Cobas Integra 400 Troubleshooting
Contents
1. 2 Call Roche Service if the status of the system is Fatal Error This section lists those problems that may occur when results are obtained from the instrument Quality control results out of range Quality control results are obtained but they are outside the expected range for the test gt Control or a diluent in the wrong position E 22 Use Status Missing amp Blocked to check which items are missing 2 Use Status Samples to check the current positions of all on board controls and diluents 3 Replace the controls or diluents in their correct positions as required User Manual Version 2 0 COBAS 16 Troubleshooting INTEGRA 400 Results gt Control material has deteriorated or was incorrectly reconstituted 1 Use Status Samples to check the current positions of all on board controls 2 Replace the controls with fresh or freshly prepared material in the correct rack positions gt Lot specific assigned values are not correct e Check the values in Configuration Controls Lot gt Pipetting error The volume of fluid delivered by the dosage pipettes is incorrect Leakage on page E 25 Air bubbles in one or more pipettes on page E 26 Dripping pipettes on page E 26 Dripping probes on page E 27 gt Reagent in the cassette has deteriorated 1 Check the cassette expiration date in Status Cassettes If the cassette has reached its expiration date replace it with a ne2. Water supply or cleaner not properly connected 1 In Status Analyzer check whether the cleaner is running low If necessary replace the cleaner Check the connections to the cleaner and water supply Perform the Prime the fluid system service action Replacing the cleaner on page B 41 Waste water and power connectors on page E 29 Prime the fluid system on page D 33 Dripping pipettes If a visual inspection shows that either of the pipettes is leaking you must take immediate action gt Pipette not correctly installed e Reinstall the pipette Replace plunger tip dosage pipette B or C on page D 41 amp Piston worn out 1 Replace piston or pipette 2 Ifthe piston only is replaced and drips reappear after replacement replace the complete pipette Replace plunger tip dosage pipette B or C on page D 41 E 26 User Manual Version 2 0 INTEGRA 400 Dripping probes User Manual Version 2 0 16 Troubleshooting Hardware Ifa visual inspection shows that either of the probes is leaking you must take immediate action Loose tubing connections 1 Check that the tubing connectors are firmly screwed into place and tighten if necessary do not over tighten any connections 2 Replace the complete probe and tubing assembly if necessary Replace probe B or C on page D 44 Damaged tubing or probe e Replace the complete probe and tubing assembly if necessary Re
3. B Click to change the size of the message log Working with messages You can confirm messages display or print details on a message review confirmed messages or display Help on a message Chapter 4 Online Help Confirming messages A shortened form of each message is stored on the New Messages tab on the View Message dialog box When you confirm a message it is automatically removed from the New Messages tab and transferred to the Message Log tab The system can carry on running even if there are unconfirmed messages Recommendation Do not confirm a message until you are sure that you have resolved the problem that caused it to appear in the first place The running man on the Messages button remains until you confirm 1 The message that caused it to be displayed 2 All subsequent messages that could have caused a running man to be displayed E 8 User Manual Version 2 0 INTEGRA 400 15 Messages Working with messages gt To confirm a message 1 Click Messages on the navigation bar The View Message dialog box is displayed 2 Click the New Messages tab if necessary 3 When you have fixed the problem select the message and click Confirm The selected message is automatically transferred to the message log Tips Double click a message to get more information Follow any Help or instructions contained in the message to remove the cause or causes of the message if you have not already fixed the prob
4. Stop Tests in process are completed C Stop Terminate run and discard testin process A Stop pipetting samples but finish processing tests that are already in progress B Stop all system operations immediately The system aborts all current activities The system may need special attention before it can resume its normal operation Tips e Ifthe system is already in Standby when you click Stop it goes into Sleeping e Ifyou stop the run immediately all the partially run tests are stopped In practice this means you lose all the reagent control calibrator and sample material for any tests that have been started but not yet completed e The background color of the Status button tells you what the current system state is green means Operating unless there is a resource alert e You can also use F12 to stop the processing The Start button serves to start or restart a run When the system is in the Stopped AutoService or Operating status the text of the Start button changes to Restart Tips e Clicking Restart causes the system to perform a re scheduling of all patient orders For example clicking Restart after inserting a new rack into the system while in Operating status causes the system to start pipetting on the sample rack that is positioned furthest to the left e You can also use F11 to restart the processing E 11 15 Messages COBAS Stopping and restarting the system INTEGRA 400 Re initializing When
5. To replace the fuse you need the following tools and materials O Replacement fuses O 4mm screwdriver gt To replace a mains fuse 1 Switch off the instrument at the main switch A Wait for the power down to complete display will be black Switch off the mains supply manually Isolate the instrument from the mains power supply by removing the power connector from the back of the instrument If you do not know how to do this do not attempt this procedure 5 When you are sure that the instrument is isolated from the mains power supply remove the left side panel B E 32 User Manual Version 2 0 COBAS 16 Troubleshooting INTEGRA 40000 Checking and replacing fuses 7 Using a small screwdriver turn the fuse holder counter clockwise The fuse is spring loaded and pops out as you turn the fuse holder 8 Place the new fuse into the fuse holder and reinsert 9 Replace the left side panel B 10 Reconnect the instrument to the mains power supply 11 Switch on at the main switch A 12 If the fuse fails again contact Roche Service User Manual Version 2 0 E 33 16 Troubleshooting Checking and replacing fuses INTEGRA 400 Replacing controller board fuses The controller board fuses protect the electronic controller circuit boards that are located under the main front cover To see if a fuse has failed check the LEDs there is one for each fuse a green LED means that the fuse is
