of storeoperated Ca channel function J Cel IBiol 169 435 445 2005 5 L Zhang Y Yu J Roos J A Kozak T J Deerinck M H Ellisman K A Stauderman M D Cahalan STIM1 js a Ca sensor that activates CRAC channels and migrates from the Ca store to the plasma membrane Nature 437 902 905 2005 E J Baxter L M Scott P J Campbell C East N Fourouclas S Swanton G S Vassiliou A J Bench E M Boyd N Curtin M A Scott W N Erber A R Green Cancer Genome Project Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders Lancet 365 1054 1061 2005 C Jame
103. 596 Suc Leu Leu Val Tyr AMC GST UDL GST Merok Ltd eSECT Proteasome Isolation Kit 539176 1 kit 72 000 5 auo 006 8 31 50 http www cosmobio co jp iT Cosmo Bio News No 55 ls Fluoro Jade C
104. M A Bl zquez The right time and place for making flowers Science 309 1024 1025 2005 8 Bornholdt Less is more in modeling large genetic networks Science 310 449 451 2005 R Brent L Lok A fishing buddy for hypothesis generators Science 308 504 506 2005 A Sawa S H Snyder Two genes link two distinct psychoses Science 310 1128 1 129 2005 Reference 1 DO EO OO NW TRWM C Darwin The Power of Movement in Plants Murray London 1880 F W Went On growth accelerating substances In the caoleoptile of Avena sativa Proc K Ned Akad Wet 30 10 19 1986 N Dharmasiri S Dharmasiri M Estelle The F box protein TIR is an auxin receptor Nature 435 44 1 445 2005 S Kepinski 0 Leyser The Arabidopsis F Dox protein TIR1 is gn auxin reCceptor Nature 435 446 451 2005 T Huansg 0 Eriksson F Parcy 0 Nilsson The mRNA of the Arabidopsis gene FT moves from leaf to shoot apex nd induces fIOwering Science 309 1694 1696 005 M Abe Y Kobayashi S Yamamoto Y Daimon A Yamaguchi Y Ikeda H Ichinoki M Notaguchi K Goto T Araki FD a bZIP protein mediating Signals from the floral pathway integrator FT at the shoot apex Science 309 1052 056 2005 P A Wigge M C Kim K E Jaeger W Busch M Schmid J U Lohmann D Weigel Integration of spatial and termporal information during floral induotion In Arabidopsis Science 309 10
105. Substance P 36 HRP x 5 A B TMB 2N a i R amp D Systems Inc RSll PGE gt 27 5 pg 79 39 2 500 pg 2 KGE004 1 kit 63 000 10 1 pg 19 6 1 250 pg LTB4 27 6 pg ml 39 2 500 pg 2 KGE006 1 kit 68 000 Substance P 31 5 pg 0 39 2 500 pg 9 KGE007 1 kit 68 000 Cortisol 0 071 ng mk 0 156 10 ng 79 KGE008 1 kit 52 000 Parameter V Creatinine Assay Jaffe
106. _ Ub ATP Mg Ub E1 EG E3 mixture CBB
107. E 1 9 RING 1 BRCA 1 RING E3 2 7 RING E3G 400 RING 70 000 100 000 9 mm 48 48 K48 6 4 K6 K11 K 8 K63 K6G3 DNA K63
108. INTERNATIONAL INISIGIN In AR DI9IOII aDODtOSIS acetylation deacetylation dene regulation kinases phosphatases lipid research neuroscience DroteaSeS ubiquitin proteasome 2006 3 1 135 0016 2 2 20 URL http www cosmobio co jp N Tel 03 5632 9610 03 5632 9620 Fax 03 5632 9619 March 2006 No 0S
109. shHNA RNAi Suresilencing W shRNA Promega GeneClip M U1 Hairpin Cloning System GFP Linealized pGeneClip M hMGFP Vector Promega Cat No C8790 Linealized pGeneClip V Neomycin Vector Promega Cat No C8780 70 0 SureSilencing shRNA 100 Se 80 0 5 60 0 oO oo lt 40 0 O gt PA cr ll _ RARA _ SIAT STAT3 ITGA MTA2 NFBKIA 6 HEK 2993 shRNA Real time RT PCR 70
110. ON OFF UP DOWN 75W 140W 120kcal h 50Hz 7I 50Hz 2m 50Hz 13mm 230 W X395 D X455 H mm 25kg 7 15 CT 15WS ST 15WS FT 15WS 50 CHIP50 FT 50WS CT 50WS NG6 ST 50WS NG50 3 UCD 250 900 000 TEL 03 56328 9610 FAX 03 5632 9619 IO 1
111. Young Core transcriptional regulatory Circuitry in human embryonic stem cells Cell 122 947 956 2005 J Ptacek G Devgan G Michaud H Zhu X Zhu J Fasolo H Guo G Jona A Breitkreutz R Sopko R R McCartney M C Schmidt N Rachidi S J Lee A S Mah L Meng M J Stark D F Stern C De Virgilio M Tyers B Andrews M Gerstein B Schweitzer P F Predki M Snyder Global analysis of protein Dhosphorylation In yeast Nature 438 679 684 2005 Citation E M Adler N R Gough L B Ray 2005 Signaling breakthroughs of the year Sci STKE 2006 eg 1 2006 Year American Assooiation for the Advancement of Science All rights reserved PTTT Web STKE Signal Transduction Knowledge Environment Science Web STKE http stke sciencemag Org 4 http www cosmobio co jp STKE index html STKE 4 srkE Protocols Original Protocol
