A pdf version - internet Primate Aging Database
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1. Below are all records matching your data query criteria Click the New Query button to run another query using Detail Data Query different criteria or click Cancel button to return to the logged in page Submit Data Detailed Data Query Result Data Counts Log Off Cf Rh 18 Ct Rh 22 Figure 3 5 Detailed Data Query Results Screen Revision 2 0 17 8 11 2005 Internet Primate Aging Database User s Manual SS UNA National Primate Research Center University of Wisconsin Madison WPRC Profile Codebook FAQ Detailed Data Query Save Result iPAD SYSTEM iNTERNET PRIMATE AGING DATABASE Data Record Maintenance Statistical Measures Detail Data Query Your search result has been saved successfully click here to get file Copyright 2004 Board of Regents University of Wisconsin System Figure 3 6 Detailed Data Query Results via CSV option mS INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison iPAD Overview WPRC Profile Codebook FAQ File Download x Detailed Dat oa Some files can harm your computer If the file information below Your search result t click here to get file looks suspicious or you do not fully trust the source do not open or save this file File name 1_1111408229002 csv File type Microsoft Excel Worksheet From ipadprod nore org A This type of file could2. are currently found in iPAD We also have blood chemistry data e g albumin total proteins glucose etc as well as body weights The database consists of both cross sectional and longitudinal data with age for a variety of non human primate species The iPAD contains data from a number of different primate research facilities and therefore pooled data across sites may represent different housing conditions diets and assay procedures Al subjects were control animals Oe non experimental and deemed healthy at the time of measurement Data values for each age represent a mean of the measures for an individual subject for a three month period Figure 3 1 iPAD Overview Screen Revision 2 0 5 8 11 2005 Internet Primate Aging Database User s Manual WNPRC Profile The WNPRC Profile page offers a profile of the Wisconsin National Primate Research Center based at the University of Wisconsin Madison WNPRC is the current manager of the Primate Aging Database Through the development of the Internet Primate Aging Database system Wisconsin has made valuable information in the iPAD accessible to the worlds of aging and primate research The WNPRC Profile page provides insight into the type of research sponsored at the WNPRC as well as at the other seven National Primate Research Centers EC iPAD SYSTEM E INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison iPAD Overview WPRC
3. The user can specify whether they wish to see the data broken down Quarterly Half yearly or Yearly iPAD Overview WPRC Profile Detailed Data Query Search the iPAD database by specific attributes to retrieve individual data points Provide data parameters in the fields below Select the format in which you wish to receive the results then click the Search button to query the database In Internet Explorer or Netscape use Ctrl click to select muttiple options to return all available data records In Safari use ep click to select multiple options to return all available data records Select Primates Aged Birth zl to 10 Years e Species Sites Measurements up to 5 options leave biank to select ALL up to 3 options Pygmy Marmoset a a a Smithsonian National Zoological Park Glucose Squirrel Monkey New England NPRC Blood Urea Nitrogen Stumptail Macaque zl Oregon NPRC sl Creatinine zi Note Please check ali that apply or leave your selections blank to select ALL Sex Diet Housing MW Male I Chow I indoors IT Female I Other Outdoors IT Mixed Unknown Select how you wish to search data points by Quarterly Halt Yearly C Yearly Select the format in which you wish to receive the query results View results online Export results to a csv file for download Seren ze es Figure 3 4 Detailed Data Query Selection Screen Should there be one or more primates that
4. 6 5 7 1 77 22 CERh 90 25 75 3 4 3 6 4 44 48 58 6 2 23 CERh 91 25 75 3 2 44 5 1 56 6 7 8 2 8 5 24 Cha 25 75 3 2 3 6 4 4 4 49 58 6 9 25 Internet Primate Aging Database User s Manual RSS 1 INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison Codebook Fad Data Record Maintenance iPAD System Login Page Statistical Measures You are now logged in to the iPAD System and can utilize any of the following iPAD features by clicking the Detail Data Query gt corresponding button on the left navigation bar Submit Data Data Record Maintenance Review accept or reject data submitted by other researchers e Detail Data Query Search the iPAD database by specific attributes to retrieve individual data points Submit Data Upload or manually enter your own data Statistical Measures Search th Yee Explorer xi Bis Data Counts Number of data poil S Are you sure you want to log off the iPAD system Data Counts Log Off DaDSveIEM 3 iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison iPAD Overview WPRC Profile Codebook FAQ Log Off Successful You have successfully logged off the Internet Primate Aging Database System If you have logged off in error and need to access the system again click the Login button on the left navigation bar You will be required to reenter your username and pas
