こちら - 3D MATRIX [medical technology]
Contents
1.2. DDS
3. pH
4. IR http www sharedresearch jp 27 33 2012 4 25 7777 2012 4 12 2012 4 1
5. SR mc SR mc f http www sharedresearch 1D 3 31 12 6 03 5834 8787 Email info sharedresearch jp http www sharedresearch jp 35 35 Shared sseareh
6. IT 3 2 http www sharedresearch jp 3 II 1 D 0 3 x 1 9 7 35 Shared eseareh 2012 4 25 7777
7. Sires MTA
8. 4 1992 MIT Shuguang Zhang R A D 3 RADA 16
9. MIT MIT MIT 2001 5 3 D Matrix Imc 3 D Matrix Imc 100 3 D Matrix Europe SAS 100
10. amp 2
11. 2 100 MTA MIT 3 D MatrixInc 2003 4
12. 3 D Matrix Inc 2004 3 D Matrix Inc 2000 4
13. 2007 10 579 1 448 3DM Investmen LLC Massachusetts Institute of Technology 2009 11 00 1 20 4 JAIC TAIB JAIC Asian Balanced Private Equity http www sharedresearch jp 26 35 Shared Geseareh 2012 4 25 7777 Fund 2010 9 2010 9 Pharmaceutical Co LTD 200 400 300 600
14. 2013 2014 4 2014 4 2014 E 4 E 4 2013 4 EU 2015 4
15. sr_inquiries sharedresearchjp 07 4 08 4 09 4 10 4 11 4 12 4 1 10 10 402 158 1 100 805 2 4 5 60 6 594 8 467 641 37 2 65 482 300 637 3 16 3 304 7 187 222 259 60 510 256 187 223 296 61 534 255 a 1 893 2
16. 2015 4 2012 4 CE EU CE 2013 4 2012 4 2015 4 2012 2013 4 EU CE fH HT TDM 621
17. 2 DDS DDS SPP
18. 2011 4 PMDA TDM 621 1 http www sharedresearch jp 5 7 35 2012 4 25 7777 P 158 232 406 482 509 533 SR 1 100 300 256 255 1 991 401 778 453 453 452 11 4 12 4 13 4 14 4 2 977 705 892 634 634 472 2011 10 24 2014 4
19. PMDA FDA 2 3 TDM 711 TDM 641 TDM 631 TDM 621 RADA16 TDM 621 97
20. C 1987 C 1 2008 1 30 2008 12 14 6 1 2009 11 30 2010 1 2007 12 160 2008 1 2009 3
21. ul SR
22. http www sharedresearch jp 23 35 Shared Gesearch 2012 4 25 7777 2012 4 http www sharedresearch jp 24 35 Shared esearch 2012 4 25 7777
23. http www sharedresearch jp 17735 shared eseareh 2012 4 25 7777 US 5670483 2014 11 29 TE Ft 4 US 6548630 2003 4 15 2017 7 21 PuraMatrix WO 06 014570 2008 259860 MM US 5955343 1999 9 21 2014 8 21 US 6800481 2004 10 5 2017 3 25 PuraMatrix OO US 7098028 2006 8 29 2023 3 16 5 a US 7449180 2008 11 30 2021 2 5 uraMatri EP 717398 2008 1
24. 1 2013 4 2 3 2013 4 2013 4 2014 4 E
25. http www sharedresearch jp 18 35 Shared sseareh 7777 2012 4 2S MIT J lt aaa 2012 4 60
26. TDM 641 TDM 641 TDM 641 TDM 621
27. http www sharedresearch jp 27 35 SNeredQoewrdh 2012 4 25 7777 http www sharedresearch jp 28 35 Shared Sseareh pt sy 2012 4 25 7777
28. 2012 4 1 2011 5 PMDA TDM 621 2 E rr a 400 TDM 621 400 190 210 204 204
29. 1 4202 2009 Medmarket Diligence 1 4503 1 3401 CSL 1 4559 AH
30. TDM 621 TDM 621 2 TDM 711 2011 7 FDA IDE 2012 4 12 4 11 4 158 400 594 8 233 87 146 9 21 7 406 254 256 3 63 6 482 59 241 300 14 7 510 9 247 256 2 3 534 9 246 255 SR
