RI Brochure - Micro Video Instruments, Inc.
Contents
1. KI ne Hardware No Cold Spots Integra 3 Inspired Intelligent Super fast Indispensable The definitive micromanipulator 1 TM amp Integra 3 The world s most advanced micromanipulation system Accurate ke rS a Integra 3 Featuring Thermal image Ihermosdafe when placed on Ultimate Thermal Control for Integra 3 heated metal plate Ultimate Thermal Control with Thermosafe THERMAL IMAGES TAKEN WITH 40X OBJECTIVE IN PLACE ON AN INVERTED MICROSCOPE o N Designed for making life Comparison with other systems Without Thermosafe With Thermosafe Every detail of the Integra 3 is geared Thermal images above and below display the cooling effect Market leading glass ITO insert with objective RI heated metal insert with Thermosafe air towards one goal to ensure you create the of the objective in the centre of the dish with and without heating system with objective best possible conditions for ICSI and sample Thermosafe manipulation One feature that makes this possible is our ka and world leading Possible Hot Cooled Area Possible Hot Uniform Dish Temperature Thermosafe warm air technology f N Spots of Dish Spots No Hot Spots No Cold Spots Put simply this is an integral heating system y TN that helps to keep samples at the optimum 1 Y ea A T aT AT T T _ fpf ff ff ff ff fff ff f2. cleared As the only moveable laser for ART Saturn lasers are spearheading a revolution in hatching and biopsy techniques in labs all over the world Saturn S5 Lasers Specifications Nikon TMD D200 300 TE200 300 TE2000 Ti Leica DMIRB DMI3000B 4000B 6000B DMIL a Ti Sa An st IDE TUE Olympus IMT2 1X50 70 1X51 71 81 1X53 73 83 i Zeiss Axiovert 40 100 200 Axio Observer 630 650nm spot targeting solid state diode laser red pilot beam guarantees the position of the invisible ablation laser IMT2 IX50 70 Axiovert 40 100 200 IX51 71 81 1X53 73 83 Axio Observer Custom designed objective for optimum laser transmission crystal clear imaging and minimal laser pulse times Tested and proven not to exhibit astigmatism with Saturn 5 Laser Systems 1480nm 400mW solid state diode laser Pulse length range 0 001 2 0ms 1 2000 us Class 1 laser product IEC 60825 1 2007 Tested and proven not to exhibit thermal lensing 220mm x 180mm x 34mm Compatible with CRi Oosight and SpindleView systems RI Viewer imaging software included with digital laser targeting Operating systems Windows 8 Windows 7 Windows Vista Windows XP 100 240VAC 50 60Hz The RI IMSI solution allows morphological screening of sperm cells at very high magnification and in real time Studies suggest that this can lead to higher pregnancy rates Ouality Imaging Speed and affordability are important
3. f iff fff 4 temperature It emits warm air towards the Petri dish precisely and uniformly The result of this is a fail safe guarantee with no more cold spots no more hot spots and no more ha gt tt w Thermosafe ambiguity There is also a stage temperature 40 x Objective Thermosafe Ale Ma Heated Cools Dish Air Heating Objective from Metal health indicator light to reassure you that Dish surface when placed Dish surface when placed System Cooling the Vaan the integrated heated stage is functioning on market leading glass on heated metal plate Dish correctly ITO without Thermosafe without Thermosafe Integra 3 Integra 3 takes micromanipulation to new heights You push the boundaries We try to remove them Together we re a pretty good team because we both believe in a pioneering approach Integra 3 is the latest evidence of our relentless desire at RI to maximise your expertise and make your day go as smoothly and successfully as possible Temperature is critical but time is also crucial Integra 3 is ultra responsive and effortlessly smooth so it s quick and easy to use thanks to RI s advanced mechanical design You can change micropipettes in seconds which can transform the efficiency of your lab overnight We have increased the size of the integrated heated stage by 40 but kept the footprint to a minimum to keep your work area uncluttered We ve added a whole spectrum of other f
4. g the subtle details in moving sperm images The camera s large sensor has high sensitivity pixels for bright high contrast images The pixel count is a perfect match for the resolution of the optics and allows smooth video at 15 frames per second RI IMSI is supplied with the easy to use RI Viewer software the only application you need for ICSI and IMSI Capture record annotate and measure with intuitive zoom and pan RI IMSI Specifications RI HMC 60x 0 7 or 63x 0 7 Depending on Microscope RI HMC WD45mm NA 0 6 Depending on Microscope RI HMC Hoffmann Modulation Contrast System High sensitivity 1 4MP 2 3 colour CCD 21 1600 x 1200 DICOM compliant medical imaging monitor Imaging software included Up to 7000x without loss of resolution Quality Assurance All RI medical devices carry the CE mark The CE mark shows that RI s products comply with the Essential Safety Requirements of the European Medical Device Directive 93 42 EEC as amended Many of our medical devices also have USA FDA market clearance Health Canada medical device licenses and certification in Taiwan and China We are continuously working to expand our registration with the relevant medical device authorities across the world Within RI a dedication to quality permeates all that we do All RI products are designed developed and manufactured within an ISO 13485 enviro