5. Age Range 4 6 years Gender Male Revision 2 0 13 8 11 2005 Internet Primate Aging Database User s Manual WA iPAD SYSTEM iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madisor WPRC Profile Codebook FAQ Statistical Measure Statistical Measures Search the iPAD database by specific attributes to review statistical analysis cal measures parameters in the fiel ick the Search button to query the database lorer or Netscape use Ctrl click to select multiple options to return all available data records In Safari use click to select multiple options to return all available data records Select the format in which you wish to receive the Sites Species Measurements Age Group a Pigtail Macaque a aj WAT Smithsonian National Zook Pygmy Marmoset e 4 6 New England NPRC Rhesus Macaque A GNE Blood Urea Nitrogen 6 10 Oregon NPRC zl Larei Monkey creatinine sl jun sl Note Please check ali that apply or leave your selections blank to select ALL Sex Diet Housing MV Male Chow Indoors I Female I Other TC Outdoors I Mixed Unknown Select the format in which you wish to receive the query results View results online Export results to a csv file for download Ges ees Figure 3 1 Statistical Measures Selection Screen By not selecting diet or housing attributes the user has selected all diet types and all housing con
6. Primate Aging Database User s Manual Chapter 1 Defining User Roles Public User The Public User is defined as any internet user who visits the homepage of the iPAD system From that particular page the Public User can request a new user account from the System Administrator by filling out the form on the Login Request page In addition the Public User will also have the ability to review the Data Counts of the system to see how many data points exist in the system at the time of their visit Because data are continuously being added as measurements are taken on healthy animals the number of data points change on a regular basis Lastly the Public User can select each of the tabs at the top of the homepage including the WNPRC Profile page the Data Codebook page and finally the Contact Us page to send comments to the System Administrator Research User The Research User is someone who has applied for read only access to the iPAD system database It is assumed that this person is someone who is either a researcher working at a contributing site such as one of the National Primate Research Centers or someone who is studying the effects of aging or primatology This user has access to additional reporting capabilities such as the Statistical Measures and the Detailed Data Query In addition to all the capabilities that were enumerated for the Public User a Research User can now produce custom queries to examine data within the database
7. meet the user s selection criteria then individual data points are displayed in spreadsheet format as shown in figure 3 5 Each row represents data for an individual primate identified by an ID in the first column under the Primate List column header The next column over is the current age of that individual Each column following the age is the quarterly mean value that exists for that primate for that measurement There may not be a measurement for each time segment The user can then scroll up or down as well as to the left or right to be able to see each data point within the window provided for the results The other option is to output the information into a csv file for importing into EXCEL or another data manipulation tool that can read in comma separated values as data This allows the user to conduct further analysis with their tool of choice It makes more sense to view the Detailed Data Query output as a csv file rather than online if a user is interested in further analysis since it consists of individual data points Figures 3 6 through 3 8 show the various screens one would see if the csv option is selected and what the resulting output looks like Revision 2 0 16 8 11 2005 Internet Primate Aging Database User s Manual LS SN RS sek iPAD SYSTEM L I A Y iNTERNET PRIMATE AGING DATABASE National Primate Rassarch Pehl WPRC Profile Codebook FAQ Data Record Maintenance Detailed Data Query Result Statistical Measures
