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ABI PRISM™ 6700 Automated Nucleic Acid Workstation Site

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3. Applied Biosystems i E m EI E v uu n x Y d ou a Ed a ES d a A Instrument Safety 4 13 Input Output Connections Location The locations of the input output connections on the ABI Prism 6700 Automated Nucleic Acid Workstation are shown in the figure below The input output connections are also labeled on the instrument Fuses Power input Serial cable to PC Air output System fluid Waste o GR1684b 4 14 Instrument Safety Acronyms and Abbreviations Acronyms and Abbreviations Used in MSDSs Introd
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5. Ove LS Layout Printer optional a T o E CS IL 1 e Tape back up optional Cable Connections This graphic shows the appropriate cable connections for the 6700 instrument and accessory equipment Cla Printer optional Power cords Power cords attach here Power cord Serial Tepe Switch Box cable acKUP Datab LI UPS optional Sever Monitor E bg optional Database client ia 6700 Instrument SD Keyboard Hi Baiste M d Reader Mouse amp and E 8 Waste fluid E mouse pad Bottles System fluid under table Site Preparation 2 17 Laboratory Ventilation Requirements Venting Heat Production This instrument produces no gaseous waste It does not require installation under a fume hood Always comply with all applicable local state provincial or national laws and regulations and practices for venting waste Note The instrument has the capability to be connected to a plenum to direct the venting of the heated air The thermal output of the i
6. 2 19 POWER Sig 33 3 1115151111111 1 2 19 Power Lane ett ner eee eee 2 19 eebe ae Pad AE 7 1 09 2 19 Power Rating scissile 1 2 19 3 3 33 3 E E 10 2 19 Power COLAS sce tases e 111 1 109 2 19 3 ee Nk 3 2 20 Power Line Regulator 8 hai 2 20 Voltage 3 3 111 5590 2 20 Power Out gesz oci cub eo net aida donee ea ERA RR TES 2 20 Electric Shock Warning 2 20 3 Chemical Safety uaa 3 1 About This Chapter cs 11 9 90 3 1 In This Chapter ss 1 3 1 Material Safety Data Sheet Information 3 2 About MSDS Sii NR ee Ein eS 3 2 3 A RU 0 3 2 Ordering MSDSs from Applied Biosystems 3 2 Ordering MSDSs from Other Manufacturers 3 2 Hazardous Chemicals and Biological Materials 3 3 OVER VIC W Snes rende ee A E EEE ia A EN EA 3 3 Handling Hazardous Chemicals 3 3 Handling Biohazardous Material
7. 2 2 Operator Train 1 1 er 2 2 Performance Verification 2 2 Ordering Supplies 8 Li Sn Re 0 2 2 Preinstallation and Installation Overviews 2 3 Overview of Preinstallation Process 2 3 Overview of the Installation Process 2 4 Preinstallation Checklists 2 5 About These Cneck lists 2 211 1 30 2 5 iii Components Supplied by Applied Biosystems 2 5 Oti Site Personnel Ser 10 2 6 Laboratory Facility Requirements 2 7 Equipment and Consumables Required 2 9 Items Shipped with This Instrument 2 10 Summary Let ssa 3 ea a 2 10 6700 384 Well Upgrade Kit 1 en 2 10 Do Not Move or Unpack Instrument 2 10 Unpacking Chemicals 2 11 6700 Chemistry Install Kit for the 96 Well Output Block 2 11 6700 384 Well Upgrade Chemistry 2 12 Plastic Consumables for the 96 Well Output Block 2 12 Plastic Consumables for the 384 Well Output Block
8. 3 4 Hazardous Waste 1 0 3 5 OVERVIEW lan RIRs 5 5 3 5 Instrument Waste System 3 5 Handling Chemical Waste 3 6 Storing Hazardous Waste 3 6 Disposing of Hazardous Waste 3 6 4 Instrument Safety OVEIVIEW dea iY ade 7 1 0 4 1 About This Chapi ss 1 10 4 1 In This Chapter a 3 111 1 090 4 1 Instrument Operation 1 nana 4 2 sale Operan 7 1090 4 2 Routine Maintenance for Safe Operation 4 2 Instrument Labeling ees ei a ER an 4 2 Instrument Safety Labels 4 2 Siena Words a a Ben so bar 4 2 Labels That May Be Found on the Instrument 4 3 Safety Alert Symbols ot eu o LE til rn xS LESE 31 0 4 4 El ctrical Symbols o texere ne 4 4 Nonelectrical Symbols ss eem ertet ek RIDE S Ed 4 4 Safety Alert Symbols Frerich s e 4 5 Safety Alert Symbols German 4 6 vi Safety Alert Symbols Italian 4 7 Safety Alert Symbols Portuguese 4 8 Safety Alert Symbols Spanish
9. 2 13 Packing Kit for the 96 Well Output Block 2 13 Laboratory Safety Requirements 2 14 On Site Representative i ana en an ran 2 14 Required Safety Equipment 2 14 Laboratory Space Required oe 2 15 Dimensions and Weight 2 15 Instrument Storage Area 2 15 Laboratory Bench or Table 2 15 Computer Cart or Table li a EUER Hai 2 16 Location of Database Client CPU 2 16 Location of the Computer Monitor and Keyboard 2 16 Clearance 1 2 17 Typical Laboratory Layout 2 17 Cable Connections rio 0 2 17 Laboratory Ventilation Requirements 2 18 3 A ea aa 2 18 Heat Production iov erp EAR CERRO esed e 2 18 Laboratory Environmental Requirements 2 18 Altitude 11 2 18 Temperature and Humidity 2 18 ON NN RSR RR 2 18 Emission Immunity Statement 2 18 Electrical Requirements
10. 4 9 Safety Alert Symbols Chinese 4 10 Safety Alert Symbols Japanese 4 11 Safety Alert Symbols Korean 4 12 Satety Alert Symbols That 1111 1 1 4 13 Input Output Connections 4 14 Epcaniohi 2 oce nn eben este 11 1 4 14 A Acronyms and Abbreviations Acronyms and Abbreviations Used in MSDSs A 1 Introduction oi it a ae en a A 1 Organizations Regulations and Scientific Terminology A 1 Units of Measure 311 A 2 Chemicals ia dann in a A 3 Introduction Overview About the Site Preparation and Safety Guide In This Guide The ABI Prism 6700 Automated Nucleic Acid Workstation Site Preparation and Safety Guide is sent to all customers who have purchased an Applied Biosystems instrument This guide provides the information you need to fully prepare your site for the arrival and installation of the instrument Complete preparation helps ensure a smooth installation process as well as correct and safe instrument operation This guide for the ABI Prism 6700 Automated Nucleic Acid Workstation contains the following chapters and appendix Title Description Introduction Provides orientation t
11. Comply with all local state provincial or national laws and regulations related to chemical storage handling and disposal Introduction 1 3 Chemical Waste PATI CHEMICAL WASTE HAZARD Wastes produced by Applied Biosystems Hazard Warning instruments are potentially hazardous and can cause injury illness or death Read and understand the material safety data sheets MSDSs provided by the manufacturers of the chemicals in the waste container before you store handle or dispose of chemical waste Handle chemical wastes in a fume hood Minimize contact with and inhalation of chemical waste Wear appropriate personal protective equipment when handling chemicals e g safety glasses gloves or protective clothing After emptying the waste container seal it with the cap provided Dispose of the contents of the waste tray and waste bottle in accordance with good laboratory practices and local state provincial or national environmental and health regulations 1 4 Introduction Technical Support To Reach Technical We strongly encourage you to visit our Web site for answers to frequently asked Support Through questions and for more information about our products You can also order technical the Internet documents or an index of available documents and have them faxed or e mailed to you through our site The Applied Biosystems Web site address is http www appliedbiosystems com techsupp To submit technical questions
12. 9 Storage cabinet with adjustable shelf The Database Client CPU must be located within 1 25 m 4 ft of the switchbox monitor keyboard and mouse Note The monitor may be stacked on top of the Database Client CPU 3m 10 ft of the 6700 instrument 1 25 m 4 ft of the Database server tower 2m 6 ft of the printer optional The computer monitor and keyboard should be situated to allow for proper ergonomics during use The following guidelines are recommended Benchspace or pull out tray provided so that the keyboard is positioned directly in line with the monitor Open space under the keyboard so that the operator can sit comfortably directly facing the monitor 4 Workspace provided next to the monitor 2 Heicks Test Station Tech Table can be ordered from The Corner Office 1045 Sansome Street Suite 100 San Francisco CA 94111 Phone 415 362 5595 Fax 415 362 5599 Clearance A total vertical clearance of 153 cm 60 in is required for adequate ventilation and for servicing The instrument will not be installed without this clearance A clearance of 15 cm 6 in is needed at the rear of the instrument to provide adequate ventilation Additional clearance is required for servicing Do not block access to the rear of the instrument Typical Laboratory This graphic shows the front view of a typical laboratory layout
13. A laboratory bench of the correct dimensions to accommodate the system is in place and is situated so that the instrument is accessible to the installer on all four sides The bench supporting the instrument must have sturdy casters and be able to tolerate at least 225 kg 500 Ibs See Laboratory Space Required on page 2 15 for details A second bench or computer cart is in place It must have the correct dimensions and weight tolerance to accommodate the Windows NT Database Client CPU and monitor which can be stacked server tower keyboard mouse and handheld barcode reader These items together weigh 56 2 kg 125 lbs See Laboratory Space Required on page 2 15 for details Verified that the final instrument location has at least 153 cm 60 in of total vertical clearance table top to ceiling and 15 cm 6 in of rear clearance IMPORTANT The instrument will not be installed without this clearance The CPUs will be no more than 1 25 m 4 ft from the instrument Met other requirements specified in Laboratory Space Required on page 2 15 Met requirements specified in Laboratory Environmental Requirements on page 2 18 Verified that third party movers will unpack the instrument and position it on the laboratory bench Situated the computer to allow for proper ergonomics during use Ventilat ion and Waste Room ventilation accommodates instrument heat output o