112. 000 NK105 78 000 AI Adult Right breast NF106 62 000 NK106 78 000 at 1 3 4 5 Adult Left Axillary Skin NF107L 62 000 NK107 78 000 Adult Right Axillary Skin NF107R 62 000 Adult Left hand dorsum NF108 62 000 NK108 78 000 Adult Left forearm NF109 62 000 NK109 78 000 Adult Eyelid Skin NF110 62 000 NK110 78 000 Adult Left forearm volar NF111 62 000 NK111 78 000 Adult Right wrist NF113 62 000 NK113 78 000 Adult Right thigh NF114 62 000 NK114 78 000 Child Right abdominal Scar NF115 62 000 Adult Earring Clelts NF116 62 000 NK116 78 000 Adult Forehead NF117 62 000 NK117 78 000 Adult Abdominoplasty NF118 62 000 NK118 78 000 CellResearch Corporation Pte Ltd 3 4 OS Human Dermal Fibroblasts isolated from Normal 8 Human olold bro plasls MN Skin i a Pbroblasis P3 i MM 1 i V NEST one ff NVEST one _ Adult Right wrist KF101 265 000 a EE Adult Te earlobe KF103 265 000 G G Adult Left deltoid KF104 265 000 NSKF10
113. 03 5632 9619 S Ep EE cDNA 4C 0C 70C 196C Phage Display DNA 200bp 2 000Dbp pV VI HRP TMB single solution cDNA SPRING CG EN Ready to use
114. 4 5 P Inst1 4jPo P a P Inst4jP Inst1 3 4 jPa Echelon Biosciences InC Ins 1 3 P2 Q 0013 Ins 1 4 Ps Q 0014 Ins 1 5 P2 Q 0015 Ins 1 2 6 Ps Q 0126 Ins 1 4 5 Ps Q 0145 Ins 1 3 5 Ps Q 0135 Ins 1 3 4 5 Pa Q 1345 0 5 mg 102 500 0 5 mg 146 000 0 5 mg 428 04 146 000 0 5 mg 551 99 146 000 0 5 mg 551 99 107 000 0 5 mg 551 99 146 000 0 5 mg 675 93 146 000 1 0W Cosmo Bio News No 55 S Ep 4C 0C 7O0C 196C
115. ATP Mg E1 E2s amp E3s 26S Ubiquitin Conjugation Kit K Reticulocyte Lysate Rabbit BC11 1 mg 10 000 BC12 5 ml 30 000 BC13 10 md 45 000 Fraction Rabbit BC14 50 mg 10 000 Fraction II Rabbit BC15 10 mg 20 000 E1 E2 E3mixture Rabbit BC16 100 pb 50 000 Ub n Lysozyme Ub Bovine Lysozyme hen egg white BC24 100 pl 30 000 MK Mouse 20G10 CHK Mouse 21A8 MS Rat Mouse Anti Lysozyme Anti Ubiquitin Chain Anti Ubiquitin WB IP IHC BC20 400 pk 50 000 WB IP IHC BC21 50 000 50 000 WB IP IHC HKDM 3 S Ub Sepharose Ub Bovine 20 BC18 1 mg 60 000 TEL 03 56328 9610 FAX 03 5632 9619 6 Cosmo Bio News No 55 Cosmo Bio News No 55 i 4C G0C 7OC
116. Bio News No 55 Cosmo Bio News No 55 Ei CAMP CAMP Snyder David Porteous 4B PDE4B PDE4B DISC1 disrupted in scChizophrenia 1 PKA cAMP DISC1 PDE4B PDE4B Snyder 2
117. OPD4000 SMP30 D N Blood Group antigen ACM AB24217 100 ug 64 000 BMP30 o D Box Binding Protein ACM AB26157 50 g 64 000 NCR2 ACM AB25911 50 pk 64 000 PAD Peptidylarginine Deiminase SMP30 Detyrosinated c Tubulin ACM AB24622 50 2 64 000 NCR3 ACM AB26250 50 pb 64 000 0 DHX36 BL2420 BET A300 525A 0 1 mg 63 000 Neuromedin B Receptor CMN AB9221 50 Ag 77 000 PAD DISC1 Mid ZYM 40 6900 100 g 65 000 NeUIOIUIGGID U Receptor 1 GPR66 CMN AB9455 50 g 77 000 5 PAD PAD PAD3 PAD4 5 SML_ DOCK9 BL2262 BET A300 530A 0 02 mg 63 000 Neuropeptide FF 2 Receptor CMN AB9225 50 g 77 000 Rl Dopamine Receptor D1 CMN AB9141 50 g 77 000 NKX2 8 ACM AB26054 50 pg 64 000 Dopamine Receptor D4 CMN AB9422 50 g 77 0
118. per a EN BIDMN DL Echelon Biosciences Inc ECL a Cell Biolabs Inc CBL 13 gt 4 flash BAC M Oxford Expression Technologies OET 14 cDNA Spring Bioscience SBS 1 5 Full Moon Biosystems Inc FMB SureSilencing V ShRNA SuperArray Bioscience Corporation SPA 16 Easy Trangater V America Pharma Source LLC APS 17 RNaseDNA Molecular Bio Products MBP ed LBN 18 Tdp 1 Topogen Inc TOP 19 ie El Parameter Kit R amp D Systems Inc RSD 20 NM tL ae Human PMN Elastase ELISA Biovendor Laboratory Medicine Inc BVL 21 Human Clara Cell Protein ELISA Biovendor Laboratory Medicine Inc BVL CellResearch Corporation Pte Ltd CRC 22 WEST one INtRON Biotechnology Inc INB 23
119. 00 NMDAR2A phospho Y1292 ACM AB16644 100 Lg 42 000 Anti SMP30 Rabbit HU MS RAT ROI001 30 000 Dopamine Receptor D5 CMN AB9509 50 g 51 000 Nogo B ACM AB26398 50 g 64 000 Anti PAD2 Rabbit HU ROI002 30 000 DPP10 ACM AB25857 50 g 64 000 Nogo C ACM AB26401 50 g 64 000 Anti GFAP Rabbit HU MS RAT ROI003 30 000 DSPG3 RSD AF2875 100 g 75 000 NS 0 Host Cell Proteins ACM AB25809 100 g 64 000 Cosmo Bio News No 55 Bf Cosmo Bio News No 55 2005 Science AAAS American Association for the Advancement of Science a STKE STKE STKE 2006 Breakthroughs of the year 2005 AAAS S005