8. of such biomarkers If you are unfamiliar with the various measures this manual will not be a substitute for proper training in the field of primate research One of the more informative sections of the site which is publicly accessible is the Data Codebook section This part of the site contains tremendously useful information on the information that can be more closely examined within the iPAD system There are pages which describe the different sites that have contributed data and the site conditions in particular the methods of anesthesia used at each site the method machine used for the analysis of blood chemistry and hematology panels housing conditions and animal diet Other information found in the Data Codebook includes in depth Factsheets on each species represented in the data a like to Primate Info Net PIN a site created and managed by the Wisconsin National Primate Research Center WNPRC Library and information about the types of measurements contained in the database This type of information should be invaluable to anyone interested in primates The next few sections will go into more detail describing the user categories and system functionality Each will be illustrated where possible with actual screen shots of Revision 1 0 1 8 11 2005 Internet Primate Aging Database User s Manual the system as a graphical means for familiarizing the user with the screens and their function Revision 2 0 2 8 11 2005 Internet
9. Internet Primate Aging Database User s Manual Login The last screen accessible to the Public User is the Login Screen shown below in Figure 2 8 Depending on the account provided the user will have a varying number of functions at their disposal RR iPAD SYSTEM iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison iPAD Overview WPRC Profile Codebook FAQ iPAD System Login Page Enter your username and password below to access the Internet Primate Aging Database system It you have not received a username and password click the Request Login button on the lett User Name Password Gel zc Figure 2 8 iPAD Login Screen Should the Login fail an error message will appear Figure 2 9 The User Name and Password for this system are both case sensitive In other words the User Name Mary Brown is different from mary _brown just as the password SECRET is different from Secret or secret iPAD SYSTEM iNTERNET PRIMATE AGING DATABASE National Prim Univ Validation Error Request Login You must correct the following error s before proceeding Data Counts m us Cannot find user name MyUserName iPAD System Login Page Enter your username and password below to access the Internet Primate Aging Database system If you have not received a username and password click the Request Login button on the lett UserName MyUserNa
10. NPRC Profile the Data Codebook and Contact Us option to contact the System Administrator or their designee to ask additional questions about the system or the data available through the system In addition to the tabs at the top of each page there is a menu on the left side of each page that will vary from user to user depending on their role and the features they have access to iPAD SYSTEM EO iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Madis iPAD Overview WPRC Profile WELCOME TO iPAD The internet Primate Aging Database iPAD is a multi centered relational database of biological variables in aging captive nonhuman primates Through joint initiative of the National Institute on Aging intramural and extramural programs National Center for Research Resources NCRR and the National Primate Research Center at the University of Wisconsin Madison WPRC we have organized a database to study biomarkers of aging in nonhuman primates iPAD also provides an invaluable veterinary and clinical resource and can generate normative data for numbers of animals across research settings iPAD now contains over 400 000 data points for body weight blood chemistry and hematology tor healthy non experimental subjects across time Many blood variables that are obtained for a routine clinical screen e g differential WBC RBC hematocrit hemoglobin mean corpuscular volume etc
11. Profile Codebook FAQ WPRC PROFILE The Wisconsin National Primate Research Center is one of eight federally supported NIH NCRR National Primate Research Centers and the only one in the Midwest More than 250 center scientists through competitive grants conduct research in primate biology with relevance to human and animal health The Primate Center is based in the Graduate School of the University of Wisconsin Madison The Center has strong research and teaching links to the UW Schools or Colleges of Medicine Letters and Science Agriculture and Life Sciences and Veterinary Medicine WINPRC Mission statement Our mission is to increase our understanding of basic primate biology and to improve human health and quality of life through research To accomplish this the WPRC e Helps discover treatments preventions and cures for human disease Generates new knowledge of primate biology from the molecular and whole animal levels to the understanding of primate ecosystems Facilitates research progress by providing expertise resources and training to scientists worldwide e Collects primate information and disseminates to the research community and to the public Discoveries Enabled by Primate Center Resources Embryonic stem cell culture and differentiation Monkey ES cells from WPRC distributed worldwide Beneficial effects of controlled dietary restriction on primate health New therapies for glaucoma and presbyopi