31. siRNA 21 23 RNA siRNA RNA RNAi RNA mRNA MTA Material Transfer Agreement
32. 59 9 3 http www sharedresearch jp 4 35 4 1 385 683 E 10 24 JASDAO 2011 10 23 2011 Shared Geseareh 2012 4 25 7777 TDM 621 TDM 621 2 TDM 711 2011 7 FDA IDE
33. SR E Shared Geseareh 2012 4 25 7777 1 2 3 0 2013 4 TDM 621 2009
34. 2012 4 2 2011 12 9 2012 4 2 2 400 TDM 621 341 9 N hy 676 2 535 2011 400
35. 7 000 5enl 5914 598 180 re 2173 0 171 0 171 3 170 7 5 000 4 000 3 000 2 000 1 000 J a i 2006 2007 2008 2009 TDM 621 1 E 07 08 ll 09 10 11 12
36. TDM 711 2011 3 FDA IDE IDE 3 http www sharedresearch jp 23 35 SNeredQoewrdh 2012 4 25 7777 07 4 08 4 09 4 10 4 544 589 33 39 17 39 594 666 7 6 19 22 537 467 42 38 578 505 604 533 304 986 733 1 198 1 199 12 16 4 24 0 0 15 9 31 49 0 0 0 0 0
37. TDM 631 TDM 631 TDM 631 1 1 TDM 631 X B
38. PuraMatrixrw PuralMatrixTM Ac R A D A R A D A R A D A R A D A CONH R A D http www sharedresearch jp 8 35 Shared sseareh 2012 4 25 7777 HE 4 E
39. TDM 621 2013 4 2013 4 2012 2013 4 CE EU CE TDM 641 TDM 631 TDM 711 2013 4 2013 4 2013 4 H 2014 4 2014 http www sharedresearch jp 2014 4 E 4
40. Drug Delivery System 0 pH http www sharedresearch jp 33 35 Shared Geseareh 2012 4 2
41. MIT Exclusive Patent License Agreement MIT 2004 10 3 D MatrixImc License and Supply Agreement 3 D Matrix mc 2007 10 3 D MatrixInc f 3 D Matrix Inc MIT v
42. Massachusetts Institute of Technology IMTT Shuguang Zhang 2004 1992 MIT Shuguang Zhang MIT MIT 2001 5 3 D Matrix Inc 2004 5 2004 10 3 DMatrixInc LICENSE AND SUPPLY AGREEMENT
43. PuraMatrix 2007 10 3 D Matrix Inc 2008 2 Becton Dickinson and Company SUPPLY AGREEMENT PuraMatrix RADA16 2008 3 2008 10 2009 4 2009 7 2009 8 PMDA 2010 1 2010 8
44. RI TDM 621 3 12 4 12 4 1Q Me 3Q 4Q 400 0 0 36 4 1 100 yo 40 47 45 yoy a 150 104 112 yo 210 151 157 300 yo 52 6 204 195 158 256 yoy 51 1 204 196 159 255 7o 51 1 SR http www sharedresearch jp 3 35 Shared sseareh 2012 4 2 7777 2012 4 3 2012 3 9
45. pH ADME 30 DDS MIT MIT
46. http www sharedresearch jp 32 35 Shared sseareh 2012 4 25 7777 Scaffold GLP Good Laboratory Practice pH
47. TDM 641 2012 2 E 7 FDA IDE 2012 2 20 2011 Wk Phase I
48. HH TDM 711 IDE 2012 2 Forsyth Institute 2010 9 4 ES a E TDM 711 FDA TIDE 2011 1 siRNA E
49. 2 http www sharedresearch jp 34 35 Shared esearch 2012 4 25 7777 SR
50. 3 4 RADA16 lt SS SS I se 2 IA my A A a 2 10
51. ON OO 2 fed a 2 H EE A ee nh
52. 15 7 35 TDM 711 E TDM 711 e Shared eseareh e 2012 4 25 7777 TDM 711 GLP 7 C DDS DDS
53. Excelsior Medical Co Ltd 14 000 1cc SR b TDM 641 TDM 641 TDM 641
54. a TDM 711 TDM 711 E http www sharedresearch jp 3 1
55. SR mc SR mc Shared Research SR mc SR mc SR mc SR mc
56. CRO i MT 1 E 2013 4 TDM 621 E PII II i 2
57. Ma 2 3 4 8 5 6 7 1 PMDA FDA TDM 621
58. 7777 bFGF PDGE PuraMatrix R A D 16 RADA16
