(57)【要約】 本発明は、骨健康の維持又は骨疾患の予防、緩和及び
Contents
1. 10 20 30 50 3 JP 2005 513078 2005 5 12 00000002. oa L3 MOO 10 20 30 50 JP 2005 513078 2005 5 12 4 10 20 30 1000 1000
3. 11 JP 2005 513078 A 2005 5 12 CI DEP TI j Ug ldiuiiiiuuiiiuliuiullidiliililiililisuiLihlkili 000000 Cyperus rotundus 2012 10 50 Iris pallida 2022 10 TREE OMIM st SAKRO 00000000000000 1000000000000000000000000000000000 9 000000000 00000000 0000 000 00 0000 0000000 00 0000 10 20 30 JP 2005 513078 2005 5 12 12 734 Amelanchier alnifolia 10 HBF 738 205 E 7557 LO lt T N H ui uw 3 S 9 A wy 3 S S Ocimum gratissi
4. JP 2005 513078 2005 5 12 9 1000 100000000 100000 1000000000 1000 1100000000000 10 20 0000000000 00000000000 30 10 JP 2005 513078 2005 5 12 0000 ug ml Acorus calamus Amelanchier EX MeOH 219 Artemisia HAZ Hh BEBE
5. 100 10000000000000000 1000000000000000 100 100 100000000 100000 50 JP 2005 513078 2005 5 12 5 1000 n 1000 10 20 30 100 100 0
6. Form PCT ISA 210 continuation of second sheet July 1992 17 JP 2005 513078 2005 5 12 INTERNATIONAL SEARCH REPORT Internati Application No PCT EP 02 14120 G Continuation DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document with indication where appropriate of the relevant passages Retevant to claim No X DATABASE Section Ch Week 200176 Derwent Publications Ltd London GB Class BO4 AN 2001 657430 XP002198194 amp CN 1 307 887 KONG 2 15 August 2001 2001 08 15 abstract 1 4 6 19 X DATABASE WPI 1 18 Section Ch Week 200144 Derwent Publications Ltd London GB Class 804 AN 2001 409765 XP002198195 amp CN 1 292 274 CHEN 2 25 April 2001 2001 04 25 abstract X DATABASE 1 14 18 Section Ch Week 200120 19 Derwent Publications Ltd London GB Class BO4 AN 2001 192235 XP002198196 amp CN 1 274 599 A ZHOU J 29 November 2000 2000 11 29 abstract X DATABASE WPI 1 19 Section Ch Week 200127 Derwent Publications Ltd London GB Class 804 AN 2001 264633 XP002198197 amp RU 2 162 334 C TITIEVA N M 27 January 2001 2001 01 27 abstract X DATABASE WPI 1 18 Section Ch Week 200103 Derwent Publications Ltd London GB Class 804 AN 2001 016794 XP002198198 amp CN 1 267 526 A CHEN Y 27 September 2000 2000 09 27 abstract X DE
7. nnnnnnnnnnnnnnnnnnnnnnmn 00000 JP 2005 513078 2005 5 12 7 10 o 0000000000000000000000 20 1000000 100 1000000 10000000000000000 30 1000000 1000000 10000000000000000 100
8. 20 100 00000000000 aC 30 14 JP 2005 513078 2005 5 12 740 205 26 8 70 D Bey hPryet 30 2 10 0 738 TA 768 25 746 15 JP 2005 513078 2005 5 12 0000000 INTERNATIONAL SEARCH REPORT PCT EP 02 14120 CLASSIFICATION OF SUBJECT MATTER A IPC 7 A23L1 30 A61K35 78 A61P19 00 According to International Patent Classification IPC or to both national classification and IPC B FIELDS SEARCHE
9. 35 78 35 78 1 16 IOD 18 130 045 3Y 122 31 343 3 14 19 02 19 08 19 10 AP GY KE LS SD SL SZ TZ UG ZM ZW EA AM AZ BY KG KZ RJ TJ EP AT BG CH CY CZ DK EE ES Fl FR GR I E I T LU M PT SE 9 SK TR ON BF B 330 GN GQ GM M NE SN TD TG AG AL AT AZ BB BG EZ CA CH CN GQ QJ DK DM EG EE ES Fl Q G H MH HJID IL IN TS J P KG KP KR KZ LG LK LR LS LT LU LV M MG W Z M PH PL PT RJ SD SE SG SK SL TM TN TR TT TZ UA UG L5 UZ W YU ZA 0000 0000000000 000 000 0 2 75 5 AB52 AB56 1 G25 MO 7 52 25 2 MOA MAI
10. this International Search Report covers all searchable claims searchable claims could ba searched without effort justifying an additional fee this Authority did not invite payment of any additional fee As only some of the required additional search fees were timely by the applicant thie International Search Report covers only those claims for which fees were paid specifically claims Nos No required additional search feas were timely paid by the applicant Conssquently this International Search Report is restricted to the invention first mentioned in the claims it is covered by claims Nos Remark on Protest C The additional