12. Wisconsin National Primate Research Center Internet Primate Aging Database Public and Research User s Manual Revision 2 0 July 2005 All rights reserved by the Wisconsin National Primate Research Center amp National Institutes of Aging Internet Primate Aging Database User s Guide All rights reserved to the Wisconsin National Primate Research Center University of Wisconsin Madison The National Institutes of Aging amp The National Opinion Research Center University of Chicago Revision 1 0 March 2005 Revision 2 0 July 2005 Table of Contents Preface System OVEIVMIEW dacerscnnicn ec naeeneaaS 1 Chapter I Denne User Roles 15 lt ccesseorcusnarottencarantaniaenssnnavigisuniansttuaedenannbuataunbagsteghabes 3 Emer leese 3 Research EE 3 EE e ele 3 Chapter 2 The Public TE 5 IPAD OVETVIEW semisesnepiihenn aa E 5 Figure 3 1 iPAD Overview Breet sisi casesescsssecesestoasvatsanesnnaszncsnsesosncenastnedasasaiaceiess 5 CEET 6 Figure 2 2 WNPRC Profile Screen ss cacacnssnacaidsawancuniinswunsiatieawnbioudnebbsawnsenunabavanasewies 6 Data Codeb gk EEN 7 Figure 2 3 iPAD Codebook Sereet sissacsscascsesandatsadapdctnasiodsinadinaronmbedctaiapddcaaenceceis 7 Contact eee ace iia sey as ede casa ee RRE T AE AAA a eae 8 Figure 2 4 Contact EE 8 entgeet eranen E eebe 9 Figure 2 5 Login Request Screen sis csasesesesancsesestsasenndennsnoestsonasesosanmasivedanenmianeveds 9 D t COUN E 10 Figure 2 6 Data Counts S
13. a How HIV infects host and escapes immune system Knowledge used to develop current SIV therapies Risk factors for endometriosis Figure 2 2 WNPRC Profile Screen Revision 2 0 6 8 11 2005 Internet Primate Aging Database User s Manual Data Codebook This portion of the site allows users to gain some insight to the world of primate research and the different types of animals that are housed at these various research centers Through the Data Codebook a user can examine extensive Factsheets about various primates involved in research locate links to institutions that have contributed data examine details about a particular measurement being collected read about various site conditions and link to Primate Info Net PIN a network of original content and links to resources about nonhuman primates created and administered by the WNPRC library Under Taxonomic Groups Factsheets about the different species represented can be found Additionally a link to PIN can be found here in order for users to explore more material about nonhuman primates Under Sites the site address contact name and email address of each of the contributing institutions can be found The Site Conditions page provides further details about the housing conditions the various anesthesia methods used at the different sites the hematology and blood chemistry methodologies and technologies used for analysis and the diet provided at each of the research fa
14. ble on the left The left table allows the user to manipulate by clicking on the or buttons to expand or contract the visible categories Starting at the top you will see Total for all measures in the database If you used the mouse to click Total then the Data Count Detail a breakdown of counts by measurement would be displayed in the table on the right iPAD SYSTEM o INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madisor IPAD Overview WPRC Profile Codebook FAQ Data Counts Number of data points by site species and sex The following is a collap unts by Total Site Species and Sex Click the or icons to expandicollapse the list name to see a detailed breakdown of data within that category The detail data will load in the frame on the right hand side of the page DATA COUNTS BY CATEGORY SELECTED CATEGORY DETAIL DI Total 409236 Data Count Detail NO CATEGORY SELECTED Figure 2 6 Data Counts Screen Should the user hit Total will expand out to display all of the species in the database If you then expand further the next level shown within each species would be the list of sites which house this type of animal Expand once more and you would see within species and site the count broken down by gender Always to the right of each Revision 2 0 10 8 11 2005 Internet Primate Aging Database User s Manual category in red is the cur
