JP 2011-501758 A 2011.1.13 (57)【要約】 本発明
Contents
1. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 7 IU U 10 JU IUD UD 20 DU O n 302. 5 JP 2011 501758 A 2011 1 13 HHHHHHHHHHHH um HHHHHHHHHHHH O HHHHHHHHHHHH HHHHHHHHHHH HHHHHHHHH HHHHHHHHH HHHHHHHHH O 10 20 30 40 50 6 JP 2011 501758 A 2011 1 13
3. 10 20 30 40 50 55 JP 2011 501758 A 2011 1 13 T xm i 8 8 3 8 8 RT PCR qRT PCR onadagi OWadTY LL d He 10000000 1000000 100000 10000 1000 100 HERE PE EY 56 JP 2011 501758 A 2011 1 13 sa za es Yo 2 Sr 4 Sz E lt oz a 3 E G A ES Xy ID H A D in 1D H TM UL n m o o e o e o o N o N o o o o o o e T O TN ME Re CBE 96 BERT i H i FE i E i E kg i DAad i owad m i van i EE H E i des i ay i E i Medd H Li us i gamang a i H JE i EM B ji i
4. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 32 10 20 30 40 BU O 1
5. JP 2011 501758 A 2011 1 13 50 U 10 20 30 40 50
6. U IU HHHHHHHHH IU HHHHHHHLH ju U HHHHHHHHH 10 20 30 40 50 48 JP 2011 501758 A 2011 1 13
7. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 49 10 20 30 C 40 50
8. 10 20 30 u z M 40 50 JP 2011 501758 A 2011 1 13
9. JP 2011 501758 A 2011 1 13 37 O O 10 20 O O 30 40 50 IHH HH 0 O 0 C
10. 11 JP 2011 501758 A 2011 1 13 U U U U U uu HHHHHHHHHHIH HHHHHHHHHHIH
11. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 10 20 30 40 50 JP 2011 501758 A 2011 1 13 46 10 20
12. 30 40 50 UI O D D O JP 2011 501758 A 2011 1 13 15 10 O 20
13. 10 20 30 40 50 3 JP 2011 501758 A 2011 1 13 10 20 30 40 50 JP 201
14. 30 40 50 JP 2011 501758 A 2011 1 13 16 10 20 30 40
15. JP 2011 501758 A 2011 1 13 27 10 20 30 40 50 JP 2011 501758 A 2011 1 13 28 10 20 30 40 la p0
16. 50 JP 2011 501758 A 2011 1 13 36 10 20 30 40 50
17. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 20 10 20 30 D 40 50 uui
18. 51 JP 2011 501758 A 2011 1 13 U U U 00000 10 20 30 40 50 JP 2011 501758 A 2011 1 13 52
19. 30 40 50 U D D O n JP 2011 501758 A 2011 1 13
20. 30 40 50 JP 2011 501758 A 2011 1 13 30 10
21. 10 20 30 40 50 42 JP 2011 501758 A 2011 1 13 10 20 30 40 50 43 JP 2011 501758 A 2011 1 13
22. DU O DU O DU O DU O n 40 DU O D O BU IUL 50 DU O IOD JP 2011 501758 A 2011 1 13 8 10 n DU O D D O DU O
23. DU 0 JP 2011 501758 A 2011 1 13 23 10 20
24. 10 20 30 40 50 kl JP 2011 501758 A 2011 1 13 53 10 20 30 40 50
25. JP 2011 501758 A 2011 1 13 26 10 20 30 40 O DU 50
26. 3 a ED 3 m m eum roma ra AR _ EJ L3 L3 L3 EJ L3 EJ m 30 0U JU 40 IUD IUD IUD 50 DU D
27. JP 2011 501758 A 2011 1 13 21 10 20 30 C 40 50 JP 2011 501758 A 2011 1 13 22 10 20 30 40 50
28. HHHHHHHHHHHHHHHH HHHHHHHHHH UOUOO0O0000000000000000000000000000000000 UOUOO0OO0O000000000000000000000000000000000 HHHHHH HHHHHH HHHHHH HHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH UOU0O0000000000000000000000000000000000050 HHHHHHHHHHHHH 000000 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHUHHHHHHHHH UOU0O0000000000000000000 00000000000000050 UO0U0O000000000000000000000000000000000000 41 JP 2011 501758 A 2011 1 13
29. 50 33 JP 2011 501758 A 2011 1 13 10 20 30 40 50 JP 2011 501758 A 2011 1 13 34 10 20
30. U 54 JP 2011 501758 A 2011 1 13
31. O DI D DU O 50 JP 2011 501758 A 2011 1 13 29 10 20 DU
32. DU O 50 JP 2011 501758 A 2011 1 13 MOO 0 10 20 30 40 50 18 JP 2011 501758 A 2011 1 1
33. 10 20 30 40 50 JP 2011 501758 A 2011 1 13 12 10 20 30 40 50 O O JP 2011 501758 A 2011 1 13 13 10 20