120. 022 1 000 g 150 000 Stanniocalcin 1 AF2958 75 000 Adrenoceptor a 2c CMN AB9409 50 g 51 000 Follicle Stimulating Hormone FSH COR CR2109M3 1 7jg 80 000 PADI4 PAD4 ACM AB26071 100 g 64 000 SULT4A1a b AP2610A 27 200 Adrenoceptor B 2 CMN AB9410 50 g 77 000 Follicle Stimulating Hormone ReceptorlFSHR CMN AB9425 50 g 77 000 PAEL Receptor GPR37 CMN AB9245 50 g 77 000 SUPT5H AB26259 64 000 Adrenoceptor B 3 CMN AB9411 50 g 77 000 FormyI Peptide Receptor 1 FPR1 CMN AB9155 50 g 77 000 PATE ZYM 40 4100 100 g 65 000 Aflatoxin B1 aldehyde reductase member2 GNW CB A22294 100 ug 69 000 Formy Peptide Receptor Like 1 FPRL1 CMN AB9427 50 g 77 000 PCMF ACM AB16296 50 g 64 000 Tachykinin Receptor 1 AB9297 77 000 AKAP9 ACM AB25805 50 g 64 000 Formyl Peptide Receptor Like 2 FPRL2 CMN AB9426 50 g 90 000 Pds5B BL2352 BET A300 537A 0 02 mg 63 000 Tachykinin Receptor 2 AB9493 90 000 ALK 80 DBS RMAB 007 0 5m 79 000 c 1 3 fucosyltransferase GNW CB A22682 100 ug 69 000 Pepper Mild Mottle Virus BRA 161712 0 2 mg 44 000 Tachykinin Receptor 3 AB9299 77 000 Aminoacylase 1 GNW CB A22335A 100 g 69 000 1 Peropsin CMN AB9468 50 Ag 90 000 TAOK1 BL2382 AS300 524A 63 000 Antigen 85 A GNW CB A22813 100 ug 69 000 GCM1 ACM AB26137 50 g 64 000 Petunia Asteroid Mosaic Virus BRA 170822 0 2m 53 000 TAS1R1 AB9435 77 000 ApoB LDL 18 MAB 3715 7 0 25
121. 1 E E3 ES a HECT RING EG E6 AP E3 p53 RING GCF APC RING E3 E 1 HING c CDbI c CDI SHP
122. 1 265 000 ee oO a YY Adult Right hand HSF102 I 1 8 000 1 1 16 000 2 1 32 000 3 1 64 000 4 Adult Left arm HSF103 265 000 Adult Right foot HSF104 265 000 Adult Left hand HSF105 265 000 NSHSF105 265 000 iNtRON Biotechnology Inc NB Adult Right forearm HSF106 265 000 NSHSF106 265 000 1 1vial 5x 105cells WEST one Western Blot Detection System 16031 100 mg 9 500 16033 200 mg 2 Cosmo Bio News No 55 Cosmo Bio News No 55 23 S Tandem WV IHC PT MIC5 ED S 8 HiLyte Fluor V 4C 0C 7O0C 196C DOJIINDO MOLEC
123. 24961 100 pg 64 000 Meprin B Subunit MEP1B RSD MAB28952 100 Lig 42 000 Claudin 13 ZYM 40 4900 100 g 68 000 Metadherin Mid ZYM 40 6500 100 ug 65 000 Collagen4 oc 1 KAM MC 887 1m 129 000 MGC4618 ACM AB26133 50 g 64 000 Collagen4 c3 KAM MC 886 1 9 129 000 MGL HCB HM1081 100 ug 49 000 mm Collagen4 a 5 KAM MC 885 1 129 000 MIER1 ACM AB26254 100 Lg 64 000 1 COLQ ACM AB26139 50 g 64 000 Mirafiori Lettuce Big Vein Virus BRA 161622 0 2 mg 53 000 1 TP PT EE SD SMP30 Senescence Marker Protein 30 30 PADG CO ST RSD BR 57 E 50 sa CG EE amp EB Link DBS 0 100 0 ZOO 34KDa 2 6 9 76kDa PAD I 6 Connexin 39 C term ZYM 40 6200 100 LE 68 000 MRC5 Host Cell Proteins ACM AB25807 100 LE 64 000
124. 4 265 000 a r Child Right helix ear KF105 265 000 LL 1 1 1 1 G G Adult Left earlobe KF106 265 000 Adult Left anterior earlobe KF107 265 000 EE Adult Left posterior earlobe KF108 265 000 a Adult Right elbow KF109 265 000 KK109 468 000 Child Left cheek KF110 265 000 NSKF110 265 000 KK110 468 000 1 2 Adult Right back KF111 265 000 NSKF111 265 000 KK111 468 000 Adult Right cheek KF112 265 000 NSKF112 265 000 KK112 468 000 3 4 3 4 Adult Left earlobe Helix KF113 265 000 KK113 468 000 EE le 1 1 l 3 a Adult Right back KF114 265 000 NSKF114 265 000 KK114 468 000 wEsTone 1 WEST one Keratinocytes isolated from normal skin adjacent to Keloid available G G CellResearch Corporation Pte Ltd egCRCT I 1 J 1 1 1 Human Hypertrophic Scar derived Fibroblasts P3 ei en Pi LL 1 G L 1 1 G WEST one G Adult Left wrist HSF10
125. 4C 60C 70C 196C SUMO SUMO Small ubiquitin related modifier E 1 Aos 1 Uba Aos 1 E N Uba2 C Uba SUMO SUMO E2 UbcHd SUMO C RanGAP1 SP100 p53 I Bo PML vitro EG SUMO SUM01 3 C
126. 5 HU ADV 129 MEKK3 HU ADV 162 Cre HU ADV 005 as 154 000 50u 70C DN Dominant Negative CA Constitutively Active Temperature Sensitive Mutant 2004 19 Null Adenovirus Vector 293AD Cell Line Cell Biolabs Inc B ADV 001 50 pk 123 000 AD 100 1 vial 70 000 QuickTiter Adenovirus Titer Immunoassay Kit 5 CS Anti Hexon Antibody 1000X Secondary Antibody HRP Conjugate 1000X DAB Substrate 25X Diluent 10X Ad p gal Positive Control 103 104 105 Anti Hexon QuickTiter Adenovirus Titer Immunoassay Kit VPK 109 1 kit 100 Y92 000 Cosmo Bio News No 55
