Metal Scavenger Guide
Contents
1. Ex cc are po dian qr pese ge 150 2002. Si TMT Si Thiol Si TMT Si TMT 30 5
3. 5 ppm 1 ppm Pd 1 K MS 2 e ALOR CERNIT L OPERE s e 4C King A O Yasuda N Topics in Organometallic Chemistry 2004
4. Pd ICP S B OH Pd PPhj 04mol 0 4mol9 500 mg 3 mL O CL NC N Na NaCO 24ME 2 4 lt B HU 100 mg 3 mL 500 mg 3 mL 100 mg 3 mL Si Thiol ICP Pd 86 45 Si TMT ICP Pd gt 99 95 Si Thiol S Si TMT S TMT Pd 4 Pd Pd dppf CL 7 P P M Si Thiol Si TMT 5 Pd 1000ppm 500 mg 3 mL iMAnm Pd dppf Cl Si TMT Si Thiol
5. 6 SPE 7 Pd 800 ppm 1 lt 10 ppm KMS 2 500 mg 6 mL Si TMT Si TMT Pd Si TMT
6. CS 1 MP TMT ERRAK Pa Kd Pd Pd Pt Ru Rh 2
7. Si TMT MP TMT 6 S Rana Unpublished Results Biotage 2008 Method as per Heo Y Song Y S Kim B T Heo J Tetrahedron Lett 47 2006 3091 3094 1 0 5 1 2 3 1 4 5 10
8. Kg 6 RE 9 500 mg 6 mL 1 mmol 1 mol Pd 1 3 5 2 3 Pd Si TMT Pd 50
9. THF DMF DMSO 4 9495 0010 10g 9495 0025 25g 9495 0100 100 g 9495 0500 500 g 9495 1000 1000 g 12 Si Propylsulfonic Acid SCX 2 Si propylsulfonic acid SCX 2 0 7 mmol g Q 77 c H 52 um 2 4 1 DMF DMSO 4 9536 0010 10g 9536 0025 25 9 9536 0100 100 9 9536 1000 1000 9 MP TMT3 g SCX 2 30 Si TMT 3g Si TMT 500 mg 6 mL 5 Si Thiol 10 g Si Trisamin
10. E 6 9 2 pH pH pH 2 10 pH pH gt pH 10 1000ppm TPP Pd ll pH 1 1000ppm TPP Pd I pH 1 9 T T T T 0 T T T MP TMT SiTMT SiThiol SCX 2 Si Trisamine MP TMT SiTMT SiThiol SCX 2 Si Trisamine 3 4
11. Pd 4 5 5 Si TMT Pd 800 ppm 1 lt 10 ppm pH 1 ICP 2 4 50 5 ppm 10 20
12. Pd 800 ppm Pd 10 ppm 5 ppm 2 TMT MP TMT TMT 2 5 4 1 8 3 Pd 4 MP TMT TMT THF DMF 50 50 Pd CD PPh 2 mL 8 852 ppm Pd 16 TMT 100 TMT 16 MP TMT 4 5 Davies G Jordan S and Rana S OPRD FT Lauderdale April 2009 T 3 Si Thiol Si TMT Pd Si TMT Si Thiol
13. 6 15 2 1000 ppm TPP Pd II 2 gt 10 1000ppm TPP Pd II 2 gt 40 A A 7 N P E E 0 T T T T MP TMT Si TMT SiThiol SCX 2 Si Trisamine Si Thiol SCX 2 Si Trisamine 7 Pd MP TMT Si TMT 8
14. MP S THF DMF 9 10 MP IMT 2 46 gt 0 5 mmol g 150 355 um 45 100 mesh gt 90 ona MP TMT 5 THTF
15. 4 801506 3g 801469 10 g 801470 25g 801471 100 g 801472 1000 g Si TMT 24 6 0 3 mmol g 60 um RM ISOLUTE Si TMT3 30 THTF DMF DMSO 4 9538 0003 3g 9538 0025 25 9 9538 0100 100 g 9538 1000 1000 g Si Thiol 1 3 Si Thiol Si SH 1 3 mmol g 39 63 um H nM RE 2 6 1 12885818346 2 38 THF 4 9180 0010 10 0 9180 0025 259 9180 0100 100 g 9180 0500 500 g 9180 1000 1000 g Si Trisamine 2 1 2 2 1 mmol g fE 65 um