6. dialog is displayed Create C Roche Instrument Report Version txt E 35 16 Troubleshooting COBAS Contacting Roche Service INTEGRA 400 5 When the report has been generated the Problem Report dialog box is displayed again The report has been completed Do you want to copy the report to floppy disk s You will need 1 disk s Warning All existing files on the disks will be ereased Message ID 28 1230 6 Insert the disk any data on the disk will be destroyed 7 Click Yes Tips e You can also create a problem report from the message dialog box for some types of messages e You need one or more disk 3 5 inch floppy disk to store the report e Contact your Roche contact person and send the disk to your local Roche Service organization e Ifyou turn off the main switch and turn on again you may get a message prompting you to create a problem report before the system re initializes You can ignore this message Remote diagnostics Use the Roche remote diagnostics support service whenever you have a problem that you cannot resolve This service allows a Roche Service engineer to log on and control the system remotely For this level of support a modem must be connected to the specified serial port on the instrument gt To enable a remote diagnostic session 1 Check that the modem is connected to the serial port COM 2 and to a telephone line with a direct external connection that
7. is no connection to another telephone user Data connectors on page E 30 2 Ensure that the system and the modem are on You do not have to be logged on the Service engineer will automatically log on using the remote access service 3 The Roche Service engineer can now access your system remotely Customer confidentiality When a service engineer logs on to your system remotely patient demographics are automatically switched off so that any patient information is not directly available in the remote session or on the monitor screen on the instrument Sample results are however available on the remote system as are records of calibrations controls and service actions A message will be displayed on your system informing you that the system is currently accessed by remote access E 36 User Manual Version 2 0 INTEGRA 400 Make a note of the following information Problems with chemistry User Manual Version 2 0 16 Troubleshooting Contacting Roche Service When you report a problem to Roche Service please have the following information available e Analyzer serial number e Maintenance information see service notes in the Service work area e System software version e TAS version of the test in question e TAS version installed on the system e Description of the problem e Description of the last operations carried out immediately before the problem arose For chemistry troubleshooting you shoul
8. log 1 Click Messages on the navigation bar The View Message dialog box is displayed Click the Message Log tab 3 Click Print Tip The message log contains messages that have been confirmed and therefore have been automatically removed from the list on the New Messages tab Stopping and restarting the system Stop processing Stop E 10 You often need to stop the system when you are troubleshooting The method you choose depends not only on what you need to do in terms of corrective action but also what the system is doing the system state and how your throughput will be affected There are two levels of stopping 1 Stopping and continuing processing 2 Shutting down and restarting the system Check the messages and Help to see which method is recommended for a particular case If the system is in the Operating state for example when it is processing tests you can interrupt sampling or to stop sampling once the current actions are finished by clicking Stop on the navigation bar The precise function of the buttons depends on the current system status User Manual Version 2 0 INTEGRA 400 n gt Restarting the system Start User Manual Version 2 0 15 Messages Stopping and restarting the system When clicking Stop the Stop Action dialog box is displayed which offers the Sampling Stop and the Stop options Stop Action x AN Stop has been pressed Indicate action to take Sampling
9. mans seen 32 Replacins controller Board USES ri nae nere r ee een 34 Contacting Roche Service anreisen 35 Creating a prod emi Tepo susanne 35 Remote GIA CIO SCICS nassen een 36 E 15 INTEGRA 400 Introduction 16 Troubleshooting Introduction Effective troubleshooting on a COBAS INTEGRA 400 system requires a good understanding of all basic operating procedures for the instrument and the system software However you can avoid most common problems if you observe the recommended procedures at all times and if the operating environment is effectively controlled For new users in particular there are the usual familiarization problems including e Connecting various parts of the computer system if necessary e Locating the main switch and function keys e Starting up the program and logging on e Finding your way around the user interface All the information you need is available either in the User Manual or in the online Help For details on flags error messages and recommended actions for ISE related problems see Flags and user actions on page F 35 and General ISE troubleshooting on page F 42 Information about problems The user interface keeps you informed about the status of the instrument as a whole and about particular hardware software and chemistry problems as they arise It does this through e Messages displayed on the screen e Status work area e Buttons on the navigation bar e Flags on r
10. started SUPER 7 16 98 14 42 Diagnostics not started SUPER Message 7 of 10 Help On Message Print N G se Icon showing the severity of the message if any The date and time when the message was created Short message text Click to get Help on the selected message if available Name of the user logged on at the time the message was created The selected message Double click to display details on this message Click for Help on this dialog box this does not give Help on the selected message Tips The system stores only the most recent confirmed messages in the message log The log has a limited capacity and so the system automatically deletes the oldest messages in the log when it needs more space for new ones The message log contains only confirmed messages 15 Messages COBAS Optionstab INTEGRA 400 Options tab Use the Options tab to specify the maximum number of messages stored in the message log Type a number in the Buffer Size text box and click Save You can increase or decrease the size of message log buffer as required A buffer size of 100 means that a maximum of 100 messages are stored in the log The system saves the most recent messages and if the log is full and deletes the oldest messages to make way for the more recent ones m View Message x New Messages Message Log Options Message Log Buffer Size I A Specifies the number messages in the message log