34. 20 30 40 50 DU 9 JP 2011 501758 A 2011 1 13 U U D HHHHHH U U U 000000000
35. UNIVERSITAET MAINZ 55122 21 Saarstrasse 21 551 22 Mainz Germany 520000 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH 2 JP 2011 501758 A 2011 1 13 lO U HHHHHHHHHHHHH HHHHHHHHHHHH U U HHHHHHHHH HHHHHHHH U HHHHHHHHHHHH U
36. nn n DU 40 JO 50 0 0 JP 2011 501758 A 2011 1 13 25 10 20
37. 20 30 40 50 IOD 31 JP 2011 501758 A 2011 1 13
38. HHHHHHHHILH U 10 20 30 40 50 JP 2011 501758 A 2011 1 13 10 10 20 30 40 50 O n
39. C Uu n n C 38 JP 2011 501758 A 2011 1 13 10 20 30 U HHHHHH ES LR 2 ali 3 Bg 39 Si zm H
40. i si 8 8 8 E 8 8 8 8 8 5 8 8 8 3 o 2 a 8 5 N Ri HE ae IX BL ese SEK Mog mi 0 KAFE LEE 300000 250000 200000 150000 400000 50000 MESE PX BY FT LRA BRE LAR e e 8 8 3 8 E 8 H 8 8 a E P RI BESS IX BY 250000 57 e e e e e e e 9000000 8000000 JP 2011 501758 A 2011 1 13 GAP LATED o o o e e o 9 e e 3 e e S 8 8 8 8 8 e M o 2 A HESS CH 6000 o 3 a 7 8 Bias Bi 4000 3000 2000 1000 AERE EBY 58 JP 2011 501758 A 2011 1 13 FERME s a i i i al i i i i i E g E B i B H i j E a H H E E H B EBI H Es E E IE i i NE i i i til i i i i ES 3 s i B CREE H i ilie 5000 4500 4000 3500 3000 2500 2000 1500 1000 500 0 60000 50000 40000 30000 20000 10000 m aR E m a i E p 3 E i E ri ORR LE 1000000 900000 800000 700000 600000 500000 400000 300000 200000 100000 0 2500 2000 1500 1000 500 0 BER CBE m H
41. 30 40 50 JP 2011 501758 A 2011 1 13 24 10 JO U IUD D D 20 30 BU O
42. 30 40 50 JP 2011 501758 A 2011 1 13 14 10 20 n
43. 30 40 50 Ho IU D DU O JP 2011 501758 A 2011 1 13 35 10 20 30 40
44. 4 o O Fur cab N EU Sg 0 co LN N 00005 4 o Lm E 000001 4 o N a 000054 000002 000057 ZEN 00000 Oo Lm esperas curan zy Sen a wu us mr so sw eo terres a 7 0 00005 000004 Z 000054 000002 000057 El Gong TAE nu BE 36 CBE PRES zu HERE KEY zu GR T a Best ELI 00000L 000054 000002 000052 00000 000056 000007 0000Sb 000005 000002 000007 000008 000008 000000 000002 0000091 0000091 HEKE HERK 60 JP 2011 501758 A 2011 1 13 i i i i a i i Bl i A 1 H i i a i i H i b g i JE d i s i i E i i i i H H H i i i H i i i i ge i H i CE i H E ME E MEE i i w i i i H H i i i ES i i a H H 1 A b s E a i i E i i i H l i i i i DEM u SE E i i i i i i b i i E i i u i i i u i i x i R i i i i Ora HE H H BES H H HUELE SNSd H E 5000 3500 3000 2500 1500 1000 500 400000 350000 300000 250000 200000 150000 100000 50000 4500 4000 r3 EX Be KERE BY i i i i B E H i i i i i E i i T E i i E i i i y H a i H H LE ik H kul 4 i l
45. H z fi im Sh S uM 14 AT Bik YSB PBMC PBMC to tol 8 ele o o ro to o ro o ro ro o NI 9E JP 2011 501758 A 2011 1 13 10 20 JP 2011 501758 A 2011 1 13 40 o o o 4 N m E mi a ar ak URS ar OR ak w tid did 408 eg fa 400 gm 1 1 1 kol d aga tega K 8 38 SES me geja E B ae ae Be Be E Ee EEE S EEE EA ik 3H E H IN a co O HE i oo M gi E eo eon m co e a t mI A Io st st lt 0 Ol blo ope lm olo o o ml nl 4 almlmimlal jo gt lo o wn ipeo e lzlziziz m gt O I o wiZizjt IMIZIZIZI glm Ye ol l if lal gt lol J wol J IS id I Also o 5 lt E EE aelolalalalk slol lololololelolzlalolzhaolololpol s o m s l m amp lalzizizizjojolelzjojzizizizjajnjolsajalzizjzjalsjalzizjolz A n a Y 40 50