127. 56 1059 2005 8 HUtelmaier D Zenklusen M Lederer J Dictenberg M Lorenz X Meng G J Bassell J Condeelis R H Singer Spatial regulation of actin translation by Sro dependent phosphorylation by ZBP1 Nature 438 512 515 2005 A GiraldeZ R Cinalli M Glasner A Enright J M Thomson S Baskerville S Hammond D Bartel A Schier MicroRNAs regulate Drain morDhogenesis in zeDrafish Science 308 833 838 2005 N Vo M E Klein 0 Varlamova D Keller Yamamoto R Goodman S Impey A CAMP response elerment Dinding protein Induced microRNA regulates neuronal morphogenesis Proc Nati Acad Sci U S A 102 16426 16431 2005 5 Tomita H Adesnik M Sekiguchi W Zhang K Wada J R Howe R A Nicoll D S Bredt Stargazin modulates AMPA receptor gating and trafficking by distinct domains Nature 435 1052 1058 2005 5 K Park M D Nguyen A Fischer M P S Luke E B Affar P B Dieffenbach H C Tseng Y Shi L H Tsai Par 4 links dopamine signaling and depression Cell 122 275 287 2005 J M Beaulieu T Sotnikova S Marion R Lefkowitz R Gainetdinov M Caron An Akt 8 arrestin 2 PP2A signaling complex mediates dopaminergic neurotransmission and behavior Cell 122 261 273 2005 J K Millar B S Pickard S Mackie R James S Christie S R Buchanan M P Malloy J E Chubb E Huston G 8 Baillie P A Thomson E V Hill N J Brandon
128. 6 tagged ISG15 ubiquitin crossOreactive protein UCRP UbcH7 UW9135 Energy solution 0 1M MgATP pH 7 0 50 UbcH9 un tagged RanGAP1 1k Bo PML SUMO 1 E3 UW9320 UbcH10 His6 tagged E2 C cdc2 UW8715 te UbcH12 His6 tagged in vo NEDD8 Uba3 APP BP1 NEDD8 UW9145 UbcH13 Mms2 His6 tagged 63 UW9565 Katherine Ferrell Caroline R M Wilkinson Wolfgang Dubiel and Colin Gordon BIOMOL International LP _ BMO_ Information additional to that published in Trends in Biochemical Sciences 65 2 83 88 2000 UW8975 AFR
129. 8 29 Anopheles gambiae G9 Vivier Nolan Heard 4 Marc Vidal ji jj
130. 83L H86L HU ADV 203 p38 a MS ADV 104 c Raf HU ADV 132 PAK1 T423E HU ADV 204 p38 oc DN MS ADV 105 c Raf DN HU ADV 133 PAK H83 86L K299R HU ADV 205 p38B HU ADV 106 MEKK1 HU ADV 135 PAK1 L107E T423E HU ADV 206 p38 B DN HU ADV 107 MEKK1 DN HU ADV 136 PAK1 K299R HU ADV 207 p38 y HU ADV 108 MAPKAPK2 MS ADV 137 NFkB Signaling p38y DN HU ADV 109 MAPKAPK2 DN MS ADV 138 lk B a HU ADV 301 p38 8 DN HU ADV 111 MAPKAPK2 CA MS ADV 139 lk B c S32A DN HU ADV 302 ERK2 HU ADV 112 PRAK DN HU ADV 141 IKK B DN HU ADV 303 ERK2 DN HU ADV 113 SOK1 HU ADV 142 Rel B HU ADV 304 JNK1 HU ADV 114 SOK1 DN HU ADV 143 NOD 2 HU ADV 308 JNK1 DN HU ADV 115 SOK1 CA HU ADV 144 Tyrosine Kinases ERK5 HU ADV 116 Ras N17 DN HU ADV 145 Src HU ADV 401 ERK5 DN HU ADV 117 Ras V12 CA HU ADV 146 Fyn HU ADV 403 MEK1 DN HU ADV 118 Ras V12S35 HU ADV 147 Fyn DN HU ADV 404 MEK1 CA HU ADV 119 Ras V12C40 HU ADV 148 CSK HU ADV 405 MKKS3 HU ADV 120 Rac HU ADV 149 CSK DN HU ADV 406 MKK3 DN HU ADV 121 Rac1 N17 DN HU ADV 150 Cell Cycle Control MKK3 CA HU ADV 122 Rac1 L61 CA HU ADV 151 p53 HU ADV 501 MKK6 HU ADV 123 Cdc42 HU ADV 152 p53 HU ADV 502 MKK6 DN HU ADV 124 CDC2 N17 DN HU ADV 153 DCC HU ADV 504 MKK6 CA HU ADV 125 Rho A N19 DN HU ADV 156 ejalige MKK7 HU ADV 126 Rho A L63 CA HU ADV 157 B galactosidase HU ADV 002 MKK7 DN HU ADV 127 MKK4 DN HU ADV 160 SEAP HU ADV 003 MKK7 CA HU ADV 128 MKK4 CA HU ADV 161 GFP HU ADV 004 MEK
131. 9 000 Endogenous Retrovirus Type K Gag Protein ABI HERM 1841 5 100 ug 108 000 Olfactory Receptor OR10R2 CMN AB9461 50 g 90 000 Sphingolipid Receptor Edg1 S1P1 AB9488 77 000 ADAM 23 GNW CB A21429 100 g 69 000 Endothelin Type B Receptor Like Protein 2 CMN AB9147 50 g 90 000 Olfactory Receptor OR16 OR23 CMN AB9235 50 g 90 000 Sphingolipid Receptor Edg3 S1P3 AB9289 77 000 Adapter related protein complex 3 B 2 subunit GNW CB A21448A 100 ug 69 000 Engrailed and Invected ACM AB12454 200 g 64 000 2 5 oligoadenylate synthetase 1 GNW CB A22064F 100 g 69 000 Sphingolipid Receptor Edg5 S1P2 AB9489 77 000 Adapter related protein complex 3 o2 subunit GNW CB A22217F 100 ug 69 000 a Enolase GNW CB A22683 100 ug 69 000 ovomucoid CB 1 CBN CH 004 0 1 mg 50 000 Sphingolipid Receptor Edg6 S1P4 AB9490 77 000 Adenylate kinase isSoenzyme 6 GNW CB A21282 100 ug 69 000 Epoxide hydrolase ACM AB23850 100 pk 64 000 P Sphingolipid Receptor Edg8 S1P5 AB9293 63 000 ADP ribosylation factor 7 GNW CB A21248 100 ug 69 000 Erysimum Latent Virus BRA 170922 0 2 mg 53 000 P2Y9 GPR23 CMN AB9444 50 g 90 000 SREB3 AB9491 90 000 ADP ribosylation factor Iike protein 4A GNW CB A22257F 100 g 69 000 F P2Y10 CMN AB9476 50 g 90 000 39S ribosomal protein L28 mitochondrial CB A21943 69 000 Adrenoceptor co 1d CMN AB9115 50 g 77 000 FLVCR ACM AB26075 100 ug 42 000 p24 DTV ANT0