14. Then The MSDS document number or the Document on Demand index number Enter one of these numbers in the appropriate field on this page The product part number Keyword s Select Click Here then enter the part number or keyword s in the field on this page c You can open and download a PDF using Adobe Acrobat Reader of the document by selecting it or you can choose to have the document sent to you by fax or email By automated telephone service Use Documents on Demand on page 1 7 By telephone in the United States Dial 1 800 327 3002 then press 1 By telephone from Canada To order in Then dial 1 800 668 6913 and English Press 1 then 2 then 1 again French Press 2 then 2 then 1 By telephone from any other country See Regional Offices Sales and Service on page 1 8 For chemicals not manufactured or distributed by Applied Biosystems call the chemical manufacturer Documents on Free 24 hour access to Applied Biosystems technical documents including MSDSs Demand is available by fax or e mail or by download from our Web site To order documents Then by index number a Access the Applied Biosystems Technical Support Web site at http www appliedbiosystems com techsupp b Click the Index link for the document type you want then find the document you want and record the index numb
15. RETTA ERA NIE Applied Biosystems HEAR ERRATA o ARR EH LEIFR FERRO INE RR EYE gt ARF RANE FVD ABBAS PH MIRZE gt RRP E EWPHBHBEDS Bai gt ARF PPR ALDARA BH B8 ME gt eee emt gt TEN TER ER Him RARA ESE ESTHER ER ARF RASA SS Bl ARF DASA n Best e PACHA ELT PE AO IE A FUETE gt IVO AAA REM CE o gt gt ie egtoo FEB URE NY Applied Biosystems FIRE JF TT RATER AER LT FIR AU VC ec LD gt LAAN eA RA ERE OE gt gt gt 4 10 Instrument Safety ELOY BRIT TI SALE OD Y 7 ERI Applied Biosystems Xi amp I f amp FH amp dvcU coSa B ev 27 amp rX nUz d COSSETIBRECARANTOWASBAS REL RAT SHREDS AIT TEL BRAT vy FOA AVOMBERLET EBRATYFOFIOWUBERLET HURA UAEBRAL YFOAY AIOMBERLET CORRE HW eAORBOTD LY 0 Ch 737 2 ETA CORE ESE EIT 2 AE PAIS DEI 6 7 5 2 Fim FERLET CORTA RHBRNIRRBEOHARNLAAMFERLET CORRS RHRRVEROSRRLBEOHARLAAMFERLET BE
16. de ces symboles il est imp ratif de se conformer aux consignes de s curit appropri es Position marche de l interrupteur d alimentation principale Position arr t de l interrupteur d alimentation principale Positions marche arr t de l interrupteur d alimentation principale bouton poussoir Borne pouvant tre reli e la mise la terre d un autre appareil Ce n est pas une borne de mise la terre prot g e Borne de mise la terre de protection devant tre reli e la terre avant d effectuer tout autre raccordement lectrique l appareil Borne recevant ou fournissant une tension ou un courant de type alternatif Borne pouvant recevoir ou fournir une tension ou un courant de types alternatif et continu Indique la pr sence d une haute tension et avertit l utilisateur de proc der avec pr caution P50 O00 Avertit l utilisateur de la n cessit de consulter le manuel pour obtenir davantage d informations et de proc der avec pr caution Symboles non Le tableau suivant donne la signification des symboles d alertes de s curit non lectriques lectriques qui figurent sur les appareils Applied Biosystems Danger associ la pr sence d un appareil de chauffage Proc der avec pr caution pour viter de se br ler au contact de pi ces ou d l ments chauds gt gt Indique que l appareil renferme un laser Ins
17. 6150 101 101 Hungary Budapest 36 0 1 270 8398 36 0 1 270 8288 Italy Milano 39 0 39 83891 39 0 39 838 9492 Norway Oslo 47 23 12 06 05 47 23 12 05 75 Poland Lithuania Latvia and Estonia 48 22 866 40 10 48 22 866 40 20 Warszawa Portugal Lisboa 351 0 22 605 33 14 351 0 22 605 33 15 Russia Moskva 7 502 935 8888 7 502 564 8787 South East Europe Zagreb Croatia 385 1 34 91 927 838 385 1 34 91 840 Spain Tres Cantos 34 0 91 806 1210 34 0 91 806 1206 Sweden Stockholm 46 0 8 619 4400 46 0 8 619 4401 Switzerland Rotkreuz 41 0 41 799 7777 41 0 41 790 0676 The Netherlands Nieuwerkerk a d IJssel 31 0 180 392400 31 0 180 392409 or 31 0 180 392499 Telephone Fax Region Dial Dial United Kingdom Warrington Cheshire 44 0 1925 825650 44 0 1925 282502 All other countries not listed Warrington 44 0 1925 282481 44 0 1925 282509 Japan Japan Hacchobori Chuo Ku Tokyo 8120 477392 Toll free within Japan or 81 3 5566 6230 81 0 477120 Toll free within Japan or 81 3 5566 6507 Latin America Caribbean countries Mexico and 52 55 35 3610 52 55 66 2308 Central America Brazil 0 800 704 9004 or 55 11 5070 9694 95 55 11 5070 9654 Argentina 800 666 0096 55 11 5070 9694 95 Chile 1230 020 9102 55 11 5070 9694 95 Uruguay 0004 055
18. 654 55 11 5070 9694 95 Introduction 1 9 Site Preparation Overview About This Chapter This chapter describes the preparation of the laboratory and personnel that must take place before the ABI Prism 6700 Automated Nucleic Acid Workstation arrives It also describes the instrument installation process In This Chapter This chapter contains the following topics Topic See Page Before You Start 2 2 Preinstallation and Installation Overviews 2 3 Preinstallation Checklists 2 5 Items Shipped with This Instrument 2 10 Laboratory Safety Requirements 2 14 Laboratory Space Required 2 15 Laboratory Ventilation Requirements 2 18 Laboratory Environmental Requirements 2 18 Electrical Requirements 2 19 Site Preparation 2 1 Before You Start Preinstallation Operator Training Performance Verification Ordering Supplies 2 2 Site Preparation Before the 6700 system is installed the installation site must be prepared so that the instrument can operate correctly and safely To simplify the installation procedure follow the requirements presented in Preinstallation Checklists on page 2 5 Training of operators is one of the primary goals of installation The Overview of the Installation Process on page 2 4 shows the blocks of time each user should set aside to work with the Applied Biosystems service representative during the installation process If it is not possib
19. HAZARD Never collect or store waste in a glass container because of the risk of breaking or shattering Reagent and waste bottles can crack and leak Each waste bottle should be secured in a low density polyethylene safety container with the cover fastened and the handles locked in the upright position Wear appropriate eyewear clothing and gloves when handling reagent and waste bottles Waste The following are guidelines for storing hazardous waste 4 4 4 4 Always use secondary containment when storing chemical waste Store waste for only short periods of time Store only small amounts of waste in the laboratory Store waste away from direct sunlight or sources of heat on or off the instrument Disposing of As the generator of potentially hazardous waste it is your responsibility to Hazardous Waste 3 6 Chemical Safety 4 4 4 Characterize the waste generated with your applications Ensure the health and safety of all personnel in your laboratory Ensure that instrument waste is stored transferred transported and disposed of according to all local state provincial or national regulations Instrument Safety Overview About This Chapter This chapter provides you with the safety information you need to prepare your laboratory and personnel for the installation and use of the ABI PRism 6700 Automated Nucleic Acid Workstation The safety labels and safety alert symbols that may be found on this instrument are
20. UEL Upper explosive limit uorU Unknown UN United Nations This designation identifies hazardous chemicals in the process of worldwide transportation Units of Measure The following table lists abbreviations for common units of measure Abbreviation Unit of Measure number C degrees Celsius SE degrees Fahrenheit pL microliter um micron umol micromole AUFS absorbency units full scale Btu British thermal unit ft foot gal gallon h hour i d inside diameter in inch kVA kilovoltampere L liter m meter mg milligram A 2 Acronyms and Abbreviations Abbreviation Unit of Measure mL milliliter mm millimeter o d outside diameter P N part number psi pounds per square inch sec second V volt VA voltampere VAC volts alternating current W watt Chemicals The following table lists abbreviations for common chemicals Abbreviation Definition A adenine AA amino acid 1Ac acetyl Acl acetylimidazole Acm acetamidomethyl AGO acetic anhydride ACN acetonitrile ACT activator vessel BHA resin benzhydrylamine resin t BOC tert butyloxycarbonyl Bzl benzyl Br Z 2 bromobenzyloxcarbonyl t Bu tert butyl 0 cytosine CHO formyl CHsBzl 4 methylbenzyl CH 0Bz 4 methoxybenzyl CI Z 2 c
21. Washington DC U S Government Printing Office For sale by the Superintendent of Documents U S Government Printing Office Stock no 017 040 00547 4 2 U S Department of Health and Human Services Occupational Safety and Health Administration 1998 Occupational Safety and Health Standards Toxic and Hazardous Substances Bloodborne pathogens 29 CFR 1910 1030 3 4 Chemical Safety Hazardous Waste Overview Instrument Waste System This instrument may generate hazardous waste Follow these guidelines for hazardous waste NUNNA CHEMICAL WASTE HAZARD Wastes produced by Applied Biosystems instruments are potentially hazardous and can cause injury illness or death Read and understand the material safety data sheets MSDSs provided by the manufacturers of the chemicals in the waste container before you store handle or dispose of chemical waste Venting hazardous waste may require local state provincial or national air permits 4 Minimize contact with and inhalation of chemical waste Wear appropriate personal protective equipment when handling chemicals e g safety glasses gloves or clothing Handle chemical wastes in a fume hood Dispose of the contents of the waste tray and waste bottle in accordance with good laboratory practices and local state provincial or national environmental and health regulations 4 After emptying the waste container seal it with the cap provided The waste for this instru
