NEHODS User Guide - Newcastle Hospitals
Contents
1. 0191 2824445 NEHODS User guide v1 1 Page 4 of 7 The Newcastle upon Tyne Hospitals NHS pa L EN NHS Foundation Trust A Tis it NR LAANA j E a e Daas T 1 torte N Wa W i ATTRA a moa a Oa a a A y l E LMA NEHODS Northern England Haemato Oncology Diagnostic Service 10 Referral of investigations from NEHODS 1 Tissue biopsies with non haematological malignancies are passed on to and reported in conjunction with the appropriate subspecialist team at the Royal Victoria Infirmary Newcastle 2 Bone marrow aspirate samples from patients with acute promyelocytic leukaemia have a sample of cDNA sent to Prof David Grimwade at Department of Haematology Guy s and St Thomas s Hospital London This is the national reference centre for these investigations 3 Genomic DNA and cDNA from patients with atypical myeloproliferative disorders are referred to Professor Nick Cross at the Wessex Regional Genetics Laboratory Salisbury This is the national reference centre for these investigations 11 NEHODS information Further information regarding the service can be found on NEHODS webpage www newcastle hospitals org uk services 20913 aspx General Service Enquires Lead Clinician Dr Peter Carey peter carey nuth nhs uk 0191 28 24743 Operational Manager Gavin Cuthbert gavin cuthbert nuth nhs uk 0191 2418703 If there are problems or complaints about the service please call us We aim to re2. The Newcastle upon Tyne Hospitals NHS TU N NHS Foundation Trust ER a SSF lt q a LAA A NEHODS Northern England Haemato Oncology Diagnostic Service NEHODS User Guide Scope Purpose This user guide provides key information about the NEHODS SIHMDS service and its users including lists of key contacts both within the service and within the Northern Region Haematologists group 1 Introduction NEHODS provides an integrated diagnostic service covering all aspects of the diagnosis and monitoring of haematological malignancies and related conditions The service has facilities for flow cytometry immunohistochemistry metaphase and interphase cytogenetics studies and a wide range of molecular investigations Further details of the service can be found on the NEHODS webpage www newcastle hospitals org uk services 20913 aspx 2 Contacting NEHODS The full postal address of the laboratory is NEHODS Blood Sciences Flow Laboratory Level 3 Leazes Wing Royal Victoria Infirmary Richardson Road Newcastle upon Tyne NE1 4LP General NEHODS Enquiries 0191 282 5028 0191 282 5078 Lab Email tnu tr nehods nhs net HaemoSys enquiries andrew taylor nuth nhs uk or Haemosys support nhs net Tel 0191 2821584 Appendix a shows contact details for the full NEHODS staff Appendix b shows contact details for the Northern Region Group of Haematologists 3 Requesting Investigations Copies of the request form can be obtaine
3. WELL 1x5 ml Lithium Heparin tube for Cytogenetics Please MIX WELL 2 x5 slide transport containers Peripheral Blood PB Send in EDTA tube or Lithium Heparin 5 ml required please mix well Two PB smears Bone Marrow Aspirate Fresh bone marrow aspirate BMA smears and marrow sample in EDTA and Lithium Heparin tubes Cerebro spinal fluid CSF samples should be kept refrigerated between 2 8 C Sterile container target minimum volume 0 5mls Bone Marrow Trephine biopsy Should be fixed in 10 Formalin Unfixed Tissue Sample Unfixed tissue samples keep biopsy moist with a little normal saline and keep refrigerated between 2 8 C If possible a portion of the sample should be placed in 10 formalin Fixed Tissue Block Protect the front face of the paraffin block with tissue paper Secure package Referred lymphoma tissue blocks should be sent with slides and a copy of the local report to the Department of Cellular Pathology level 3 New Victoria Wing Royal Victoria Infirmary Newcastle NE1 4LP These samples should not be booked onto HaemoSys NEHODS User guide v1 1 Page 2 of 7 The Newcastle upon Tyne Hospitals NHS TU N NHS Foundation Trust ER a SS lt q a LAA A NEHODS Northern England Haemato Oncology Diagnostic Service 1 All unfixed samples should be delivered to the laboratory within 24 hours If a sample is delayed beyond this point it may not be possible to carry out a full range of investigations