132. Activation of T Cells DBS MOB 414 1 7 99 000 Sirtuin Type 1 ABI TM 501 55 150 g 67 000 ZNF207 AB26258 64 000 CBP Associated Factor ABI TM 701AX 55 150 Lg 67 000 LLO DTV ANT0007 1 000 g 158 000 Sirtuin Type 3 ABI TM 511 55 150 g 67 000 ZNF212 AB26044 64 000 Cdk4 inhibitor B ACM AB26094 50 g 64 000 LOC153222 ACM AB26262 50 g 64 000 Sirtuin Type 4 ABI TM 521 55 150 g 67 000 ZNF306 AB26142 64 000 CDK5RAP2 BL2317 BET A300 554A 0 1 mg 63 000 LR11 CMN AB9374 100 g 57 000 Sirtuin Type 7 ABI TM 541 55 150 g 67 000 ZNF336 AB26163 64 000 CELSR1 CMN AB9417 50 g 90 000 Lysophosphatidic Acid Receptor Edg2 LPA1 CMN AB9441 50 g 77 000 2 20 3 I CELSR3 CMN AB9419 50 5 77 000 Lysophosphatidic Acid Receptor Edg4 LPA2 CMN AB9442 50 Lg 77 000 ABG G02 0FF Centaurin c 2 ACM AB26067 100 ug 42 000 LVsophosphatidic Acid Receptor Edg7 LPA3 CMN AB9199 50 jg 77 000 006 3 1 Chemokine C C motif Receptor Like 1 CMN AB4248 50 Lg 77 000 NM Chemokine C C motif Receptor Like 2 CMN AB4249 50 g 90 000 M Blood Group antigen ACM AB24215 100 g 64 000 LR or LE 5 ChT1 ACM AB
133. Anti Mouse HRP 4017 1 1 kit 50 130 000 Tandem IHC Staining Kit for Bim Anti Rabbit ALP Anti Mouse HRP 4018 1 1 kit 50 130 000 1 Tandem IHC Staining Kit for Bcl 2 Anti Rabbit ALP Anti Mouse HRP 4019 1 1 kit 50 130 000 Pr 0 a Tandem IHC Staining Kit for Bcl x Anti Rabbit ALP Anti Mouse HRP 4020 1 1 kit 50 130 000 50 200mg Tandem IHC Staining Kit for ER c phospho Anti Rabbit HRP Anti Mouse ALP 4021 1 1 kit 50 130 000 0 MS W II Tandem IHC Staining Kit for Keratin 8 Anti Rabbit ALP Anti Mouse HRP 4022 1 1 kit 50 130 000 0 MG 0 RO OO NN op O QQ op O Tandem IHC Staining Kit for Keratin 18 Anti Rabbit ALP Anti Mouse HRP 4023 1 1 kit 50 130 000 4 Sg 5 Sg 8 Tandem IHC Staining Kit for p53 Anti Rabbit HRP Anti Mou
134. C K Ea Z J Chen Identification and charaoterization of MAVS a mitochondrial antiviral signaling protein that activates NF kappaB and IRF9 Cell 122 669 682 2005 L G Xu Y Y Wang K J Han L Y Li Z Zhai H B Shu VISA is an adapter protein required for Virus triggered IFN beta signaling Mol Ce 19 7 7 740 2005 G Altan Bonnet R N Germain Modeling T cell antigen discrimination based on feedback control of digital ERK responses PLoS Biol 3 e356 2005 K Sachs 0 Perez D Pe er D A Lauffenburger G P Nolan Causal protein Signaling networks derived from multiparameter single cell data Science 308 523 529 2005 N A Heard C C Holmes D A Stephens D J Hand G Dimopoulos Bayesian COclustering of Anopheles gene expression time Series Study Of immune defense response to multiple experimental challenges Proc Natl Acad Sci U S A 102 16939 16944 2005 J R Pomerening S Y Kim J E Ferrell Jr Systems level dissection of the cell cycle oscillator Bypassing positive feedback produces damped oscillations Cell 122 565 578 2005 0 Brandman J E Ferrell Jr R Li T Meyer Interlinked fast and slow positive feedDack Ioops drive reliable Cell deCisions Science 310 496 498 2005 L A Boyer 1 Lee M F Cole S E Johnstone S S Levine J P Zucker M G Guenther R M Kumar H L Murray R G Jenner D K Gifford D A Melton R Jaenisch R A
135. EE 0 day 5 WW i a 2002 CRC a a MI oe 1 TN HO 2weeks mm 2weeks CRC Ene iOn Stabilizer 1 12weeks Ru esa A WEST one V B A CellResearch Corporation Pte Ltd 500 Spray 3 MEST_onerV 0 per Oe click HRP tagged 16weeks mE me 10 RGD Human Dermal Fibroblasts P3 Normal Human Keratinocytes P3 _ 0 2 Ab 1 2 20 10 5 2Lg Adult Breast NK101 78 000 Adult Breast NK102 78 000 Child Right duplicate thumb NF103 62 000 NK103 78 000 Child Groin NF104 62 000 NK104 78 000 Adult Lateral arm NF105 62