11. COBAS INTEGRA 400 Troubleshooting Part E describes messages generated by the system what they mean and how to deal with them It also describes specific problems and gives step by step procedures on how to deal with them INTEGRA 400 Messages 15 Messages Table of contents General problem solving techniques User Manual Version 2 0 This chapter explains how to identify and interpret messages and suggests ways of reacting to these messages In this chapter Chapter 15 POU EINES ee een meer 4 DIE so Duo ana ee ee ee nro nee 5 NEW NIE 0 0 ee ee ee ee le Dre 6 Message LO TAD ans a 7 DPM OS TAD seadeciess ce AO NUR ORERIEN a EEEHIENEEG SIEH EURUERER CENT DEN EUESURSEN aA 8 Workine Wiih messages ee ee een ine 8 COMMENTS Message sauna N 8 Display ne messaseletals rs Rein 9 Printinsmessase orria e r ENEE E E 10 Stoppie and restarting the Systirin E A N aai 10 DOPP OCES O a E E A EE 10 SEIKE DAA ee E E E S 12 15 Messages COBAS About messages INTEGRA 400 About messages Messages inform you about errors or other events that have occurred on the system The system displays important messages as popup message dialog boxes for example Hardware Warning x IN A hardware error has occurred in the Fluid controller Message ID 14 3238 03 010 63 q 08 010 Click Help for further information The icon displayed on the message dialog box reflects the severity of the problem Symbol Meaning Information me
12. barcode scanner window if necessary Check whether the barcode setup including the reading of the installation barcodes was properly completed Check whether the printing quality of the barcode labels is sufficient Check whether there is condensation on the barcode labels External connectors The connectors that you may need to check are located either at the back of the instrument A or on the right side near the back B as shown below A Waste water and power connectors not visible here B Data connectors Waste water and power connectors The waste water and power connectors are located at the back of instrument Mains input connector Mains supply to optional printer Water reservoir level sensor Not used Waste reservoir level sensor Water reservoir connector A B C D E F G User Manual Version 2 0 E 29 Waste reservoir connector 16 Troubleshooting aah External connectors INTEGRA 400 Tips e Do not touch mains cables if your hands are wet e Do not attempt to connect or disconnect either of the mains cables if the instrument is switched on e If any power connector becomes worn or frayed it must be replaced immediately with an approved cable Contact your Roche Service representative e You must connect the waste sensor if you are using a separate waste container that is the instrument is not connected to the main laboratory waste system e Yo
13. bcomponents has failed Also the LEDs for the fuses for the controller boards are not lit when the fuse has blown normally they are bright green A complete set of replacement fuses is delivered in the start up kit The order number for these fuses is listed in the COBAS INTEGRA 400 Installation Manual If you use a fuse that has too low a rating it will almost certainly blow again This wastes time but is not in itself dangerous If you use a fuse that has too high a rating your system will not be protected from excessive currents This is very dangerous and can lead to a situation where a fire develops Even without a fire you can get temperature control problems or other electrical faults if the underlying problem reoccurs Fire hazard For continued protection replace fuses only with fuses of the same type and rating Danger of electrocution Always disconnect the instrument from the mains before attempting to replace any fuse Do not attempt to work with fuses if your hands are wet or if there is excess moisture on any fittings or components E 31 16 Troubleshooting COBAS Checking and replacing fuses INTEGRA 400 Replacing a mains fuse There are two mains fuses both of which must have the same current rating which depends on the mains voltage supplied to the instrument Mains voltage Fuse rating 230 VAC 8A 115 VAC 15 A I z Q The mains input voltage is pre selected by a switch inside the voltage selection unit
14. ck the printer cable This is a standard PC printer cable connected from the LPT1 25 pin connector on the analyzer to the Centronics type connector on the printer itself e Check that the printer power connector is connected at both ends A 3 pin Euro connector plug end of the cable must be connected to the back of the analyzer and a 3 pin Euro connector socket end of the cable must be connected to the power input on the printer e Check that the water supply is connected The analyzer will not initialize properly if a water supply is not connected e Check that the water sensor is connected if you are getting your water supply from a water container The water sensor must be inside the water container e Check that the waste outlet is connected to a suitable waste container or to a waste drain e Check that the waste level sensor is connected if your waste is going to a waste container The waste level sensor itself must be inside the waste container Checking and replacing fuses How do I know whether a fuse has blown Where do I get the fuses from Why is the correct fuse important Danger User Manual Version 2 0 A set of fuses protects the analyzer from excessive electrical currents If a fuse blows a message is displayed to inform you that you need to replace that particular fuse Typically you get one or more messages from the appropriate controller informing you that the power to one or more su
15. d also have the following additional information available Item Lot number Cassette Calibrator Control Diluent You may also need the following O The last calibration and control results O A printout of the cassette status O A printout of the raw data of the specific test s E 37 16 Troubleshooting COBAS Contacting Roche Service INTEGRA 400 E 38 User Manual Version 2 0
