RG10040 - 極東製薬工業株式会社
Contents
1.2.
3. DDH DNA A 1 SDS No RG101450 3 4 13
4. 6
5. DDH DNA 1 A 4 SDS No RG101453 3 2 5 3 CAS No 1 NaOH 1310 73 2 2 4 1 410 4 5
6. 9 2 10 C 8 2 ACGIH 1 STEL 1000ppm 1 9 pH 117 C 78C
7. 7 1 ACGIH 1
8. 2 10 C 8 AM 10ppm ACGIH 1 TWA 10ppm Skin 1 10ppm 30mg m 9 pH
9. DDH DNA A 1 SDS No RG101450 3 3 13 2 3 2 3
10. 3 N N CAS No HCON CH 68 12 2 99 2 680 54827 17 7 3 3 5 5 CreHzoNg N N 4
11. 11 1 LD50 3 000 mg kg 3 920 mg kg 4000mg kg 4 320 mg kg 3200mg kg 7 170 mg kg EHC 114 1991 5 LD50 3 500 mg kg 1 2002 5000mg kg 11 140 mg kg 11 000mg kg EHC 114 1991 5 GHS LC50 9400mg m3 2 47mg L 4 90
12. 14 UN2265 N N 3 15 PRTR 4 2 7 1 4 4 N_ N 2 6 2 1 1 4 30 N N 65 2 1
13. CERI NITE No 8 2005 CERI NITE No 8 2005 2 1 2 RIS 1990 AST ALT NTP TOX22 1992 SGPT SGOT
14. 1 in vivo NTP DB 2005 1 1 NTP DB 2005 ACGIH 7th 2001 NTP DB 2005
15. 2 10 C 8 ye ACGiIH 1 TWA 10ppm skin 9 pH DDH A 6 SDS No RG101455 3 3 5
16. 1 3
17. DDH a C 2 SDS No RG101461 3 2 7 1
18. 6 DDH 2 A 2 SDS No RG101451 3 3 7 7
19. EG ns 6
20. 7 DDH DNA A 1 SDS No RG101450 3 5 13 2 10 C 8 RO
21. 200 ppm 2000 NN 2005 1B 1991 2 B IARC71 1999 3 ACGiIH TLV 2001 A4 Group 2B CERI NITE No 8 2005
22. 6 DDH C 1 SDS No RG101530 3 3 7 7
23. 1 2 3 1 3 3 CASNo CHJCHCHCHLOH 123 51 3 1 2 217 2 CHCI 67 66 3 24 2 37 C H O 108 95 2 25 3 481 EDTA2Na CuH N Na 0 2H O 6381 92 6 2 1265 4 5
24. LD50 LD50 gt 20g kg Rabbt LC50 47702mg m 4h Rat LD50 450mg kg 1200mgkg 908mgkg 2000mg kg 450mgkg 1 117mg kg EHC 163 1994 DDH DNA A 1 SDS No RG101450 3 7 13 LD50 635mg kg 4 GHS 3 LD50 375mg kg Rat LD50 670mg kg Rabbit LC50
25. eae TT 1 NaI 2000 68 1 1 3
26. 14 Hn ny 1 UN1105 2 UN1888 3 UN1671 1 2 3 1 3 2 3 6 1 1 2 3 I 1 3 2 15 1 4 4 4 DDH DNA A 1 SDS No RG101450 3 13 13 65 2 1 38 11 2 2 2 1 3
27. DDH C 1 SDS No RG101530 3 1 7 2014 11 1 1 DDH C 1 7 8 03 5645 5664 FAX 03 5645 5703 10040 03 5645 5664 2 N N GHS GHS 3 3 H331 1H318 2 H341 1B H350 1B H360 1 2 H370 H371 1 2
28. 1 13 14 1 UN1823 1 Sodium hydroxide solid 1 8 1 I 15 57 2 18 2 9 319
29. 6 7
30. n 10 11 LD50 6000 mg kg Rat LD50 6000 mg kg Rabbit LD50 gt 3900 ppm Rat 6h LD50 6000mg kg ACGIH 7th 2001 LD50 6000mg kg ACGIH 7th 2001 17000mg kg ACGIH 7th 2001 GHS ACGIH 7th 2001
31. 9 pH n 0 11 1 LD50 1350mg kg Rabbit LD50 325mg kg SIDS 20022
32. CAS No 1 C H OH 64 17 5 99 5 2 202 4 15
33. ARCvol44 1987 SIDS 2009 DFGOT Vol12 1999 SIDS 2009 1A SIDS 2009 SIDS 2009 IARC vol44 1987 ACGIH
34. 5 ON ee 6 DDH a C 2 SDS No RG101461 3 3 7