15. cilities The Measurements page provides the definition description clinical application and scientific units for each of the biomarkers in the database as well as links to PrimateLit and PubMed to locate current related papers on each of the measurements A sampling of related papers is provided for each measurement in this section as well PE ING iPAD SYSTEM iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsi son WPRC Profile Codebook FAQ Frequently Asked Questions Table of Contents Measurements NOTE The data collected is presumed to be from healthy animals although incidences of clinical and subclinical data may be included but not noted in the records Site Conditions Figure 2 3 iPAD Codebook Screen Revision 2 0 7 8 11 2005 Internet Primate Aging Database User s Manual Contact Us The Contact Us section can be used to ask questions or provide feedback to the System Administrator at WNPRC RS iPAD SYSTEM Le INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madison WPRC Prole P CoaebookFAG Login Contact Us Request Login Data Counts We always appreciate feedback from users and other interested parties If you have any questions or concerns regarding the Internet Primate Aging Database or if you just want to say hello please fill out the form below A representative will contact you if re
16. ditions Once the parameters have been collected click Search Here we see that there were a total of 122 data points used to calculate a Mean Body Weight of just over 9 pounds with a Standard Deviation of 1 773 Notice that there is a button near the bottom of the selection screen to allow the user to choose whether the output is viewed online default or if the data accessed should be sent to a comma separated variables or csv file This file can be imported into EXCEL or most other spreadsheet database or statistical applications When data is exported to a spreadsheet it will appear like in Figure 3 3 This allows the user to save the results for later review or as we will see in the Detailed Data Query section additional analysis can be run on the data The selection screen in Figure 3 1 allows the user to select multiple items within the drop down menus by using either the Shift or Ctrl keys under Windows To accomplish this with a contiguous block the user would use the left mouse button to highlight the first item in the block to be selected Next holding the Shift key the user would locate the last item in the block to be marked and click the left mouse button to highlight the entire block To select multiple items in one of the drop down menus that are not contiguous the user would use the left mouse button to again select the first item then subsequent items would be selected by holding down the Ctrl key and using the left mouse bu
17. ere a ncccassnacacasrupcanarannstonnaupsasaraunsiausanonauersnatinanaleraunreel 10 Figure 2 7 Data Counts Screen fully espanded 11 LOS Meen E A A E AE es 12 Figure 29 Failed Login aie sccecssasctegsvs meniran eienaar E E EE 12 Chapter 3S y stem F NCHON Snein cays Gud eee ee eee 13 en EE THREE 13 Figure 3 1 Statistical Measures Selection Screen cscceescecesseeeeeeeeeesnneeeeanees 14 Figure 3 2 Statistical Measures Results Screen eeeseeeesseeeesneeeeeneeeesneeeeenees 15 Figure 3 3 EXCEL Output shown within the browse 15 RRE EE 16 Figure 3 4 Detailed Data Query Selection Screen ceeesseeesneeesneeeeenneeeeanees 16 Figure 3 5 Detailed Data Query Results Screen i eeeceeeeseeeeneeeeeteeeeeneeeeeanees 17 Figure 3 6 Detailed Data Query Results via CSN option sssssssssessssrsessseree 18 Figure 3 7 Opening the sO ET 18 Figure 3 8 Viewing the CSN Fille scsssscorssssorsresorsnsvosstsesenssesoncceseaosoesseters 19 WSO DTT E A dca evan aden sae adaaes A E E EE AT 19 Figure 3 12 System Log Off Confira 0 ds elccpy oar sgn anlobanetans sae dannisnetaadh sandets 20 Figure 3 13 Successful System Log Heda eekleg 20 Appendix A Species of Primates in PAI 21 Internet Primate Aging Database User s Manual Preface System Overview The Internet Primate Aging Database iPAD is the second generation of computerized database system whose primary pu