22. from North America or Europe Step Action 1 Access the Applied Biosystems Technical Support Web site 2 Under the Troubleshooting heading click Support Request Forms then select the relevant support region for the product area of interest 3 In the Personal Assistance form enter the requested information and your question then click Ask Us RIGHT NOW 4 In the Customer Information form enter the requested information and your question then click Ask Us RIGHT NOW Within 24 to 48 hours you will receive an e mail reply to your question from an Applied Biosystems technical expert To Contact In the United States and Canada technical support for this instrument is available in ABI PRISM 6700 the following ways Technical Support To contact Technical Support by Use Telephone 1 800 762 4001 Press 6 5 30 a m to 5 00 p m Pacific Time Fax 1 240 453 4613 E mail pcrlab appliedbiosystems com See Regional Offices Sales and Service on page 1 8 for sales and service representatives outside of the United States and Canada Introduction 1 5 Ordering MSDSs You can order free additional copies of MSDSs for chemicals manufactured or distributed by Applied Biosystems using the contact information below 1 6 Introduction To order MSDSs Then Over the Internet a Go to our Web site at www appliedbiosystems com techsupp b Click MSDSs If you have
23. off the items below after scheduling them with your laboratory personnel 2 6 Site Preparation Date Confirmed Action Set aside 2 uninterrupted days for in lab training for appropriate personnel during installation See Overview of the Installation Process on page 2 4 for details Designated one person to be the laboratory safety representative This person is familiar with laboratory safety procedures knows the location of all safety equipment and will be available to the Applied Biosystems engineer while the engineer is at your facility Designated one person as the Information Technologist IT This person will be responsible for supplying the service engineer with any information required to network the computer system Designated one person as the laboratory database administrator This person is familiar with operating a Microsoft Windows NT server and using Oracle database software Laboratory Facility Check off each item as you verify that the instrument location meets each of the requirements Requirements NI Date Confirmed Requirement Safety Met requirements specified in Laboratory Safety Requirements on page 2 14 Instrum ent Location Verified that the doors hallways and staircases from the receiving dock to the storage area if applicable and to the laboratory will accommodate the instrument s 91 cm 36 in crated width
24. provided in several languages The inputs and outputs of the instrument are also provided In This Chapter This chapter contains the following topics Topic See Page Instrument Operation 4 2 Instrument Labeling 4 2 Safety Alert Symbols 4 4 Input Output Connections 4 14 Instrument Safety 4 1 Instrument Operation Safe Operation Routine Maintenance for Safe Operation This guide provides only site preparation information Before operating this instrument read the information in the AB PRISM 6700 Automated Nucleic Acid Workstation User s Manual concerning hazards and potential hazards Ensure that anyone involved with the operation of the instrument is instructed in both general safety practices for laboratories and specific safety practices for the instrument Detailed safety information topics that will be covered in the user s manual for this instrument include Electrical safety Lamp safety Pressurized bottle safety Robotic arm safety Maintain the instrument in good working order If the instrument has been subjected to adverse environmental conditions such as fire flood or earthquake a Applied Biosystems service representative should inspect the instrument We recommend that a Applied Biosystems service engineer check the instrument yearly to verify that The safety interlocks protecting the user from various hazards are working properly The protective housing is f
25. time of installation but most of them are not supplied by Applied Biosystems A service representative will contact you to confirm that everything is checked off before making an appointment for installation The following components are supplied by Applied Biosystems Check off the items after performing the actions Date y Confirmed Action Received instrument s and inspected the crates and boxes Verified that the appropriate number of containers were delivered Reported any damage or discrepancies to your Applied Biosystems service representative Verified that instrument s serial number s and system configuration as shown on the packing list and in Items Shipped with This Instrument on page 2 10 are the same as ordered Reported any discrepancies in instrument serial numbers or system configuration or damage to the crates or boxes to your Applied Biosystems service representative Read all sections of this Site Preparation and Safety Guide Read and understand the MSDSs provided with the Installation Chemistry Kit Unpacked and stored the contents of Chemistry Install Kit checking the contents against the invoice or the list on page 2 11 Checked the contents of the Plastics Install Kit against the invoice or the list on page 2 12 Checked the contents of the Packing Kit against the invoice or the list on page 2 13 Site Preparation 2 5 On Site Personnel Check
26. A Japan 220 10 50 60 Hz 1 3 6 100 10 8 0 USA Canada 120 10 50 60 Hz 1 6 6 Europe pre 1992 220 10 50 60 Hz 1 3 6 EC 230 10 50 60 Hz 1 3 4 UK pre 1992 240 6 10 50 60 Hz 1 3 3 Australia 240 6 10 50 60 Hz 1 3 3 It is strongly recommended that the instrument have a dedicated power line and ground or a power line with an uninterruptible power supply UPS Applied Biosystems recommends the Smart UPS Series SU1400 NET manufactured by Applied Power Conversion APC This instrument requires a 3 prong grounded receptacle in the United States The electrical receptacle must be located within 2 5 m 8 ft of the instrument rear panel Do not use extension cords This instrument is rated for a maximum draw output of 800 W Certain types of electrical noise are greatly exaggerated by poor or improper electrical ground connections To prevent these problems it is strongly recommended that there be a dedicated line and ground between the instrument and building main electrical service In the USA Canada and Japan the instrument is supplied with a detachable cord equipped with a standard 3 prong plug In Europe and Australia the instrument is supplied with an detachable electrical cord equipped with a standard EC plug The computer can be plugged into any standard electrical receptacle after it has been configured for the proper voltage Site Preparation 2 19 Voltage Quality Po
27. ABI Prism 6700 Automated Nucleic Acid Workstation Site Preparation and Safety Guide 4 Applied AS Biosystems Copyright 2001 Applied Biosystems All rights reserved For Research Use Only Not for use in diagnostic procedures Information in this document is subject to change without notice Applied Biosystems assumes no responsibility for any errors that may appear in this document This document is believed to be complete and accurate at the time of publication In no event shall Applied Biosystems be liable for incidental special multiple or consequential damages in connection with or arising from the use of this document ABI PRISM and its Design and Applied Biosystems are registered trademarks of Applera Corporation or its subsidiaries in the U S and certain other countries AB Design Applera and VIC are trademarks of Applera Corporation or its subsidiaries in the U S and certain other countries AmpliTaq AmpliTaq Gold and TaqMan are registered trademarks of Roche Molecular Systems Inc Oracle is a registered trademark of the Oracle Corporation All other trademarks are the sole property of their respective owners Printed in the USA 03 2001 Part Number 4304419 Rev C Contents 1 Introduction OVEIVIEW 1 11 9 1 1 About the Site Preparation and Safety Guide 1 1 In This Guide cos dos ses 777 7 78 8 7
28. EN NDERNMZTT builQctoo BEHHZOLTIETZAFNESELH LT ERBLTTOTCK ESL 7 2 X 9 14 Applied Biosystems Xi amp Cf amp RH amp fv CU ARES E0Y 7 CT Ost ICH DERERLEF COXmO s S8 CERT SGA BSB gt CL ONALAR JI AENG T To PP RENICL F LELWTUWS LENTES Instrument Safety 4 11 oA AB TS A7 NE CSO XE Applied Biosystems 22 LE 7 JIE EY EH HA YH CH oa 757 717 Sd HAE AS Hast Om AAS SS SPO TLIC 0 2182 AN LANA QE DEPL ER Ol ASE FATA 4 dA ASAT 48748 ES UE OS o ASE ASO CHE 717 9 NS AA AMAA HANS USS HEHHEE 0 32 asi SN 3 oH LCH 0 718271714 HHE 47 H80 470A AAS HEN eisisiopor SE Sez AN ASAS HERA CH 902137123 As um EE AVS BA BS ULICI ol 7 amp 7r gi ra Ju rlo El D JA F Ec ats AL sug T USC An 0 7182 140 SSS HELIO ASASO FAL AS BUENOS gt gt roared 0121220 AAs BE 7 AU SSNS AVE AS Le FOIE AS SELIC 47 489 zer Applied Biosystems 217 01 SALE H amp 7 HA zal WALK 4 12 Instrument Safety NE o SEAS ABS IO o SHAN SAE YE AAS PEO Ast SYS 1517 Slo Selo EH CH Pb ol ASE HORZ FILHO zx ers LIEFALICF A A a Q
29. ER E 1 1 About Premstallati eec nes ee 1 2 Preparing Your SE cis Ais ahs ie tlle bier ale Ade BEES 1 2 Choosing a Location Suse aa ns 1 2 About Safety EE 1 2 Using the Instrument Correctly 1 2 User Attention Words 1 2 About Chemical Safety eh ae eats ee GR E e E ERR E ne 1 3 About Material Safety Data Sheets MSDSSs 1 3 About Waste Disposal 1 3 Chemical Hazard Warning 1 3 Chemical Waste Hazard Warning 1 4 Technical Support 3 ese er STR GD SE 1 5 To Reach Technical Support Through the Internet 1 5 To Contact ABI PRISM 6700 Technical Support 1 5 Ordering MSDSS ss ps rta ea aa EI AEE 1 6 Documents on Demand 1 7 To Obtain Customer Training Information 1 7 Regional Offices Sales and Service 1 8 Site Preparation OVEIVIEW 1 1 5 2 1 About This Chapter esis an a re ae ale 2 1 In This Chapter ii RE ANC 2 1 Betfore YoU Start coo Ken a 1 1 1 1 1 1 2 2 Preinstallation