4. d from the laboratory or downloaded from www newcastle hospitals org uk services 20913 aspx or generated within HaemoSys Things to double check before sending samples e We need THREE items of patient identification including NHS number e Are all the tubes labelled we cannot accept unlabelled specimens e Are all the lids fastened leaking specimens compromise analysis and are a health risk If there are changes in the patient s condition or relevant new information emerges after the specimen is sent please contact the laboratory so that additional investigations may be NEHODS User guide v1 1 Page 1 of 7 The Newcastle upon Tyne Hospitals NHS fen mu A SERET NHS Foundation Trust P TEREE nul en NR MANN E ll ae Apes TTI say SS Vin uz N 7 N o aMMa A Jinn 8 AA x NEHODS Northern England Haemato Oncology Diagnostic Service initiated if required Investigations on tissue blocks and stored DNA can generally be carried out on archived material without time limit 4 Sample Requirements and Transport Book request on to HaemoSys See website www newcastle hospitals org uk services 20913 aspx for the HaemoSys Booking In SOP A Diagnostic Kit is available from NEHODS comprising Transport box UN3373 PathoShield 8 pre labelled with the address above Sealable internal bag with unique tracking number Please make a note of this 2 x5 ml EDTA tubes for Flow Cytometry and or DNA extraction Please MIX
5. indicated with HaemoSys appearing on the right hand side of the Test summary screen Integrated reports Following completion of testing integrated reports are published on HaemoSys by the NEHODS Clinical Team These final reports are either delivered to the local LIMS system or posted to the referring clinician These reports are also available for download as pdf within HaemoSys Lymphoma NEHODS reports are available through the APEX computer system Paper reports are sent to the referring pathology departments Urgent reports can be faxed if required Please e mail queries to CellularPathology Secretaries nuth nhs uk 8 Turn around times NEHODS Test Target Turn around time Bone marrow aspirate morphology 72hrs Flow cytometry Immunophenotyping 72hrs Urgent FISH karyotyping 72hrs Integrated report compilation from completion of all testing 72hrs Molecular Genetics JAK2 MPL BCR ABL monitoring BRAF KIT TPMT 10 days clonality Molecular Genetics MYD88 CSF3R FLT3 NPM1 14 days Routine Cytogenetics karyotyping FISH arrays 21 days Lymphoma reporting 2 weeks Molecular Genetics MLPA CLL 4 weeks 9 Clinical Advice and Interpretation Please phone NEHODS office 0191 282 5028 for clinical advice Please telephone the Cellular pathology secretaries for lymphoma queries either contacting the lymphoma service secretary Karen Manners 0191 2825564 or the general office number
6. l 0191 233 6161 Professor Graham Jackson Graham Jackson nuth nhs uk z Dr Venetia Bigley venetia bigley nuth nhs uk Dr Roderick Oakes Thurs Fri Roderick Oakes nuth nhs uk Roderick oakes nhs net Dr Wendy Osborne wendy osborne nuth nhs uk Dr Arian Laurence Arian Laurence nuth nhs uk Dr Erin Hurst Erin Hurst nuth nhs uk Chris Williams2 northumbria Dr Chris Williams healthcare nhs uk chris williams15 nhs net g North Tyneside General Dr Rachel Wells rachel wells northumbria healthcare nhs uk _rachel wells4 nhs net tel 0344 811 8111 Dr Chris Tiplady Chris Tiplady northumbria healthcare nhs uk christopher tiplady nhs net ue x charlotte bomken northumbria o 2 Dr Charlotte Bomken healthcare nhs uk charlotte bomken nhs net Dr Mari Kilner mari kilner nhct nhs uk mari kilIner nhs net e z Wancbeck General Dr Simon Lyons Simon Lyons northumbria healthcare nhs uk simonlyons nhs net e Dr Ian Neilly ian neilly northumbria healthcare nhs uk ian neilly nhs net 2 tel 0344 811 8111 George Holmes northumbria Dr George Holmes healthcare nhs uk George Holmes nhs net Northumbria Emergency ava rota of Consultants from North Care Hexham General Tyneside and Wansbeck tel 0344 811 8111 a Dr Roderick Oakes Mon 5 Cumberland Infirmary Weds Roderick Oakes ncuh nhs uk Roderick oakes nhs net E tel 01228 523 444 rota of Consultants from North ra Tyneside and Wansbeck TEE Dr Roderick Oakes Mon T est cumbertan Weds Roderick Oakes