35. SIDS 2009 12 9 1 1 1 1 1 EC50 Chlorella alza 1000mg L 96 h LC50 Fathead minnow gt 100mg L 96 h LC50 Ceriodaphnia quaarangula 5012 mg L 48 h 96 LC50 gt 100mg L SIDS 2005 48 LC50 5012mg L SIDS 2005 96 EC50 1000mg L SIDS 2005 1 00 x 10 6mg L PHYSPROP Database 2005 89 by BOD 7 13 DDH
36. DDH C 1 SDS No RG101530 3 4 7 n 10 11 1 1 1 1 LD50 3000 mg kg 3 920 mg kg 4 000mg kg 4 320 mg kg 3 200mg kg 7 170 mg kg EHC 114 1991 5 LD50 3 500 mg kg 1 2002 5 000mg kg 11 140 mg kg 11 000mg kg EHC 114
37. N N 1 CAS No HOOCCH C OHXCOOH CH COOH 77 92 9 a 2 1318 Na HPO 7558 79 4 1 497 HCON CH 68 12 2 9 2 680 NN 4 5 1 0 1
38. 15 4 3 2 7 1 4 5 3 57 2 18 2 9 547 16 1 MSDS No JW190178 2010 7 26 W01W0101 1509 JGHEJP 2014 10 23 WO1WO116 1704 JGHEJP 2014 9 24 WO1W0119 0836 JGHEJP 2014 4 11 WO1WO106 0042 2013 12 12 2 3 4 ezCRIC 2014 SDS
39. Q 100ppm 2 3ppm 3 ACGIH 1 STEL 125ppm TWA 100ppm 2 TWA 10ppm 3 TWA 5ppm skin 1 TWA 100ppm OEL TWA 360mg m OEL ISHL ACL 100ppm 2 TWA 14 7mg m OEL TWA 3ppm OEL skin ISHL ACL 3ppm 3 9 pH DDH DNA A 1 SDS No RG101450 3 6 13 n
40. IARC 1 IARC Vol 44 1987 2007 1 IARC vol 96 Access on Oct 2009 IARC vol 96 EU IARC vol44 1987
41. 3 Mugnussen and Kligman skin sensitization test EHC191 1994 MEST NITE No 32 2005 NITE No 32 2005 1 DDH DNA A 1 SDS No RG101450 3 9 13 NTP IARC ACGIH 2 3 1 2 3 2 2 3 2 3 2 1 2 in vivo in vitro 3 1 GUCLID 2000 CERI NITE No 16 2004 IARC 73 1999 CaPSAR 2001 EHC 163 1994 DFGOT vol14 2000 NTP DB access on December 2005 in vivo in
42. ACGIH 7th 2001 2 ACGIH 7th 2001 90 2 Priority 1 DDH A 6 SDS No RG101455 3 5 5 12
43. GHS 2N8 4N16 6N 24 15 896 1696 2496 DDH DNA 1 A 4 SDS No RG101453 3 4 5 1 SIDS 2009 5 4 ACGIH 7th 2001 1 pH 12 005 w W Merck 14th 2006
44. Y GHS 12 1 EC50 Desmodesmus subspicatus 500 mg L 96 h DDH a C 2 SDS No RG101461 3 6 7 1 LC50 Lepomis macrochirus 6300 mg L 96 h LC50 Oncorhynchus mykiss 9800 mg L 96 h LC50 Pimephales promelas 10410 mg L 96 h 1 EC50 Daphnia magna 7500mg L 48 h EC50 Daphniamasgna 8485 mg L 48 h EC50 Daphnia magna 6800 13900 mg L 48 h 96 LC50 gt 100mg L 1995 1 00 x 106mg L PHYSPROP Database 2005 1 44 by BOD 1 0 3 0 8 20ppm 13
45. 1 100mg kg 1000mg kg DDH DNA A 1 SDS No RG101450 3 11 13 3 1 2 3 NITE No 16 2005 NITE No 16 2005
46. 1 1 CERI NITE No 32 2005 EHC 161 2000 ATSDR 1998 CERI NITE No 32 2005
47. 7 2 10 C 8 DDH DNA 1 A 4 SDS No RG101453 3 3 5 1 ACGIH 1 Ceiling 2mg m 1 2mgm
48. Patty 5th 2001 Patty 5th 2001 3 DFGOT 1996 1 HSDB 2003 2 90 lt
49. EHC 114 1991 1 Maximization EHC114 DDH C 1 SDS No RG101530 3 5 7 1 1 1 1 1 1 1991 1 CERI NITE No 8 2005 in vivo in vivo in vivo