59. Excelsior Medical Co Ltd Daewoong 2011 10 1 352 700 1 07 4 08 4 09 4 10 4 11 4 4 7 7 0 7 0 8 5 9 5 EPS 39 614 3 39 414 9 42 400 4 7 870 6 58 896 1 60 9 EPS DPS 0 0 0 0 0 0 0 0 0 0 0 0 BPS 59 531 5 137 228 4 97 502 8 137 634 2 120 159 5 1 893 2 792 2 817 3 392 3 792 4 567 EPS 99 0 98 5 106 0 19 7 147 2 60 9 EPS DPS 0 0 0 0 0 0 0 0 0 0 0 0 BPS 148 8 343 1 243 8 344 1 300 4 SR 2011 7 1 100 948 201
60. TDM 621 TDM 621 TDM 621 http www sharedresearch jp 12 35 Shared sseareh 2012 4 2
61. MBA 1999 JASDAQ7774 2002 2370 COO 2003 10 2005 2007 1998 1 2005 http www sharedresearch jp 30 7 35 2012 4 2
62. 2012 4 gt 1 gt tN 1 2012 3 5 2012 a gt EB 9 abies gt http www sharedresearch jp 10 7 35 2012 4 25 7777 A a TDM 621
63. 13B1X10105 2010 9 3 D Matrix Imc IDE FDA Daewoong Pharmaceutical Co LTD PARTNERSHIP AGREEMENT Excelsior Medical Co Ltd LICENSE AGREEMENT 2011 5 PMDA PMDA 2011 7 3 D Matrix mc EFDA IDE 2012 1 2012 2 http www sharedresearch jp 29 35 lt Shared Geseareh 2012 4 25
64. 3 D Matrixmc a 0 MIT Scientific Founders 2007 10 3 D Matrix mc 1992 MIT Shuguang Zhang 2001 5 MIT 3 D Matrix Imc 2003 4 3 D Matrix Inc MIT Exclusive Patent License Agreement 2004 5 2004 10 3 D MatrixInc LICENSE AND SUPPLY AGREEMENT 3 D Matrixmc
65. CPC Scientific Inc TDM 621 2011 5 PuraMatrix Becton Dickinson and Company A6K E siRNA DDS 3 3 http www sharedresearch
66. http www sharedresearch jp 22 35 SNeredQoewrdh 2012 4 25 7777 2 000 5 6 1 800 5 4 1 400 Proprietary 8 0 1 200 Nonproprietary 1 9 1 000 cw 800 2 8 0 a 0 14 6 0 Millennium Research Group US Market for Dental Biomaterials 0 2010 6 o 4 2 2008 2009 2010 2011 2012 2013 2014 MIT CSL
67. 30 TDM 621 122 482 2010 4 65 310 60 334 61 TDM 621 2010 4 2011 4 PMDA 2010 8 2010 9 Daewoong Pharmaceutical Co LTD PARTNERSHIP AGREBEMENT Excelsior Medical Co Ltd LICENSE AGREEMENT
68. 30 50 2016 1 344M ipArA 1 600 M 1 400 1 200 1 000 800 600 400 200 0 CY06 CYO07 CY08 CY09 CY10E CY11E CY12E CY13E CY14E CY15E CY16E SEALANTS HEMOSTATS a H 80 10 113 685 11 526 60 10 5 6 Millennium Research Group
69. 6 7 35 1 2012 4 25 7777 2013 4 2015 4 SR 2014 4 2015 4 2012 4 2013 4 2014 4 2015 4 2016 4 2017 4
70. 3 3 ea E 70 H E http www sharedresearch jp 19 35 100
71. TDM 621 TDM 621 http www sharedresearch jp 11 35 Shared eseareh 2012 4 25 7777 1 Tmformed Consent 2 3 TDM 621
72. 7777 3 D MatrixInc 2007 10 3 D Matrix Inc 2009 4 10 8 33 New Media Japan Inc 6 29 3DM Investment LLC 6 14 4 29 3 54 Excelsior Medical Co Ltd 3 54 4 3 32 2 78 2 22 2 22 SR 2011 10 30 3DM Investment LLC MIT 3 D Matrix Inc
73. RADA16 TDM 621 TDM 621 TDM 621 1 TDM 621 pH gt TDM 621 TDM 62 1
74. 7777 2007 INSEAD MBA 2011 8 20 18 39 8 2 2 IR 2 4 http www sharedresearch jp 31 7 35 shared Gesearch 2012 4 25 7777 SO IDE Imvestigational Device Exemption FDA