5. nment All materials and packaging used within the manufacturing process of RI medical devices are comprehensively tracked and logged to ensure full traceability We hold certification to ISO9001 15013485 including CMDCAS and FDA GMP and Medical Device Directive 93 42 EEC as amended Continual evaluation of our products has led to the creation of the finest range of devices on the market that clinics aspire to own and Use For further information please refer to our website Research Instruments Ltd Bickland Industrial Park Falmouth Cornwall TR11 4TA UK Tel 44 0 1326 372 753 Fax 44 0 1326 378 783 e mail sales research instruments com visit www research instruments com MKTG BR 677 2 27 08 2013 All information correct at time of print Specifications are subject to change without notice or obligation on the part of the manufacturer
6. olution 0 1 C LCD touch screen displays for temperature control USB Type B socket for connection to PC running RI Viewer software Refer to software manual for further information Connected PC to be compliant with IEC 60950 1 Aluminium heated stage plate 40mm travel in X and Y 28mm per turn Choice of SAS air SAS SE air and SOS oil Maximum weight of microscope mounted components excluding front and rear adaptors 10 4kg Actual weight is configuration dependent Footprint not including microscope width 56cm depth 38cm Input 100 240VAC 50 60Hz Max 1 8A Class Output 12VDC Min 11A 132W Temperature 15 C 59 F to 40 C 104 F Humidity 15 to 85 RH non condensing The moveable Precise Saturn laser means I can ablate the zona exactly where want to Curved Biopsy Mode without having to move the embryo Samantha Knight SPIRE London Fertility Clinic UK 4 Easy to Use Saturn 3 Lasers Fixed and Directional Laser Systems Safest Power Multi Pulse Mode Saturn 5 Lasers The Saturn 5 Biopsy Mode is helping you to advance improvements in biopsy methods potentially reducing procedure time and lowering the incidence of blastocyst collapse and the need to mechanically tear off cells Using the Biopsy Mode you can draw a straight or curved line along the sample and then select the number and size of the holes on it then simply fire The laser
7. s which are visible on screen and are printable plus a built in laser simulator for training and demonstration purposes RI Viewer is available in a range of languages For Blastocyst Trophectoderm Biopsy the Saturn 5 Active is unparalleled in its ease of use The directional laser allows the user to make multiple ablations across the trophectoderm cells without needing to move the blastocyst This gives the user superb accuracy safety and incredible speed For Blastomere Biopsy Polar Body Biopsy and Blastocyst Collapsing for vitrification the Saturn 5 Active directional laser allows the embryo to stay in the desired position and focus so that ablations can be made wherever required without additional manipulation Our unique Biopsy Mode also allows safe multi pulse drilling along a predetermined line For Assisted Hatching the directional laser means that accurate ablations can be made without the need to hold the embryo making it very quick and accurate with no additional consumable costs Using Saturn 5 Active you will find these procedures are almost effortless and can be performed quickly and accurately These procedures can require difficult embryo manipulation when performed using fixed lasers Using a Saturn 5 Active has clear advantages to the welfare of the embryo Saturn 5 Laser Systems are Class 1 laser products as defined by international laser safety standards They are CE marked and FDA
8. tion purposes The Integra 3 includes two of our SAS air syringes as standard These syringes offer superb control and eliminate the need for oil Also available is the SAS SE for superfine air control or our SOS oil syringe with a guick fill feature for minimum set up time Integra 3 Specifications Great British Biotech Quality since 1962 The Integra 3 is very proudly built at our high tech factory in the South West of Britain We ve made thousands of micromanipulators since the early sixties each one assembled under the dutiful eye of the designers who developed them TMD D200 300 TE2000 TE200 300 Ti IMT2 1X50 70 IX51 71 81 1X53 73 83 Our commitment to quality durability and reliability has been there since day one This is why our Integra has proven to be the micromanipulator of choice for ART clincs worldwide DMIRB DMI3000B 4000B 6000B DMIL Axiovert 40 100 200 Observer Axiovert A1 X Y and Z movement from one lever X side to side Y front to back Z up and down Sub micron resolution 1 0mm Adjustable X and Y travel 5mm Z travel X and Y movement 10 micron resolution 4mm X and Y travel Fast pipette location Pipette angle adjustment 16 to 40 degrees Thermosafe Air Heating System with Heated Metal Insert 25mm standard 16mm optional ITO Heated Glass Insert optional Accuracy better than 0 1 C when calibrated against known reference Res