18. for review either on their computer screen or export results for later examination and statistical manipulation into files on their system Data Contributor The next level of user is the Data Contributor As with the Research User this user role builds upon the capabilities of the previous two roles and adds the ability to actually submit data to the system Data Contributors are staff of one of the research centers that house primates and collects data points such as body weight or certain hematological measurements These users have the ability to either upload data files for import or directly enter data points into the system The usefulness of iPAD increases as more data are contributed It is the goal of WNPRC and its sponsoring agencies the National Institutes of Health NIH and the National Institute on Aging NIA to widen the number of species and increase the number of data points for existing species in the database If you are interested in contributing data from non experimental healthy Revision 2 0 3 8 11 2005 Internet Primate Aging Database User s Manual primates please notify the System Administrator via the Login Request or Contact Us pages Revision 2 0 4 8 11 2005 Internet Primate Aging Database User s Manual Chapter 2 The Public View iPAD Overview The homepage presents an overview of the iPAD system There is a set of tabs at the top of each page to allow the user to see the iPAD Overview the W
19. harm your computer if it contains malicious code Would you like to open the file or save it to your computer Open L sm Cancel More info KR Always ask before opening this type of file sconsin System Figure 3 7 Opening the CSV File Revision 2 0 18 8 11 2005 Internet Primate Aging Database User s Manual Figure 3 8 Viewing the CSV File The Statistical Measures and Detailed Data Query are the only additional tools that the Research User has at their disposal that the Public User does not Log Off When the user selects the Log Off option on the menu the system prompts them to confirm that they in fact wish to logout as displayed in Figure 3 12 Upon confirmation of the desire to log out the system displays the screen in Figure 3 13 Revision 2 0 19 8 11 2005 a7 E el ER e el fee cel eae DEE ee Ce Ee ER M 1 Body Weight 2 Primate Li Age in Ye 1 75 20 2 0 2 25 225 25 25 275 2 75 3 0 30 325 325 35 35 375 375 40 40 425 4 25 4 5 3 CHRh 49 19 5 4 CHRh 50 29 5 5 CR 29 5 6 CR 29 7 CERh 55 28 75 8 CERh 57 29 5 9 CB 28 6 7 10 CF Rh 62 27 75 79 9 11 CERh 66 27 75 12 Cf Rh 70 27 75 75 79 13 CERh 74 27 6 3 75 8 9 10 1 14 CfRh 75 27 5 5 2 6 5 6 7 15 C Rh 76 27 45 5 2 6 1 6 8 16 CERh 77 27 59 8 2 8 7 9 05 17 CFRh 81 26 75 47 5 1 6 3 6 8 79 18 CF Rh 82 26 75 5 1 57 69 74 8 19 CERh B4 26 75 3 8 43 53 57 6 1 20 CERh 85 26 75 5 1 6 1 5 65 21 Cf Rh 89 26 35 43 45 4 85 58
20. iversity of Wisconsin Madison WPRC Profile Codebook FAQ Data Counts Number of data points by site species and sex The following is a collapsable list of data counts by Total Site Species and Sex Click the or icons to expandicollapse the list or click a category name to see a detailed breakdown of data within that category The detail data will load in the frame on the right hand side of the page DATA COUNTS BY CATEGORY SELECTED CATEGORY DETAIL El Total 409236 Data Count Detail Owl Monkey Aotus trivirgatus Hew England NPRC Male E Owl Monkey 1135 E New England NPRE 1135 Pygmy Marmoset 628 Rhesus Macaque ALL 1738298 Squirrel Monkey 15799 Ze T Category Count Ages Female 478 Gera DI Bonobo 3234 Blood Urea Nitrogen 35 1 14 Creatinine 35 1 14 H Chimpanzas Gees Total Protein 35 1 14 Cottontop Tamarin 15780 aan 35 1 14 H Crested black Macaque 55 Alkaline Phosphatase 35 1 14 H Golden Headed Lion Tamarin 1288 Ser Glut Pr DI White Cheeked Gibbon 79 35 1 14 DI Western Lowland Gorilla 6722 ap 1 44 SE Golden Lion Tamarin 899 Longtail Macaque ass Dehydrogenase 35 1 14 Common Marmoset 2185 El pe E Orangutan ALL 8207 Galtin SES Pigtail Macaque 37978 Phosphons Selfie Potassium as 4 44 ZI H Figure 2 7 Data Counts Screen fully expanded Revision 2 0 11 8 11 2005
21. me Password Joe el zs Figure 2 9 Failed Login Revision 2 0 12 8 11 2005 Internet Primate Aging Database User s Manual Chapter 3 System Functions Once a user has successfully logged into the iPAD system additional capabilities are displayed on their menu left column depending on their permissions The next level of access above the Public User is the Research User who can run a variety of queries using either the Statistical Measures tool or the Detailed Data Query The next level up would be the Data Contributor who in addition to the two query tools can also upload or data enter new records for consideration to be added to the database Statistical Measures The Statistical Measures query tool allows users to develop a summary of statistical averages of the various measurements referred to in the Data Counts section Here the user can select search parameters including site species measurement and age group A user can further refine the search by selecting sex diet and type of housing of the species of interest The end result is a report including mean standard deviation and standard error of the chosen measurement s as well as the total number of data points from which the statistics are derived and the total number of primates from which the measurements were taken An example query might be to select the following attributes Site California NPRC Species Rhesus Macaque Measure Body Weight