46. FR GB GR FR HJ IE IS ET LT LU LV MG MI NL NO PL PT RO SE SI SK T R OX BF B GG 0 M G GN QQ M NE SN TD TG AE AG AL AM AT AU BB BG BH BR BEY BZ CA CH CN Q2 CR QJ CZ LE K PM DO EZ EG EE EG ES Fl BOG AGG FN FR HJ ID IL IN TS JP KE K G KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG M My MYM M MZ NA NG N NO NZ OM PG PH PL PT RO RS RU SG SD SE SG SK SL M ST SV SY TJ TM TN TR TT TZ UN UG UB WZ V W ZA MAN 74 100110928 72 U uuu HU UL 72 UL U U OOOD 72 LU UL LU UL IU 48024 AAO1 AA2 BA54 48063 Q01 19 40084 AAL3 7 40085 AA4 5 40087 AAO1 AM 44045 AAIL GMO DN5 EM2 FA72 FA74
47. 1 501758 A 2011 1 13 4 UD IU U 10 20 30 U 40 IUD DU D DU O DU O ID DU n O00 50
48. 3 10 20 30 40 50 19 JP 2011 501758 A 2011 1 13 U U U U U U uuu U U ODDO HHHHHH HHHHHHH
49. 545 549 553 557 560 563 566 570 574 577 580 583 587 591 595 599 602 606 610 613 617 620 624 Also encompassed are methods to use these antigens 67 JP 2011 501758 A 2011 1 13 INTERNATIONAL SEARCH REPORT E Intemationel appilcation No _ Informatian on patent family members PCT EP2008 008924 cited in search report membela date WO 2007031222 22 03 2007 2006291717 Al 22 03 2007 CA 2620712 Al 22 03 2007 CN 101305020 A 12 11 2008 EP 1762575 Al 14 03 2007 JP 2009507868 T 26 02 2009 KR 20080052664 A 11 06 2008 US 2003099974 Al 29 05 2003 NONE WO 2006083986 A2 10 08 2006 CA 2596469 A1 10 08 2006 1846576 A2 24 10 2007 WO 2006100089 A2 28 09 2006 DE 102005013846 A1 05 10 2006 EP 1861118 A2 05 12 2007 JP 2008537546 T 18 09 2008 Form PCT ISA 210 pateri family annar fAnril 2006 DI nt a 0000 81 16 46 35 00 48 00 3Y 3 3 14 33 574 2006 01 2006 01 2006 01 2006 01 2006 01 2006 01 68 1646 35 00 48 00 39 395 35 14 33 574 33 574 JP 2011 501758 A 2011 1 13 L3 LT Co AP BYCH M KE LS MWE SD SL SZ TZ UG ZM ZW EA AM AZ BY KG KZ M RUT TM EP AT BE BG CH CY CZ LE OK EE ES Fl
50. HEALTH amp HUMAN US BARRRETT CARL US RISS JOSEPH U 10 August 2006 2006 08 10 the whole document KOSLOWSKI M ET AL Frequent nonrandom activation of germ line genes in human cancer CANCER RESEARCH AMERICAN ASSOCIATION FOR CANCER RESEARCH BALTIMORE MD US vol 64 no 17 3 1 September 2004 2004 09 01 pages 5988 5993 XP002309835 ISSN 0008 5472 the whole document TURECI OZLEM ET AL Computational dissection of tissue contamination for identification of colon cancer specific expression profiles THE FASEB JOURNAL OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY MAR 2003 vol 17 no 3 March 2003 2003 03 pages 376 385 XP002471061 ISSN 1530 6860 the whole document WO 2006 100089 A2 GANYMED PHARMACEUTICALS AG DE SAHIN UGUR DE TUERECI OEZLEM DE 28 September 2006 2006 09 28 the whole document PROKOPENKO P G ET AL Antigenic structure of ovarian cancer metastases BULLETIN QF EXPERIMENTAL BIOLOGY AN MEDICINE JUN 2001 vol 131 no 6 June 2001 2001 06 pages 561 563 XP002471062 ISSN 0007 4888 the whole document Form POTASA 210 continuation of second sheet April 2005 65 JP 2011 501758 A 2011 1 13 International application No PCT EP2008 008924 INTERNATIONAL SEARCH REPORT Box No i Observations where certain claims were found unsearchable Continuati
51. JP 2011 501758 A 2011 1 13 19 JP uw A 11 2011 501758 P2011 501758A 43 23 1 13 2011 1 13 51 Int Cl FI A61K 45 00 2006 01 A61K 45 00 ZNA 4BO24 C12N 15 113 2010 01 C12N 15 00 G 4B063 C12N 15 09 2006 01 C12N 15 00 A 4CO84 c12Q 1 68 2006 01 C12Q 1 68 A 4CO85 COZX 16 32 2006 01 CO7K 16 32 40087 RK 68 21 2010 530332 P2010 530332 71 504346260 86 22 20 10 22 2008 10 22 Y 85 22 6 23 2010 6 23 86 PCT EP2008 008924 55131 87 W02009 053041 12 87 21 4 30 2009 4 30 71 509256849 31 07020730 3 32 19 10 23 2007 10 23 33 EP JOHANNES GUTENBERG 54