9. to you and with this in mind RI has developed a carefully chosen package for Intracytoplasmic Morphologically selected Sperm Injection IMSI for routine clinical use Practicality first Offering the perfect compromise between image quality and ease of use RI IMSI is designed for real lab conditions With the RI set up you can perform IMSI with sufficient image clarity to detect large or numerous vacuoles and the morphological details necessary to select the sperm The set up means you can use plastic Petri dishes and dry objectives avoiding the inconvenience and expense of traditional IMSI to ensure fast and efficient use of the technique TBartooy Betal 2002 Real time fine morphology of motile human sperm cells is associated with IVF ICSI outcome Journal of Andrology Vol 23 No 1 January February 2002 2 cassuto N et al 2009 A new real time morphology classification for human spermatozoa a link for fertilization and improved embryo guality Fertility and Sterility Vol 92 No 5 November 2009 S RIMSII Clinical IMSI High tech solutions RI IMSI includes a high sensitivity camera medical grade monitor and versatile imaging software Working with Modulation Optics Inc Rl provides a unique highly sensitive optical system with a 60x objective ensuring a high resolution source image The monitor offers colour depth and accuracy superior to standard PC monitors and is perfect for accurately reproducin
10. unctions and features that improve on our previous model the Integra Ti You ll find they all add up to making the Integra 3 the most intuitive and natural micromanipulation system the world has ever known This shines up underneath the stage as soon as it sees your hand to help you see when changing objectives A 3 5 inch touch screen display can check temperature track time with a stopwatch and count the number of injections done The electronic height gauges track the vertical movement of the fine controller When you perform ART micromanipulation procedures accuracy is paramount Integra 3 offers the finest possible movement on the XYM stage and fine and coarse levers centring knobs and a choice of oil or air syringes for the control of specimens SAS SE Air SOS Oil SAS Air Syringe Syringe Syringe If you need to keep track of samples or procedures just hit the shortcut buttons to film or photograph any stage of the process There s a stopwatch to keep track of timings too You can use the Integra 3 as a stand alone machine or if it s connected to a computer we can supply the RI Viewer software With RI Viewer you can use the shortcut keys and sync up with Saturn laser and IMSI systems Enjoy razor sharp full screen imaging from the microscope with digital magnification and a modern clean user interface It also offers line measurement tools and a built in simulator for training and demonstra
11. will ablate exactly along the chosen path It means you no longer need to move the holding pipette at all Indeed for assisted hatching a holding pipette is not required It is that easy The Saturn 5 Biopsy Mode is quickly proving to be an essential tool in the practice of biopsying across the world Multiple safety features reassure you that the Saturn laser is the safest laser on the market To keep your embryos safe features include the Exclusion Zone The Saturn employs a higher laser power to apply less total energy to make a specified hole size in comparison to lower power laser systems As Saturn 5 s pilot laser travels down the same fibre optic path as the ablation laser it guarantees consistent positioning You can calibrate and verify hole size and firing position with sub micron accuracy simply and quickly leaving more time for your procedures 400 350 300 400mW _ 250 3 TS 2 200 a lag Uu lt UJ 150 100 50 0 2 4 6 8 10 12 14 16 Diameter of Hole Produced um 175 mW 300mW e400 mW Directional Laser Target Blastocyst Biopsy Biopsy Mode In addition to its intuitive use and safety assurances the new Saturn 5 features class leading software RI Viewer The software offers uncluttered full screen imaging from the microscope digital magnification and a modern clean user interface RI Viewer also offers a recording function line measurement tool
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