No.1591 - 国立病院機構 仙台医療センター
Contents
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11. utut DL DTE l 450 P gp BCRP 1 1 BCRP CYP3A P gp CYP3A
12. CYP3A CYP3A CYP2C19 2C9 3A4 2 1912 9 4 in vitroj CYP3A 2014 11 DSU 234 HUB US C B ORR L3 O O E s pz 55 0000
13. 2014 11 DSU 234 CDE BR ooo 200000 u DSM 000 000 000 DSM American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorder
14. BCRP
15. E jun 5 O O L3 L3 LJ 4E Lr 1 m E i 3
16. utut DL DTE l 450 P gp BCRP 1 1 BCRP CYP3A P gp CYP3A
17. 2014 11 DSU No 234 P 00000000000000
18. 30mg 15ny HIV 30ny 15mg Y GTP ALT GPT AST GOT ALP LDH 000000000000 2014 11 DSU 234
19. CK CPK
20. 00000000000 2014 11 DSU No 234 CA KS RA 000 2000000
21. 5 500m 25mj 5 50m amp 5 0o00 UUUUUUUUUUUUUUUUUUUUU C oo BD RAE AER ES o o E o o o o o ED RAE DAI o o D E IL o oo o o o 2014 11 DSU 234
22. 0000 000 E 00000000 Meijiseikal 0 0 O pod00000 000000000 M0000 poed000000000 000000000000 pagado 0000000000000 DODO0DO 000000000000 000000 pegado 0000000000 m00000000000000 0000000000000 00000 000000
23. 15mL min 60kg 30mg 2 30nL nin 50nL nin 15nL min 30nL 30mg PT INR APTT 40kg
24. 2014 11 DSU 234 000000000 M000000 SE 000 000 Bcn 000 00000000 0000 000
25. Bin aaa EA A EA E 0000 una P450 4 000000000000000 000000000000000000 0000000000000 0000000000000000 2014 11 DSU No 234 000 00000000000 C Ea 00018 0000 108mg
26. u t 1 50 000 75 000 rmi 2 000 3 000 2 50 000 2 000 1 5my kg HBV HBV HBV
27. 00000000000 00000 2014 11 DSU No 234 i C OO DBCS O o 0 00 00 0000 0000 4
28. 0000000000000 000 000000000 0 D AAA 00001078 000 0000 2014 11 DSU No 234
29. 2014 11 DSU 234 100 50my
30. 2014 11 DSU 234
31. ec BB DOE RICH TR 00000 0000 0000 1 1 a 1
32. 000000000000000 Ae o MO BET TH EP a 0000 1 SGLT2
33. AST GOT ALT GPT Y GTP ALP LDH BUN BUN TSH TSH FTs CRP 2014 11 DSU No 234 SA poo 000000 0000 0000
34. S mE BABIES HH 0000 NID MODULE 00000000000000000 0000 BOTE BEDE EOE BU pu en 0000 24 2014 63 887 893 Dau poo
35. 2014 11 DSU No 234
36. 000000000000000000000 00000000 0000000000 000000 c 000000000000000000000 0000 0000
37. 1 SGLT2 0000000000000000 2014 11 DSU No 234 i
38. AUC 4 0000000000000 E 2014 11 DSU No 234 000 00000 0000 0000 000000000000000000
39. 2 5 2 0000000000000 2014 11 DSU No 234 ANE NoE RR RR 000 000000
40. P gp BCRP
41. 000000000000000 MEM U 000080000000000000000 uum o o o CA BA 0000 0000 00000000000
42. Toxic Epidermal Necrolysi TEN Stevens J ohnson 000000000000000 00000 O 0 000 s aaa qa 01 0000 MID 000080000000000000 0000000000000 0000000000 0000000000000000 0000000000000 0000000 0000000000000 00 000000 pogo 000000000 000000000
43. poo 0000 eijiseika 0 D 0000000000 0000 2014 11 DSU 234 CA 000 0000000000000 0000 0000 000000000000000000
44. 2014 11 DSU 234 B
45. 80my kg 40my 0000 0000 2014 11 DSU 234 ege pr gp EIER POR D000000000
46. 00000000000 e qa FIBER ED 200000 0000 0000 2014 11 DSU No 234
47. 0000000000000 A POS D Bag BYENE ANENE DD 000 P 2014 11 DSU No 234 1 SGLT2
48. 55 55 0000000 000000 000000000 0 0 0 0 0 0 0 000000000 000000000000 0000000000000 000000000000 00000000000 00000000 000000000 0 0 0 0000000 000 000 0 000 0 0 000 0 0 0 000 0 000 000000000 000 0 000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 uu 0 0 0 0 Phi E BU BERE 0000
49. H 2014 11 DSU 234 CA RU RR PR P EI RH B 000 00000000000000 0000 0000 HBs HBc HBs er IEEE ABIT 00000 uut
50. 2014 11 DSU 234 E 2 5
51. 1 PT INR 2 3 PT APTT FXa APTT 4 PT INR 30mg 15mg 60mg 30my PT INR 24 PT INR PT INR 5 24
52. pg000000000000 000000000 pog000000000 000000000 pg0000800000 0000000000000 mod0 000000000000 mod0 00000 Modo 0000 0000000000 poed000000000000000000 000 0 000000000000 0 0 0 00000000 0000000 000 000 0 000 000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 aaa re aaa 0000 0000