30. Outside North America Sales and Service 1 8 Introduction Region Telephone Dial Fax Dial Africa and the Middle East Africa English Speaking and West Asia Fairlands South Africa 27 11 478 0411 27 11 478 0349 Africa French Speaking Courtaboeuf Cedex France 33 1 69 59 85 11 33 1 69 59 85 00 South Africa Johannesburg 27 11 478 0411 27 11 478 0349 Middle Eastern Countries and North Africa Monza Italia 39 0 39 8389 481 39 0 39 8389 493 Eastern Asia China Oceania Australia Scoresby Victoria 61 3 9730 8600 61 3 9730 8799 China Beijing 86 10 64106608 or 86 10 64106617 86 800 8100497 Hong Kong 852 2756 6928 852 2756 6968 India New Delhi 91 11 653 3743 3744 91 11 653 3138 Korea Seoul 82 2 593 6470 6471 82 2 593 6472 Malaysia Petaling Jaya 60 3 79588268 603 79549043 Singapore 65 896 2168 65 896 2147 Taiwan Taipei Hsien 886 2 2358 2838 886 2 2358 2839 Thailand Bangkok 66 2 719 6405 66 2 319 9788 Europe Austria Wien 43 0 1 867 35 750 43 0 1 867 35 75 11 Belgium 32 0 2 532 4484 32 0 2 582 1886 Czech Republic and Slovakia Praha 420 2 35365189 420 2 35364314 Denmark Naerum 45 45 58 60 00 45 45 58 60 01 Finland Espoo 358 0 9 251 24 250 358 0 9 251 24 243 France Paris 33 0 1 69 59 85 85 33 0 1 69 59 85 00 Germany Weiterstadt 49 0 6150 101 0 49 0
31. UIDE CHEMICAL HAZARD Be sure to familiarize yourself with the MSDSs before using reagents or solvents As the generator of potentially hazardous waste it is your responsibility to perform the actions listed below Characterize by analysis if necessary the waste generated by the particular applications reagents and substrates used in your laboratory Ensure the health and safety of all personnel in your laboratory Ensure that the instrument waste is stored transferred transported and disposed of according to all local state provincial or national regulations Note Radioactive or biohazardous materials may require special handling and disposal limitations may apply VN CHEMICAL HAZARD Some of the chemicals used with Applied Biosystems instruments are potentially hazardous and can cause injury illness or death Read and understand the material safety data sheets MSDSs provided by the chemical manufacturer before you store handle or work with any chemicals or hazardous materials Minimize contact with and inhalation of chemicals Wear appropriate personal protective equipment when handling chemicals e g safety glasses gloves or clothing For additional safety guidelines consult the MSDS Do not leave chemical containers open Use only with adequate ventilation Check regularly for chemical leaks or spills If a leak or spill occurs follow the manufacturer s cleanup procedures as recommended on the MSDS
32. a presenza di alta tensione e invita l utente a procedere con cautela Questo simbolo invita l utente a consultare il manuale per ulteriori informazioni e a procedere con cautela PPUIYBH B80O Simboli non elettrici Segue un glossario illustrato dei simboli degli allarmi di sicurezza non elettrici trovati su strumenti Applied Biosystems Questo simbolo illustra un rischio di alte temperature Procedere con cautela quando si lavora in queste aree per evitare ustioni causate da componenti a temperature elevate Questo simbolo indica la presenza di laser nello strumento gt gt Instrument Safety 4 7 Simbolos de alerta de seguranca S mbolos el tricos A tabela a seguir constitui um gloss rio ilustrado de todos os s mbolos el tricos usados nos instrumentos Applied Biosystems Sempre que um desses s mbolos aparecer num instrumento siga os procedimentos adequados de seguranca Este s mbolo indica que o interruptor de energia el trica est na posic o ligado Este s mbolo indica que o interruptor de energia el trica est na posic o desligado Este s mbolo indica a posic o ligado desligado de um interruptor principal de energia el trica do tipo bot o de press o Este s mbolo indica que um terminal pode estar conectado a uma refer ncia de aterramento de sinal de um outro instrumento Este n o um terminal terra protegido Este s mbolo indica que este u
33. are present The verification plates will be tested on the ABI PRISM 7700 Sequence Detection System Note The 6700 Chemistry Install Kit will be shipped before the instrument arrives Storage P N Description Quantity Conditions 4305901 ABI PRISM 6700 Cell Lysate Control Kit 2 kits 15 to 25 C 1 tube High CLC 1 tube Low CLC 0 6 mL High and 0 6 mL Low RNA Standards 4308329 TaqMan Ribosomal RNA Control Reagents 2 kits VIC Dye 4310982 TaqMan RNase P Instrument Verification 2 plates 2108 C Plate 4309169 TaqMan One Step RT Master Mix 3 kits Reagents Kit 4308456 Model 6700 System Fluid 1 bottle Room 4305893 Nucleic Acid Purification Elution Solution 2 bottles temperature 4305895 Nucleic Acid Purification Lysis Solution 2 bottles 4305891 RNA Purification Wash Solution 1 2 bottles 4305890 RNA Purification Wash Solution 2 2 bottles Site Preparation 2 11 6700 384 Well Unpack the 6700 384 Well Upgrade Chemistry upon receipt and store the chemicals Upgrade Chemistry and reagents as indicated in the table below The chemicals in this kit are completely consumed during the installation and initial testing of the instrument Please verify that all items are present The verification plates will be tested on the ABI PRISM 7900HT Sequence Detection System Storage P N Description Quantity Conditions 4327317 DNA Template Kit 384 Well Verifi
34. astics Install Kit and the Site Preparation and Shipping Dept Safety Guide to arrive at the customer site before the instrument The instrument arrives via air freight at the customer s loading dock storage area 5 Customer Customer performs the following steps a Read the Site Preparation and Safety Guide b Open the Chemistry Install Kit box c Read the MSDSs provided in the shipment d Check the contents of the Chemistry Install Kit Plastic Consumables box and Packing Kit with their invoices or the lists on 2 11 through 2 13 e Unpack and store chemical reagents 6 Customer Customer performs all of the preparations in the Preinstallation Checklists beginging on page 2 5 7 Third Party Third party movers arrive unpack and position the instrument on Movers the laboratory bench or table 8 Applied Shortly after the instrument is delivered a service engineer calls Biosystems the customer to verify that i ti 4 All the preparations on the preinstallation checklists have been performed All components of the 6700 Starter Kit have arrived 9 Applied Service Administration generates a service request for Biosystems instrument installation and customer training Service Administration 10 Applied A service engineer calls to arrange a date for the 2 day Biosystems installation and customer training process Service Engineer Site Preparation 2 3 Overview of the The table below summari
35. cation for 1 kit 15 to 25 C ABI Prism 6700 Workstation 4304437 2X Universal Master Mix Kit 1 kit 4316831 RNAse P Detection Reagents Kit 2 kits 4323306 TaqMan RNase P Instrument Verification 1 plate 2to8 C Plate 384 Well Plastic Consumables The Plastics Install Kit P N 4313514 containing the following plastic consumables for for the 96 Well the 96 well output block is also shipped with the instrument The supplies in this kit are Output Block completely consumed during the installation and initial testing of the instrument Please verify that all of these items are present These plastic consumables will be used on the ABI PRISM 7700 Sequence Detection System P N Description Quantity 4311758 6700 Splash Guards 1 box of 20 4306737 96 Well Optical Reaction Plate with Barcode 1 box of 20 4306286 Archive Covers 1 box of 10 4306377 Conductive Pipette Tips 1000 uL 1 box of 24 racks 4306375 Conductive Pipette Tips 200 uL 2 boxes of 24 racks 4305936 Microcentrifuge Tubes and Caps 2 mL 1 box of 500 4312639 Optical Cover Compression Pads 1 kit with 5 pads 4307726 Optical Heat Seal Covers 1 box of 100 4304831 Reagent Reservoirs 120 mL 1 box of 32 4305932 Reagent Tubes with Caps 10 mL 1 box of 40 4305673 Total RNA Purification Trays 1 box of 10 2 12 Site Preparation Plastic Consumables for the 384 Well Output Block The following plastic consumables a
36. er c Use the index number when requesting documents following the procedures below by phone for fax a From the U S or Canada call 1 800 487 6809 or delivery from outside the U S and Canada call 1 858 712 0317 b Follow the voice instructions to order the documents you want Note There is a limit of five documents per request through the a Access the Applied Biosystems Technical Support Web site at Internet for fax or http www appliedbiosystems com techsupp e mail delivery b Under Resource Libraries click the type of document you want c Enter or select the requested information in the displayed form then click Search d In the displayed search results select a check box for the method of delivery for each document that matches your criteria then click Deliver Selected Documents Now or click the PDF icon for the document to download it immediately e Fill in the information form if you have not previously done so then click Deliver Selected Documents Now to submit your order Note There is a limit of five documents per request for fax delivery but no limit on the number of documents you can order for e mail delivery To Obtain Customer The Applied Biosystems Training Web site provides course descriptions schedules Training and other training related information The Web site address is Information www appliedbiosystems com techsupp training html Introduction 1 7 Regional Offices
37. f 2730 Btu h 0 8 kw Established proper handling and disposal method s for hazardous chemical waste and biological waste if applicable Site Preparation 2 7 2 8 Site Preparation NI Date Confirmed Requirement Electrica A dedicated power line and ground for the 6700 system is strongly recommended A line conditioner or uninterruptible power supply UPS on the power line is recommended Applied Biosystems recommends Smart UPS SeriesSU1400NET manufactured by Applied Power Conversion APC One standard power outlet within 2 5 m 8 0 ft of the instrument location is required preferably near the back of the instrument Separate power outlets on the same dedicated line are required for the CPUs monitor and printer and tape backup system if any Met requirements specified in Electrical Requirements on page 2 19 Equipment and You must supply the following items for installation Check off each item as you verify Consumables Required its availability Date Y Confirmed Item ABI PRISM 7700 or 7900HT Sequence Detection System available on both days of installation A tape backup system is highly recommended Applied Biosystems recommends the Exabyte 8700 Eliant 820 SW 14 GB 8 mm tape backup The dimensions for this system are 23 cm 9 in width x 28 cm 11 in depth x 8 cm 3 in height weight 2 2 kg 5 lbs PC com