16. ISO9001 2008 GMP e MSDS e BSE TSE qu B a Biota i I j s 1 MP TMT Pd xs catalyst Br EAS PdCI PPh A HO Na CO aq 80 24 SH XY Q AN SH OMe HO 5 10 4 16 33400 PPM Pd ICP 190 PPM Pd ICP 0 5 mol 96 800 900 ppm 10 ppm A PAAR MP TMT5 Pd Pd 100 1000
17. 6 205 245 Carey J S Laffan D Thompson C Williams M T Org Biolmol Chem 2006 4 2337 2347 European Agency for the Evaluation of Medicinal Products Guidelines on the Specification Limits for Residues of Metal Catalysts or metal reagents 2008 accessed December 2009 http www emea europa eu pdfs human swp 444600en pdf 4 Welch C J Albaneze Walker J Leonard W R Biba M DaSilva J Henderson D Laing B Mathre D J Spencer S Bu X Wang T Org Proc Res Dev 2005 9 198 205 UJ NJ H 2 SEM x 120 s FAENA Reri SN NIN AGER SE HY BEP N cb Je RSE BS MA e 150 350 OAC PPh3 PPh3 CL dppf Cl E n E Q Pd Pd Pd Pd Pd OAc Pd PPh3 Pd PPh3 CL Pd dppf Cl Si Thiol OAo PPh3 PPh3 CL dppf Cl Pd Pd Pd Pd MI Si Trisamine Pd OAcC Pd PPh3 Pd PPh3 Cb Pd dppf CL M II a ABN AN EN BN M Suzuki Heck Sonogashira Ulman etc Suzuki Heck Sonogashira Ulman etc Suzuki Heck Sonogashira Ulman etc Various Suzuki Heck Sonogashira Ulm
18. Metal Scavenger Guide www biotage co jp T 136 0071 1 14 4 6F TEL 03 5627 3123 FAX 03 5627 3121 532 0003 5 1 28 4F TEL 06 6397 8180 FAX 06 6397 8170 URL http www biotage co j p E mail Japan_info biotage com 2010 2013 Biotage All rights reserved All brand and product names are trademarks or registered trademarks of their respectmeaoes The information contained in this document is subject to change without notice mscj 130218 CONTENTS 2 3 4 5 ESO AUG 6 8 9 7 11 14 E BC i D CE Se fe CEU SED Sic PGM
19. an etc Rh Ru Pt Ni Rh Rh Ru Pt Ni Rh Rh Ru Pt Ni Rh H z L1 Sr OvoE ET CBESIUBSERI 5 10 5 10 5 10 5 10 liz De EN NASAN 2 20 wt 2 20 wt 2 20 wt 2 20 wt 2 20 wt e ccw pod Magn aet WD Exp E iky aG Aaa BE 1 A x CU SEM ISO LOD FTIR MSDS TSE
20. e 10 9 K MS 2 1 13 L1 LII Bw o WM l l Bm M Bwawe 00 men W Xm m M pBawek 0 0 Ww mm 000000 0 0 Wo 0 0M mox 00 1 8 po 0 S Ww J M powe 0 Ww MW Bu 0 WM wow vem a dX 1I 1 MP ensi Lo m o o m et me pem o y peemwee 00000 y W peo 0 00 WW mro No 8 pue 0 Ww 8j M pe a 0 8 meme 0 80 8 8 a B B wWW biotage co jp 14
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