53. 000000000000000000 P 2014 11 DSU No 234
54. AST GOT ALT GPT 0000 A 2 gt Uu E B e N S DDD 00000000 0000 c p0 P tg 000 0 00 DO un a Aa o o
55. 0 2000000000000 000000000000 2014 11 DSU 234 euge mpra EB A AED 000 00000000 0000 0000 000000000000000000 000000000000000000 AST ALT AST ALT GPT
56. 00000000000 2014 11 DSU No 234 ege E EE RE DS EL LR EL EHE 000 00000 NOAA DPP 4 GLP 1 GLP 1 QA GLP 1 SGLT2 S ll a
57. 2014 11 DSU 234 2014 11 DSU 234 12
58. 2014 0000000000000 2014 11 DSU No 234 A 000000
59. cGMP CYP3A4 CYP3A4 AUCoa CYP3A4 AUC 16 Cmax AUC 10
60. 0000000000000 0000000000000 2014 11 DSU No 234 UUM o o aaa anda 0000 1 SGLT2
61. 36 m OCOD p 25mg emm 37 m Hi RU A ACV A RBA A HU 7 AS 38 m 39 m 39 a pumakuna em 1 m 0000 po00000000000 p0000000000000000 pg8000000000000000000 pod000000000000 po800008000000000000000 pog0000000000000000000 pog000000000000 poedg0000000000000 po000
62. 1 GLP 1 GLP 1 SGLT2 L
63. H 2014 11 DSU 234 2014 11 DSU 234
64. 2014 11 DSU 234 100my 50my kg 80my kg 40my HIV
65. EJ 11 OO L3 L3 EIL ET EX III 2014 11 DSU No 234 C aaa 000000 0000 0000 000000000000000000 000000000000000000 Cmax
66. Z EU 24u g ES esa 10 gg 5 Ty 11 2529 OSAT eM HH 11 OEMS DAA DRA mm 12 167 GEE 13 ERIAN GE 458 OSAT e 13 BAVI GT WR FUT VERBA CERT RAM T m 14 15 EH AE RA CR TINE 40mg P 16 MZ REY U22227 BE eee eene 17 9 BUE nennen 20 m i FRE 25mg EE 20 ByruZUVZTVERHGABMSCACUAVVZNHERM nennen 21 m TAVIVIF k FI TRIT BE 20mg 21 m EM DATING Za X 99 77 V 1 871 5 FU 250mg 1000mg 99 eene nennen 23 BIER Q2 AMRVIAVS3aM 40mg ees Pene CD 25 50mg 200mg 200mg 96 EN 300mg Z 3 E 27 m Jame Tuay u IT io e eger 27 PIEYRE N 28 mi t u 100mg O 30 MUELA RAI O a 31 mut u UE EV BEK ULPIA EE eene 33 E USE WAYRA 35 W RLERCOEZAUA b lU Z UE A AA
67. RS DOR POR FRU aa 000 Dun 0000 0000 000000000000000000 25mg 5mL 100mg 10 15mL 5 200 500ml 0 75my CE EE CET HU HI 00000
68. C3 C3 C3 C3 SO 3 C3 C3 C3 SO 3 C3 C3 C3 C3 C3 Im r3 r3 C3 CO 2 C3 C3 C3 mi 3 CO CO O O O 3 C3 C3 C3 C3 INE Ej EG TJ E td 2 3 C3 C3 C3 C3 C3 MIE VL EE 13 O O a O um O Dg a ono 20 ger d EZE sa C3 r3 E3 9 Dn gt El Bog o Ds I LLL E E ETE 1 E s 00 E ET 5 000 EPI EA TEIG EA METER 15 2 CTI dc mg LIII L E EI E EJ E E rrr O OOO a A 3 O m J xa Pali zs maa EJ i 3 CO O C3 EP ET GEL ET L I SO O E3 EI qu 0 mi L3 ET ET sZ T Jm 3 ET O mi 3 O C3 EF SES EA UE 3 LIEN i 3 OOO a rJ 3
69. z 5 u a B e N a 0000 0000 000 0000 000 000 uu SGLT2
70. 2014 11 DSU No 234 CE DEE PCR 000 0000000000 000 0000000006 0000060 UUUUUUU 000000060 000000 0000 000000000000000 0000000000000 000000000 00000000000000000 0000000000000 000 000000000000 M00000000000 000000000000 CAMA img 0000000000 00000000000 00000000000 00000 0000000000000 0000000000 00000000000 000000000 Aaa
71. UUM o o aaa 0000 1 SGLT2
72. CAMERE IS No 1591 R2 6F11 FA 6B MOTE a ve AMA pe hE RE WfR4104 ORADE Drug Safety Update 233 2014 10 TREX RO SKET ENELEOT ORAS e 39 XI o WC UL x 2145 XM Drug Safety Update 2014 11 No 234 JE E 55 BA D SE tn Fs E m FS Z Qu E 200 y zZF7S2Z2Z JG EK 100mg 200mg ZEYT 1000mg 3 m TAVIVIF V BACKS TRIT BE 20 3 EFAS IIRA NT EI 40mg 4 CABEZA 0 5 mm 4 MZ GEREN GEGSISRIEJHLA 3L AM L 0 5 4 DNA JE 5 m 7 zF7S22 EDS AR 2 2d 200 TENTAR ZE AM E 100mg 200mg 1 5 m ZK AABT A SS 6 Kalue TORA ZVEZA D SE 7 7 m gt Z Zk 0 005 nas 8 ILLA AA s 8 BLASTER GARR 8 TARA 9 40mgIR V 72777 49 TE 20mg 100mg 9 m ku 2 TTS25mg 9 m RZ 10 7124 h 20091 296 HU FREE O YX 209 MM 10
73. 000000000000000 0900900000000 0000000000Mejisekpopboo 0000000000000 0000000M000000 pog000000000 2014 11 DSU No 234 aS 000 0000000000 000000000000000 0000000000000000 00000000000000000000000 000000000000000000 000000000000000000 000000000000000000000 0000000000000000 CEE URE BOS OE OTD TD
74. 1 SGLT2 000000000000000 a aa U EME BEI 0000
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