50. 2 10 C 8 10ppm TWA 10ppm Skin 10ppm 30mg m3 9 pH DDH a C 2 SDS No RG101461 3 4 7 n 10
51. H318 H341 H351 H361 H336 H401 H411 H370 H373 H302 H311 H314 H318 H340 H360 H401 H370 H372
52. in vivo SIDS 2009 IARC 1988 1B in vitro DFGOT Vol12 1999 SIDS 2009 NTP DB 2009 CHO 1 DDH 2 A 2 SDS No RG101451 3 5 7 1 1 1 SIDS 2009 ACGIH A3 ACGIH 2009 2 109 6 1 39 6 2 ACQIH 2009
53. 15 2 6 2 1 1 4 30 N 65 2 1 59 Ni 1 4 4 4 30C DDH C 1 SDS No RG101530 3 7 7 65 C N_ N 57 1 18 14 1 2 N N 57 2 18 2 9 299 Ni N 28 3 N N 1 2 2 1 1 232 N N PRTR 16
54. Patty 5th 2001 CERI NITE No 16 2004 IRIS 2001 2 F1 CERI NITE No 16 2004 DDH DNA A 1 SDS No RG101450 3 10 13 3 2 3 2 RIS 2001 CERI NITE No
55. 326 16 1 WO01WO0119 1376 JGHEJP 2014 5 14 2 3 4 ezCRIC 2014 SDS DDH A 6 SDS No RG101455 3 1 5 2014 11 1 1 DDH 6 7 8
56. NIN 2005 1B 1991 2 B IARC71 19999 3 ACGIH TLV 2001 A4 1 Group 2B 1 CERI NITE No 8 2005 1 CERI NITE No8 2005 CERI NITE No 8 200
57. 1 EC50 Desmodesmus subspicatus 500 mg L 72 h EC50 Desmodesmus subspicatus 500 mg L 96 h 1 LC50 Leuciscus 0s 4600 9300 mg L 96 h LC50 Brachydanio rernio 9135 mg L 96 h 1 EC50 Daphnia masgna 500 mg L 48 h 96 LC50 gt 100mg L 1998 1 00 x 106mg L PHYSPROP Database 2005 1 13 14
58. 1 H372 1 H226 H381 H331 H341 H350 H360 H370 H371 H372 DDH C 1 SDS No RG101530 3 2 7
59. 26700mg PHYSPROPDatabase 2005 96 LC50 1 24 2 03mg L CICAD58 2004 2 2 BCF 13 BOD 0 2 3 48 LC50 3 1mg L EU RAR 2002 2 BOD 85 og Kow 1 46 PHYSPROP Database 2005 13
60. NTTE No 16 2005 1 1 3 CERI NITE No 32 2005 EHC 161 199 IATSDR 1998 CERI NITE No 32 2005 1
61. K90 CaHNOn 9003 39 8 6 1048 6 1007 9011 18 1 8 561 1 HCONH 75 12 7 50 2 681 4 15 DDH A 6 SDS No RG101455 3 2 5 SNh
62. SDS DDH 2 A 2 SDS No RG101451 3 1 7 2014 11 1 1 FAX DDH A 7 8 03 5645 5664 03 5645 5703 10040 03 5645 5664 2 1 GHS 1 GHS 1 1 1 1 2 2A
63. 96 LC50 gt 100mg L 1995 1 00 x 106mg L PHYSPROP Database 2005 44 by BOD 1 03 gt 08 20ppm 13 14 1 UN2265 NN 3
64. 28 3 3 2 1 6 6 57 1 1 8 2 4 9 29 57 2 1 8 2 9 48 160 474 PRTR 1 2 2 1 1 127 349 16 1 WO01WO113 1201 JGHEJP 2014 7 8 WO1W0103 0260 JGHEJP 2014 6 5 WO01WO116 0102 JGHEJP 2014 4 2 W01W0104 2952 JGHEJP 2014 5 27 2 3 4 ezCRIC 2014
65. 1 WO1W0103 0552 JGHEJP 2014 7 3 W01W0119 0286 JGHEJP 2014 5 14 WO1W0104 0291 JGHEJP 2014 1 9 2 3 4 ezCRIC 2014 SDS DDH a C 2 SDS No RG101461 3 1 7 2014 11 1 1 DDH a C 2 7 8 03 5645 5664 FAX 03 5645 5703
66. 1B 1A 3 3 1 1 2 H225 H319 H335 H336 H340 H360 H372 H373 DDH 2 A 2 SDS No RG101451 3 2 7