75. pe SR Weaknesses http www sharedresearch jp 20 35 Shared Geseareh 2012 4 25 mm 7777 MIT MIT 2014
76. 7777 TDM 621 8 Informed Consent 2 agi TDM 621 2010 1 97 2011 4
77. aa SW Strengths WWeaknesses Strengths MIT i
78. 1 13 14 170 50 300 http www sharedresearch jp 21 7 35 Shared cseareh 2012 4 25 7777 6 2016 1 344 iDATA Research
79. RADA16 TDM 621 E TDM 641 TUONO TOU 4 TTT TDM 641 2012 4 2012 2 c TDM 631 RADA1l6 http www sharedresearch jp 14 35 2012 4 25 7777 TDM 631 TDM 631
80. 2011 5 i 4538 lt X 10 http www sharedresearch jp 13 35 Shared Geseareh 2012 4 2S 7777 Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd Daewoong Pharmaceutical Co LTD
81. 07 4 08 4 09 4 10 4 11 4 12 4 1 10 10 402 158 1 100 805 2 4 5 60 6 594 8 1 2 111 233 355 406 467 641 65 482 300 11 0 5 27 187 222 259 60 510 256 3 1 21 187 223 296 61 534 255 a SR 2011 4 158 2010 4 402 6 150 2010 4 400 641 2010 4 174
82. TDM 621 7 Ps 1 2011 5 PMDA TDM 621 2012 2012 4 2012 TDM 621 2010 9 17 Daewoong Pharmaceutical Co LTD PARTNERSHIP AGREEMENT Excelsior Medical Co Ltd LICENSE AGREEMENT
83. E 1 1H DDS bFGF PDGF E
84. 2012 4 3 3 400 400 E TDM 621 498 98 7 130 14 26 32
85. D D Asp COOH NH2 A A Ala R 4 R Arg ADME ADME Absorption Distribution Metabolism Excretion ADME
86. PDF wwwrsharedresearch jp 1 MIT 7777
87. Pa http www sharedresearch jp 7 7 35 2012 4 25 7777 Massachusetts Institute of Technology MTT 1 4 1 MIT MIT 2 3
88. TDM 621 PMDA TDM 621 i 149 2011 5 1 4538 rY Ao ys TDM 621 2 TDM 711 2011 7
89. 0 0 0 31 49 1 109 1 359 1 099 1 349 1 063 1 596 11 282 958 687 1 167 1 150 21 22 0 0 544 589 SR 3 D Matrix mc 70 2019 4
90. 792 2 817 3 392 3 792 4 567 EPS 99 0 98 5 106 0 19 7 147 2 60 9 EPS DPS 0 0 0 0 0 0 0 0 0 0 0 0 BPS 148 8 343 1 243 8 344 1 300 4 544 589 594 666 7 6 19 22 578 505 304 986 733 1 198 1 199 12 16 0 0 31 49 0 0 0 0 31 49 282 958 687 1 167 1 150 0 0 28 434 13 18 573 498 ROA 123 2 34 6 34 5 6 3 44 6 ROE 133 1 36 0 36 0 6 6 46 1 92 5 97 1 93 7 97 4 95 0 SR 2012 4 25 7777
91. 1 8 1 4 3 792 2011 10 544 400 344 400 2012 1 4 567 200 12 07 4 08 4 09 4 10 4 11 4 1 28 434 2 13 18 FCF 1 2 40 452 573 498 A 75 79 B 11 10 C 1 FCF Ni A B O 467 SR
92. 100 550 300 456 256 477 255 478 TDM 621 TDM 621 1 4538 1 4221 2012 4 9 TDM 621
93. 2 31 2022 2 5 PuraMatrix US 7713923 MIT 2010 5 11 2024 6 24 PCT SR 3 D Matrix Inc MIT AMENDED AND RESTATED EXCLUSIVE PATENT LICENSE AGREEMENT FIRST AMENDMENT SECOND AMENDMENT THIRD AMENDMENT TO AMENDED AND MIT 3 D Matrix Inc MIT SR 2014
94. jp 16 35 1 Shared Geseareh 2012 4 25 7777 Excelsior Medical Co Ltd TDM 641 on NO MIT OA 2009 4 1 8001 Daewoong Pharmaceutical Co LTD
Download Pdf Manuals
Related Search