16. d in Configuration Result Handling apply to the workflow in your laboratory and change the result handling if applicable See the Online Help for details Aborted e Test aborted Test was aborted either by stopping the run and selecting STOP Terminate Run and discard tests in progress or by switching off the instrument Recommended action Restart the run ISE Not on board e Activator not on board e Deproteinizer not on board e Etcher not on board e No ISE solution available Recommended action 1 Open the Not on Board folder in Status Missing amp Blocked to see the solutions that are not on board and their correct rack positions Remove the ISE rack from the instrument Load the required activator deproteinizer etcher or ISE solutions on their correct ISE rack positions 4 Reinsert the ISE rack into slot O The ISE Rack Replaced dialog box is displayed 5 On the dialog box select the ISE solutions that you have replaced Q Leave the checkboxes cleared for ISE solutions you have not replaced Empty e Activator is empty e Deproteinizer is empty e Etcher is empty e ISE solution is empty E 20 User Manual Version 2 0 INTEGRA 400 Recommended action Not ready Recommended action Disabled Recommended action No electrode Recommended action Error Recommended action User Manual Version 2 0 16 Troubleshooting Blocked orders tests calibrations or controls 1 Open the Em
17. d take the necessary action 2 Ifthe initialization is incomplete and no error is shown contact Roche Service Blocked orders tests calibrations or controls User Manual Version 2 0 The following main conditions must be fulfilled before you can successfully run any test on the INTEGRA 400 e All required reagents diluents cleaners calibrators and controls are on board and have enough volume to run the test e The last calibration and control results are accepted for calibration and control tests e The sample is on board and has enough volume to run the test e The test and the measurement modules are enabled e The instrument and the measurement modules are in an error free state If any of these conditions are not fulfilled the test will be blocked and the cause must be eliminated To check the cause of blocked orders tests calibrations or controls Click Orders on the navigation bar Click the Worklist tab Open the Blocked folder and select a blocked order Detailed information of the selected order is displayed in the area on the right 4 Make a note of the Blocked Status Text and look up the corresponding recommended actions in the list below E 17 16 Troubleshooting Blocked orders tests calibrations or controls INTEGRA 400 Cassettes and cleaner Not on board Recommended action Empty Recommended action Not Enough for Worklist Recommended action Tips Double click a blocked o
18. e all the slots for cassette racks 6 If this does not fix the problem contact Roche Service Computer system and accessories This section lists problems that may be associated with the computer system including connection problems and other basic problems with the computer monitor printer and barcode reader gt Cables detached or damaged 1 Ensure that all the required connections to your instrument are made Connections check list on page E 30 2 If any cables are damaged contact Roche Service amp Monitor not on 1 Check that the instrument is plugged into the laboratory mains 2 Check the main fuses Replacing a mains fuse on page E 32 3 If this does not fix the problem contact Roche Service gt Printer connections and printer indicators OK but still no printout Check the printer settings in Windows NT 2 Check that the printer driver currently used as the default corresponds to the printer actually connected Modify the printer settings if necessary 3 Switch the printer off and back on again to re initialize If a printing is still not possible shut down the system Restart and wait until the system is initialized 5 Ifthe problem reoccurs contact Roche Service E 28 User Manual Version 2 0 COBAS 16 Troubleshooting INTEGRA 40000 External connectors gt Barcode scanner cannot read the barcodes Check that the barcode scanner window is free of grease and dirt Clean the
19. ections Leaking tubing or connections in the fluid system may lead to pipetting errors Leakage on page E 25 Air bubbles in one or more pipettes on page E 26 Dripping pipettes on page E 26 Dripping probes on page E 27 gt Evaporation or deterioration of the sample 1 Use fresh material if possible 2 Ifthe sample is in a secondary cup transfer a new aliquot to a new cup from the original primary sample gt System water quality is unsuitable 1 Check the quality of the input water according to the instructions provided by the manufacturer of the deionized water supply system You must use reagent grade type 1 water or equivalent If the water quality is not within specification take the necessary action as recommended by the manufacturer of the deionized water supply system gt The wash station is defective Check for leakage on the bench under the wash station 2 Check that the waste connector is properly connected and that the tubing is not clogged 3 If any leaks persist contact Roche Service Leakage on page E 25 Air bubbles in one or more pipettes on page E 26 Dripping pipettes on page E 26 Dripping probes on page E 27 Test results low or drifting Results are obtained but the values obtained are lower than expected Results are obtained but the values show a consistent trend to drift either up or down from their expected values gt Pipetting incorrect sa
20. er there are messages waiting to be viewed The background color also indicates the severity of the message Button Background Meaning Gray The messages that are occurring need no action from the user ao should deal with these messages promptly to a Yellow Warning messages waiting to be dealt with You ensure that a critical situation does not develop Red flashing Error or critical messages waiting to be dealt A Running with You should deal with the causes of these messenger messages immediately You can clear the red and yellow versions of the Messages button by confirming all Warning and Critical error messages Confirming messages on page E 8 15 Messages New Messages tab COBAS INTEGRA 400 New Messages tab Use the New Messages tab on the View Message dialog box to review all currently unconfirmed messages listed by time New Messages Message Log Options zZonmo OUV D 6 27 96 17 00 6 26 96 14 31 8 26 98 14 31 6 26 96 14 29 Rack position slot position 13 not defined A hardware problem has been detected in the resource controller ISE solution standard 1 not on board Error in file c roche instrument Log Trace tra occurred 7 16 96 17 01 Diagnostics not started SUPER G Message 3of5 Help On Message Confirm Print H Icon showing the severity of the message if any The date and time when the message was created Short me