136. I HCB HP9038 100 g 64 000 Proteasome 20S B 7 ACM AB22641 50 2 64 000 TNFSF18 AB25948 64 000 Axons of the Drosophila CNS ACM AB12455 100 Lg 64 000 HEK293 Host Cell Proteins ACM AB25806 100 Lg 64 000 R Tomato Black rRng Virus 113112 44 000 B Histone H1 2 ACM AB17677 100 g 64 000 Radish Mosalic Virus BRA 162412 0 2 mg 44 000 Tomato Bushy Stunt Virus 161822 53 000 Bag5 ACM AB24314 100 ug 64 000 HOXA13 ACM AB26084 50 g 64 000 RBM10 ACM AB26046 100 Lg 64 000 Total Goat Milk Proteins AB25824 64 000 BAL ZYM 40 4400 100 g 65 000 REST BL2502 BET A300 539A 0 1mg 63 000 TRAFD1 AB25942 64 000 BD 1 PTI 500 P253 50 g 39 000 IG BP 5 PTI 500 P232BT 50 g 62 000 Roquin BL2413 BET A300 514A 0 1 Mg 63 000 Triticum vulgaris AB20528 64 000 BD 3 PTI 500 P241 100 Lg 62 000 IL 12 C15 6 MAB 3451 3 250 0 25 mg 34 000 RRM2 ACM AB26170 50 g 64 000 Trophinin 05 946 56 000 Bean Common Mosaic Necrosis Virus BRA 162112 0 2 mg 44 000 J RSF Complex Large Subunit ABI TM 561 55 150 g 67 000 Turnip Yellow Mosaic Virus 162522 53 000 Bean Common Mosalic Virus BRA 162012 0 2 7 44 000 JC BK Viruses Polyomavirus ACS MEDCLA375 1 ml 144 000 RSF Complex Small Subunit ABI TM 551 55 150 g 67 000 TXNL1 AB26171 64 000 Brain Specific Angiogenesis Inhibitor 1 BAI1 CMN AB9364 50 g 51 000 JIK TAOK3 BL1823 BET A300 535A 0 1mg 63 000 S U Brain Specific Angiogenesis Inh
137. IM proteins to the peripheral structures in Store Operated Calcium influx Sci STKE 2005 tw262 2005 A Constitutively active JAK2 mutant underlies polycythemia vera Sci STKE 2005 tw 165 2005 Antiviral signaling from the mitochondria Sci STKE 2005 tw324 2005 Modeling signaling networks Sci STKE 2005 tw157 2005 A model of regulation Sci STKE 2005 tw378 2005 Connections Maps Conneoctions Map Database Sci STKE http stke sciencemag org cm Perspectives G Balazsi Z N Oltvai Sensing your surroundings How transcription regulatory networks of the cell discern environmental signals Sci STKE 2005 pe20 2005 C Hisatsune K Mikoshiba Novel compartment implicated in calcium signaling lsit an induced coupling domain Sci STKE 2005 pe53 2005 W G Kaelin Jr Gleevec Prototype Or outlier Sci STKE 2004 pe12 2004 H K Manji 1 Gottesman T D Gould Signal transduction gnd genes to behaviors pathways in psychiatric diseases Sci STKE 2003 pe49 2003 J P Morris IV M T McManus Slowing down the ras lane miRNAs as tumor suppressors Sci STKE 2005 pe41 2005 A Pollack Coactivation of D1 and D2 dopamine receptors In marriage a case of his hers and theirs Sci STKE 2004 pe50 2004 E E Schadt A Sachs S Friend Embracing complexity inching closer to reality Sci STKE 2005 pe40 2005 H Vaucheret MicroRNA dependent tran
138. J UbcH10 K UDc13 MMS BIOMOL International LP BVO Ubiquitinylation Kit AFR BMO UW9920 105 000 ES 5665 E 1 E G E3 3
139. K2 KH13048G KH13048N MTA2 KH13564G KH13564N NFKBIA KH00170G KH00170N NKIRAS1 KH13574G KH13574N NRAS KH00200G KHO00200N PAK1 KH01505G KHO01505N PAK2 KH15987G KH15987N PDK1 KH20207G KH20207N PDK2 KH00810G KHO00810N PIK3CA KH01355G KH01355N PIK3CB KH00789G KHO00789N PIK3CD KH06292G KHO06292N PIKSR1 KH00713G KH00713N PIK3R2 KH00709G KHO00709N PLCB1 KH02818G KHO02818N PLCB4 KH02809G KHO02809N PLCG1 KH00710G KH00710N PRKAA1 KH00043G KHO00043N PRKDC KH01309G KHO01309N RARA KH00472G KHO00472N RASSF1 KH08711G KH08711N RELA KH01812G KHO01812N RPS6KA1 KH02298G KHO02298N RPS6KA2 KH05699G KHO05699N RPS6KAG6 KH01983G KHO01983N RPS6KB1 KH00791G KHO00791N SRC KH00103G KHO00103N STAT1 KH00811G KHO00811N STAT3 KH00708G KHO00708N TNFRSF5 KH00296G KHO00296N TP53 KH00213G KHO00213N 1 000 80C 1 Cosmo Bio News NOo 55 S Ep ER Easy Trangater M America Pharma Source Easy rangater M SIiRNA DNARNA
140. T FT FD 1 mRNA 1 mRNA Ravi lyengar 1 Huttelmaier
141. ULAR TECHNOLOGIES INC DNA 2 50 200 g RabMAb IM A
142. ayer et al 1999 In Proteasomes D Wolf and W Hilt eds Berlin Springer Verlag in press 32 Mizushima et g 1998 Nature 395 395 398 33 Mizushima et al 1998 J Biol Chem 273 33889 33892 34 O Brien et al 1999 Science 286 458 481 35 Schmidtke et al 1996 EMBO J 15 6887 6898 36 Shintani et al 1999 EMBO J 18 5234 5241 37 Tamura et al 1998 Cell 95 637 648 38 Terrell et al 1999 Mol Cell 1 193 202 39 Tomkinson et al 1999 Sciences 24 355 359 40 Wigley et al 1999 J Cell Biol 145 481 490 41 Yaron et al 1997 EMBO J 16 6486 6494 42 Zhu et al 1996 Proc Natl Acad Sci 93 3275 3279 43 Zhu et al 1997 J Biol Chem 272 51 57 1993 00 0 UM il UN 50
143. empcmWrscdko 250 Dk Ii a 10X6cm 15 0 Santa Cruz Biotechnology Inc AmpliCruz SC 45049 1 kit 16 000 24 Cosmo Bio News No 55 Cosmo Bio News No 55 8 S S 8 4C 0C 70C 196C EE ER BOREBA TR FASTKIT
