MWPHARM++ USER MANUAL
Contents
1. 14 4 mi Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim MEDINWARE FITTING SCREEN To fitt the PK parameters click on Fit button To Bayes fitting check the Bayes checkbox In case of missing Bayesian Parameters click on B button to generate Bayesian Parameters and then run the fitting ul X File Model Chart Object Help O OOSBIOIOG SARA SBM Neme Jmwe I Notes MwPham FITTING tobramycin tobramycin icu C1 ICASUS 003 21 08 1936 Bayes Algorithm Iterations W55 179 91 24833 RMS 4241609167 0 873148039 Akaike 141 9547975 Wa ria ble Generate Bayesian Parameters Par Error 36 Var Error 96 150 I Show only fitted parameters Time h Parameter i Population iti Final TE 005 T h mL min 1 73m 0 0026 3 M 4 bt Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim MEDINWARE After the fitting there are the individual PK parameters on the Status screen Individual parameters can be deleted by clicking on POP button ul x File Model Chart Object Help Model Resuts Notes MnPharn STATUS Renal Function mL min ICASUS 003 21 08 1936 140 Weight Height Sex Race RF Weight Measure RF Schwartz Constant k Renal Function Jelliffe I 1 serum creatinine level Serum Cr2. Clicking on the P buttons it is possible to load pratical regiments to the user regiment to adjust loading dose maintenance dose time interval and number of doses BG File Model Chart Object Help Model Results Notes MwPharm DOSE CALCULATOR tobramycin Mobramycinicu Cf C01 c mg l C Log Scale ICASUS 003 21 08 1936 14 14 12 10 3 6 4 2 0 o 10 20 30 40 50 60 FO USR EXA P1 P2 P3 Profile Targets Route Input Duration Load 278 1 240 240 240 240 mg Max mg L L_ Single Infusion Dose 2564 140 160 200 240 mg Min mg L Tint 19 45 12 12 24 24 h Ave mg l Reference Levels ROD Ndos 2 4 3 2 2 Tint h Variable COT1 C Max 8 78 12 00 7 65 8 78 9 07 10 80 mg L Min 1 94 1 00 1 69 1 94 0 42 0 50 mg L Method Target MIN_MAX Tmax L 0 50 0 50 0 50 0 50 0 50 0 50 h L_ Algorithm EXP Tmin 12 00 19 45 12 00 12 00 24 00 24 00 h Speed ms Ave 4 57 4 48 3 98 4 57 2 85 3 38 mg L Add to History p55 101 100 100 101 101 100 R M 4 o Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim
3. Serum Creatinine Creatinine Clearance 48 7 mL min 1 73m P30 P40 P50 47 3 mL min Reference Patients Pathology Population tobramycin tobramycin icu C1 CL 2 71 L h V 19 80 L 0 9268 Mo Login Patient Status Case History Simulation Fitting Dosing Users Settings About oooooooooo MEDINWARE CASE SCREEN To administer a drug to the patient select appropriate one from the left column 1 In the middle column will show the drug for specific groups of patients specific PK parameters By selection the drug from the middle column 2 and clicking on Insert button 3 1s the drug assigned to the patient Application newly allows user to define 1ts own cases user can change PK parameters of the particular drug but at the same time not overwrite the original parameters of the drug To continue to the History screen click on Load button 4 ul x File Model Chart Macro Help Mode sas Netes utm CASES tobramycin tobramycin icu C1 ICASUS 003 21 08 1936 Drug Model Itobramycin icu C1 Drug tobramycin ATC PMID 3 Model Itabramycin icu C1 pne UU _ sulfamethoxazole tobramycin icu C1 24 09 1994 00 30 4 tobramycin icu C1 tacrolimus temazepam terbutaline tetracycline theophylline thiopental ticarcillin E a tobramycin tobramycin adult C2 tobramycin adult cf C1 tobramycin adult cf C2 XX ittobramycin adu