21. esults from samples calibrations and controls You can also often see that something is wrong before any results are produced A dripping probe for example will affect the generated results Preventative maintenance User Manual Version 2 0 The most common sources of problems are related to service actions and water purity e For service actions the main problem is a failure to keep to the maintenance schedules as defined by the service actions Ensuring that the instrument is correctly maintained is the most effective thing that you can do to reduce problems e Poor water quality can cause problems over a long period of time and can be difficult to troubleshoot especially if the water quality varies from day to day System water quality is unsuitable on page E 24 E 16 INTEGRA 400 16 Troubleshooting Start up problems Start up problems This section lists potential problems arising from start up or system initialization Mains power connector is not plugged in 1 Switch off the instrument 2 Insert the plug into the socket 3 Switch on the instrument Laboratory power supply has been interrupted 1 Check other electrical power sources and inform your in house service personnel 2 When the power is re established the system will restart automatically wait until the system is initialized System cannot initialize due to a fault in one or more of the analyzer modules 1 Check the displayed message s an
22. lem from the original message dialog box If you need to refer to the message again use the message log Displaying message details User Manual Version 2 0 gt To display message details Co B elp On Message Print Help cose Click Messages on the navigation bar Click either the New Messages or Message Log tab Double click a message The View Message Detail dialog box is displayed View Message Detail Xx Date amp Time fi 9 04 2000 14 46 Message ID 19 583 Message A Not enough fluid was detected in slot J position 10 sample volume is too small for the tube being used transfer he sample to a smaller tube if possible g Internal Information Threadname 0x66 DAM_ExpRec Session ID No Session 0 Message 8 of 158 A Long text of the message B Click for Help on this message C Service and diagnostics information D Click for Help on the dialog box not message Help E 9 15 Messages Stopping and restarting the system Printing messages INTEGRA 400 You can print a list of messages from either the New Messages tab or the Message Log tab To print a list of messages 1 Click Messages on the navigation bar The View Message dialog box is displayed Click the New Messages tab Click Print Tip This procedure prints only non confirmed messages for problems that have not yet been resolved To print the message
23. lts are accepted you may request a rerun though 1 Accept the last calibration or control results in the Validate tab in the Results work area 2 Ifthe last calibration or control result was not accepted because it was flagged follow the recommended action for the displayed flag Accepting flagged calibrations without taking appropriate action will cause all subsequent patient results also to be flagged e No calibration definition available e No control definition available Install the required calibration or control definitions See Online Help for details e No fluid in sample cup No fluid level was detected in a tube or cup Possible reasons are o The tube or cup is empty o The tube or cup is overfilled Wrong tube definition Do one of the following e Refill the sample tube or cup e Remove some sample from the tube or cup e Check the parameters Trigger Point and Lower Sample Margin in Configuration Lab Sample Tubes E 19 16 Troubleshooting Blocked orders tests calibrations or controls INTEGRA 400 Tests Disabled e Test disabled Possible reasons are o Test was manually disabled o Test was automatically disabled due to a flagged calibration or quality control result This is the case if the flag action is set to Stop Test in Configuration Result Handling Recommended action 1 Open Status Test Status 2 Select the required test 3 Select Test Enabled Tip Check if the rules define
24. mple or reagent volumes 1 Perform the service action Deproteinize Probes 2 Perform the service action Clean Probes Manually 3 Perform a Check Test E 24 User Manual Version 2 0 INTEGRA 400 Hardware Cuvettes Leakage User Manual Version 2 0 16 Troubleshooting Hardware 4 If this is unsuccessful a Replace the probes b Check the pipettes and pistons c Check for leaks Leakage on page E 25 Air bubbles in one or more pipettes on page E 26 Dripping pipettes on page E 26 Dripping probes on page E 27 Sample has deteriorated Sample has deteriorated for example due to instability of the analyte 1 Use fresh material if possible 2 Ifthe sample is in a secondary cup transfer a new aliquot to a new cup from the original primary sample This section lists problems associated with hardware functions particularly regarding the cuvettes and the fluid system Cuvettes must meet stringent optical specifications before they can be used on the instrument Defective cuvettes are discarded automatically System discards a large number of unused cuvettes Remove several cuvettes from the reservoir 2 Check whether they are cloudy scratched or dirty If so empty the cuvette reservoir manually and refill with new cuvettes 3 If this is unsuccessful open the analyzer cover and carefully remove some cuvettes from the cuvette buffer slide with tweezers If these cuvettes are scratched o
25. or messages in View Message New Messages 2 Select the message and click Help on Message to open the Online Help 3 Follow the recommended actions of the selected message E 21 16 Troubleshooting Results Hardware errors Abs error Recommended action FP error Recommended action FP disabled Recommended action Fatal error Recommended action Results INTEGRA 400 e Error in Abs Module Hardware error in the absorbance photometer module 1 Check for new hardware error messages in View Message New Messages 2 Select the message and click Help on Message to open the Online Help 3 Follow the recommended actions of the selected message e Error in FP Module Hardware error in the fluorescence polarization module Check for new hardware error messages in View Message New Messages Select the message and click Help on Message to open the Online Help 3 Follow the recommended actions of the selected message e FP module disabled The FP module was disabled 1 Open Configuration General System 2 Select FP Module to enable the FP measurements Tip The instrument must be in Standby for enabling the FP module e Fatal HW error The system has a fatal hardware error The robotic transfer the ISE module and the analyzer including absorbance and FP module are not working due to a serious hardware problem No measurement of tests is possible 1 Check the status of the system in Status Analyzer
