PDFファイル - 医薬品医療機器総合機構
Contents
1. 22. R1 R2 FAIA Oe HEAR IG RE D gt FE ME HB BR PERL AR AURA BEE IE BE A HN
3. 2012 12 4 2008 10 3 13A2X00206000114 1 2 3 A 5
4. 6 TREU 7 HIV HBV HCV 121 20 1 000 ppm 0 1 IZ 1 1 2 3 4
5. 4 1 2 8 2 1 Exp R1 29 3 mL R2 4 1 mL 225 R1 R2 1 Dandliker W B et al Biochem Biophys Res Comm 1961 5 p 299 304 2 WHA ZEAE Kimi 1988 p 119 121 3 Committee on patient preparation and specimen handling Clinical Laboratory Handbook for Patient Preparation and Fascicle IV Slokie IL American Pathologists 1985 4 1989 15 p 285 291 5 Quattrocchi F collection tubes on drug concentrations 1985
6. 100 r 0 996 y 1 03x 0 16 y x Yan 3 USP United States Pharmacopeia A 2 3 1 2 3 4 5 1 000 ppm 0 1
7. 5 1 PASS haba al II Ca SE ae 6 7 8 MV 9 15 25C 1 ESA 2 3
8. 778 1 2 3 9 gmL 8 Chlorotheophylline 200 8 4 1 7 Dimethlxanthine 150 5 4 3 Methylxanthine 150 3 4 Theobromine 197 1 4 Caffeine 150 0 8 Doxofylline 160 0 4 Aminophylline 15 75 6 1 3 Dimethyluric acid 672 lt 0 6 7 B Hydroxypropyl theophylline 200 lt 0 5 Dihydroxypropyl theophylline 200 lt 0 2 B Hydroxyethyl theophyline 200 lt 0 2 Diphenhydramine 10 ND Acetaminophen 200 ND Allopurinol 50 ND Ephedrine 12 ND Epinephrine 16 ND Hypoxanthine 149 ND Isoproterenol 50 ND 1 Methyluric acid 700 ND Phenobarbital 400 ND Phenylbutazone 450 ND Phenytoin 200 ND Uric acid 210 ND ND 3 1 3 1
9. 18L 10gL 1 30 3 2 3 4 5 AREA BC RM EL OURAN D ER EA E LO AL UC EB SE aE BE gt RE HR PERL GABE O E 5 TDM EN 1 9 gt 35 MENA ER o 1 71 NAEPP Expert Parel Report 2 3
10. 2 x 1 1 20C 60 2 15 5 g mL 1 000 mg dL 28 5 mg dL 1 730 mg dL 12 g dL 10 St John s Wort
11. 0 3636453 001 G D LOOESYVIEITO 03636453001 G
12. TDM I 1 1 0pz g m ROS u g mL 30 60 mP CF 2 10 3 3 16 yu g mL 18 27 ug mL DE 5 CV 10 4 40 0 18 40 u g mL 800 0 16 40 u g mL 0 TOMI A mean 2SD 400 n 25 AFI 7800 20 2
13. TDM I FA Cea 2 2 8 C 3 TOMI FP TDM 400 4 800 1 130L 104L 97 3L 5 ay PRU 27 u L 37 2 485 nm 515 nm
14. 5 0 339362 6 7 2001 43 3 p 560 579 8 No 160 2000 5 9 TDM 2006 2006 Turner Warwick M oral administration of theophylline compounds p 25 0A T 105 0014 2 6 1 0120 600 152 T 105 0014 2 6 1 0120 600 152 Specimen Handling College of Effect of serum separator blood Ther Drug Monit et al 10 NY Study of theophylline plasma levels after Br Med J 1957 3 3 O
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