38. f Standard laminate top Standard power coat paint 9 T mold edge Optional 8 outlet power strip Note Depending on the height of the majority of the users you may choose another table height or choose an adjustable height table The deckspace is 24 cm 9 5 in from the tabletop and the total distance from the front of the deckspace to the back is 53 cm 21 in 1 Heicks Flat Bench can be ordered from The Corner Office 1045 Sansome Street Suite 100 San Francisco CA 94111 Phone 415 362 5595 Fax 415 362 5599 Site Preparation 2 15 Computer Cart or Table Location of Database Client CPU Location of the Computer Monitor and Keyboard 2 16 Site Preparation The computer keyboard and optional tape back up and printer must be located to the left of the 6700 instrument preferably on a sturdy multi level cart This allows the computer monitor and keyboard to be situated near the instrument for easy operator access during run setup Applied Biosystems recommends the Heicks Test Station Tech Table or a similar model with the following specifications 36 in width x 30 in depth x 34 in height Adjustable 15 in x 12 in single post mounted shelf Drop in riser shelf 6 outlet power strip with 15 ft power cord ESD main worksurface ESD grounding kit Storage cabinet with adjustable shelf Pull out keyboard tray 20 in x 18 in lower shelf 4 in total lock casters Optional 2 pocket binder storage
39. he On Off position of a push push main power switch This symbol indicates that a terminal may be connected to another instrument s signal ground reference This is not a protected ground terminal This symbol indicates that this is a protective grounding terminal that must be connected to earth ground before any other electrical connections are made to the instrument 0 A terminal marked with this symbol either receives or delivers alternating current or voltage A terminal marked with this symbol can receive or supply an alternating and a direct current or voltage This symbol indicates the presence of high voltage and warns the user to proceed with caution Pb This symbol alerts you to consult the manual for further information and to proceed with caution Nonelectrical The following is an illustrated glossary of all nonelectrical safety alert symbols found Symbols Applied Biosystems instruments 4 4 Instrument Safety This symbol illustrates a heater hazard Proceed with caution when working around these areas to avoid being burned by hot components gt gt This symbol indicates that a laser is present inside the instrument Symboles des alertes de s curit Symboles lectriques Le tableau suivant donne la signification de tous les symboles lectriques qui figurent sur les appareils Applied Biosystems En pr sence de
40. he bottle fracturing when it is pressurized during operation Chemical Safety 3 3 Handling Customers may choose to use this instrument to process materials such as tissues Biohazardous cells or blood that might be biohazardous The 6700 contains a self enclosed fume Material hood that meets Biosafety Level 2 specifications For proper use of the instrument the outer door must be locked in the down position BIOHAZARD Biological samples such as tissues and blood have the potential to transmit infectious diseases Follow the U S Department of Health and Human Services guidelines and the guidelines found in Occupational Safety and Health Standards Toxic and Hazardous Substances concerning the principles of risk assessment biological containment and safe laboratory practices for activities involving clinical specimens You can obtain additional information by connecting to the government Web site http Awww cdc gov 4 All lab personnel who handle biohazardous materials must have received biohazards safety training All personnel must have the appropriate personal protection equipment PPE Always operate the instrument with the fume hood on The instrument waste should be treated as biohazardous 1 U S Department of Health and Human Services Centers for Disease Control and Prevention and National Institutes of Health 1999 Biosafety in Microbiological and Biomedical Laboratories 4th ed Richmond J Y and McKinney R W eds
41. hlorobenzyloxycarbonyl CPG Controlled Pore Glass DCA dichloroacetic acid DCC dicyclohexylcarbodiimide DCM dichloromethane DCU dicyclohexylurea DIEA diisopropylethylamine DMAP 4 dimethylaminopyridine DMF dimethylformamide DMSO dimethylsulfoxide DNA deoxyribonucleic acid Acronyms and Abbreviations A 3 Abbreviation Definition Dnp 2 4 dinitrophenyl Et ethyl EtOH ethanol Fmoc 9 fluorenylmethyloxycarbonyl G guanine HBTU 2 1H benzotriazol 1 yl 1 1 3 3 tetramethyl uronium hexafluorophosphate HLP high loaded polystyrene HMP resin p hydroxymethylphenoxymethyl polystyrene resin HOAc acetic acid mBHA resin 4 methylbenzhydrylamine resin MeOH methanol Mob 4 methoxybenzyl Mtr 4 methoxy 2 3 6 trimethyl benzene sulfonyl Mts mesitylene 2 sulfonyl NMI 1 methylimidazole NMP N methylpyrrolidone N methyl 2 pyrrolidone OBt ethyl ester OMe methyl ester PAM resin phenylacetamidomethyl resin PEG polyethylene glycol RV reaction vessel SSPS solid phase peptide synthesis T thymine TETD tetraethylthiuram disulfide TFA trifluoroacetic acid TFMSA trifluoromethane sulfonic acid THF tetrahydrofuran Tos 4 toluenesulfonyl tosyl Tri trityl U uracil Z benzyloxcarbonyl A 4 Acronyms and Abbreviations Headquarters 850 Lincoln Centre Drive Foster City CA 94404 USA Phone 1 650 638 5800 Toll Free In N
42. ht elektrischen Symbole 4 6 Instrument Safety Dieses Symbol zeigt eine Gefahr durch die Heizung an Gehen Sie vorsichtig vor wenn Sie in der Nahe dieser Bereiche arbeiten damit Sie sich nicht an heiBen Komponenten verbrennen gt gt Dieses Symbol zeigt das Vorliegen eines Lasers im Innern des Ger ts an Simboli degli allarmi di sicurezza Simboli elettrici La tabella seguente 6 un glossario illustrato di tutti simboli elettrici utilizzati su strumenti Applied Biosystems Ogni volta che tali simboli compaiono sugli strumenti rispettare le procedure di sicurezza appropriate Questo simbolo indica la posizione On dell interruttore di alimentazione generale Questo simbolo indica la posizione Off dell interruttore di alimentazione generale Questo simbolo indica la posizione On Off di un interruttore di alimentazione generale a pulsante Questo simbolo indica che un terminale pu essere collegato alla messa a terra di un altro strumento Non un terminale di terra protetto Questo simbolo indica un terminale protettivo di messa a terra che deve essere collegato a terra prima di realizzare qualsiasi altro collegamento elettrico allo strumento Un terminale contrassegnato con questo simbolo riceve o fornisce tensione o corrente alternata Un terminale contrassegnato con questo simbolo pu ricevere o fornire tensione o corrente alternata e continua Questo simbolo indica l
43. le to schedule this training time please call Applied Biosystems Service Administration to reschedule the installation Calibration of the instrument and verification of performance will be performed by an Applied Biosystems service representative during the installation Before installation be sure to contact Sales Administration or your sales representative to order the additional supplies necessary for the ongoing operation of the instrument The chemicals shipped with this instrument will be completely consumed during the installation and initial testing of the instrument Preinstallation and Installation Overviews Overview of The table below summarizes the stages of the preinstallation process Preinstallation Process Person Stage Responsible Action 1 Customer Customer orders instrument from Applied Biosystems 2 Applied For customers in the United States Service Administration alerts Biosystems third party movers who will be responsible for unpacking the Service instrument and positioning it in the laboratory Administration 3 Third Party Third party movers contact the customer to arrange a convenient Movers schedule for unpacking and positioning the instrument in the laboratory If the movers do not contact you in a timely manner please call Applied Biosystems Service Administration 4 Applied The shipping department ships the 6700 Starter Kit Chemistry Biosystems Install Kit and Pl
44. les liminer WARNING Risk of electric shock Disconnect power cord from supply before replacing fuses or removing power supply module from instrument AVERTISSEMENT Risque de choc lectrique D brancher le cordon d alimentation avant de remplacer les fusibles ou de retirer le bloc d alimentation de l instrument WARNING For continued protection against risk of fire replace only with Listed and Certified fuse of the specified type and ratings AVERTISSEMENT Pour une protection continue contre les risques d incendie utiliser uniquement des fusibles agr s et certifi s du type et du courant nominal sp cifi s WARNING Hot lamp AVERTISSEMENT Lampe br lante WARNING Hot Replace lamp with an Applied Biosystems lamp AVERTISSEMENT Composants br lants Remplacer la lampe par une lampe Applied Biosystems WARNING Disconnect supply cord before opening Grounding circuit continuity is vital for safe operation of equipment Never operate equipment with grounding conductor disconnected AVERTISSEMENT Debrancher le cordon d alimentation avant d ouvrir La continuit du circuit de masse est essentiel a la s curit du fonctionnement de l appareil Ne jamais utiliser l appareil avec la prise de terre d branch e WARNING For protection against fire hazard replace only same type and rating of fuse AVERTISSEMENT Pour assurer la protection contre les risques d incendie