search fees were accompanied by the applicant s protest No protest accompanied the payment of additional search fees Form PCT ISA 210 continuation of first sheet 1 July 1998 21 JP 2005 513078 2005 5 12 INTERNATIONAL SEARCH REPORT Internati Application No PCT EP 02 14120 Publication Inter nation on patent family Members Publication date 23 09 1999 Patent document cited in search report WO 9947149 Patent family member s date 19812204 Al 04 11 1999 AT 225182 T 15 10 2002 A AU 3146699 A 11 10 1999 BR 9908256 A 12 12 2000 CA 2321444 Al 23 09 1999 CN 1293575 T 02 05 2001 DE 59902932 01 07 11 2002 DK 1064009 T3 04 11 2002 WO 9947149 Al 23 09 1999 EP 1
11. 100000000 100000 50 JP 2005 513078 2005 5 12 8 10 10000 100000 20 10000000 1000000 30 50 000000000000000000
12. 19 JP 51 Int C1 A61K 35 78 A23K 1 16 A23K 1 18 A23L 1 30 AG61K 31 045 33 498 2003 553 934 2003 553934 SEX 144F 127 10A 2002 12 10 FRR 1646 10A 2004 6 10 JP 2005 513078 2005 5 12 PT A 55 3 2005 513078 P2005 513078A 43 SERETTSESH 128 2005 5 12 FI 2 2 A61K 35 78 G 2B005 AG1K 35 78 H 2B150 AGIK 35 78 J 4B018 AGIK 35 78 N 4C086 AGIK 35 78 Q 4C088 RK A 23 B RRAS 71 HERA 590002013 VEIT F FUFAL VAN LF PCT EP2002 014120 Vitn 1800 74 W02003 053167 55 3E E1527 2003 7 3 74 REBA 100066692 01204838 5 E 32 13 12 11 2001 12 11 74 EBA 100072040 Bx Net EP AN OE TAREA 100102897 5 74 100097870 FEE mt lt 54 5700 L3 L3 L3 E E L L3 L3 L3 E Mm OO oana L3 EJ r Comtnol P E 740 205 inhibition 4 70 ml Davia 40 304 20 x 10 0 2 JP 2005 513078 2005 5 12
13. 225 IR 5 d 10 677 10 Cyperus rotundus 7 HF 205 E gt 50 25 0 50 EFE 750 officinalis AYRE HALT HR MeOH x 239 Rosmarinus gt gt 0 5 Me0H 2004 officinalis 0 0 11 2005 25 0 HF 1 2074 FRY 10 RIF 2069 1 00000 100 0000000000000000000000000000000 100 0000000000 000000000 1000 00000000 00000000000000000000 1000 0000 000000000 1000000000 100000000 0000000000000 00000000000000000 000000 0000000000000000000000000000000000 00000000000000000000000000000000000 6000000 0000000000000000000000000 100000 00 0000000000000000000000000000000 10 20 30 50
14. oled n neta the principle or theory underlying the E earlier document but published on or after the international document of particular relevance the claimed invention filing date cannot be considered novel or cannot be considered to L document on priority claim s or involve an inventive step when the document Is taken alone which Is cited to establish the publication date of another document of particular relevance the claimed invention citation or other special reason as specified cannot be considered to involve an inventive step when the O document referring an oral disclosure use exhibitlon or document is combined with one or more other such docu other means ments such combination being obvious to person skilled document published prior to the international filing date but in the art later than the priority dale claimed amp document member of the same patent family Date of the actual completion of the international search Date of maifing of the international search report 6 March 2003 24 04 2003 Name and mailing address of the ISA Authorized officer European Patent Office 5818 Patentlaan 2 NL 2280 HV Rijswijk Tel 431 70 340 2040 Tx 31 651 epo i Fax 131 70 340 3016 Heirbaut M Form PCT ISA 210 second sheet July 1992 16 JP 2005 513078 2005 5 12 INTERNATIONAL SEARCH REPORT internati application No PCT EP 02
15. 00000 JP 2005 513078 2005 5 12 6 10 20 1000 1000 100 100000 30 10000 100000 50 00000000000000000000000000