52. articular relevance the claimed invention filing date cannot be considered novel or cannot be considered to ki hy pocumen mien ma VON hat porty caim e or Involve an Inventive step when the document is taken alone Gana NO saa la pu m caia anoiner Y document of particular relevance the claimed Invention citation or other special reason as specified cannot be considered to involve an Inventive step when the O document referring to an oral disclosure use exhibition or document is combined with one or more olher such docu other means ments such combination being obvious to a person skilled P document published prior io the international filing date but in the art later than the priority date claimed amp document member of the same patent family Date of the actual completion of the intemational search gt Date of meding of the Intemational search report 19 March 2009 27 07 2009 Name and maling address of the ISA Authorized officer European Patent Office P B 5818 Patentlaan 2 NL 2280 HV Rijswijk Hedge Mp on Novak Giese Sabine Form POT ISA 210 second sheet April 2005 64 JP 2011 501758 A 2011 1 13 INTERNATIONAL SEARCH REPORT International application No PCT EP2008 008924 C Centinuation DOCUMENTS CONSIDERED TO BE RELEVANT Category Caailon of document with indication where appropriate of the relevant passages Relevant to clalm No WO 2006 083986 A2 RETARY DEPT OF
53. h fees were paid specifically claims Nos 4 No required additional search fees were timely pald by the applicant Consequently this international search report is restricted to tha Invention first mentioned in the claims It is covered by clalms Nas see annex Remark on Protest C The additional search tees were accompanied by the applicant s protest and where applicable the payment of a protest fee The additional search fees were accompanied by the applican protest but the applicable protest 188 was not paid within the lime limit specified in the invitation LI No protest accompanied the payment of additional search fees Form PCTASA 210 continuation of frst sheet 2 April 2005 66 JP 2011 501758 A 2011 1 13 International Appication No PCT EP2008 008924 FURTHER INFORMATION CONTINUED FROM PCTISA 210 This International Searching Authority found multiple groups of inventions in this international application as follows Invention 1 Claims 1 48 partially Invention 1 A pharmaceutical composition comprising a tumor associated antigen having a sequence encoded by a nucleic acid which is characterized by SEQ ID NO 541 Also encompassed are methods to use these antigens Inventions 2 564 Claims 1 48 partially A pharmaceutical composition comprising a tumor associated antigen having a sequence encoded by a nucleic acid which is characterized by SEQ ID NO 1 540