4. 1951 01 81 1935 41411955 Standard M 4 Login Patient Status Case Users Settings About A L Number Icel cee 10083 1C604a Icee4b 10065 10066 1C067 1C068 Icaga 1C616 NeeL 1N602 Ne e s 1N604 INGOS 1N606 IN887 1N668 INOG 1N616 e EXAMPLE 1 e EXAMPLE 2 e EXAMPLE 3 e EXAMPLE 4 HISTORY 1 1682 ees ICASUS 86607 ICASUS 065 ICASUS 069 ICASUS 616 INPEM 8681 INPEM 682 INPEM 8683 INPEM 664 INPEM 8685 INPEM 8686 INPEM 8687 INPEM 86688 INPEM 669 INPEM 616 Adult Dialysis CAPD Neonate Tour De Pharm MW TEST D TEST E TFST R MEDINWARE Select the patient and click on Load button to load existing patient from the database a File Model Chart Macro Help OI0OBEISIOO A PATIENT Patient Number Name and Initials Date of Birth Sex Address Postcode Zipcode City Family Doctor Requesting Physician Ward Room Number Description Medication Date Fi c Dob 11 11 1956 11 11 1945 21 08 1936 11 11 1946 11 65 1993 11 11 1922 11 11 1992 11 11 1915 13 69 1998 11 11 1924 11 11 1977 26 04 1926 27 12 1929 26 04 1923 22 11 1984 22 83 1921 31 10 1942 15 84 1918 30 08 1926 11 85 1938 27 12 1949 Cee4a Icae4b cees 1C066 1C067 1C068 ICcega Ice1e 1N661 1N662 1N663 1N664 INGOS 1N666 1N607 1N668 INOG Nele ICASUS 083 ICASUS ICASUS ICASUS ICASUS ICASUS ICASUS ICASUS ICASUS INPEM 661 INPEM 882
5. INPEM 663 INPEM 664 INPEM 885 NPEM NPEM NPEM 66 NPEM INPEM 818 19 87 1939 8 EXAMPLE 1 Adult 19 87 1939 8 EXAMPLE 2 Dialysis 19 87 1939 8 EXAMPLE 3 CAPD Last Medication tobramycin 14 07 1994 8 EXAMPLE 4 Neonate 19 07 1939 HISTORY Tour De Pharm 06 11 1959 1 MW 01 61 1951 182 TEST D 01 01 1935 1234 TEST E al a 1958 31 IFST R imag ia M 4 Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim Age 58 years Date of Change MEDINWARE STATUS SCREEN Specify the data of your patient weight height sex etc ul x File Model Chart Macro Help 0I0OO0BEIOIOOIA 1AQAIDRE Nm ite CI STATUS Renal Function mL min ICASUS 003 21 08 1936 140 Weight 1 68 m Height i 21 3 kg m Sex Lbm 60 0 kq Race Lbme 60 0 kg RF Weight Measure Fim 49 3 kg RF Schwartz Constant k Age 58 years Renal Function emitte 11 1 serum creatinine level Serum Creatinine 2005 umol L l 339 ma dL Creatinine Clearance 48 7 mL min 1 73m Std Ped ped is pag 47 3 mL min Reference Patients Pathology Population tobramycin Itobramycin icu CT CL 2 11 L h V 19 80 L 0 9268 MEDINWARE Select apropriate renal function File Model Chart Macro Help STATUS Renal Function mL min ICASUS 003 21 08 1936 140 Weight 1 68 m Height i 21 3 kg m Sex 60 0 kg Race 60 0 kg RF Weight Measure 49 3 kg RF Schwartz Constant k 58 years Renal Function
6. MEDI WARE MWPHARM USER MANUAL LOGIN SCREEN After launch and load it is necessary to log in By default until the user changes it via Username admin and Password admin or Username user and Password user New version supports multiple user accounts each user can have their own drug and patient database or partially or fully shared with another specific user File Model Chart Macro Object Help Model MwPharm O MWAPHARM gt Therapeutic Drug Management Name MwPharm Version 1 1 2 0 ex Username Login PATIENT SCREEN MEDINWARE Click on Standard button to create new record in the patient database Fill the Patient Number Name Date of Birth and Sex and click on Insert button New patient will be inserted into the database a File Model Chart Macro Object Help 01I00EEIGIO0O A Notes MuPham PATIENT Patient Number Name and Initials Date of Birth Sex Address Postcode Zipco City Family Doctor Requesting Physici Ward Room Number Description Medication Date Age 35 years Last Medication Date of Change AS R Mln ie 0 vix E Dob 11 11 1958 11 11 1945 21 08 1936 11 11 1946 11 85 1993 11 11 1922 11 11 1932 11 11 1915 13 09 1998 11 11 1924 11 11 1977 26 04 1926 27 12 1929 22 83 1921 31 10 1942 15 84 1918 30 68 1926 11 65 1930 27 12 1949 19 07 1939 19 07 1939 19 07 1939 14 87 1994 19 07 1939 06 11 1959 01 81
7. MEDINWARE To zoom the graph select particular time interval all File Model Chart Macro Help Mode Ress Notes MwPham Mam SIMULATION tobramycin tobramycin icu C1 ICASUS 003 21 08 1936 25 B El Conc 0 0000 mg L E O cave 0 0000 mg L Effect n a Dauc 0 0000 mg L day m Oaucc 0 0000 mg L day Dose 1 I gt ccr Ju mal L C Cher mL min C ClerN mL min 1 73m A al m UU Bsa m DItbme kg O Ew kg tobramycin mg L i O Total mg mg kg BW noc a O iu e Date 24 09 1994 dd mm yy Time 00 30 hh mm 5pan 0 00 00 d hh mm 50 l 0 0000 days h Time h MEDINWARE To find out exact concentration AUC etc use the arrow buttons to move the blue indicator Values will show on the right side of the screen ul x File Model Chart Object Help 0 9000E 0 00 5 99Q RE nme we I Model Results Notes MwPharm SIMULATION tobramycin tobramycin icu C1 ICASUS 003 21 08 1936 25 2 01 mg L 5 57 mg L MaA 20 3 23 mg L day 42 55 mg L day CP umol L la un mL min mL min 1 73m m kg kg tobramycin mg L p c mg mg kg BW 04 10 1994 dd mm yy 19 40 hhimm 10 19 10 d hh mm o 50 100 150 200 250 300 10 80 days Time h eese M o E