26. place probe B or C on page D 44 Valve is defective A Hardware Warning message may be displayed but not necessarily stating that a valve is defective e Contact Roche Service Blocked or partially blocked probes If you suspect that a probe is blocked or partially blocked 1 Perform a Check Test 2 Ifthe flow checks do not meet the specifications clean or replace the probes as necessary Replace probe B or C on page D 44 Damaged probes 1 Check the probes visually for damage and replace if necessary 2 Check whether there is any physical obstruction that might have damaged the probe if so remove the obstruction Replace probe B or C on page D 44 Due service actions not performed Due service actions related to pipettes and probes were not performed on schedule e Use Service All and perform all due service actions E 27 16 Troubleshooting COBAS Computer system and accessories INTEGRA 400 Temperature control If the ambient temperature exceeds 30 C the refrigerant pressure becomes too high and the cooling system generates a hardware error 1 Switch off the instrument at the main switch 2 Ensure that at least one cassette slot is empty to improve the air circulation inside the cooling box Switch on the main switch Allow the system to start up and complete its initialization Run the system with at least one spare cassette rack slot for about ten minutes After this you can us
27. pty folder in Status Missing amp Blocked to see the empty activator deproteinizer etcher or ISE solution and their correct rack positions Remove the ISE rack from the instrument Refill the empty activator deproteinizer etcher or ISE solution Reinsert the ISE rack into slot O The ISE Rack Replaced dialog box is displayed 5 On the dialog box select the ISE solutions that you have replaced Leave the checkboxes cleared for ISE solutions you have not replaced ISE module is not ready The ISE module is not initialized Possible reasons are The last ISE initialization was not successfully completed o Not all required solutions are available for example Activator or Std 1 o The ISE module was recently enabled but no ISE initialization was performed e Make sure all solutions are on board e Perform the service action Initialize ISE module in Service All e ISE module disabled The ISE module was disabled manually 1 Open Status ISE 2 Select Enable ISE Module to enable the ISE measurements Tip The instrument must be in Standby for enabling the ISE module e No ISE Electrode The ISE electrode is not defined or disabled 1 Open Configuration General ISE 2 Select the required electrode setting 3 Click OK 4 Open Status ISE 5 Select Lithium Potassium Chloride or Sodium to enable the required electrodes e Error in ISE module Hardware error in the ISE module 1 Check for new hardware err
28. r dirty contact Roche Service Fluid leaks can sometimes occur especially when service actions for example Replace Dosage Pipette Plunger Tip are not properly completed Leaking pipettes 1 Check that the pipette is firmly screwed into place and tighten if necessary do not over tighten any connections 2 Ifthe leak is from the barrel of the pipette replace the pipette or piston E 25 16 Troubleshooting COBAS Hardware INTEGRA 400 gt Leaking tubing or tubing connections 1 Check that the tubing connectors are firmly screwed into place and tighten if necessary do not over tighten any connections 2 Check the external water and external waste tubes and ensure they are properly connected and not damaged 3 Turn off the external water supply and reconnect or replace the water tubes if necessary 4 Ifthe leakage is from the internal fluid system on the instrument perform a shutdown and switch off the system then contact Roche Service Air bubbles in one or more pipettes Air bubbles are a sign that the fluid system most likely a pipette is leaking or that the cleaner is running low or the water supply is not properly connected gt Pipette not correctly installed 1 Reinstall the pipette or the piston ensuring no air bubbles are trapped 2 Check for air bubbles appearing after reinstallation 3 If air bubbles reappear call Roche Service Replace plunger tip dosage pipette B or C on page D 41 gt
29. rder in Results Validate to see the Blocked Status Text To get help on a blocked item select the Blocked Status Text and press F1 Reagent not on board Cleaner not on board Place the required reagent or cleaner cassette in a cassette rack Insert the cassette rack into the cassette area Reagent is empty Cleaner empty Locate the rack position of the empty reagent or cleaner cassette in Status Cassettes Remove the cassette rack from the cassette area Replace the empty cassette with a new one Reinsert the cassette rack into the cassette area The item is loaded but there is not enough of it to run the tests in the current worklist 1 2 Locate the rack position of the cassette in Status Missing amp Blocked Place an additional cassette of the same kind on a rack Calibrators controls and diluents Not on board Recommended action E 18 1 2 Tip No calibrator on board Control not on board Diluent not on board Load the required calibrators controls or diluents on their correct rack positions Insert the rack into a free slot in the sample or cassette area To check the correct calibrator control or diluent position do one of the following Open the Not on Board folder in Status Missing amp Blocked to see the missing calibrators controls or diluents and their correct rack positions Click a test folder in Status Test Status to see the calibrator control or diluent info