16. 064009 Al 03 01 2001 HU 0200921 A2 28 12 2002 JP 2002506827 T 05 03 2002 PL 342486 Al 04 06 2001 TR 200002686 T2 21 12 2000 US 6235287 Bi 22 05 2001 AU 748535 B2 06 06 2002 AU 1960199 26 07 1999 Wo 9935116 Al 15 07 1999 EP 1045822 Al 25 10 2000 JP 2002500209 T 08 01 2002 JP 2001302539 A 31 10 2001 5256401 07 11 2001 EP 1277475 Al 22 01 2003 WO 0180874 A1 01 11 2001 WO 0145725 28 06 2001 AU 2446801 A 03 07 2001 WO 0145725 A2 28 06 2001 US 2002025348 1 28 02 2002 GB 2355189 18 04 2001 NONE WO 0101996 A 11 01 2001 WO 0101996 A1 11 01 2001 AU 5511300 A 22 01 2001 WO 0064438 02 11 2000 0 0064438 Al 02 11 2000 AU 4092300 A 10 11 2000 EP 1173165 A1 23 01 2002 JP 2002542286 T 10 12 2002 US 2001012523 A1 09 08 2001 AU 6332999 A 26 04 2000 EP 1117418 A1 25 07 2001 JP 2002526415 T 20 08 2002 WO 0020015 Ai 13 04 2000 US 6274176 B1 14 08 2001 NONE US 5908628 01 06 1999 NONE CN 1302636 11 07 2001 NONE CN 1322553 21 11 2001 NONE CN 1307887 15 08 2001 NONE CN 1292274 25 04 2001 NONE 1274599 29 11 2000 NONE Form POT ISA 210 patent family annex July 1892 22 JP 2005 513078 2005 5 12 INTERNATIONAL SEARCH REPORT Internatio 7 PCT EP 02 14120 Publication Inf etion on patent famliy members Publication Patent tamily date member s RU 2162334 C 27 01 2001 RU 216233
17. 14120 C Continuation DOCUMENTS CONSIDERED TO BE RELEVANT Category Gitalion of document with indication where appropriate of the relevant passages Relevant to claim No X WO 01 45725 A HOFFMAN KEITH BASU AMARESH 1 4 6 19 US ANCILE PHARMACEUTICALS INC US 28 June 2001 2001 06 28 claims 3 4 6 15 18 X GB 2 355 189 A BABIKIAN YOUSEF HAIK 1 10 18 April 2001 2001 04 18 page 4 line 15 page 5 line 10 claims 1 11 examples 1 3 X WO 01 01996 A MIN XU PRINCE RICHARD 1 19 LEWIS AU UNIV WESTERN AUSTRALIA AU GU 11 January 2001 2001 01 11 claims 22 24 25 28 X WO 00 64438 A KELLY GRAHAM EDMUND 1 19 NOVOGEN RES PTY LTD AU HUSBAND ALAN JAMES 2 November 2000 2000 11 02 claims 1 4 5 9 15 19 21 28 30 31 41 43 X US 2001 012523 A1 MUHLBAUER ROMAN CONRAD 1 19 9 August 2001 2001 08 09 claims 1 10 15 X US 6 274 176 B1 GLOMSKI PETER ET AL 1 19 14 August 2001 2001 08 14 claims 1 4 X US 5 908 628 A HOU LIPING 1 19 1 June 1999 1999 06 01 claims 1 4 9 10 14 16 X DATABASE WPI 1 19 Section Ch Week 200163 Derwent Publications Ltd London GB Class 804 AN 2001 558222 XP002198192 amp CN 1 302 636 A TAN C ii July 2001 2001 07 11 abstract X DATABASE WPI 1 19 Section Ch Week 200219 Derwent Publications Ltd London GB Class B04 AN 2002 140742 XP002198193 amp CN 1 322 553 A CHEN 2 21 November 2001 2001 11 21 abstract
18. 198 14 725 A RUEPP MICHAEL 0 1 19 7 October 1999 1999 10 07 claims 1 3 8 11 X CN 1 169 863 XIE JINGLONG 1 19 14 January 1998 1998 01 14 abstract Form PCT iSA 210 continuation of second sheet July 1992 18 JP 2005 513078 2005 5 12 INTERNATIONAL SEARCH REPORT pplication No PCT EP 02 14120 C Continuation DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document with indication where appropriate of the relevant passages Relevant to claim No WO 01 03716 A SUN FARM CORP SUN ALEXANDER 5 05 18 January 2001 2001 01 18 page 3 paragraph 3 page 4 paragraph 5 US 2001 024664 A1 HUMMERT SUSAN 1 AL 27 September 2001 2001 09 27 page 5 paragraph 72 WO 99 55351 A LEKO VLADIMIR 4 November 1999 1999 11 04 page 5 line 24 page 6 line 22 claims 1 4 DATABASE WPI Section Ch Week 199836 Derwent Publications Ltd London GB Class D16 AN 1998 426120 XP002198409 amp RU 2 102 460 UFA WINE WKS 20 January 1998 1998 01 20 abstract WO 02 13840 A UNIV BERN MUEHLBAUER ROMAN CH 21 February 2002 2002 02 21 claims 7 21 23 Form 210 continuation of second sheet July 1982 19 JP 2005 513078 2005 5 12 Intemational Application No 02 4120 FURTHER INFORMATION CONTINUED FROM 210 Continuation of Box I 1 Although claims 14 19 are direc