45. lowing dimensions Component Width Depth Height Total Weight Instrument 142 cm 84 cm 99 cm 159 kg 56 in 33 in 39 in 350 Ib Computer 43 cm 42 cm 44 cm 22 kg monitor 17 in 16 5 in 17 2 in 49 lb Database 45 cm 45 cm 21 cm 16 6 kg Client CPU 18 in 18 in 8 5 in 37 lbs Mouse and 53 cm 18cm 4cm 1 kg keyboard 21 in 7 in 1 5 in 2 lb Database 17cm 42 cm 44 cm 16 6 kg Server CPU 6 5 in 16 5 in 17 2 in 37 lbs Printer and or Varies Customer supplied tape back up Note Dimensions and weights are subject to minor changes An area of at least 175 3 cm x 114 3 cm x 161 3 cm 69 in x 45 in x 63 5 in must be allocated at the receiving and storage area for the crated 6700 instrument Third party movers will unpack the instrument and position it on the laboratory bench or table The instrument requires a movable laboratory bench or table with sturdy casters The bench must be able to accommodate the size and weight of the system All four sides of the instrument must be accessible to the installer Although the waste lines exit at the back of the instrument the waste bottles should be placed under or in front of the laboratory table for easy accessibility Applied Biosystems recommends the Heicks Flat Bench or a similar model with the following specifications 72 in width x 30 in depth x 34 in height 4 in swivel lock casters 18 in deep lower shel
46. ls 50 of a specified population LEL Lower explosion limit MSHA Mine Safety and Health Administration recommends respirators NFPA National Fire Protection Association publishes recommended regulations for local or state governments in the United States hazardous rating system developed by this association NIOSH National Institute of Occupational Safety and Health USA recommends exposure levels and respirators oc Open cup testing for flash point Acronyms and Abbreviations A 1 Term OSHA Explanation Occupational Safety and Health Administration USA sets chemical exposure levels PEL Permissible exposure limit the federal OSHA limit usually expressed as time weighted average TWA for an 8 hour work shift PPM Parts per million Prop 65 A California law requiring warnings for chemicals that are known to the state to be carcinogenic or to cause reproductive harm RCRA Resource Conservation and Recovery Act RTECS Registry of Toxic Effects of Chemical Substances SARA Superfund Amendments and Reauthorization Act a federal act administered by EPA SCBA Self Contained Breathing Apparatus STCC Standard Transportation Commodity Code STEL Short Term Exposure Level published by ACGIH Lowest published toxic concentration TLV Threshold limit value the ACGIH recommended TWA usually for an 8 hour work shift TWA Time weighted average
47. m terminal de aterramento de protec o que deve ser ligado a terra antes de se fazer qualquer outra ligac o el trica ao instrumento Um terminal marcado com este s mbolo recebe ou transmite tens o ou corrente alternada Um terminal marcado com este s mbolo recebe ou fornece tens o ou corrente alternada ou cont nua Este s mbolo indica a presenca de alta tens o e avisa o usu rio para proceder com cuidado PP 1 oeroo Este s mbolo serve como alerta para que se consulte o manual a fim de se obter mais informac es e que se proceda com cuidado S mbolos A seguir apresentamos um gloss rio ilustrado de todos os s mbolos de alerta de n o eletricos Seguran a nao relacionados electricidade encontrados nos instrumentos Applied Biosystems 4 8 Instrument Safety Este s mbolo representa um perigo devido a aquecedor no local Proceda com cuidado ao trabalhar em reas pr ximas a aquecedores para evitar queimaduras devidas ao contato com componentes quentes gt gt Este s mbolo indica que h um laser dentro do instrumento Simbolos de alerta de seguridad S mbolos el ctricos En la siguiente tabla se muestra un glosario ilustrado de todos los s mbolos el ctricos que se utilizan en los instrumentos de Applied Biosystems Cuando tales s mbolos figuran en los instrumentos lleve a cabo los procedimientos de seguridad apropiados Este s mbolo indica la posici n de e
48. ment is collected in a 4 L 1 gallon plastic container Dispose of the waste when the waste bottle is half full Fluid wastes are flushed through the vacuum station to the waste bottle HEPA filters protect the system from aerosol contamination System fluid is isolated and recycled through the instrument but should be changed regularly to avoid bacterial contamination If the system fluid is changed regularly it is not considered hazardous material The composition of the chemical waste may vary depending upon the protocols used the number of samples the volumes specified and the reagents included in the protocols Chemical Safety 3 5 Handling Chemical When handling chemical waste Applied Biosystems strongly recommends that you Waste 4 Read the waste profile s in this chapter before handling or disposing of hazardous waste Read all applicable MSDSs before handling or disposing of hazardous waste Ensure that the waste container is correctly installed Always handle hazardous materials beneath a fume hood that is connected in accordance with all installation requirements Always wear chemical resistant gloves safety glasses and protective clothing when handling hazardous waste material During transfer ensure that the waste container is tightly sealed with the waste cap provided Dispose of hazardous waste in accordance with all local state provincial or national regulations Storing Hazardous CHEMICAL STORAGE
49. ncendido del interruptor principal Este s mbolo indica la posici n de apagado del interruptor principal Este s mbolo indica la posici n de encendido apagado de un interruptor principal de presi n Este s mbolo indica que existe la posibilidad de conectar esta terminal a la toma de tierra de referencia de otro instrumento Esta no es una toma de tierra protegida Este s mbolo indica que la toma de tierra protegida debe ser conectada a tierra antes de realizar cualquier otro tipo de conexi n el ctrica al instrumento Una terminal marcada con este s mbolo recibe o suministra corriente o tensi n alterna Una terminal marcada con este s mbolo puede recibir o suministrar corriente o tensi n alterna y continua Este s mbolo indica la presencia de alta tensi n y advierte al usuario que proceda con precauci n gt 1 Dr 00 Este simbolo indica que consulte el manual para obtener mas informaci n y que proceda con precauci n S mbolos no A continuaci n se presenta un glosario ilustrado de todos los s mbolos de seguridad y el ctricos alerta no el ctricos que aparecen en los instrumentos de Applied Biosystems Este s mbolo indica peligro de altas temperaturas Proceda con cautela cuando trabaje cerca de estas zonas para evitar quemarse con componentes calientes gt gt Este s mbolo indica que hay un l ser dentro del instrumento Instrument Safety 4 9
50. npack it and position it on the bench For details see Overview of Preinstallation Process on page 2 8 PHYSICAL INJURY HAZARD Do not move or unpack instrument cartons This instrument is heavy Any incorrect lifting or moving of the instrument can cause painful and sometimes permanent back injury The instrument may tip over if moved or unpacked incorrectly causing serious injury to persons in its path or damage to the instrument itself Unpacking the instrument will also void your warranty with Applied Biosystems Unpacking Chemicals 6700 Chemistry Install Kit for the 96 Well Output Block You must unpack the Chemistry Install Kit which is boxed separately from the instrument Read the MSDSs supplied with the chemicals and store the components as specified under 6700 Chemistry Install Kit for the 96 Well Output Block on page 2 11 CHEMICAL HAZARD Some chemicals used with Applied Biosystems instruments are hazardous and can cause injury illness or death Always read the appropriate MSDSs before interacting with the instrument and chemicals in any way Hazardous Chemical Warnings are prominently displayed on the labels of all hazardous materials Unpack the 6700 Chemistry Install Kit P N 4308328 upon receipt and store the chemicals and reagents as indicated in the table below The chemicals in this kit are completely consumed during the installation and initial testing of the instrument Please verify that all items
51. nstrument is 2730 Btu h 0 8 kW Consult your facilities department regarding ventilation requirements for this level of heat output Laboratory Environmental Requirements Altitude Temperature and Humidity Pollution Emission Immunity Statement Ce 2 18 Site Preparation This instrument is for indoor use only and for altitudes not exceeding 2000 m 6500 ft above sea level The laboratory temperature should be maintained between 15 and 30 C 59 85 F The instrument can tolerate up to 80 relative humidity Avoid placing the instrument adjacent to heaters cooling ducts or in direct sunlight The installation category overvoltage category for this instrument is II and it is classified as portable equipment The instrument has a pollution degree rating of 2 and may be installed in an environment that has non conductive pollutants only For our European customers any product marked with the CE label meets the European EMC Directive 89 336 EEC and the Low Voltage Directive 72 23 EEC This product meets Class B emission limits Electrical Requirements Power Power Line Electrical Outlets Power Rating Grounding Power Cords IMPORTANT You must be able to disconnect the main power supply to the instrument immediately if necessary The following table specifies the electrical operating range for the instrument in various parts of the world Location Voltage VaC Frequency Amperage
52. o this guide and Customer Support contact information Site Preparation Provides installation requirements and the preinstallation checklists Chemical Safety Provides general chemical handling guidelines and instrument waste profiles if any Instrument Safety Explains safety alert symbols on instrument and shows instrument input and output connections Acronyms and Abbreviations Explains terms used in Material Safety Data Sheets MSDSs and in this guide Introduction 1 1 About Preinstallation Preparing Your Site Preinstallation checklists start on page 2 5 of this guide An Applied Biosystems Choosing a Location About Safety Using the Instrument Correctly User Attention 1 2 Introduction Words employee will contact you to verify that everything on the checklists has been done before making an appointment for installation When deciding where to put the instrument keep in mind the following 4 You must be able to disconnect the main power supply to the instrument immediately if necessary You must be able to comply with local state provincial or national air quality regulations while venting the exhaust from this instrument Use this instrument as specified by Applied Biosystems If the instrument is used in a manner not specified by the manufacturer the protection provided by the instrument may be impaired Five user attention words appear in the text of all Applied Biosystems
