About web-HUMAN
Contents
1. between one combined multiple variable plot vs many single variable plots The rudiments of the user selection of variables for both graphic and tabular output is covered in the Introductory Tutorial cited at the beginning of this document It can be accessed from this tutorial link link and is also available on web HUMAN s opening page More advanced uses of the monitoring of the physiologic response pattern of variables by both graphic and tabular methods can be found in many of the Manual tutorials and examples e g A fundamental more advanced set of examples of the mechanics of the selection and display of variables both tabular and graphic occurs embedded in the 3 screen by screen How to do it experiment tutorials in the User Manual and are also linked right here link Can I export data from a web HUMAN simulated experiment to for example graph the results in another application Yes data can be exported For example the web HUMAN Manual also contains a section with instructions on how to pass data from web HUMAN to Excel for a fuller custom graphic analysis Exporting data to Excel for graphing or further data massaging link How many physiological systems does web Human contain e HUMAN is a comprehensive systems level simulation that incorporates many major sub systems HUMAN is a fairly comprehensive model that incorporates the major systemic responses of the cardiovascular respiratory renal ac2. About web HUMAN An overview with direct links to how to do it Help pages version 7 5a Oct 7 2013 Note well The major ongoing revisions to this document are now complete I Basic web HUMAN What is web HUMAN Web HUMAN is an integrative systems physiology teaching simulation that presents educators and students with full web access to Tom Coleman s classic physiology simulation program HUMAN while delivering it via an interactive web interface that also provides the user with many additional functional learning and informational enhancements a The HUMAN simulation what is it HUMAN itself was developed originally as a research tool in the lab of Dr Arthur Guyton at the University of Mississippi under the direction of Dr Tom Coleman It was later refashioned by Dr Coleman into a teaching simulation b web HUMAN what is it Web HUMAN was developed for in house use as a physiology teaching tool at Skidmore College with the idea of making the Coleman HUMAN model available to our students via an internet browser of their choice thus freeing the student and their physiology courses from dependence on any particular hardware software or physical location By being out on the internet and thus open to all it has become increasingly used by a variety of courses at other colleges universities and physiologically oriented health professions programs There as at Skidmore web HUMAN is employed in physiology simulati
3. e experiment can be found via either of the links below 1 High Altitude A sample one variable experiment investigating human response to a high altitude 12 500 ft environment PDF version What type of simulated experiments can I run in web HUMAN Simulated experiments can be done in a impressively wide variety of subcategories including but not at all limited to the five sample areas listed immediately below e Challenges to standard physiology e g exercising the model at different levels of intensity 02 consumption and monitoring the resulting cardiac respiratory salt and water balance responses A step by step example of a such a challenge to standard physiology an aerobic exercise experiment can be found via either of the following links 2 Endurance Exercise A sample multi variable experiment investigating human response to a simulated exercise bout PDF version e Comparative and environmental challenges e g one might move the model to high altitude decreased barometric pressure or thermally challenge the model by moving it into a high or low temperature environment and observe the related integrated responses to the hypoxia or thermal challenge A step by step example of a such a comparative physiology experiment ascent to high altitude is linked below 1 High Altitude A sample comparative environmental physiology experiment investigating human response to a high altitude 12 500 ft environment PDF ve
4. enal of generic vasoactive cardio active renal and certain other select drugs It gives the user the ability to 1 administer pharmaceuticals 2 adjust their dosage levels and 3 select their frequency of administration An example of the administration of a pharmacologic agent norepinephrine can be found in the web site s Teaching Tutorials Experiments section as linked below Norepinephrine Infusion Response A pre stored Teaching Tutorial Experiment link How is the physiological response monitored in web HUMAN The response change in the values of physiologic variables to a perturbation can be monitored by tracking the output response of variables in both tabular and graphic in format Tabular Output The default web HUMAN output is a tabular readout of the response of the physiologic variables vs time In any given experimental run users can select six from among over 137 user available physiological variables to monitor in the main output table The rudiments of the user selection of variables for tabular output is covered in the Introductory Tutorial cited at the beginning of this document It can be accessed from this tutorial link link and is also available on web HUMAN s opening page Graphic Output We also provide the ability to graph the response pattern of up to all six of the variables selected vs time The user can chose between normalized change from baseline value or absolute value plot formats and