30. ressing Alt F4 maintenance functions even after you have switched off These functions ensure that the system v7 Because the COBAS INTEGRA 400 has an internal battery the system performs certain essential Q especially the ISE module can be restarted on request without manual intervention E 12 User Manual Version 2 0 INTEGRA 400 Restarting the system after shutdown User Manual Version 2 0 15 Messages Stopping and restarting the system You should perform a restart only after the screen has become dark To restart the system 1 Switch on the main switch The system undergoes the complete startup procedure The COBAS INTEGRA 400 program is automatically restarted Log on Shift F3 when the Log On dialog box is displayed Tips After restarting o Windows NT is automatically restarted You do not have to log on to Windows NT o The COBAS INTEGRA 400 program is automatically started The system is re initialized When you log on type in your user ID and password as usual You must rerun tests that were in progress when the system was stopped E 13 15 Messages COBAS Stopping and restarting the system INTEGRA 400 E 14 User Manual Version 2 0 INTEGRA 400 16 Troubleshooting Table of contents Troubleshooting General problem solving techniques User Manual Version 2 0 This chapter explains how to identify and fix problems that can affect the running of the COBAS INTEGRA 400 It e
31. rmation of the selected test If you see for example a status of Diluent not on board and you replace the diluent while the system is in Standby the values for Status and Next Cal in the Test group are not updated until the system is in Operating status The information in the Diluents group however is updated immediately You may have to click Re Start on the navigation bar to get the system to Operating mode User Manual Version 2 0 INTEGRA 400 Empty Recommended action Not accepted Recommended action No definition Recommended action Samples No fluid Recommended action User Manual Version 2 0 16 Troubleshooting Blocked orders tests calibrations or controls e Calibrator empty e Control empty e Diluent is empty 1 Open the Empty folder in Status Missing amp Blocked to see the empty calibrators controls diluents and their correct rack positions Remove the required rack from the instrument Refill the empty calibrator control diluent and cups or tubes Reinsert the rack into a free slot in the sample or cassette area e Last calibration is not accepted e Last control not accepted The last calibration or control result was not accepted and a further calibration or control request has been made either by the system as a result of a cassette change for example or by the user Note that you can only request a further calibration or control once the calibration or control resu
32. ssage Often a prompt to ask you if you really want to do something Warning Alerts you to some condition or consequence but the system as a N whole can keep running Some of these types of messages may mean one or more measurement modules may not be able to run tests Critical error The system cannot continue You must fix the problem and then restart the system All messages are listed on the New Messages tab on the View Message dialog box until you confirm them gt Toreacttoa message On the message dialog box click Si to turn off the audible alarm if necessary Read the message and take appropriate action Click Help for additional information if available FF Q N Click Report if you want to create and save a problem report Creating a problem report on page E 35 Ol Click Close when you have read the message Confirm the message Confirming messages on page E 8 E 4 User Manual Version 2 0 INTEGRA Messages butt 400 on Clearing the Messages User Manual Version 2 0 button 15 Messages About messages Tips e Ifyou need to refer to the message again after confirmation use the Message Log tab Message Log tab on page E 7 e All messages that generate a dialog box are listed on the New Messages tab on the View Message dialog box Double click a message for more details The background color of the Messages button shown on the navigation bar indicates wheth
33. ssage text Click to get Help on the selected message if available Name of the user logged on at the time the message was created The selected message Double click to display details on this message Click to confirm the selected message Click for Help on this dialog box this does not give Help on the selected message Tips You click Confirm to inform the system that you have fixed the problem in the message If you have not fixed the problem the system will either not restart or the same message will reappear again if the same conditions are met Confirmed messages are automatically transferred to the message log User Manual Version 2 0 INTEGRA 400 Message Log tab User Manual Version 2 0 15 Messages Message Log tab Use the Message Log tab on the View Message dialog box to review messages that you or other users have already confirmed as resolved Double click any message to display the Message Detail dialog box m View Message x NewMessages Message Log Options 8727798 17 01 FP high voltage W out of range 300 700 L E 8 27 98 17 00 Database logon failed LABTO3 6 27 98 17 00 Rack position slot position 13 not defined ADMIN 8 26 98 14 31 A hardware problem has been detected in the resource controller 6 26 98 14 31 ISE solution standard 1 not on board F 6 26 98 14 29 Error in file c roche instrument Log Trace tra occurred 7 16 98 17 01 Diagnostics not
34. the system is in Standby you can re initialize if necessary Sometimes you will be asked to do this in the recommended actions for a particular message You would also need to do this if your troubleshooting procedure caused you to knock or move an initialization post for example gt To re initialize the system Click Stop on the navigation bar if necessary Click Service on the navigation bar Choose Tools gt Initialize System System initialization takes a few minutes to complete 4 Click Restart if necessary Tips e The system must be in Standby or Fatal Error state when you initialize e The prompt displayed after you click Restart is not listed here Stop processing on page E 10 In all messages and recommended actions in the Help your reaction to this prompt is assumed e Step 4 is not required if Autostart is enabled in Configuration General System System shutdown A system shutdown means that the COBAS INTEGRA 400 program is closed down and the system comes to a complete stop Shut down the system by pressing the main switch A to the zero position The system informs you that it will be closing down in 10 seconds After shutdown e All tests and procedures in progress are stopped e The COBAS INTEGRA 400 main window is closed e When the shutdown is complete the monitor screen becomes dark Tip You can also perform a shutdown by choosing File gt Shut Down or by p