7. ncuh nhs uk Roderick oakes nhs net tel 01946 693 181 zZ Dr Chris Tiplad Chris Tiplady northumbria healthcare nhs uk christopher tiplady nhs net South of Tyne Sunderland Royal tel 0191 565 6256 Dr Scott Marshall Dr Susanna Mathew Dr Victoria Hervey Dr Yogesh Upadhye Dr Shikha Chattree Dr Hana Beshti susanna mathew chs northy nhs uk victoria hervey chs northy nhs uk Yogesh Upadhye chsft nhs uk shikha chattree chsft nhs uk hana beshti chsft nhs uk scott marshall3 nhs net yogesh upadhye nhs net shikhachattree nhs net Queen Elizabeth Gateshead tel 0191 482 0000 South Tyneside tel 0191 404 1000 James Cook Univ Hosp tel 01642 850 850 North Tees Hartlepool tel 01642 617 617 list ast updated Gavin Cuthbert 08 06 2015 NEHODS User guide v1 1 Dr Annette Nicolle Dr Geoff P Summerfield part time Dr Yogesh Upadhye Dr Scott Marshall Dr Mike Galloway Dr Susanna Mathew Dr Victoria Hervey Dr Dianne Plews Dr Angela Wood Dr Ray Dang Dr Jamie Maddox Dr Marianna David Dr Mohsen Norouzi Dr Rajesh Mamadigi Dr Maria Szubert Dr Khalid Hassan Dr Padmaja Lokireddy annette nicolle ghnt nhs uk geoffrey summerfield ghnt nhs uk Mike Galloway stft nhs uk susanna mathew chs northy nhs uk victoria hervey chs northy nhs uk diane plews stees nhs uk angela wood stees nhs uk Ray Dang stees nhs uk jamie maddox stees nhs uk marianna david stees nhs uk mohsen noro
8. nuth nhs uk dawn barge nuth nhs uk terry coaker nuth nhs uk cancer cytogenetics nuth nhs uk tnu tr cancer cytogenetics laboratory nhs net molecular genetics nuth nhs uk info newgene org uk gavin cuthbert nuth nhs uk katrina wood nuth nhs uk chris bacon nuth nhs uk despina televantou nuth nhs uk karen manners nuth nhs uk Page 6 of 7 Ji R aMMa val aS g The Newcastle upon Tyne Hospitals NHS lr y fl i NHS Foundation Trust J a oh A NEHODS Northern England Haemato Oncology Diagnostic Service Appendix b Northern England Haematologist list please contact NEHODS if you require a copy of this MDT Trust Hospital Haematologists Trust email address nhs net Dr Peter Carey Peter Carey nuth nhs uk Royal Victoria Infirmary Dr John Hanley John Hanley nuth nhs uk johnhanley nhs net tel 0191 233 6161 Dr Kate Talks Kate Talks nuth nhs uk tel Dr Tina Biss tina biss nuth nhs uk v Dr Brigit Greystoke brigit greystoke nuth nhs uk E Dr Jonathan Wallis Jonathan Wallis nuth nhs uk 2 Dr Gail Jones Gail Jones nuth nhs uk gail jones7 nhs net e Dr Tobias Menne Tobias Menne nuth nhs uk t menne nhs net Professor Matt Collin Matthew Collin nuth nhs uk matthew collin nhs net r ka Northern Centre for Cancer Professor Stephen G O Brien lucy manning nuth nhs uk stephen o brien1 nhs net S Care Freeman Hospital Dr Anne Lennard Anne Lennard nuth nhs uk anne lennard nhs net 3 v te
9. particularly those involving flow cytometry cytogenetics or RNA extraction In these circumstances definitive diagnosis may not be possible If there is going to be an unavoidable delay please keep samples in the following conditions before transportation Peripheral blood and bone marrow samples keep refrigerated between 2 8 C 2 For childhood acute leukaemia samples or if Burkitt lymphoma or acute promyelocytic leukaemia is a suspected diagnosis please call the laboratory immediately 0191 2825028 For Burkitt lymphoma please also make extra smear slides in view of apoptosis of lymphoma cells during transport 3 Samples that require DNA and or RNA extraction please ring the lab if there is going to be