8. QA TRE Neme ite I HISTORY tobramycin tobramycin icu C1 ICASUS 003 21 08 1936 t i Unit Mo Interv MEDINWARE SIMULATION SCREEN By cheching the boxes user can show different curves in the graph concentration average concentration AUC under every peak AUCC from zero to the infinity creatini clearance etc To run the fitting move to the Fitting screen LE File Model Chart Macro 9 t AM 55 0 8 9 B ia Name Type Fh Model Results Notes MwPham SIMULATION tobramycin tobramycin_icu_C1 ICASUS 003 21 08 1936 25 B El Conc 0 0000 mg L E O cave 0 0000 mg L Effect n a 20 auc 0 0000 mg L day m C Auce 0 0000 mg L day bose Fae E Occ 131 00 pmol L a 15 Octer 41 30 mL min E Ha O clerN 42 51 mL min 1 73m E y E O Bsa 1 68 m E O Lbme 60 00 kg LI 8 10 Bw 60 00 kg E C Total 0 0000 mg 0 0000 mg kg BW m 1c 5 a lini Date 24 09 1994 dd mm yy Time 00 30 hh mm 0 Span 0 00 00 d hh mm 0 50 100 150 200 250 300 O days h Time h Page Size Full o x gt Y Scale IN X Scaleh lt lt gt gt gt Edit Save Load amp gt Mj Login Patient Status Case History Simulation Fitting Dosing Users Settings About AA
9. eatinine EET umoal L a mardL Creatinine Clearance 48 7 mL min 1 73mY 5td P20 P30 P40 P50 P60 P70 P80 F30 47 3 mL min Reference Patients Pathology Individual tobramycin Htobramycin ie CL 2 94 L h ty EE h V 2243 L j 0 8967 M 4 mi Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim MEDI WARE DOSING SCREEN On Dosing screen it is possible to show different dosing regiments by checking to boxes ul x File Model Chart Object Help oo Y la E Be al Name fs Type Model Results Notes MwPharm DOSE CALCULATOR tobramycin tobramycin icu Cf 01 mg l Log Scale ICASUS 003 21 08 1936 14 12 10 3 6 4 2 0 o 10 20 30 40 50 60 FO USR EXA P1 P2 Pa Profile Targets Route Input wi 2e Duration Load 278 1 240 240 240 240 mg Max mg L Single Infusion Dose 256 4 140 160 200 240 mg Min mg L Tint 18 45 12 12 24 24 h Ave O mg l Reference Levels ROD Ndos 2 E 3 2 2 Tint h Variable COT1 C Max 12 00 12 00 7 65 8 78 9 07 10 80 mg L Min 1 00 1 00 1 69 1 94 0 42 0 50 mg L Method Target MIN MAX Tmax L 0 50 0 50 0 50 0 50 0 50 0 50 h LJ Algorithm EXP Tmin 19 45 19 45 12 00 12 00 24 00 2400 h Speed ms Ave 4 48 4 48 3 93 4 57 2 85 3 38 mg L Add to History E pss L 100 100 100 101 101 100 R M 4 em Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sim MEDI WARE
10. lt ic C1 ittobramycin adult ic C2 ittobramycin adult k C1 tobramycin adult k C2 tobramycin child 16 16y C1 tobramycin child 16 16y C2 gt tobramycin child 1 5y C1 gt triamterene trimethoprim tubocurarine valproic acid wancocin wancomycin vecuronium verapamil warfarin ittobramycin c ittobramycin c ittobramycin c ittobramycin c ittobramycin c tobramycin c ittobramycin c ittobramycin c hild 1 5y C2 hild 1 6m C1 hild 1 6m C2 hild 5 18y C1 hild 5 18y C2 hild 6 12m C1 hild amp 12m C2 hild cf C1 tobramyci n child cf C2 tobramycin neonate 8 5 1m C1 zidovudine tobramycin neonate 8 5 1m C2 Drug Model C Date Dug U Delete Update Insert Delete Default Update Insert Delete Active L E M nf Login Patient Status Case History Simulation Fitting Dosing Users Settings About Sm MEDI WARE HISTORY SCREEN Fill the drug administration history date time road of administration and dosing Moving cursor to the red triangles the help will show To run the simulation click on Sim button or move to the Simulation screen To save the patient history get back to the Case screen and click on Update button under right column File Model Chart Macro Help QOOBEIGIOOIA 1A
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