22. oved If you already have a username and password click the Login button on the left NOTE Fields marked with are required First Name Last Name Institutional Email A D D Address Department Mivision Research Interests Species of Interest Fax Institutional Affiliation Research Organization California NPRC S If Other please specify Highest Academic or Professional Degree Position Title Supervisor Advisor Email Address Proposed use of the Primate Aging Database lam interested in submitting data in the future Clear Cancel Figure 2 5 Login Request Screen Revision 2 0 9 8 11 2005 Internet Primate Aging Database User s Manual Data Counts The only publicly accessible data is in the Data Counts section It allows the casual user to see the total number of available data points that are included in each measurement category These counts are broken down by each species type site and gender of primates in the database It does not allow for the examination of specific measurements or specimens just a count of the total number of data points found in the database The following screens depict how a user might see information and how they can view current counts On the left there is a table of Data Counts by Category The table on the right will display the Data Count Detail for all of the measures in the database when the user clicks on a particular category in the ta
23. quested Your Name Your Email Comments Submit Comments Figure 2 4 Contact Us Screen Revision 2 0 8 8 11 2005 Internet Primate Aging Database User s Manual Login Request The Login Request screen is available to all users to submit a formal request to the System Administrator for an account to access additional system capabilities The form allows the user to provide key information necessary for the approval process In addition to the user s basic information such as name phone number and institutional email address the system also requires that an organizational affiliation be identified including the institution name department the requestor s supervisor s email address as well as the requestor s research interests position and proposed use of the information in the database This request is submitted and filed with the System Administrator and potentially reviewed by the iPAD Steering Committee for approval Upon approval the requestor will be notified whether their request has been approved or denied and if approved this notification will be followed up with a username and password S RK iPAD SYSTEM E INTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madisor iPAD Overview WPRC Profile Codebook FAQ Login Request Please provide the following information to receive a username and password You will be notified via email when your request has been appr
24. rent count of measures for that particular category starting at the Total category The screen below shows that the user has expanded down to the lowest level gender within owl monkeys at the New England PRC The total count of measurements for owl monkeys is displayed to the right of the title next to New England PRC on the right is the count of measures for that site notice that since New England is the only site listed under Owl Monkey that the count for the species and site are identical Under New England you see both Male and Female displayed with a count to the right of them You now are able to determine how much data is available in the system for a given species site and gender At any point at any of these levels you can click on the category you are interested in and display a breakdown of measurements and their counts for that category In addition to seeing the count of measurements in the database you also see displayed the age range in years of the primates from which these measurements were taken This should provide trained researchers sufficient information to decide whether the data contained within the database would be useful for their particular research If this is the case they could then apply for a user account using the Login Request page allowing them to run more sophisticated analysis once they have access to the system Pas iPAD SYSTEM Z iNTERNET PRIMATE AGING DATABASE National Primate Research Center Un
