PDFファイル - 医薬品医療機器総合機構
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1.2. 9 2 2 8C 1 Bxp R1 R2 21 0 mL 7 6 mL R1 R2 1 2 3 4 5 6 7 8 Quattrocchi F Collection Tubes on Drug Concentrations Monitoring 1983 5 3 p 359 362 Valdes R Jr et al Clin Chem 1989 15 4 p 285 291 et al Effect of Serum Separator Blood Therapeutic Drug Standards of laboratory practice cardiac drug monitoring 1998 44 5 p 1 096 1 109 TDM 2004 p 107 mA SEED
3. TDM I TERE 1 1 0 ng mL 15 ng mL 10 mm 0 05 0 20 2 15 3 2 5 CV 10 2 3 4 5 065 ng mL CLSI EP1
4. 2013 3 5 2012 12 4 13A2X00206000059 1 2 3 4 R1
5. 4 5 St John s Wort E 7 6 nn 1 202 IIHZAREILEINS es 7 ng mL Digitoxigenin 25 309 Digitoxigenin mono digitoxoside 25 156 Digitoxigenin bis digitoxoside 25 129 Digoxigenin mono digitoxoside 25 13 4 Dihydrodigitoxigenin 25 12 2 Ouabain 1 000 0 4 Digoxin 20 ND Digoxigenin 5 ND Digoxigenin bis Digitoxoside 5 ND Dihydrodigoxigenin 25 ND Teststerone 25 ND Prednisone 25 ND ND
6. 3 4 5 2 6 7 N 8 eh 15 25 1 PN ae ie ol
7. 4 5 1 000 ppm 0 1 6 GS 7 HIV HBV HCV 121 C C 20 PAE LEB Ae FAD 1 000 ppm 0 19 1 1 2
8. 2006 2000 No 160 TDM 2006 3 3 DARE D IN NEAR T 105 0014 2 6 1 0120 600 152 T 105 0014 2 6 1 0120 600 152 COBAS is a trademark of Roche Roche O 3639703 001 H H LOOZSOZG6EITO O3639703001 H
9. 9 3 6000 1 TDM I 2 2 8C 3 6000 TDM I TDM SMS NAOHD 6000 4 800 1 105
10. R2 C MP Kinetic Interaction of Microparticles in a Solution KIMS u MP ARE MP 1 Li 2 8 C 24
11. 20C 1 2 D2 cobas 2 1 TERESA 15 ng mL 1 000 mg dL 45 mg dL 1 000 mg dL 10 g dL 10 2 100 IU mL 3 HAMA RE
12. L 6 UL 37 gs 2 4 5 UL 6zL 37C C4 3 38L 6L 3706 4 5 659 nm 5 TDM Kt 1 ng mL 15 25 oP eh mg m HER TER NEE ED 2
13. 7 A 3 1 231 r 0 968 y 0 935x 1 355 y x Lin 2 51 r 0 995 y 1 014x 0 300 y ERA x USP United States Pharmacopeia 1 2 3
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