35. u must connect the water sensor if you are using an external water reservoir Data connectors These connection sockets are for serial data communications networking and printer output The connectors are located on the right hand side of the instrument near the back NVI NVI xnv Z WOO WOO bid CE EE e O L WOO AUX Auxiliary connector not used COM 1 Serial communications connector host connection COM 2 Serial communications connector modem connection COM 3 Serial communications connector not used mo 0 WB gt LPT 1 Parallel port Printer connection Tip e Serial ports if used are configured by your Roche Service representative Connections check list Use this list if you need to check that your system is properly connected Mains connection Check that the main power cable is plugged in at both ends e Check that the mains switch on the wall socket is in the ON position E 30 User Manual Version 2 0 INTEGRA 400 Serial communications for host computer installations only Printer connections optional Water supply Waste outlets 16 Troubleshooting Checking and replacing fuses e Check that host computer connection COM 1 is made This connection is required for automatic exchange of orders and results between the host computer and the analyzer e Check the modem connection COM 2 for remote diagnostics if applicable to your system e Che
36. w cassette when the rack is released 2 Check the results of the last calibration and control If the results deviate significantly from the previous calibration order a new calibration If the results are still wrong check the calibrator or the control material If these are OK replace the reagent cassette 3 Check when the next calibration is due Status Test Status If the due time is some time away and the last calibration was performed some time back order a new calibration Test results not reproducible Results are obtained but are frequently flagged In particular when a particular test 1s rerun the results are not consistent with earlier values gt Air bubbles or foam on the surface of the sample Carefully remove air bubbles or foam from the surface of the sample 2 When transferring samples to secondary cups pipette the sample carefully to avoid the introduction of air bubbles or foam 3 Insert sample racks carefully to avoid disturbing the samples gt Fibrin clots or particles in the sample 1 Re centrifuge the sample if necessary 2 Alternatively transfer some sample free of clots or particles into a secondary cup User Manual Version 2 0 E 23 16 Troubleshooting COBAS Results INTEGRA 400 gt Probes not clean 1 Perform the service action Deproteinize Probes 2 Perform the service action Clean Probes Manually 3 Ifthis does not work replace the probes gt Leaking tubing or conn
37. w the recommended procedures Search the online Help for the information you require You can perform a full text search to help you find this information If this fails contact your system supervisor for further advice If you still cannot solve the problem make a note of any special conditions that you think might be relevant Create a problem report See Creating a problem report on page E 35 Contact Roche Service In the first instance contact the Roche remote diagnostics support service This service allows a Roche service engineer to log on and control the system remotely See Remote diagnostics on page E 36 For this level of support a modem must be connected to the specified serial port on the instrument Creating a problem report You can automatically create a problem report on a floppy disk This report collates all the messages and other system information that the Roche Service engineers will need if you cannot solve a particular problem on your own You should create the report if possible before contacting Roche Service gt To create a problem report on diskette Click Messages on the navigation bar Click the Options tab Click Report The Problem Report dialog box is displayed Problem Report x Do you want to add DB export to the problem report Message ID 28 4160 4 Click Yes to add a database export to the report User Manual Version 2 0 The Create Problem Report
38. working The layout of the controller board fuses is as follows VDOOOOSD ot ee zi b NG ik E Lamp Supply FP Lu Pu EN San Lun ZN Fn oa Fuse 2 AT 20 n BM AR DM Zn OM GM so Co ae Que Lo ze Iov NO F2 23023230363 gt 3 283 gt 0 x oO gt L 5u zu L gt L su yu eu x ro 3 N lt N lt cc c gt N Lamp Supply ABS Be F Fuse 6 3 AT N x A Supply 15 V Fuse 2 AT Supply 36 V Supply 100 V Fuse 5 AT Fuse 3 2 AT gt To replace a controller board fuse 7 3 9 Wait for the instrument to go into Standby Lift the main front cover A and lock it in the raised position Identify the fuse s to replace LED not lit Make a note of the fuse type and rating as shown next to the fuse Switch off the instrument at the main switch Wait for the power down to complete display will be black Open the controller rack cover and using a small screwdriver turn the fuse holder counter clockwise Replace the failed fuse with a fuse of the same type Reinsert the fuse Switch on the instrument 10 If the problem occurs again contact Roche Service E 34 User Manual Version 2 0 INTEGRA 400 16 Troubleshooting Contacting Roche Service Contacting Roche Service Roche Service can help you solve many problems that you are unable to solve for yourself However before you contact Roche Service l Check this chapter to see if your particular problem is described If it is follo
39. xplains how to view and respond to system generated messages and how to troubleshoot problems that do not generate messages A description of how to identify and replace fuses is also included If you encounter any problems that you cannot resolve information about contacting Roche Service is also provided In this chapter Chapter 16 Introduction 16 Information about problems anheben 16 Preventativemanlenantee kernel 16 LAT UB Problems ne ne ee see EE EE E E E 17 Blocked orders tests calibrations or controls sseseessssnesseenesseenesseeseesseseesseseessesee 17 Gassettesand ceanen o a Gadcasec A AATAS 18 Calibrators controls and diluents cceacaneeeeeeeneseeennnnnssennnnnsnnnnnnnnnnnnnnnnnnnnnnnn nenn 18 STD Ines een ren 19 Test entire t ten 20 SE aan ae 20 Flat Iware et or ee re 22 Re SS ee 22 Quality control results out of TAN Be wc II 22 Test results notreproducib lenien e T E re asses aa geese e T 23 Testresults low or Ins a RR ATNA 24 Hardware nenne 25 UV CLLES een na ee 25 Eeakase anne A N 25 Air bubbles in One Or more pipetles serie 26 PDE 1S Pipete seele ihn 26 Dippie probs naeh 27 Temperature no eines Nie 28 Computer system and ccesonesn a nr RI 28 External COMMECIOT Sia ss Rasen 29 Waste water and Power connectersse c ha Rus 29 Dataconnectors a s ER tee eoneet iuneas ehe 30 Connect ons check TiSi ee eisen 30 Chreckins and PEP ACTS TU Se See EEr NANE e EEEREN ENEE 31 Beplacns a
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