53. ool white teflon tip tightener 5 225044 Tubing vinyl 0 25 in internal diameter 0 375 in 25 ft outside diameter Site Preparation 2 13 Laboratory Safety Requirements On Site Representative Required Safety Equipment 2 14 Site Preparation We request that a representative from your laboratory be in the vicinity and available to the Applied Biosystems engineer at all times while the representative is at your facility This person should know all of the safety procedures for the laboratory and know the locations of all of the safety equipment Your laboratory has specific safety practices and policies designed to protect laboratory personnel from potential hazards that are present We expect that all applicable safety related procedures will be followed at all times The following safety equipment must be available Fire extinguisher Halon Eyewash Safety shower Eye and hand protection Adequate ventilation First aid equipment Spill cleanup equipment Protection from any sources of hazardous chemicals radiation lasers radioisotopes contaminated equipment radioactive wastes etc and potentially infectious biological material that may be present in the area where Applied Biosystems engineer s will be working Laboratory Space Required Dimensions and Weight Instrument Storage Area Laboratory Bench or Table The 6700 Automated Nucleic Acid Workstation components have the fol
54. orth America 1 800 345 5224 Fax 1 650 638 5884 Worldwide Sales and Support Applied Biosystems vast distribution and service network composed of highly trained support and applications personnel reaches into 150 countries on six continents For sales office locations and technical support please call our local office or refer to our web site at www appliedbiosystems com www appliedbiosystems com D Ze GERS Sa Biosystems Applera Corporation is committed to providing the world s leading technology and information for life scientists Applera Corporation consists of the Applied Biosystems and Celera Genomics businesses Printed in the USA 03 2001 Part Number 4304419 Rev C an Applera business
55. ous Chemicals Chemicals are classified as hazardous when they are physically hazardous or if they can cause acute or chronic health hazards upon exposure 4 Physically hazardous chemicals are materials that are flammable combustible under compression gases explosive oxidative organically peroxidic pyrophoric reactive or unstable or water reactive Chemicals that can cause health hazards include carcinogens materials that are toxic or highly toxic reproductive toxins irritants corrosives sensitizers materials that are toxic to the liver kidney or blood forming hematopoietic system and agents that damage the lungs skin eyes or mucous membranes Here are some of the important requirements for handling hazardous chemicals 4 Read and understand all applicable MSDSs before handling hazardous chemicals Always wear gloves safety glasses and protective clothing when handling chemicals Always provide adequate ventilation when handling chemicals Some chemicals require handling only in a properly functioning fume hood Provide secondary containment for all reagent bottles Do not store chemicals in direct sunlight or heat on or off the instrument BOTTLE FRACTURING HAZARD When replacing reagents always install a new bottle on the instrument Do not add new solution to previously used reagent bottles Some chemicals reduce the integrity of glass bottles As a result repeated use beyond 6 weeks may result in t
56. patible printer optional There is no Internet hub in the installation kit If you plan to add the 6700 Client and Server computers to your network then you must supply the following 4 2active ethernet ports 4 2 IP addresses including all TCP IP information If these are not available at the time of installation the Client will be networked to the server directly using an ethernet crossover cable Thirty 30 high density 1 44 MB capacity 3 5 in floppy disks IBM formatted A binder with plastic disk storage sleeves or a box for disk storage is highly recommended A large centrifuge that will accommodate 96 well reaction plates and generates a minimum of 1400 x g Microcentrifuge Ice bucket and wet ice Vortex mixer Laboratory freezer 20 C Additional computer supplies paper disks etc Micropipettes and tips Pipetman models P20 P200 P1000 or Eppendorf 1 10 uL 10 100 uL and 100 1000 uL Safety glasses and lab coats Chemical resistant disposable gloves Site Preparation 2 9 Items Shipped with This Instrument Summary List 6700 384 Well Upgrade Kit Do Not Move or Unpack Instrument 2 10 Site Preparation The 6700 instrument is shipped with the following for the 96 well output block ABI PRISM 6700 Automated Nucleic Acid Workstation Includes Waste Bottle Vac Station 4 L P N 4308297 and System Fluid Bottle 4 L P N 4311646 each with
57. re included in the 6700 384 Well Upgrade Kit These supplies are completely consumed during the installation and initial testing of the instrument Please verify that all of these items are present The plastic consumables will be used on the ABI PRISM 7900HT Sequence Detection System P N Description Quantity 4309849 384 Well Optical Reaction Plate with Barcode 1 box of 50 4306375 Conductive Pipette Tips 200 uL 1 boxes of 24 racks 4305932 Reagent Tubes with Caps 10 mL 1 box of 40 Packing Kit for the The following items are shipped in the 6700 Packing Kit P N 43078886A for the 96 Well Output 96 well output block Please verify that all of these items are present Block P N Description Quantity 4313100 Barcode reader QS 6000 with cable 1 4315743 Cable ethernet crossover with ferrites 1 4315744 Cable kit ferrite for AC power cable 1 4313545 Cable ethernet category 5 25 ft RJ45 RJ45 2 4314492 Cable serial DB9 M F 3M 1 4315747 Checklist packing kit 1 4310639 Coupling insert 0 25 in straight x 0 25 in barb 4 4315293 Ferrite 0 5 in cable clamp 110 OHM 25 MHz 2 4316180 Fuse 10A 250 Vac Fast 3AG 1 25 x 0 25 4 4313546 Kit cable PC Server Switch 2 4308550 Lamp cover 2 4309151 Lamp fluorescent 32W 4 pin 2 100383 Mouse pad 1 901522 Postcard 1 4315748 Procedure packing kit 1 4313543 Switch Belkin KVM PC Server 2 channel 1 4315378 T
58. remplacer uniquement par un fusible de m me type et de m me courant nominal CAUTION Hot ATTENTION Surface br lante DANGER High voltage DANGER Haute tension WARNING To reduce the chance of electrical shock do not remove covers that require tool access No user serviceable parts are inside Refer servicing to Applied Biosystems qualified service personnel AVERTISSEMENT Pour viter les risques d lectrocution ne pas retirer les capots dont l ouverture n cessite l utilisation d outils l instrument ne contient aucune pi ce r parable par l utilisateur Toute intervention doit tre effectu e par le personnel de service qualifi de Applied Biosystems DANGER Laser radiation when open and interlock defeated Avoid direct exposure to beam DANGER Rayonnement laser en cas d ouverture et d une neutralisation des dispositifs de s curit Eviter toute exposition directe avec le faisceau CAUTION Moving parts ATTENTION Parties mobiles Instrument Safety 4 3 Safety Alert Symbols Electrical Symbols The following chart is an illustrated glossary of all electrical symbols that are used on Applied Biosystems instruments Whenever such symbols appear on instruments please observe appropriate safety procedures This symbol indicates the On position of the main power switch This symbol indicates the Off position of the main power switch This symbol indicates t
59. s hazardous by their manufacturer When hazards exist warnings are prominently displayed on the labels of all chemicals MSDSs are supplied by the chemical manufacturer and provide information about Physical characteristics Safety precautions Health hazards First aid Spill cleanup Disposal procedures WII CHEMICAL HAZARD Be sure to familiarize yourself with the MSDSs before using reagents or solvents Explanations of acronyms and abbreviations used in MSDSs can be found in Appendix A of this guide Chemical manufacturers supply a current MSDS before or with shipments of hazardous chemicals to new customers and with the first shipment of a hazardous chemical after an MSDS update Replace the MSDSs in your files regularly so that the safety information is current You can order free additional copies of MSDSs for chemicals manufactured or distributed by Applied Biosystems See Ordering MSDSs on page 1 6 for details Applied Biosystems does not furnish MSDSs for chemicals used on this instrument that are not manufactured or sold by Applied Biosystems Contact the manufacturer s of those chemicals to obtain additional MSDSs Hazardous Chemicals and Biological Materials Overview This instrument may use chemicals that are hazardous PINZA INI CHEMICAL HAZARD Hazardous chemicals used with this instrument can cause injury illness or death Handle all chemicals as potentially hazardous Handling Hazard
60. secondary containment ABI PRISM 6700 Automated Nucleic Acid Workstation User s Manual P N 4304309 Database Installation and Administration for the ABI PRISM 6700 Nucleic Acid Workstation P N 4314342 Chemistry Install Kit P N 4308328 for the 96 well output block Plastics Install Kit P N 4313514 for the 96 well output block Packing Kit P N 4307886A Database Server CPU P N 4308104 Software Kit P N 4307885 consisting of ABI Prism 6700 Software CD ROM P N 4314498 Oracle v 8 5 1 Server CD ROM P N 4314497 Database Client CPU with keyboard and mouse P N 4309181 monitor P N 4307697 and switching box P N 4313543 The 6700 384 Well Upgrade Kit P N 4326908 may be ordered separately or at the same time as the instrument The following parts are shipped to the customer 6700 384 Well Upgrade Chemistry 384 Block P N 4325705 Heat seal clip P N 4327564 6700 System Software v 1 1 Kit P N 4327588 ABI PRISM 6700 Automated Nucleic Acid Workstation User s Manual updated with 384 option P N 4304309 Plastic consumables for the 384 well upgrade Do not move or unpack instrument cartons This protects you from liability if any damage occurred during shipping Inspect instrument cartons and report any damage to your Applied Biosystems service representative Do not attempt to lift the instrument carton The third party movers will move the carton to the laboratory u