25. rpose is the collection and analysis of biomarkers of aging non human primates The original system was developed in the late 1990 s using PC based systems including Microsoft Access and Visual Basic As the need to distribute access to this database to a broader audience arose it became obvious that replacing the current standalone system with either a client server based configuration or an internet based system would be the most likely candidates for the next generation The new system is purely internet based with a front end that can be accessed by the average user via a web browser There is no need for the installation of any software on the user s machine as long as they have access to a web browser such as Microsoft s Internet Explorer Netscape Navigator Apple Safari or any other popular browser that supports HTML This system was designed to facilitate not only read only access by public users and researchers it also supports three additional classes of users who can contribute new data points as well as two tiers of administrative support a site administrator and a system administrator This User s Guide will cover the first two tiers of users and the capabilities available to them Users of the system are expected to be familiar with some of the basic terminology of primatology and the biomarkers contained within the database A typical user of this information should be someone who is involved with the collection and reporting
26. sword to access the system again Click here to return to the iPAD home page Copyright 2004 Board of Regents University of Wisconsin Systerr Figure 3 13 Successful System Log Off The system has a default inactivity timeout limit of 15 minutes at which point it will automatically log the user out and require that they provide their user name and password again This can also occur during rather large queries using the Statistical Measures feature or the Detailed Data Query feature Revision 2 0 20 8 11 2005 Internet Primate Aging Database User s Manual Appendix A Species of Primates in iPAD Aotus sp owl monkey Callithrix jacchus common marmoset Callithrix pygmaea pygmy marmoset Gorilla sp gorilla Hylobates Nomascus leucogenys white cheeked gibbon Leontopithecus chrysomelas golden headed lion tamarin Leontopithecus rosalia golden lion tamarin Macaca arctoides stumptail macaque Macaca fascicularis long tailed macaque Macaca mulatta rhesus macaque Macaca nemestrina pigtail macaque Macaca nigra crested black macaque Pan paniscus bonobo Pan troglodytes chimpanzee Pongo sp orangutan Saguinus oedipus cotton top tamarin Saimiri sp squirrel monkey Revision 2 0 21 8 11 2005 Internet Primate Aging Database User s Manual Appendix B Aging Biomarkers Measures The list below is made up of all the biomarkers that currently exist in the iPAD database as of the firs
27. t release of the iPAD system Definitions for each can be found in the Codebook FAQ section of the site Albumin Albumin Globulin Ratio Albumin Protein Ratio Alkaline Phosphatase Axillary Body Temperature Basophil Basophil abs Bilirubin direct Bilirubin total Body weight Bone thickness BUN Blood urea nitrogen BUN Creat Ratio Calcium Carbon Dioxide Chloride Cholesterol CPK Creatine phosphokinase Creatinine Eosinophils Eosinophils abs Fibrinogen Fingernail growth rate GGT Gamma glutamyl transferase Globulin Glucose Glycosylated Hemoglobin Hematocrit Hemoglobin Iron Lactic dehydrogenase Lymphocyte Lymphocyte abs MCH Mean corpuscular hemoglobin MCHC Mean corpuscular hemoglobin concentration MCV Mean corpuscular volume Monocyte Revision 2 0 22 8 11 2005 Internet Primate Aging Database User s Manual Monocyte abs Neutrophil band Neutrophil band abs Neutrophil segmented Neutrophil segmented abs Phosphorus Platelets Potassium Rectal Body Temperature Red Blood Cells SGOT Serum Glutamic Oxalacetic Transaminase SGPT Serum Glutamic Pyruvic Transaminase Sodium Total Protein Total Solids Total T4 Triglycerides White Blood Cells Revision 2 0 23 8 11 2005
28. tton to highlight each item This theme of functionality is repeated throughout the system in the Detailed Data Query section Revision 2 0 14 8 11 2005 Internet Primate Aging Database User s Manual iPAD SYSTEM TO iNTERNET PRIMATE AGING DATABASE National Primate Research Center University of Wisconsin Madisor WPRC Profile CodebookiFAQ Statistical Measure Query Result Below are all records matching your statistical query criteria Click the New Query button to run another query using different criteria or click Cancel button to return to the lagged in page Statistical Measure Query Result Body Weight Rhesus Macaque ALL e sD SE Data Pts Primates 6 9 033 1 773 016 122 20 Hew Query Cancel Figure 3 2 Statistical Measures Results Screen Al zs ZS Body Weight Rhesus Macaque ALL T Name Box B C D F G 1 Body Weitht Rhesus Macaque ALL 2 Age Mean SD SE Data Pts Primates DS 6 Apr 9 033 1773 0 16 122 20 KS 5 Figure 3 3 EXCEL Output shown within the browser The ability to output to this format allows the users to save and manipulate the results and graph data in separate statistical programs Revision 2 0 15 8 11 2005 Internet Primate Aging Database User s Manual Detailed Data Query This feature allows the user to review specific measures by individual primate over a specified period of time for each given specimen that meets the user selection criteria
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