19. 4 C1 27 01 2001 Patent document cited in search report CN 1267526 27 09 2000 NONE DE 19814725 A 07 10 1999 DE 19814725 Al 07 10 1999 AU 3602199 A 25 10 1999 WO 9951250 Ai 14 10 1999 EP 1067947 A1 17 01 2001 CN 1169863 14 01 1998 WO 0103716 A 18 01 2001 AU 5919400 A 30 01 2001 CN 1370074 T 18 09 2002 EP 1194156 Al 10 04 2002 WO 0103716 Al 18 01 2001 US 2002127243 A1 12 09 2002 US 2001024664 Al 27 09 2001 US 2001006686 1 05 07 2001 AU 3098502 A 24 06 2002 WO 0247708 2 20 06 2002 AU 3893500 A 09 10 2000 BR 0009143 A 26 12 2001 CN 1362881 T 07 08 2002 EP 1171142 A1 16 01 2002 JP 2002539269 T 19 11 2002 WO 0056348 Al 28 09 2000 US 2002192305 Al 19 12 2002 WO 9955351 04 11 1999 HR 980109 A1 31 08 2000 HR 990080 Al 30 04 2001 AU 3622099 A 16 11 1999 GB 2363714 09 01 2002 WO 9955351 Al 04 11 1999 BR 9917211 A 14 05 2002 CN 1348380 T 08 05 2002 JP 2002534354 T 15 10 2002 US 2002102315 A1 01 08 2002 RU 2102460 C 20 01 1998 RU 2102460 C1 20 01 1998 WO 0213840 A 21 02 2002 AU 7375901 25 02 2002 WO 0213840 Ai 21 02 2002 Form PCT ISA 210 patent family annex July 1992 52 Int d 81 72 72 72 72 31 122 31 343 3 14 19 02 19 08 19 10 23 JP 2005 513078 2005 5 12 35 78
20. D Minimum documentation searched classification system followed by classification symbols IPC 7 A61K 231 A61P Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched Electronic data base consulted during the international search narne of dala base and where practical search terms used EPO Internal WPI Data PAJ FSTA BIOSIS MEDLINE C DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication where appropriate of the relevant passages Relevant to claim No WO 99 47149 A PLANTAMED ARZNEIMITTEL GMBH 1 19 JARRY HUBERTUS DE POPP MICHAEL DE 23 September 1999 1999 09 23 page 4 line 1 18 claims 1 6 10 12 US 6 235 287 B1 JACOBSEN NINA ET AL 22 May 2001 2001 05 22 column 4 Tine 56 column 5 line 35 claims 1 3 DATABASE WPI Section Ch Week 200204 Derwent Publications Ltd London GB Class 804 AN 2002 017683 XP002198191 amp JP 2001 302539 A MEIJI SEIKA KAISHA LTD 31 October 2001 2001 10 31 abstract Further documents listed ihe continuation of box Patent family members are listed in annex Special categories of cited documents 2 P 3 later doc published after international fling Te Tw or priority date and not in conflict with the application bul document defining the general state of the art which is not j stand Nun n considered to be of particular relevance
21. mum 7722 0 4 Ocimum gratissimum Cyperus rotundus Glycine max 20 30 0000000000000000000 00000000000 50 10000000000000000000000000000000 10000000000000000000000000000 000000000000000000000000000000000 JP 2005 513078 2005 5 12 13 10 000000000000000000000000000000
22. ted to a method of treatment of the human animal body the search has been carried out and based on the alleged effects of the compound composition Continuation of 1 1 Rule 39 1 iv PCT Method for treatment of the human or animal body by surgery 20 JP 2005 513078 2005 5 12 Inter application PCT EP 02 14120 Box Observations where certain claims were found unsearchable Continuation of item 1 of first sheet This Intemational Search Report has not been established in respect of certain claims under Article 17 2 a for the following reasons Claims Nos _ because they relate to subject matter not required to be searched by this Authority namely see FURTHER INFORMATION sheet PCT ISA 210 INTERNATIONAL SEARCH REPORT Claims Nos because they relate to parts of the International Application that do not comply with the prescribed requirements to such an extent that no meaningful International Search can be carried out specifically Claims Nos because they are dependent claims and are not drafted in accordance with ihe second and third sentences of Rule 6 4 a Il Observations where unity of invention is lacking Continuation of item 2 of first sheet This International Searching Authority found multiple inventions in this international application as follows As all required additional search fees were timely paid by the applicant
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