DIニュース№240（13/6/21）
Contents
1. 8 gt 200mg2. 18 DSM IV ER DSM IV American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th edition SM IV 10 LL 2 500mg
3. 1 1 24
4. 4
5. 9 gt 100mg 400mg 1
6. 1 1 0 596 No 37 1
7. 1 No 5O 201 1 1 2 Noe 1 F 4096 1 0 333g 5096 1 0 4g 1 3 4 1 PF 40961OOOmg 5O961800mg 3 6
8. 4 MRI 3cm lcm MRI PTP No 57 PTP 13 A 7 PT PTP
9. _ 75mg 1 75mg 50mg 4 1 1 17 5mg 35mg 5mg 1 Img 1 1 200mg Si 1 1 a 3
10. 1 5 A 5 B PHS C 1 C
11. 2 bm lh
12. L 1 aft 7 6 G 6 7 8 No 4g
13. 6 27 No 79 2013 6 et 2 06 2011 1 5 01 og 1 3 3 AB C BC A 3 A gt
14. 40 24 hese MRI MHI 1 MAI MRI 4 3 1
15. 5 gt UGCT2B7 UGT2B4 CYP3A4 CYP2D6 CYP2D6 Ultra rapid Metabolizer CYP2D6 Ultra rapid Metab
16. 6 DI 6108 6 EE 2 2 1 1 1 FAX DM 7 7mg 2g 5 Ge 25 2 5mg 5mg 25 2 26 26 nA
17. 18 16 gt 18 DSM IV 15mg Meiji Seika 12 7 17 E 1 1 18 O
18. 10cm 0 5 CT air 1 1 D HDA1c FBS
19. 6 17 DSM IV 1 1 2 189 1 1 2 184 1 6 3 189 DSM IV American Psychiatric Association Diagnostic and Statistical Manua of Mental Disorders 4th edition DSM IV 14 gt 20mg
20. ES 1 16 2 3 2 4
21. 6 gt tn 19
22. T 10 gt 0 5g 11 gt 1b 960
23. 1 8 3 12 gt 10mg 6 17 6 11
24. 26 No 79 2013 6 2006 2011 2012 Pr
25. 2 lt gt PMDA No 38 2
26. CK CPK 4 gt 5 MSD HD gt AP E
27. http WwWw_ med safe jD 101 006 1 1 4 17 03 52 1 7 025 FAX 03 5 1 7 0253 http Wwww ICdhc Qr jp htm index htm 29
28. A A B 1 No 17 1 BO 10cm
29. R 2 5 2 MR MRI MRI 6mL h
30. 24 meey No 79 2013 6 er 2 06 2011 D EE UET 3 CT CT
31. 1
32. Drug Tnformation News 25 6 2 1 NO 240 1 NO0 301 2 3 4 5 6 HP http www oita u ac jp yakub index html D 6108 E mail DI oita u ac jp 1 No 301 PMDA HP http www info pmda go jp iyaku_anzen fi1e PMDSI301 pdF 1I 1
33. 1 T 3 PMDA PMDA No 38 http www info pmda go jp anzen_pmda file iryo_anzen38 pdF PMDA http www info pmda go jp anzen_pmda iryo_anzen html 1 25 3 26
34. 1 0 30 1
35. e 8 SF 250mg 3 25 60mg CR 12 5mg 25mg 5mg XE 0 5 0 5 15mg 25u g 56 150 15mg 150mg 50mg 0 1 MT 2 1mg 4 2mg 300mg 0 5mg 1mg 5mg 0 2 200mg 40mg 0 8mL 0 5mg 25mg 50mg 25mg MI 250mg mk Ed Q
36. 1 3XJ 3 A 596 15mL 1 3 1 5mL 1 15mL 1 1 C No 41 G010 4 2 23 No 79 2013 6
37. 2 2mg emL 10mg 3 eae 10 3 10 NICU CHP 1 0 0g7 0 27g 10 1 6 1
38. 1 1 la II 1b C 1 HCV RNA 2 12 4 1 CRP
39. 6 0 5mL 1 0 1 0 1 0 4 0 5mL 3 3 pnt HI 2mg HI Img DI 17 5 H
40. PTP C PTP 18 28 mstee No 79 2013 6 006 2011 2012 5 CT 5
41. T20 25 T20 25 5mg 5mg 30mg 60mg 10mg 40mg 200mg 50mg 200mg 100mg 350mg 200 300 HI 2mg 0 1mg 0 5mg 1mg 2mg 4mg 6mg 8mg 3
42. 7 17 DSM IV American Psychiatric Associatio Mental Disorders DSM IV E 4 n 4th edition DSM IV 1 17 gt 2 Diagnostic and Statistical Manual of 25mg 18 18
43. 0 09 0 34 4 33 E 12 77 10 E 7 20 B 2012 1 3 12 6 HP No 79 http www med safe jp pdfmed safe_79 pdf ma 2006 2011 No 79 2013 6 2012 INes 2
44. 3 A B 1 8096 5 6
45. 12 6 17 DSM IV 6 11 DSM IV American Psychiatric Association Diagnostic and Statistical Manua of Mental Disorders 4th edition DSM IV 13 gt 25mg 6 17 E 18
46. CRP X 5 1 25 2 13 1 0 6 0 1 25 1
47. G oes 4 1096 4 mL 4 A B0mL no24 3 NO A NO
48. 4 1 900gg 2 30 es 3 180mL 1 18 E v 30 SE
49. 1 35 50mL h 1 8 21 No 79 2013 ee FPP 2018 aan noe
50. D Milk alkali syndrome 15 0OD 60g 40mL kg 24 50mL 1 60 120mg 1
51. gt 100mg 200mg 50 Toxic Epiderma1 Necrolysis TEN Stevens Johnson 3 3 gt 300mg
52. 7 17 18 8 7 17 DSM IV TR American Psychiatric Association DSM IV TR Diagnostic and Statistical Manual of Mental Disorders 4th edition Text Revision DSM IV TR 15 gt 25 75 18 E
53. ST 9 ST 5 25 meatee No 79 2013 6 er 2 006 2011 a he ma CV CV 1 G 1500mg 48mL 22G CV 2
54. a b c
55. 0326 2 h ttp wwwhourei mhlw go jp hourei doc tsuchi T130327I0030 pdf 2 25 3 26 2 HPV 16 18 CIN 2 3 ADEM
56. ADEM 2 MRI 3 25 1 31 3 0 3 0 21 12 273 21 12 24 12 250mg
57. 42mL L h 40 g8mL 22 No 79 2013 6 2006 2011 D BEE 20 18 D 3 A 5mg O 5mL B 13mg 3mL A
58. DI DI D RANKL 1 1 2
59. 1 3 1 240mg 1 720zg On e 1
60. 2 FF 10 25 2 2 25mg 4 5mg 26 200ng TZ 40mg RE EE 25 3 25 25 3 25 25 3 15 13 4 25 6 OD 60zg HI 2mg 14 25 5
61. 2 0 04 1 4 F 22 10 70 59 6 66 Q H 0 88 1 15 6 67 9 10 0 01 E
62. 2006 2011 ER 2012 IM ons 4 A A 1 A D 4
63. 31 5 0 23 11 E 8 000 24 2 25 1 245 25 3 26 3 29 1 lt gt 200mg 300mg CK CPK H 2
64. P2D6 Ultra rapid Metabolizer 7 gt 120mg X X X
65. olizer 1 6 lt gt 10 E UGCT2B7 UGT2B4 CYP3A4 CYP2D6 k CYP2D6 Ultra rapid Metabolizer hl CY
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