5. id base balance thermoregulatory and fluid and electrolyte balance physiological systems and in addition contains aspects of responses of the nervous system the hormone system and muscle metabolic system e HUMAN is a integrative systems simulation Significantly these individual system responses are integrated Thus a high altitude challenge reduced barometric pressure shows not only the expected hypoxia low PO2 but also the accompanying hyperventilation its resultant hypocapnia low PCO2 the effect of this hypocapnia on blood acid base status a respiratory alkalosis and the compensation over time via the kidneys compensatory metabolic acidosis The effects of this challenge and the response to it by other systems e g the cardiovascular system are also apparent How can I access and manipulate the built in Clinical Patients in HUMAN Web HUMAN has built into it a separate section of simulated Clinical Patients e User support These Patients can be examined studied with or without the aid of various levels of Hints in order to arrive at an Analysis Diagnosis e Range of cases These clinical cases include heart failure various types of renal disease congenital central vascular shunts and more e How to access amp examine Patients The User Manual s Help screen links below detail 1 the basics of how to access these clinical cases Patients Help 1 The basics How to access link 2 and how to ut
6. ilize the more advanced Hints amp Analysis Diagnosis sections that are available in the main Human Clinical Patients table Patients Help 2 Hints Analysis Diagnosis link Also note that many other clinical cases are available in the Save amp Retrieve and the One click sections of HUMAN II More advanced web HUMAN Select additional features A Select additional features On Line Help In addition to off line Help such as this document web HUMAN offers Help on line i e within the model itself as you are running your simulation This Help is of two types 1 Help on variables offers extensive cross linked information on all HUMAN variables 2 Help on how to do it do wish to take a blood gas sample administer an infusion a transfusion induce pathology etc The how to do it Help screens give you access to instructions on each of these an quite a few more A set of tutorial help pages from the Manual on how to access and use On Line Help is linked right here On line Help link B Select additional features Save amp Retrieve Web HUMAN allows registered users to save amp retrieve their simulations and those of other users This less used but rather powerful ability to Save Retrieve simulations adds multiple additional possibilities for users e Model storage Most obviously users can store their current simulation to be called back at any later time for additional examination or continuation e Sharing
7. models They can make their simulation available to others e g fellow students instructors at their choice e Folder creation One can create a named Folder e g RSM_HighAltitudeExperiments into which one s experiments are then stored The above save retrieve capabilities create many new possibilities e e g Possibilities for course use Instructors can create their own institution s folder space within HUMAN This enables much easier pedagogical use of HUMAN by a group of individuals and and also allows for student collaborative simulation work e e g Availability of a growing fund of pre stored one step click and run experiments these allow instructors and their students to utilize HUMAN without any prior knowledge of how to set the model up e e g Availability of a wide range of new sample simulations these include 1 new custom created clinical cases Patients 2 sample experiments and tutorials and much more Help pages on how to utilize the Save and Retrieve capabilities are available via the following link Save Get Help link C Select additional features of web HUMAN User Manual Web HUMAN contains quite a few additional capabilities not detailed above These and some of the material above are all available in the User Manual All simulation pages contain a link to this User Manual on the upper right of the page being viewed i e Manual In the Manual users will find many How to do it tutorials i