67. IRIS 1990 100 ppm ALP 200 ppm ALT 200 ppm CERI NITE No 8 2005 DDH C 1 SDS No RG101530 3 6 7 2 1 _ GHS 1 12 1 EC50 Desmodesmus subspicatus 500 mg L 96 h 1 LC50 Lepomis macrochirus 6300 mg L 96 h LC50 Oncorhynchus mykiss 9800 mg L 96 h LC50 Pimephales promelas 10410 mg L 96 h 1 EC50 Daphnia magna 7500mg L 48 h EC50 Daphniamasgna 8485 mg L 48 h EC50 Daphnia magna 6800 13900 mg L 48 h
68. 2 A 2 SDS No RG101451 3 7 7 14 1 UN1170 1 1 3 I 1 15 4 2 7 1 4 3 1 4 4 3 57 2 18 2 9 61 16 1
69. LD50 414 mg kg 1 2002 512 mg kg EHC 161 1994 400 mg kg EHC 161 1994 340 mg kg EHC 161 1994 445 mg kg EHC 161 1994 4 LD50 375 mg kg LD50 670 mg kg EHC 161 1994 3 LD50 850 mg kg 1 400 mg kg EHC 161 1994 3 3 GHS 1 Patty 5th 2001
70. 0 5 4 0 5 55 6196 SIDS 2009 EU C R35 severe serious hazard ACGiIH 7th 2001 DFGOT vol12 1999 PATTY 5th 2001 1 2 corosive SIDS 2002 1 no skin sensitisation SIDS 2002 IUCLD in vivo SIDS 2002 in vitro Ames test SIDS 2002 DFGOT vol 12 1999 1 12 DFGOT vol12 1999 Reproductive and developmental toxic
71. 13 C 55 F TCO 371C 19vv 33vv 533kPa 1 6 air 1 0 789 0791 DDH 2 A 2 SDS No RG101451 3 4 7 n 032 10 11 1 1 1 1 LD50 7060mg kg rat LD50 gt 2000mg kg rat LC50 20000mg L 4h rat LD50 6200 15000mg kg bw DFGOTVol12 1999 13 7g13700mg kg
72. 10040 03 5645 5664 2 N N 1 GHS GHS 3 3 H331 1 H318 2 H341 1B H350 1B H360 1 2H370 H371 1 2 1 H372 1 H262 H381 H331 H341 H350 H360 H370 H371 H372
73. DDH DNA A 1 SDS No RG101450 3 1 13 2014 11 1 1 DDH DNA A 1 7 8 03 5645 5664 FAX 03 5645 5703 10040 03 5645 5664 2 1 3 GHS 1 3 2A 1 3 1 3 2 4 1A 1 2 2 2 1 1 3
74. 03 5645 5664 FAX 03 5645 5703 10040 03 5645 5664 2 1 GHS 1 2B 320 GHS 1 1 H320 1 1 1 1 3 CAS No C H Na 07 6132 04 3 2 1323 2H 0 9048 46 8
75. HSDB 2005 3 GHS CERI NITE No 8 2005 1 75 100 14 EHC 114 1991 1 1 Maximiz
76. WO1WO105 0045 JGHEJP 2014 8 12 2 3 4 ezCRIC 2014 SDS DDH DNA 1 A 4 SDS No RG101453 3 1 5 2014 11 1 1 FAX DDH DNA 1 4 7 8 03 5645 5664 03 5645 5703 10040 03 5645 5664 2
77. 1 1 2 ICSC 12 3 1 2 3 1 2 3 1 EC50 Pseudokirchneriella subcapitata 46 42 mg L 96 h LC50 Rainbow tout 1 24 2 03 mg L 96h LC50 Pimephales promelas 11 9 50 5 mg L 96 h EC50 Daphnia masgna 260 mg L 48 h EC50 Daphnia masgna 29 mg L 48 h LC50 Ceriodaphnia quadrangula 3 1 mg L 48 h 48 EC50 260mg L IUCLD DDH DNA A 1 SDS No RG101450 3 12 13 2000
78. 1 GHS 1 GHS 1 1 1 1 1 1 1 1A RE 1 WP H314 H370 H402 H370
79. 10 11 1 2 LD50 1300mg kg Rat LD50 3250mg kg Rabbit LC50 1 Patty 5th 2001 5 ACGIH 2001 IUCLID 2000 RTECS 2000 LD50 2 592mg kg 5 LD50 3 250mg kg ACGIH 2001 5 GHS 2000ppm 8 4 ACGIH 2001
80. 3900ppm 6 4 10 75mg L ACGIH 7th 2001 3900ppm 6 4 10 75mg L DDH A 6 SDS No RG101455 3 4 5 1 ACGIH 7th 2001 3 ACGIH 7th 2001 2B ACGIH 7th 2001