144. expression system flash BAC 9 flash BAC flashBAC EE FCL LE HELL ED 1 1 Sf 1 97 9 2 1 5x 1 08cell dish 1 A 500 serum free 100ng 7 gs BAC DNA 500ng B 500mg serum free 1 3 A B 15 4 3 5 P 8C 5 1 serum free 5 6
145. ibitor 2IBAI2 CMN AB9413 50 Ag 90 000 L SALF ACM AB23195 200 Ag 64 000 USP9x 64 000 Brain Specific Angiogenesis Inhibitor 3 BAI3 CMN AB9125 50 g 90 000 Lano ACM AB25953 100 ug 64 000 SAMSN1 ACM AB21206 100 ug 64 000 V BTLA RSD AF3007 100 g 75 000 Latrophilin 1 CMN AB9191 50 g 90 000 Serotonin Receptor 1F 5 HT1F Receptor CMN AB9402 50 g 51 000 VasopreSsin V2 Receptor CMN AB9313 77 000 0 Latrophilin 2 CMN AB9440 50 g 90 000 Serotonin Receptor 2B 5 HT2B Receptor CMN AB9403 50 g 77 000 VDR NR1I1 RSD 2ZH4537H 131 000 Calcium Calmodulin Kinase 2 pThr286 BFG AB CAMKTP286 100 100 pk 122 000 Latrophilin 3 CMN AB9193 50 g 90 000 SF3a 120 SPS 204 011 100 g 94 000 Vomeronasal 1 Receptor 1 VN1R1 CMN AB9501 63 000 Calcium Calmodulin Kinase 2 pThr305 BFG AB CAMK TP305 100 100 pk 112 000 LEF 1 all isoforms KAM MC 883 100 ug 98 000 SIN 3 Associated Protein p18 ABI TM 601 55 150 g 67 000 Calibrachoa Mottle Virus BRA 170715 0 1 mg 25 000 Leukotriene B4 Receptor BLT1 CMN AB9544 50 g 81 000 SIN 3 Associated Protein p30 ABI TM 611 55 150 Lg 67 000 ZA20D3 AB26136 64 000 cAMP responsive element binding protein 3 like 1 OASIS OBG PAB 11254 100 g 50 000 Leukotriene B4 Receptor BLT2 CMN AB9547 50 g 81 000 Sirtuin Tpe 5 ABI TM 531 55 150 ug 67 000 ZFPL1 AB26057 64 000 Cauliflower Mosaic Virus BRA 162215 0 1m 25 000 Linker for
146. in ELISA Kit Anti Clara Cell Proten RD191022200 1 kit 97 000 WB ELISA RD181022220 0 1 mg 32 000 500pg m2 20pg m8 25 2 100ng m2 450nm BALF Biovendor Laboratory Medicine Inc i BV 9Wo0ender 20 Cosmo Bio News No 55 TEL 03 56328 9610 FAX 03 5638 9619 Cosmo Bio News No 55 i S S 8 4C 0C 7O0C 196C TS WEST one Ep 4C 0C 70C 196C 0
147. io News No 55 2 52 2006 3 31 50 iPod mini 1 160 200 250W AC100V 50 60Hz 4A 235 W X215 D X215 H mm 9 2kg 175 W 160 D X310 H mm 4 6kg 210 W X255 D X310 H mm 2 5kg 99 59 5 99 99 99 99 6 0 5 1 5 10 15 3 50m2 600 W X500 D X400 H mm 20kg UCD 250 CP 80R 10 1 5 2C
148. lar Bio Products i MBI 7002 475 mk 3 800 7003 1 6 400 7005 4 9 12 800 7000 12 x 250 mg 38 400 7010 250 mk 2 600 Cosmo Bio News No 55 W S TR TE DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA TDNA
149. lices FACIT 1 o 1 2 93 NC 16 FAGIT amp T 10 1 1 NC
150. mg 40 000 GEF H1 HCB HM2152 100 Lg 58 000 Pokemon FBI 1 BL2685 BET A300 548A 0 1mg 63 000 TAS1R3 AB9183 90 000 ApoB LDL 20 MAB 3715 2 250 0 25 mg 34 000 G protein a 16 ACM AB24501 100 g 64 000 Potassium Channel kv3 2 SBS E10804 200 Lg 95 000 Tau13 AB24634 64 000 Apoptotic protease activating Factor 1 GNW CB A21169 100 g 69 000 G protein B subunit like ACM AB25974 100 g 64 000 Potassium Channel Kv4 3 SBS E10694 200 ug 95 000 TFIIE y Large Subunit TM 281 55 67 000 Apple Stem Pitting Virus BRA 151822 0 2 mg 53 000 G Protein Coupled Receptor MRGX2 CMN AB9533 50 g 95 000 Potato Mop Top Virus BRA 113025 0 1 mg 29 000 TFIIE y Small Subunit TM 271 55 67 000 Arfaptin 2 GNW CB A22336B 100 g 69 000 Grapevine Leafroll Assoc Virus 2 BRA 120812 0 2 mg 68 000 POU2F3 ACM AB26045 50 g 64 000 TFIISH AB26141 64 000 ARHGAP29 GNW CB A21560 100 ug 69 000 Grapevine Leafroll Assoc Virus 7 BRA 121022 0 2 mg 78 000 PP4R1 ACM AB26231 100 ug 64 000 5 TG 3 interacting factor CB A21970F 69 000 Aubergine Stin9 ACM AB17724 100 ug 64 000 GTF2H1 ACM AB26167 50 g 64 000 Prostaglandin E Receptor EP4 CMN AB9257 50 Ag 77 000 Throxine T4 CR1053M3 80 000 Avian Influenza Matrix Protein ACM AB25918 50 g 64 000 H Proteasome 19S Subunit S5B RDI RDLPROT26S5BABR 100 pug 132 000 TMEM16A AB16293 64 000 Avian Influenza Nucleoprotein ACM AB25921 50 g 64 000 HAKA
