警告欄を参照のこと。 処方された抗血小板薬を早期に中止
Contents
1. 32. 6 J amp JKK CRD DgSOv12 Newsletter vol 5 TAXUS Express2 PaclitaxelEiuting Coronary Stent System For Our Custormer 2008 3 11 2 0227002 20 2 27
3. 3 8 CRp prsomnh8 HIV
4. CYP3A4 Hypericum perforatum CYP3A4 P P gp CYP3A4 P gp
5. 6 6 2
6. 2007 4 12 1 2008 3 11 2 Newsletter 2008 3 1 1 0120 235 9 1 1 Gooc173d B B SD web site http vwww taxus stent jp TAXUS 2
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8. lt 6 178 MI
9. 6 392 SN 2 TTP 3 f
10. 9 24
11. BUN GOT GPT CRD DES0m 1
12. 2 Cmx Tmax AUC 4 3 38 10 9 tna 14 600 mg 14 20 mg 5 3 2 8 10 AUC Cnx 82 21
13. 2 033 5 2 gt 3 16 12 2 9 Q 9 2 3 si 5 7 2 42 16 6 5 98 25 5 ATSAT 9330 02 0 4 IrT G1 360H 02 0 8 YLT 361 1 800H 0 8 0 6 0 1 800 1 1 1 7 i 50 i 1 2 smm iip ARC Academic Research 1 857 967 Consortium Definite Probable 9 76 11 7 13 1 8 4 3 6 0 1 Q
14. BCG TY21a 4 1 2
15. 8 Rapamune
16. 18 10mg 120 mg Cx Tmax AUC 1 4 1 3 1 6 6 DCA CYP3A4
17. 24 2mg 24 2 300mg 4 10ma AUC 33 80 Cmax 33 58 AUC Cx 33 5mg 300mg 2 2 2 Cx AUC 2
18. 2 1 2 1 2 6
19. 2 20 3 20
20. 2 TTP 2 2 2 2 1
21. Cmax AUC 126 141 800mg 8 Cmax AUC 4 4 4 2 Tmx 0 4 Cnsx AUC 1 6 1 7 Tmw 0 3 26 2mg 180mg 12 Tmer Cmax AUC 2 3 2 2 Cnsx AUC 1 5 Tmx 1 2
22. TTP 2 2 1 2 2 2 1
23. VLT 761 130 39 255 98 237 5 lt 2 31 3 18 6 3 se1
24. TAXUS 2 TAXUS 2 B gt gt TAXUS IV SR 4 1 Boston Scientific Delivering whats et EE _ 2 1 4
25. 130 350g Tax 3 59 2 95 Ca 0 80 0 37 ngnL to 213 96 70 1 1 2 1 30 3 3 2 12 1 8 8 2 SIRIUS RAVEL TIM
26. 3 3 2 3 8 FKBP Rapamunc Y 430 3A4 CYP3A4
27. 3 2 000 4 30 1 5 16 3 2 3 1 1 1 Nickel and Molybdenum Confact allergies in patients with coronary in stent restenosis Lancet 2000 12 1895 1897 2 Rapamune 3 4 5 Cutlip et al Clinical End Points in Coronary Stent Trials A Case for Standardized Definitions Circulation 2007 115 2344 2351 6 Jeffrey W Moses M D ct al Sirolimus Elnting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery N Engl Med 349 14 1315 1323 2003 7 CYPHER Sirolimus cluting Coronary Stent on
28. 2 20 3 16 3 25 19 12 6 527 000 30 761 3504 30 ATSAT 143 31 360 5 20 3 20 ATISAT 9 30 2 021 0 05 GL360B 1857 039 1 0 360 e57 043 eerz0BD 0 8 6 EPR DARC Me
29. 21900BZX00340000 2008 Boston Scientific Corporation or its afiiliates AH rights reserved TAXUS9 Boston Scientific Corporatfon Express2 W Boston Scientific Corporation http wwwrinfo pmda go jp Boston _ Scientrfic Delivering what s 7ex 1 14 11 wwwbostonscientificjp 3 0803 13152 5 PSST20080318 0140 SC 106AA 2008 3 11 2 2007 4 12 1 219008ZX00340000 7 36035004 TAXUS 8 PTCA ed 2 1
30. Q 8 CRD DrS091 0 0 270 360 720 1080 144D 1800 _ 10 Pe0 428 9 vnenr ee a 3 2 by 270 360 720 1080 1440 1800 8 9 3 00mm 18mm 1 2 1 2 10 10 zg 130 300 Tax h 42 18 3 7 19 Caax og mL 0 86 0 22 2 00 0 43 121 35 9 238 9 30 3 3 K 3 g 5 3 48 7 0 120 144 108 0 el Ch 500wg ny 4 2 50 3 00 3 50mm 18mm 1 2 19
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32. RAPTORT Over the Wire Delivery System and CYPHER Sirolimusxelntng Coronary Stent on RAPTORRATL Rapid Exchange Delivery System 2005 8 8 Otsuka et al Comparison of Pharmacokinetics of the Sirolimus Eluting Stent in Japanese Paticnts with Those in American Paticnts Cardiovasc Pharmacol 46 468 473 2005 9 10 Vetrovcc ct al Sirolimus PK Trial A Phannacokinctic Study of the Sirolimus Eluting Bx Velocity Stent in Patients with De Novo Coronary Lesions Catheter Cardiovasc Interw 67 32 37 2006 2 101 0063 3 5 2 03 4411 7913 1 101 0063 3 2 03 4411 7913 2 Cordis Europa N V
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34. ndamis Research Consortium Definite E hl i 2 TR az SIRIUS 93 02100 m 2 5 1 4 4 gt 8 30 353 3 2 33 4 9 8 9 36 3 0 17mm 1 00mm 024mm 0 81mm p lt 0 001 LT 1i4 361
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