81. ACGIH 2001 DDH DNA A 1 SDS No RG101450 3 8 13 EHC 163 1994 1A 1C 1A 3 EHC 161 1994 EHC 161 1994 1 1A 1C 1A 1 ACGIH 2001 2A severe eye irritation with mydriasis and keratitis in all rabbits Transluce
82. 17 8g 17800mg kg 11 5g 11500mg kg Patty 5th 2005 9 8 11 6 mkg bw 7938 9396 mg kg 15010mg kg bw 7000 11000 mg kg bw 14 6 mkg bw 11826mg kg 7800 mg kg bw 11500mg kg bw 11170 16710 mg kg bw 7060 mg kg bw 8300mg kg bw SIDS J 2009 4 OECD TG 404 1 24 1 0 00 notiritating SIDS 2009 Draize OECD TG405 moderate iritating SIDS 2009 DFGOT Vol12 1999 1 3 MMAS Modified Maximum Average Score AOI 240 ECETOCTR48 1998 7 ECETOC TR No 48 2 1998 2B
83. 2001 DFGOTVol 12 1999 DDH 2 A 2 SDS No RG101451 3 6 7 1 Patty 5th 2001 SIDS 2009 DFGOT Vol12 1999 3 ACGIH 2001
84. 16 2004 2 CERI NITE No 32 2005 Narotsky and Kavlock 1995 Nelson Patty 5th 2001 3 Ardeev Patty 5th 2001 3 1 NITE No 16 2005
85. 1991 5 GHS LC50 9400mg m3 2 4 7mg L 4 90 HSDB 2005 3 GHS CERI NITE No 8 2005 75 100 14
86. 2 2 2 2 3 4 H302 3 H311 1A H314 1 H318 1B H340 1B H360 1 H370 1 1 H372 1 DDH DNA A 1 SDS No RG101450 3 2 13 GHS 2 3 1 2 3 1 2 H401 H226 H319 H335 H336 H370 H302 H314
87. 59 N N 1 4 4 4 30C 65 C 57 1 18 14 12 N N 57 2 18 2 9 299 N N 28 3 N N 1 2 2 1 1 232 N_N 16 DDH a C 2 SDS No RG101461 3 7 7 1 WO1W0104 0291 JGHEJP 2014 1 9 2 3 4 ezCRIC 2014 SDS
88. 5 2 1 2 1 RIS 1990 AST ALT NTP TOX22 1992 SGPT SGOT IRIS 1990 100 ppm ALP 200 ppm ALT 200 ppm CERI NITE No 8 2005 2
89. ation EHC114 1991 1 1 DDH a C 2 SDS No RG101461 3 5 7 CERI NITE No 8 2005 in vivo in vivo in vivo 1 200 ppm 2000
90. ity SIDS 2002 DFGOT vol 12 19999 SIDS 2002 ACGIH 7th 2001 DFGOT vol 12 1999 PATTY 5th 2001 1 ACGIH 7th 2001 DFGOT vol12 1999 PATTY 5th 2001 12 1 LC50 Oncorhynchus mykiss 45 4 mg L 96 h 1 48 LC50 40 4mg L SIDS 2004 DDH DNA 1 A 4 SDS No RG101453 3 5 5 3
91. nt zones in the cormea were observed in four animals and a purulent haemorrhagic discharge was also reported number of rabbits unknown The effects had disappeared 2 3 weeks after application except for one rabbit tat still showed corneal opacity after 3 weeks 4 23 1 3 EHC 163 1994 1 3 EHC 161 1994 10 5 1 UCLD 2000
92. vivo in vivo 2 CERI NITE No 32 2005 NTP DB Access on Dec 2005 in vivo 1B ACGIH 2001 NTP 2005 R IARC 1999 Group 2B EU 3 ACGIH 2001 A3 EPA 1986 B2 2B 2 IARC 1999 3 ACGIH 2005 A4 IRIS 2002 D Reasonably Anticipated Group 2A Group 2B Group 3 Group 3 A3 A4 Group 2B
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