61. trument Safety 4 5 Sicherheitswarnsymbole Elektrische Symbole Die folgende Tabelle enthalt Beschreibungen aller auf den Geraten von Applied Biosystems verwendeten elektrischen Symbole Wenn diese Symbole auf den Ger ten erscheinen beachten Sie bitte die entsprechenden SicherheitsmaBnahmen Dieses Symbol zeigt die Ein Position des Hauptnetzschalters an Dieses Symbol zeigt die Aus Position des Hauptnetzschalters an Dieses Symbol zeigt die Ein Aus Position eines einrastenden Hauptnetzdruckschalters an Dieses Symbol zeigt an daB ein AnschluB an die Betriebserdung eines anderen Ger ts angeschlossen werden kann Dies ist keine gesch tzte Erdklemme Dieses Symbol zeigt eine gesch tzte Erdklemme an die geerdet werden mu bevor andere elektrische Anschl sse zum Ger t hergestellt werden Ein mit diesem Symbol gekennzeichneter Anschlu kann Wechselstrom oder spannung erhalten oder abgeben Ein mit diesem Symbol gekennzeichneter Anschlu kann Wechselstrom oder spannung und Gleichstrom oder spannung erhalten oder abgeben Dieses Symbol zeigt das Vorliegen von Hochspannung an und warnt den Anwender vorsichtig vorzugehen PPUIY BH B80O Dieses Symbol fordert Sie auf das Handbuch zwecks n herer Informationen zu konsultieren und vorsichtig vorzugehen Nicht elektrische Die folgende Tabelle enth lt Beschreibungen aller auf den Ger ten von Symbole Applied Biosystems verwendeten nic
62. uction Organizations Regulations and Scientific Terminology MSDSs use acronyms and abbreviations for certain organizations government regulations common scientific terminology units of measurement and chemicals This appendix is provided to help you understand these references while reading the MSDSs for the chemicals used in your laboratory The following table lists acronyms and abbreviations for organizations government regulations and scientific terminology Term Explanation ACGIH American Conference of Governmental Industrial Hygienists CAS Chemical Abstract Service Reference Number for Specific Pure Chemical cc Closed cup testing of flash point CFR Code of Federal Regulations Regulations published by the United States Government CERCLA Comprehensive Environmental Response Compensation and Liability Act Superfund is a federal law administered by EPA DFG MAK Federal Republic of Germany s Maximum Contamination Value in the workplace similar to PEL in the USA DOT United States Department of Transportation regulates transportation of hazardous material USA EPA United States Environmental Protection Agency regulates use disposal or emission of hazardous material USA IDLH Immediate Danger to Life and Health LCio Lowest published lethal concentration LCs Lethal concentration in air that kills 50 of a specified population L Den Lethal dose that kil
63. unctional Loose or distorted panels will not protect the user or the equipment Airflow is not hindered in any way Instrument Labeling Instrument Safety Labels Signal Words 4 2 Instrument Safety Safety labels are located on the instrument Each label consists of a Signal Word panel and a Message panel A Safety Alert symbol indicates a potential personal safety hazard If multiple hazards exist the signal word corresponding to the greatest hazard is used 4 CAUTION indicates a potentially hazardous situation that could result in minor or moderate injury to the user or damage to the instrument WARNING indicates a potentially hazardous situation that could result in death or serious injury DANGER indicates an imminently hazardous situation that if not avoided will result in death or serious injury most extreme Labels That May Be The following Danger Caution and Warning labels listed in English and French may Found on the be found on your instrument Instrument English French CAUTION Hazardous chemicals Read the Material Safety Data Sheets MSDSs before handling ATTENTION Produits chimiques dangeureux Lire les fiches techniques de 16 de mat riels avant la manipulation des produits CAUTION Hazardous waste Read the Waste Profile before handling or disposal ATTENTION D chets dangereux Lire les renseignements sur les d chets avant de les manipuler ou de
64. user documentation Each word implies a particular level of observation or action as described below Note Calls attention to useful information IMPORTANT Indicates information that is necessary for proper instrument operation P NeZ e y Indicates a potentially hazardous situation which if not avoided may result in minor or moderate injury It may also be used to alert against unsafe practices PANZA Indicates a potentially hazardous situation which if not avoided could result in death or serious injury PANNE Indicates an imminently hazardous situation which if not avoided will result in death or serious injury This signal word is to be limited to the most extreme situations About Chemical Safety About Material Safety Data Sheets MSDSs About Waste Disposal Chemical Hazard Warning Some of the chemicals used with this instrument may be listed as hazardous by their manufacturer When hazards exist warnings are prominently displayed on the labels of all chemicals Chemical manufacturers supply a current MSDS before or with shipments of hazardous chemicals to new customers and with the first shipment of a hazardous chemical after an MSDS update MSDSs provide you with the safety information you need to store handle transport and dispose of the chemicals safely We strongly recommend that you replace the appropriate MSDS in your files each time you receive a new MSDS packaged with a hazardous chemical WWE G
65. wer Line Regulator Voltage Spikes Power Outages Electric Shock Warning 2 20 Site Preparation Line voltage must be within 10 of the nominal value High or low voltages may have adverse effects on the electronic components of the instrument In areas where the supplied power is subject to fluctuations exceeding these limits a power line regulator may be required In areas where the supplied power is subject to voltage fluctuations exceeding 10 of the nominal value a power line regulator may be required High or low voltages can have adverse effects on the electronic components of the instrument Short duration high voltage spikes often cause random failures in microprocessor controlled instrumentation These spikes can be caused by other devices using the same power source refrigerators air conditioners and centrifuges or by outside influences such as lightning A dedicated line and ground between the instrument and building main electrical service will prevent such problems If your environment contains devices that are electrically noisy or you are in an area with frequent electrical storms a line conditioner with a recommended capacity of 1400 W will enhance the reliability of your system The instrument has been designed to pause from short periods of power outage loss To continue operation you must resume the run from the software provided that the line voltage did not become excessively noisy before the outage If
66. you want increased protection during a power outage install an uninterruptible power supply UPS with a capacity of 1400 W ELECTRICAL SHOCK HAZARD Severe electrical shock which could cause physical injury or death can result from working on an instrument when the high voltage power supply is operating To avoid electrical shock disconnect the power supply to the instrument unplug the power cord and wait at least 1 minute before working on the instrument Chemical Safety Overview About This Chapter This chapter contains general information about handling hazardous chemicals and waste lt also contains information for the ABI Prism 6700 Automated Nucleic Acid Workstation about Material Safety Data Sheets MSDS Applied Biosystems assumes that all operations in your laboratory will be conducted in accordance with safety practices detailed in the MSDSs for the chemicals used in your laboratory and with any local state provincial or national regulations In This Chapter This chapter contains the following topics Topic See Page Material Safety Data Sheet Information 3 2 Hazardous Chemicals and Biological Materials 3 3 Hazardous Waste 3 5 Chemical Safety 3 1 Material Safety Data Sheet Information About MSDSs Updating MSDSs Ordering MSDSs from Applied Biosystems Ordering MSDSs from Other Manufacturers 3 2 Chemical Safety Some of the chemicals used with this instrument may be listed a
67. zes the tasks the Applied Biosystems Service Engineer Installation Process performs during the 2 day installation and customer training process and indicates the personnel who must be present during the procedure 2 4 Site Preparation Database Inform Primary Admina Tech IT Contacte Scientist Operatore Day 1 Tasks SDS Verification 6700 Workstation Setup 6700 Workstation Configuration and Tests 6700 Workstation Performance Verification Day 2 Tasks 6700 Workstation Run Analysis 6700 Workstation Training a See Preinstallation Checklists on page 2 5 for the Database Administrator s skills requirements b The Information Technologist needs to be present if the instrument will be networked at the time of installation c See Preinstallation Checklists on page 2 5 for the Primary Contact person s responsibilities d Scientists are responsible for creating or changing protocols and running maintaining the instrument e Operators are responsible for running maintaining the instrument but cannot create or change protocols Preinstallation Checklists About These Checklists Components Supplied by Applied Biosystems Use the following preinstallation checklists to ensure that all preparations are made for installing your instrument All of the personnel and supplies on these checklists are required at the

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