54. on of item 2 of first sheet This international search report has not been established in respect of certain claims under Article 17 2 a for the following reasons 1 x Claims Nos because they relate to subject matter not required to be searched by this Authority namely Claims 32 and 38 Rule 39 1 1v PCT Diagnostic method practised on he human or animal body Claims Nos because they relate to parts of the International application that do not comply with the prescribed requirements to such an extent that na meaningful International search can be carried out specifically 3 o Claims Nos because they ars dependent claims and are not drafted In accordance with the second and third sentences of Rule 6 4 a Box No Ill Observations where unity of Invention Is lacking Continuation of item 3 of first sheet o This Intemational Searching Authority tound multiple Inventions in this international application as tollows see additional sheet As all required additional search fees were timely paid by the applicant this international Baarch report covers allsearchable claims 2 LJ As all searchable claims could be searched without effort Justifying an additlonai fees this Authority did not invite payment of additional fees As only some of the required additional search fees were timely paid by the applicant this international search reportcovers only those claims for whic
55. t jk B i i i im i i i H LEE i i a i 1 i i E i E ar H A i red i l i H H FSE E e GE SAL E 3 8 BEE KEY 50 45 40 35 30 3000 2500 2000 1500 1000 500 m AR m 61 JP 2011 501758 A 2011 1 13 RTR FF E BO ERE E ERES LE 1500 1000 500 140000 120000 100000 80000 60000 40000 20000 2500 2000 KERE RE HELE i i H E H 5 i i i i i i i H i i H E i i i i i H i i i i E B i uu i i gs E A E NE E e e 8 8 o e e 6000 5000 4000 3000 2000 1000 25000 20000 15000 10000 5000 KERE EX BE HERS EH 60000 40000 30000 HERE PX BY 2011501758000001 app 62 HHHHH o MT LE RE LE JP 2011 501758 A 2011 1 13 RE BE FF LEMA 1400 BESS PEEK 63 JP 2011 501758 A 2011 1 13 HHHHHHHH International application No INTERNATIONAL SEARCH REPORT PCT EP2008 008924 A CLASSIFICATION OF SUBJECT MATTER INY CO K14 47 According to International Patent Classification IPC or 10 both national classification and IPC B FIELDS SEARCHED l Minimum documentation searched classification system follo
56. wed by classification symbols CO7K Documentation searched other than minimum documentation to the extent that such documents are included In tha fields searched A Electronic data base consulted during the international search name of data base and where practical search terms used EPO Internal WPI Data BIOSIS EMBASE CHEM ABS Data Sequence Search C DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication whore appropriate of the relevant passages lt MO 2007 031222 A2 GANYMED PHARMACEUTICALS AG DE JOHANNES GUTENBERG UNI MAINZ V DE 22 March 2007 2007 03 22 the whole document 5 DATABASE GENESEQ Online 2 December 2004 2004 12 02 LILLII J ET AL Novel isolated polypeptide associated with breast cancer XP002518625 NE retrieved from EBI Database accession no ACN90758 the whole document US 2003 099974 A1 LILLIE JAMES LIS ET AL 29 May 2003 2003 05 29 the whole document x Further documents are listed in the continuation of Box C Ses patent family annex Special categories of cited documents T later document published after the international filing date szk or priority date and nat in conflict with the application but A document defining the general state of the art which ls not inci ered to be of particular rel clica to nena principle or theory underlying the E aarWar document but published on or after ihe international X document of p
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