8. ncluding the ones linked above an extensive analysis of the capabilities of web HUMAN in the Annotated List of web HUMAN variables and parameters and much more One can access the Manual via its link on each simulation page and also via the following link User Manual link In addition examples of teaching labs are provided including all of the original ones from Drs Randall and Coleman s HUMAN 81 plus ones employed at Skidmore and other institutions In addition quite a few other sample simulations are available here Links are available to material used in past web HUMAN workshops more information can be found about the underlying model itself its author Dr Coleman the co author of the microcomputer version Dr Randall and much more Bottom line Anytime you have a question or need more detailed knowledge on some aspect of using the model you have two resources available 1 off line Click on the User Manual link at the page top right 2 on line Click on 1 of the 2 on line Help links on your simulation page A word of caution in using HUMAN HUMAN is a teaching tool Models cannot contain more than is built into them We essentially present via a web interface Dr Tom Coleman s HUMAN physiological model albeit with many enhancements This simulation was written by Dr Coleman at a time when the shape of the major behaviors of these particular physiological systems was known experimentally and the interactio
9. ns between these physiological systems had been characterized Since this is almost exactly the fundamental physiology that most of us engage in teaching our students this makes HUMAN a potentially powerful teaching tool although they can certainly can yield unanticipated new interactions between systems and be used to test as yet unexplored hypotheses On the other hand this implies certain limitations One should not expect web HUMAN to contain the newer concepts of a more subtle regulatory interplay between system or for that matter newer pharmaceuticals developed to address mechanisms discovered after HUMAN itself was written nor the behavior of additional systems not modeled in HUMAN itself Those using the web site to teach fundamental physiology at the pre professional college or graduate level will likely find these limitations of model to be of little or no concern to them since their focus is likely to be fundamental physiology They should nevertheless keep these limits in mind as necessary Contact us if we can be of help Use of web HUMAN by the physiology education community has been growing steadily with approximately 100 000 plus non Skidmore simulation sessions run within the past year If you have any questions we can help you with or have any suggestions for features you would like to see please write to me rmeyers skidmore edu or to Leo Geoffrion ldg skidmore edu and we will certainly try to get back to you a
10. on lab sessions as a lecture demonstration tool and as a vehicle for student independent study How can I get started using web HUMAN Try out the Introductory tutorial This exercise takes beginners step by step and screen by screen through each of the fundamental skills needed to navigate your way through web HUMAN The Introductory tutorial can be accessed from this tutorial link link and is also available on both the opening human page and in the User s Manual How do I run an experiment in web HUMAN Simulated experiments are run by the same logical protocol used in actual in the lab experiments That is one changes certain parameters in the preparation and then observes the effects resulting from that change as they develop through time a To initiate a simulated experiment the user can change one or more of the some 67 available variables via a mouse click Thus one might take the model to high altitude by dropping the ambient barometric pressure b To monitor the effects of the user introduced change the user mouses their choice of output variables of their interest from among some 140 output variables and follows the changes in those variables through time Thus one might choose to observe the respiratory response to the altitude change by displaying the resulting arterial blood gas sample values PCO2 PO2 pH HCO3 as they change minute by minute through time A step by step example of such a high altitud
11. rsion e Clinical challenges e g one might create pathology by simulating the emphysematous aspects of COPD by decreasing available lung surface area for gas exchange Alternatively one could simulate renal failure by removing a selected proportion of the renal mass from the otherwise still functioning kidney Such a reduction in lung mean surface area available for gas exchange amp its developing consequences are illustrated step by step in the experiment linked below 3 Emphysema A sample induced clinical pathophysiology experiment investigating long term response to loss of lung diffusion surface PDF version Note that in addition to creating pathology HUMAN also has built in clinical patients see below section on Patients e artificial organs Testing one s understanding of the normal physiology by attempting to run an artificial organ so as to maintain normal levels of systems function Web HUMAN contains an artificial heart the ability to artificially ventilate a kidney dialysis module the ability to infuse electrolytes transfuse blood and more An example of the use of artificial organ control in a teaching experiment can be found in the respiratory physiology experiment employed at Skidmore College as linked below 5 Experimental Determination of Respiratory Dead Space PDF version e Testing one s understanding of basic pharmacologic intervention the web HUMAN Pharmacy contains a standard basic ars
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