a delay greater than 24 hours to discuss the storage of these samples as some tests may not be performed if the storage is incorrect or the delay is considerably longer 4 When sending samples by post a secure container should be used to conform to current postal regulations UN3373 and labelled according to the guidelines 5 It is essential that appropriate labels are attached to request forms and containers where a sample is suspected as being High Risk 6 Samples should be sent directly to NEHODS If there is any doubt about how to send a sample please contact the laboratory 0191 2825078 5 Opening times Monday to Friday 08 30 to 17 00 To ensure safe arrival of samples sent late in the day please call the laborator
10. solve most problems immediately and informally If this cannot be done please write to Dr Peter Carey in the first instance NEHODS User guide v1 1 Page 5 of 7 te mei toe 4 Nr aiii I M ra Jinn A The Newcastle upon Tyne Hospitals NHS NHS Foundation Trust J alll on NEHODS Northern England Haemato Oncology Diagnostic Service Appendix a NEHODS Contact list NEHODS Office General enquiries NEHODS laboratory Routine sample Haemosys enquiries Haemosys Systems Administrator NEHODS Clinical Lead NEHODS Clinical Team Flow Cytometry Lead Scientist Immunohistochemistry Cancer Cytogenetics Molecular Genetics NewGene NEHODS Operational Manager Lymphoma haematopathologists Cellular Pathology Lymphoma Secretary NEHODS User guide v1 1 Andrew Taylor Dr Peter Carey Dr Jonathan Wallis Dr Brigit Greystoke Dr Roderick Oakes Dr Dawn Barge Terry Coaker Gavin Cuthbert Dr Katrina Wood Dr Chris Bacon Dr Despina Televantou Karen Manners 0191 28 25028 0191 28 25078 0191 28 21584 0191 28 24743 0191 28 25648 0191 2139233 0191 28 38482 0191 28 25078 0191 282 9120 0191 2418703 0191 2418799 0191 2421923 0191 2418711 0191 28 29449 0191 28 29142 0191 28 21576 0191 28 25564 tnu tr nehods nhs net andrew taylor nuth nhs uk haemosys support nhs net peter carey nuth nhs uk jonathan wallis nuth nhs uk brigit greystoke nuth nhs uk roderick oakes
11. uzi stees nhs uk rajesh mamadigi stees nhs uk maria szubert nth nhs uk khalid hassan nth nhs uk padmaja lokireddy nth nhs uk annette nicolle nhs net geoffrey summerfield1 nhs net yogesh upadhye nhs net scott marshall3 nhs net mike galloway nhs net ray dang nhs net jmaddox nhs net mariannadavid nhs net mohsen norouzi nhs net rajesh mamadigi nhs net maria szubert nhs net khalid hassan4 nhs net padmaja lokireddy nhs net Page 7 of 7
12. y if you expect a sample to arrive after 17 00 except for routine late deliveries Staff are working in the laboratory between 08 30 and 20 00 Monday to Friday and from 09 00 13 00 on Saturday and provision can be made for urgent samples 6 Out of hours service An on call service is available for clinically urgent requests This is where there is an immediate need to commence treatment This service is accessed by contacting the consultant haematologist on call through the Newcastle Hospitals switchboard 0191 2336161 This should be done before the sample is taken 7 NEHODS Reporting NEHODS results are available using HaemoSys http www haemosys com Please see your local IT manager re access to HaemoSys or contact the System Administrator Andrew Taylor andrew taylor nuth nhs uk or Haemosys support nhs net 0191 2821584 NEHODS User guide v1 1 Page 3 of 7 The Newcastle upon Tyne Hospitals NHS LPL ra m NHS Foundation Trust mnl ex NS aN E AD Pa Tal Lattin Jinie _ 230 InN NEHODS Northern England Haemato Oncology Diagnostic Service HaemoSys contains a comprehensive user guide which is regularly updated Interim results All users must be aware that results may be entered saved into HaemoSys before test results are fully authorised Users must note that such results are interim and subject to change before authorisation of the test Authorised results Authorised Completed test results are clearly
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