151. s V Ugo J P Le Couedic J Staerk F Delhommeau C Lacout L Garcon H Raslova R Berger A Bennaceur Griscelli J L Villeval S N Constantinescu N Casadevall W Vainchenker A unigque Clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera Nature 434 1144 1148 2005 R Kralovics F Passamonti A S Buser S S Teo R Tiedt J R Passweg A Tichelli M Cazzola R C Skoda A gain of function mutation of JAK jn myeloproliferative disorders N Engl J Med 352 1779 1790 2005 R L Levine M Wadleigh J Cools B Ebert G Wernig B Huntly T Boggon 1 Wlodarska J Clark S Moore Activating mutation In the tyrosine kinase JAK jin polyCythemia vera essential thrombocythemia and myeloid metaplasia with myelofibrosis Cancer Cell 7 387 397 2005 R Zhao S Xing Z Li X Fu Q Li S B Krantz Z J Zhao Identification of an acquired JAK2 mutation in polycythemia vera J Biol Chem 280 22788 22792 2005 T Kawai K Takahashi S Sato C Coban H Kumar H Kato K J Ishii 0 Takeuchi 8S Akira IPS 1 an adaptor triggering RIG 1 gnd Mda5 mediated type 1 interferon Induction Nat Immunol 6 98 1 988 2005 E Meylan J Curran K Hofrmann D Moradpour M Binder R Bartenschlager J Tschopp Cardiff is an adaptor protein in the RIG antiviral pathway and is targeted by hepatitis C Virus Nature 437 1167 1 1 7 2005 R B Seth L Sun
152. s acting siRNA production Sci STKE 2005 pe43 2005 E Werner Meeting report The future and limits of systems biology Sci STKE 2005 pe16 2005 Review D S Charney H K Manji Life stress genes and depression Multiple pathways lead to increased risk and new opportunities for intervention Sci STKE 2004 re5 2004 Protocol D Pe er Bayesian network analysis of signaling networks A primer Sci STKE 2005 pl4 2005 Teaching Resources R D Blitzer Long term potentiation Mechanisms of induction and maintenance Sci STKE 2005 tr26 2005 Slides http stke sciencemag org cgi content full sigtrans 2005 309 tr26 DC1 A Contractor S F Heinemann AMPA receptor cycling in the synapse Sci STKE 2004 tr7 2005 Resource Details http stke sciencemag org cgi content full sigtrans 2004 255 tr7 DC1 K S Kosik A M Krichevsky A model for local regulation of translation near active synapses Sci STKE 2005 tr25 2005 Animation http stke sciencemag org cgi content full sigtrans 2005 300 tr25 DC1 D C Weinstein A journal club discussion of regulation by microRNA Sci STKE 2005 tr24 2005 Forum D L Gill R L Patterson E conference Defining calcium entry signals Sci STKE Forum gs seen January 2006 http stke sciencemag org cgi forum display stkeforum 14 34 Cosmo Bio News No 55 Cosmo Bio News No 55 Ei Virtual Journal
153. se ALP 4024 1 1 kit 50 130 000 Tandem IHC Staining Kit for ErbB2 HER2 Anti Rabbit ALP Anti Mouse HRP 4025 1 1 kit 50 130 000 1ug IgG 3mL PBS Dojindo Molecular Technologies Inc MI RnH Fluorescein Labeling Kit NH2 LKO1 3 DreD 21 000 Tandem IHC Detection Kits HiLyte Fluor 555 Labeling Kit NHz LK14 3 prep 21 000 HiLyte Fluor 647 Labeling Kit NH2 LK15 3 prep 21 000 TandemrM IHC Staining Kit DMT EE AmpliCruz Epitomics InC
154. slides non barcoded Protein slides non barcoded FMB Full Moon Biosystems Inc EMB 25 slide 84 000 50 slide 169 000 25 slide 81 000 50 slide 163 000 OO Cosmo Bio News NO S ER SureSilencing V shRNA superamay 70 RNA shRNA SureSilencing shRNA RNAi U1 GFP
155. yer et al 1996 Cancer Res 56 4620 4624 5 Brehm et al 1999 J Cancer Supplement 1 80 38 41 6 Chen et al 1997 J Biol Chem 272 24081 24087 7 Doherty et al 1987 Biochem J 241 793 800 8 Earl et al 1987 Biochem J 241 809 815 9 Freed et al 1999 Genes and Develop 13 2242 2257 10 Gerards et al 19998 J Mol Biol 275 113 121 11 Glas et al 1998 Nature 392 618 622 12 Glickman et al 1998 Cell 94 615 623 13 Groettrup et al 1997 Cancer Gene Therapy 4 308 309 14 Hicke 1999 Trends in Cell Biol 9 107 112 15 Higashitsuji et al 1999 Nature Medicine in press 16 Hiller et al 1996 Science 273 1 725 1 728 17 Hiyami et al 1999 J Biol Chem 274 28019 280825 18 Hofmann et al 1999 Cell 96 645 653 19 Jensen gg 1998 Oncogene 16 1097 1112 0 Joazeiro et al 1999 Science 286 309 312 1 Johnston et al 1998 J Cell Biol 143 1883 1898 22 Kaelin et al 1998 Trends in Genetics 14 423 426 23 King et al 1996 Science 274 1652 1659 24 Lam et al 1997 Nature 385 737 740 25 Laszlo et al 1991 J Pathol 164 203 214 26 Liakopoulos et al 1998 EMBO J 17 2208 28214 7 Lorick et al 1999 Proc Natl Acad Sci 96 11364 1 1369 28 Lupas et al 1997 Trends In Biochemical Sciences 22 399 404 29 Matunis et al 1996 J Cell Biol 135 1457 1470 30 Mayer et al 1998 Folding and Design 3 R97 R99 31 M
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